Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 11504645)

Published in Bioorg Med Chem on August 01, 2001

Authors

R E Bremer1, N R Wurtz, J W Szewczyk, P B Dervan

Author Affiliations

1: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Articles by these authors

Sequence-specific cleavage of double helical DNA by triple helix formation. Science (1987) 9.20

Second structural motif for recognition of DNA by oligonucleotide-directed triple-helix formation. Science (1991) 5.40

Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses. Biochemistry (1984) 4.20

Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation. Science (1989) 3.88

Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II). Proc Natl Acad Sci U S A (1982) 3.81

Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature (1998) 3.77

Design of sequence-specific DNA-binding molecules. Science (1986) 3.50

Methidiumpropyl-EDTA.Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA. Nucleic Acids Res (1983) 3.18

Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II). Proc Natl Acad Sci U S A (1985) 2.54

Echinomycin binding sites on DNA. Science (1984) 2.44

Recognition of DNA by designed ligands at subnanomolar concentrations. Nature (1996) 2.32

Recognition of thymine adenine.base pairs by guanine in a pyrimidine triple helix motif. Science (1989) 2.28

Regulation of gene expression by small molecules. Nature (1997) 2.27

Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study. Proc Natl Acad Sci U S A (1990) 2.18

Kinetic analysis of oligodeoxyribonucleotide-directed triple-helix formation on DNA. Biochemistry (1990) 2.17

Sequence-specific recognition of double helical RNA and RNA.DNA by triple helix formation. Proc Natl Acad Sci U S A (1993) 2.07

A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science (1998) 2.05

Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with (methidiumpropyl-EDTA)iron(II). Biochemistry (1983) 2.00

Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes. Methods Enzymol (2001) 1.97

Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA X Fe(II). Proc Natl Acad Sci U S A (1983) 1.92

Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation. Nature (1991) 1.91

Site-specific cleavage of a yeast chromosome by oligonucleotide-directed triple-helix formation. Science (1990) 1.84

Molecular recognition of B-DNA by Hoechst 33258. Nucleic Acids Res (1985) 1.80

The influence of single base triplet changes on the stability of a pur.pur.pyr triple helix determined by affinity cleaving. Nucleic Acids Res (1992) 1.80

Synthesis of a sequence-specific DNA-cleaving peptide. Science (1987) 1.78

Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin. Proc Natl Acad Sci U S A (1992) 1.74

Structural basis for G.C recognition in the DNA minor groove. Nat Struct Biol (1998) 1.74

Cleavage of chromatin with methidiumpropyl-EDTA . iron(II). Proc Natl Acad Sci U S A (1983) 1.71

Adenine specific DNA chemical sequencing reaction. Nucleic Acids Res (1987) 1.69

Site-specific cleavage of human chromosome 4 mediated by triple-helix formation. Science (1991) 1.67

Influence of pH on the equilibrium association constants for oligodeoxyribonucleotide-directed triple helix formation at single DNA sites. Biochemistry (1992) 1.66

Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving. J Biomol Struct Dyn (1984) 1.66

Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system. Biochemistry (1992) 1.65

Flanking sequence effects within the pyrimidine triple-helix motif characterized by affinity cleaving. Biochemistry (1992) 1.62

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc Natl Acad Sci U S A (1998) 1.50

Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem (2002) 1.45

Activation of gene expression by small molecule transcription factors. Proc Natl Acad Sci U S A (2000) 1.40

Design of a G.C-specific DNA minor groove-binding peptide. Science (1994) 1.39

Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides. J Mol Biol (2001) 1.39

Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients. Am J Transplant (2008) 1.36

Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s. Proc Natl Acad Sci U S A (1985) 1.33

Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA. Proc Natl Acad Sci U S A (1987) 1.32

Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp. Curr Biol (1995) 1.32

On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem Biol (1997) 1.30

Targeting the minor groove of DNA. Curr Opin Struct Biol (1997) 1.25

Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving. Science (1990) 1.23

Chemical approaches to control gene expression. Gene Expr (2000) 1.18

Binding of a hairpin polyamide in the minor groove of DNA: sequence-specific enthalpic discrimination. Proc Natl Acad Sci U S A (1996) 1.18

Specific recognition of CG base pairs by 2-deoxynebularine within the purine.purine.pyrimidine triple-helix motif. Biochemistry (1993) 1.18

Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappaB, and DNA by a designed DNA-binding ligand. J Biol Chem (1999) 1.16

Equilibrium association constants for oligonucleotide-directed triple helix formation at single DNA sites: linkage to cation valence and concentration. Biochemistry (1993) 1.16

Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates. Chem Biol (2000) 1.16

Towards a minimal motif for artificial transcriptional activators. Chem Biol (2001) 1.12

Fmoc solid phase synthesis of polyamides containing pyrrole and imidazole amino acids. Org Lett (2001) 1.10

Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA. Biochemistry (1994) 1.10

Effects of the A.T/T.A degeneracy of pyrrole--imidazole polyamide recognition in the minor groove of DNA. Biochemistry (1996) 1.10

Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA. Biochemistry (1993) 1.09

Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif. Proc Natl Acad Sci U S A (1996) 1.08

Toward rules for 1:1 polyamide:DNA recognition. Proc Natl Acad Sci U S A (2001) 1.07

The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA. Biochemistry (1999) 1.07

Expanding the recognition of the minor groove of DNA by incorporation of beta-alanine in hairpin polyamides. Bioorg Med Chem (2001) 1.06

Visualization of RNA tertiary structure by RNA-EDTA.Fe(II) autocleavage: analysis of tRNA(Phe) with uridine-EDTA.Fe(II) at position 47. Proc Natl Acad Sci U S A (1994) 1.06

Targeting the ets binding site of the HER2/neu promoter with pyrrole-imidazole polyamides. J Biol Chem (2000) 1.05

Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase. Biochemistry (1990) 1.05

Phosphorothioate oligonucleotide-directed triple helix formation. Biochemistry (1994) 1.04

Nonenymatic ligation of double-helical DNA by alternate-strand triple helix formation. Nucleic Acids Res (1992) 1.04

Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. Biochemistry (1999) 1.04

Effects of an abasic site on triple helix formation characterized by affinity cleaving. Nucleic Acids Res (1991) 1.03

Footprinting with MPE.Fe(II). Complementary-strand analyses of distamycin- and actinomycin-binding sites on heterogeneous DNA. Cold Spring Harb Symp Quant Biol (1983) 1.03

The tax protein-DNA interaction is essential for HTLV-I transactivation in vitro. J Mol Biol (1999) 1.02

Cyclic polyamides for recognition in the minor groove of DNA. Proc Natl Acad Sci U S A (1995) 1.00

Characterization of protein-DNA complexes by affinity cleaving. Methods Enzymol (1991) 1.00

Extended hairpin polyamide motif for sequence-specific recognition in the minor groove of DNA. Chem Biol (1996) 0.98

Structure of a stereoregular phosphorothioate DNA/RNA duplex. Nat Struct Biol (1998) 0.97

Orientation of the Lac repressor DNA binding domain in complex with the left lac operator half site characterized by affinity cleaving. Nucleic Acids Res (1991) 0.97

Inhibition of Klenow fragment DNA polymerase on double-helical templates by oligonucleotide-directed triple-helix formation. Biochemistry (1994) 0.96

Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. J Mol Biol (2000) 0.96

Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates. J Am Chem Soc (2001) 0.95

Extending the recognition site of designed minor groove binding molecules. Nat Struct Biol (1996) 0.95

Sequence-specific alkylation and cleavage of DNA mediated by purine motif triple helix formation. Biochemistry (1996) 0.94

Kinetic consequences of covalent linkage of DNA binding polyamides. Biochemistry (2001) 0.94

Mapping RNA regions in eukaryotic ribosomes that are accessible to methidiumpropyl-EDTA.Fe(II) and EDTA.Fe(II). Biochemistry (1994) 0.94

Structural motif of the DNA binding domain of gamma delta-resolvase characterized by affinity cleaving. J Biol Chem (1990) 0.93

Single-strand DNA triple-helix formation. Biochemistry (1990) 0.92

Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site. Biochemistry (1990) 0.91

Sequence-specific oxidative cleavage of DNA by a designed metalloprotein, Ni(II).GGH(Hin139-190). Biochemistry (1992) 0.90

Oligonucleotide-directed DNA triple-helix formation: an approach to artificial repressors? Antisense Res Dev (1991) 0.90

Solution structure of an intramolecular DNA triplex containing an N7-glycosylated guanine which mimics a protonated cytosine. Biochemistry (1997) 0.88

Triple helix-mediated single-site enzymatic cleavage of megabase genomic DNA. Methods Enzymol (1992) 0.88

Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch. Chem Biol (1998) 0.88

Kinetic analysis of sequence-specific alkylation of DNA by pyrimidine oligodeoxyribonucleotide-directed triple-helix formation. Bioconjug Chem (1997) 0.87

Evidence that a minor groove-binding peptide and a major groove-binding protein can simultaneously occupy a common site on DNA. Biochemistry (1992) 0.87

Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex. J Mol Biol (1997) 0.87

Design of artificial sequence-specific DNA bending ligands. Proc Natl Acad Sci U S A (1996) 0.86

RecA.oligonucleotide filaments bind in the minor groove of double-stranded DNA. Proc Natl Acad Sci U S A (1995) 0.84

Solution structure of a pyrimidine-purine-pyrimidine triplex containing the sequence-specific intercalating non-natural base D3. J Mol Biol (1996) 0.84

Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand. J Mol Biol (1999) 0.84