Published in Biol Chem on May 01, 2001
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev (2006) 2.74
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu Rev Pharmacol Toxicol (2008) 1.82
Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets. J Immunol (2009) 1.27
Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells. J Proteome Res (2009) 1.13
Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges. Protoplasma (2014) 1.12
Endolysosomal proteases and their inhibitors in immunity. Nat Rev Immunol (2009) 1.10
Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression. J Biol Chem (2008) 1.10
Cathepsin K is the principal protease in giant cell tumor of bone. Am J Pathol (2004) 1.10
Stefin B interacts with histones and cathepsin L in the nucleus. J Biol Chem (2010) 1.04
Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem (2008) 1.03
Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartment. J Virol (2012) 1.00
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol (2008) 1.00
Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases. Pharmacol Ther (2011) 0.98
Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research. Antiviral Res (2013) 0.98
Structural basis for the recognition and cleavage of histone H3 by cathepsin L. Nat Commun (2011) 0.95
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol (2009) 0.93
Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides (2009) 0.91
Nuclear cysteine cathepsin variants in thyroid carcinoma cells. Biol Chem (2010) 0.88
The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families. Biochem J (2007) 0.88
The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury. J Neurotrauma (2014) 0.87
Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog (2011) 0.86
Cysteine Protease Cathepsins in Atherosclerosis and Abdominal Aortic Aneurysm. Clin Rev Bone Miner Metab (2011) 0.86
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology (2010) 0.85
Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. J Alzheimers Dis (2014) 0.83
Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis. World J Gastroenterol (2004) 0.83
Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma. Onco Targets Ther (2014) 0.82
Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis. J Immunol (2012) 0.82
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. Front Neurol (2015) 0.79
Targeting Cathepsin B for Cancer Therapies. Horiz Cancer Res (2015) 0.78
The C-terminal subunit of artificially truncated human cathepsin B mediates its nuclear targeting and contributes to cell viability. BMC Cell Biol (2005) 0.78
The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk. Curr Protein Pept Sci (2012) 0.77
Detection of DSS-induced gastrointestinal mucositis in mice by non-invasive optical near-infrared (NIR) imaging of cathepsin activity. Cancer Biol Ther (2013) 0.77
Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol (2015) 0.75
Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases. PLoS One (2016) 0.75
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (1998) 3.98
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest (2000) 3.58
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest (2000) 3.47
Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood (2001) 2.99
Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99
The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A (1994) 2.79
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci U S A (1998) 2.75
A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci U S A (1994) 2.51
Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. Lancet (1996) 2.45
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci (2000) 2.21
The overactive bladder in childhood: long-term results with conservative management. J Urol (2000) 2.14
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J (2000) 2.09
Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant (2009) 2.00
Long-term effect of bone-marrow transplantation for childhood-onset cerebral X-linked adrenoleukodystrophy. Lancet (2000) 1.98
The EBMT activity survey: 1990-2010. Bone Marrow Transplant (2012) 1.96
Defibrotide in the treatment of children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention. Bone Marrow Transplant (2004) 1.84
Wolman disease successfully treated by bone marrow transplantation. Bone Marrow Transplant (2000) 1.75
The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a beta turn. Cell (1991) 1.72
Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins. Oncogene (2008) 1.67
Bone marrow transplantation for globoid cell leukodystrophy, adrenoleukodystrophy, metachromatic leukodystrophy, and Hurler syndrome. Curr Opin Hematol (1999) 1.59
The cytoplasmic tail of lysosomal acid phosphatase contains overlapping but distinct signals for basolateral sorting and rapid internalization in polarized MDCK cells. EMBO J (1993) 1.57
Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J (1999) 1.56
Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases. Exp Hematol (1999) 1.55
Proteases involved in MHC class II antigen presentation. Immunol Rev (1999) 1.54
Atmospheric detection of water dimers via near-infrared absorption. Science (2003) 1.52
Functional expression of human cathepsin S in Saccharomyces cerevisiae. Purification and characterization of the recombinant enzyme. J Biol Chem (1993) 1.49
Allogeneic bone marrow stem cell transplantation following CD34+ immunomagnetic enrichment in patients with inherited metabolic storage diseases. Bone Marrow Transplant (2003) 1.47
Hematopoietic stem-cell transplantation in globoid-cell leukodystrophy. N Engl J Med (1998) 1.47
Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant (2011) 1.46
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy. Proc Natl Acad Sci U S A (1996) 1.44
A review of the clinical pharmacokinetics of meloxicam. Br J Rheumatol (1996) 1.43
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene (2008) 1.40
Administration of recombinant human granulocyte-macrophage colony-stimulating factor to children undergoing allogeneic marrow transplantation: a prospective, randomized, double-masked, placebo-controlled trial. Pediatr Transplant (2000) 1.39
The first reported outbreak of diarrheal illness associated with Cyclospora in the United States. Ann Intern Med (1995) 1.38
Focus control system for laser welding. Appl Opt (1997) 1.37
Hematopoietic SCT in Europe: data and trends in 2011. Bone Marrow Transplant (2013) 1.34
Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes. Am J Hum Genet (1994) 1.33
Correction of human mucopolysaccharidosis type-VI fibroblasts with recombinant N-acetylgalactosamine-4-sulphatase. Biochem J (1992) 1.32
Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO J (1993) 1.31
A multi-institutional analysis of laparoscopic orchidopexy. BJU Int (2001) 1.30
A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod (2004) 1.28
International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics (2005) 1.27
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J Exp Med (1997) 1.25
Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation. Leukemia (2010) 1.25
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene (1998) 1.22
Pharmacokinetics of meloxicam in animals and the relevance to humans. Drug Metab Dispos (1998) 1.20
Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest (1990) 1.20
Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene (2010) 1.19
Subcutaneous sumatriptan in the treatment of headache during withdrawal from drug-induced headache. Headache (1991) 1.18
Randomized phase III study of granulocyte transfusions in neutropenic patients. Bone Marrow Transplant (2008) 1.18
Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis. Immunol Rev (1997) 1.16
Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). An intermediate clinical phenotype caused by substitution of valine for glycine at position 137 of arylsulfatase B. J Biol Chem (1991) 1.13
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J Neurosci (2001) 1.10
Pharmacokinetics of orally and intravenously administered telmisartan in healthy young and elderly volunteers and in hypertensive patients. J Int Med Res (2001) 1.10
Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI. Proc Natl Acad Sci U S A (1996) 1.10
Ceramide as an activator lipid of cathepsin D. Adv Exp Med Biol (2000) 1.08
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV. EMBO J (1992) 1.08
Myeloablative radiochemotherapy and hematopoietic stem-cell rescue in poor-prognosis Ewing's sarcoma. J Clin Oncol (1993) 1.07
Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol (1986) 1.06
Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases working party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant (2007) 1.05
Infrequent mutation of the WT1 gene in 77 Wilms' Tumors. Hum Mutat (1994) 1.05
Impact of megatherapy in children with high-risk Ewing's tumours in complete remission: a report from the EBMT Solid Tumour Registry. Bone Marrow Transplant (1995) 1.04
Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1. Oncogene (2012) 1.03
The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway. Oncogene (2007) 1.03
HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression. J Clin Invest (1996) 1.02
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. J Biol Chem (1996) 1.02
Short report: gastric infection by Strongyloides stercoralis. Am J Trop Med Hyg (1994) 1.01
Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS-VI patients. Am J Hum Genet (1996) 1.00
Globoid cell leukodystrophy: distinguishing early-onset from late-onset disease using a brain MR imaging scoring method. AJNR Am J Neuroradiol (1999) 1.00
Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report of the German/Austrian Pediatric Bone Marrow Transplantation Group. Bone Marrow Transplant (1997) 1.00
Pre-emptive treatment of CMV DNAemia in paediatric stem cell transplantation: the impact of recipient and donor CMV serostatus on the incidence of CMV disease and CMV-related mortality. Bone Marrow Transplant (2003) 1.00
Erythropoietin pharmacokinetics in premature infants: developmental, nonlinearity, and treatment effects. J Appl Physiol (1985) (1996) 1.00
Juvenile form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). A C-terminal extension causes instability but increases catalytic efficiency of arylsulfatase B. J Biol Chem (1994) 0.99
Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. J Biol Chem (1997) 0.99
Field investigations of an outbreak of Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: arthropod studies. J Infect Dis (1999) 0.98
Long-term results of local recurrence after breast conservation treatment for invasive breast cancer. Int J Radiat Oncol Biol Phys (2001) 0.98
Functional characterisation of decoy receptor 3 in Crohn's disease. Gut (2008) 0.98
Pre-transplant risk factors affecting outcome in Hurler syndrome. Bone Marrow Transplant (2009) 0.97
Expression of oestrogen receptor β and prognosis of colorectal cancer. Br J Cancer (2012) 0.97
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis. Oncogene (2009) 0.97
Rapid discrimination of early CD34+ myeloid progenitors using CD45-RA analysis. Blood (1993) 0.96
Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. J Biol Chem (1992) 0.96
Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood. J Clin Oncol (1997) 0.96