Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors.

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Published in Proc Natl Acad Sci U S A on September 18, 2001

Authors

J P Medema1, J de Jong, L T Peltenburg, E M Verdegaal, A Gorter, S A Bres, K L Franken, M Hahne, J P Albar, C J Melief, R Offringa

Author Affiliations

1: Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands. medema@mail.medfac.leidenuniv.nl

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