The mitotic roles of Polo-like kinase.

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J (2003) 2.31

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Mol Cell Biol (2003) 1.83

Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol Cell Biol (2002) 1.44

Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Br J Cancer (2004) 1.39

Functional dynamics of Polo-like kinase 1 at the centrosome. Mol Cell Biol (2009) 1.21

Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications. Virchows Arch (2005) 1.13

MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes. Nucleic Acids Res (2012) 1.11

SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. Neoplasia (2005) 1.08

The mammalian centrosome and its functional significance. Histochem Cell Biol (2008) 1.01

Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. J Clin Invest (2010) 0.88

Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex. J Biol Chem (2010) 0.86

BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression. J Biol Chem (2009) 0.85

High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome. Gynecol Oncol (2012) 0.84

In vitro gene regulatory networks predict in vivo function of liver. BMC Syst Biol (2010) 0.84

Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer. Cancer Res (2014) 0.83

Cell cycle trials in Salamanca: workshop on G2/M progression and associated checkpoints. EMBO Rep (2002) 0.83

Sequential Cdk1 and Plk1 phosphorylation of protein tyrosine phosphatase 1B promotes mitotic cell death. Cell Death Dis (2013) 0.82

Identification of potential Plk1 targets in a cell-cycle specific proteome through structural dynamics of kinase and Polo box-mediated interactions. PLoS One (2013) 0.81

MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules. Invest New Drugs (2009) 0.81

Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression. J Biol Chem (2011) 0.78

Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. Mol Biol Cell (2009) 0.78

Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with advanced solid tumors. Invest New Drugs (2015) 0.78

An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function for centrosomin (cnn) in Drosophila. Genetics (2015) 0.78

Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1. PLoS One (2014) 0.77

Transcriptome analysis reveals potential mechanisms underlying differential heart development in fast- and slow-growing broilers under heat stress. BMC Genomics (2017) 0.75

Dissecting protein interactions during cytokinesis. Commun Integr Biol (2011) 0.75

Increased Expression of Phosphorylated Polo-Like Kinase 1 and Histone in Bypass Vein Graft and Coronary Arteries following Angioplasty. PLoS One (2016) 0.75

Characterization of six cloned DNAs from Drosophila melanogaster, including one that contains the genes for rRNA. Cell (1975) 15.07

Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell (1989) 7.21

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell (1995) 5.68

Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol (2001) 5.34

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J Cell Biol (1996) 5.17

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci (1988) 4.77

Intestinal Obstruction in the Newborn. Ann Surg (1949) 4.61

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell (1990) 4.57

SAK/PLK4 is required for centriole duplication and flagella development. Curr Biol (2005) 4.52

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. J Cell Biol (1995) 4.26

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J (1991) 4.24

A novel arrangement of the 18S and 28S sequences in a repeating unit of Drosophila melanogaster rDNA. Cell (1977) 3.99

pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev (1998) 3.88

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell (1994) 3.86

polo encodes a protein kinase homolog required for mitosis in Drosophila. Genes Dev (1991) 3.81

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol (1999) 3.74

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol (1998) 3.72

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells. J Cell Biol (1992) 3.57

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev (1995) 3.52

Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol (2000) 3.49

Genome-wide survey of protein kinases required for cell cycle progression. Nature (2004) 3.40

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Cell (1996) 3.39

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J (1991) 3.23

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J (1998) 3.04

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J Cell Sci (1994) 3.00

The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition. EMBO J (1990) 2.99

Polo-like kinases: a team that plays throughout mitosis. Genes Dev (1998) 2.95

One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis. Cell (1990) 2.91

Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form. J Cell Biol (1997) 2.80

Revisiting the role of the mother centriole in centriole biogenesis. Science (2007) 2.59

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. Curr Biol (1995) 2.57

Nuclear export of proteins: the role of nuclear retention. Cell (1993) 2.51

Arrangements and rearrangements of sequences flanking the two types of rDNA insertion in D. melanogaster. Nature (1981) 2.50

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J (1998) 2.48

Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase. Cell (1990) 2.47

Vectors for the expression of tagged proteins in Schizosaccharomyces pombe. Gene (1998) 2.47

PCR amplification of DNA microdissected from a single polytene chromosome band: a comparison with conventional microcloning. Nucleic Acids Res (1989) 2.43

A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Cell (1995) 2.41

Drosophila polo kinase is required for cytokinesis. J Cell Biol (1998) 2.30

Growth polarity and cytokinesis in fission yeast: the role of the cytoskeleton. J Cell Sci Suppl (1986) 2.29

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell (1993) 2.26

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers. Science (1999) 2.23

Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes. Cell (1985) 2.18

Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. Proc Natl Acad Sci U S A (1982) 2.18

On the regulation and function of human polo-like kinase 1 (PLK1): effects of overexpression on cell cycle progression. Biochem Biophys Res Commun (1997) 2.17

P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. Genetics (1997) 2.14

Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150. J Biol Chem (1997) 2.13

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res (2013) 2.12

The role of isoprenylation in membrane attachment of nuclear lamins. A single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties. J Cell Sci (1994) 2.10

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). J Cell Biol (1994) 2.08

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. J Cell Biol (2000) 2.07

mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila. J Cell Biol (1999) 2.06

A cyclin associated with the CDK-activating kinase MO15. Nature (1994) 2.05

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus. EMBO J (1985) 2.02

The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein. Cell (1983) 2.02

The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle. J Cell Biol (1997) 1.98

Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif. EMBO J (1989) 1.96

Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. Curr Biol (2001) 1.90

On the nature of crossreactions observed with antibodies directed to defined epitopes. Proc Natl Acad Sci U S A (1982) 1.89

Transcription of the 'non-transcribed' spacer of Drosophila melanogaster rDNA. Nucleic Acids Res (1983) 1.88

Towards a physical map of the Drosophila melanogaster genome: mapping of cosmid clones within defined genomic divisions. Nucleic Acids Res (1990) 1.87

Protein localization to the nucleolus: a search for targeting domains in nucleolin. J Cell Sci (1993) 1.86

The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis. J Cell Sci (1995) 1.85

Cloning of a gene encoding an antigen associated with the centrosome in Drosophila. J Cell Sci (1988) 1.84

Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J Cell Sci (2001) 1.84

Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin. J Cell Biol (1988) 1.84

The nuclear lamin protein family in higher vertebrates. Identification of quantitatively minor lamin proteins by monoclonal antibodies. J Biol Chem (1986) 1.83

Structure and developmental expression of the chicken CDC2 kinase. EMBO J (1989) 1.80

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. J Cell Sci (1994) 1.79

twine, a cdc25 homolog that functions in the male and female germline of Drosophila. Cell (1992) 1.77

FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation. J Cell Biol (1998) 1.77

Casein kinase II is a predominantly nuclear enzyme. J Cell Biol (1992) 1.76

A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos. Nature (1993) 1.76

MAT1 ('menage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK. EMBO J (1995) 1.74

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol Cell Biol (2001) 1.74

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc Natl Acad Sci U S A (1995) 1.73

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes. Chromosoma (1998) 1.73

Drosophila melanogaster ribosomal DNA containing type II insertions is variably transcribed in different strains and tissues. J Mol Biol (1981) 1.72

The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation. J Cell Sci (2001) 1.71

Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. FASEB J (1991) 1.71

The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control. Genes Dev (1998) 1.70

Differential expression of nuclear lamin proteins during chicken development. J Cell Biol (1987) 1.70

Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster. J Cell Biol (2000) 1.66

In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J (1995) 1.66

The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2. J Cell Biol (1991) 1.65

The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila. Cell (1986) 1.65

Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. EMBO J (1999) 1.65

From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Genome Res (2001) 1.64

Differential replication of ribosomal gene repeats in polytene nuclei of Drosophila. Cell (1979) 1.64

Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string. EMBO J (1990) 1.64

Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis. Nature (1989) 1.63

Anchorage of a band 3 population at the erythrocyte cytoplasmic membrane surface: protein rotational diffusion measurements. Proc Natl Acad Sci U S A (1980) 1.62

Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. J Biol Chem (1995) 1.61

P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics (1997) 1.60

Metaphase arrest with centromere separation in polo mutants of Drosophila. J Cell Biol (2001) 1.60

A DNA segment from D. melanogaster which contains five tandemly repeating units homologous to the major rDNA insertion. Cell (1980) 1.59