Transcriptional transactivation by selected short random peptides attached to lexA-GFP fusion proteins.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 56998)

Published in BMC Mol Biol on August 31, 2001

Authors

M Abedi1, G Caponigro, J Shen, S Hansen, T Sandrock, A Kamb

Author Affiliations

1: Arcaris Inc (current name: Deltagen Proteomics, Inc), 615 Arapeen Drive Suite 300, Salt Lake City, UT 84108, USA. abedi@arcaris.com

Articles citing this

Nucleosome distortion as a possible mechanism of transcription activation domain function. Epigenetics Chromatin (2016) 0.76

Articles cited by this

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature (2000) 47.15

A novel genetic system to detect protein-protein interactions. Nature (1989) 43.83

A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene (1987) 25.43

Deletion analysis of GAL4 defines two transcriptional activating segments. Cell (1987) 14.13

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell (1986) 11.42

Transcriptional activation by recruitment. Nature (1997) 10.44

A new class of yeast transcriptional activators. Cell (1987) 9.53

The protein-protein interaction map of Helicobacter pylori. Nature (2001) 8.71

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc Natl Acad Sci U S A (1996) 4.70

Mutants of GAL4 protein altered in an activation function. Cell (1987) 4.44

A three-hybrid system to detect RNA-protein interactions in vivo. Proc Natl Acad Sci U S A (1996) 4.44

Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science (1994) 3.92

Cooperative DNA binding of the yeast transcriptional activator GAL4. Proc Natl Acad Sci U S A (1988) 3.72

Structure and function of transcriptional activation domains. Curr Opin Genet Dev (1995) 2.94

Contact with a component of the polymerase II holoenzyme suffices for gene activation. Cell (1995) 2.85

Quantitation of putative activator-target affinities predicts transcriptional activating potentials. EMBO J (1996) 2.34

Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen. Nat Biotechnol (1998) 1.92

Gene activation by recruitment of the RNA polymerase II holoenzyme. Genes Dev (1996) 1.90

Green fluorescent protein as a scaffold for intracellular presentation of peptides. Nucleic Acids Res (1998) 1.67

Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module. Mol Cell Biol (1994) 1.58

Solution structure of the LexA repressor DNA binding domain determined by 1H NMR spectroscopy. EMBO J (1994) 1.41

Activation of gene expression by small molecule transcription factors. Proc Natl Acad Sci U S A (2000) 1.40

Mechanisms of transcriptional activation: differences and similarities between yeast, Drosophila, and man. Curr Opin Genet Dev (1997) 1.35

Protein-peptide interactions analyzed with the yeast two-hybrid system. Nucleic Acids Res (1995) 1.31

Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells. Proc Natl Acad Sci U S A (1990) 1.24

Towards a minimal motif for artificial transcriptional activators. Chem Biol (2001) 1.12

Development of high throughput screening assays using fluorescence polarization: nuclear receptor-ligand-binding and kinase/phosphatase assays. J Biomol Screen (2000) 1.07

An artificial transcriptional activating region with unusual properties. Proc Natl Acad Sci U S A (2000) 1.07

The impact of two-hybrid and related methods on biotechnology. Trends Biotechnol (1998) 1.02

Peptide inhibitors expressed in vivo. Curr Opin Chem Biol (2001) 0.81

Expression levels of transdominant peptides and proteins in Saccharomyces cerevisiae. Yeast (2002) 0.79

Articles by these authors

Helicobacter pylori infection and gastric lymphoma. N Engl J Med (1994) 10.26

Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol Cell Biol (2000) 9.92

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature (1996) 9.77

Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med (1999) 8.32

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell (2000) 7.87

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell (1995) 7.73

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation (2000) 7.50

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet (1996) 7.35

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat Genet (1996) 6.43

An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature (1996) 6.15

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem (2000) 4.37

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev (1999) 3.88

A second serine protease associated with mannan-binding lectin that activates complement. Nature (1997) 3.64

Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. J Am Acad Dermatol (1999) 3.19

Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel. Cell (1987) 3.16

Susceptible chiasmate configurations of chromosome 21 predispose to non-disjunction in both maternal meiosis I and meiosis II. Nat Genet (1996) 3.13

Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation (2000) 2.95

Sagittal alignment in lumbosacral fusion: relations between radiological parameters and pain. Eur Spine J (2000) 2.87

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. Genes Dev (1993) 2.82

Are chronic psychiatric patients at increased risk for developing breast cancer? Am J Psychiatry (1996) 2.78

Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther (2007) 2.61

Genome-wide identification of NBS genes in japonica rice reveals significant expansion of divergent non-TIR NBS-LRR genes. Mol Genet Genomics (2004) 2.56

Porous hollow carbon@sulfur composites for high-power lithium-sulfur batteries. Angew Chem Int Ed Engl (2011) 2.50

Relationship between colonial morphology and adherence of Streptococcus pneumoniae. Infect Immun (1995) 2.50

Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics (1996) 2.44

Human aneuploidy: incidence, origin, and etiology. Environ Mol Mutagen (1996) 2.38

TLR engagement prevents transplantation tolerance. Am J Transplant (2006) 2.36

Roles for Fgf signaling during zebrafish fin regeneration. Dev Biol (2000) 2.36

The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. J Med Genet (2004) 2.33

Essential role for Gab2 in the allergic response. Nature (2001) 2.32

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron (2001) 2.31

Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum Mol Genet (1995) 2.30

Presenilin-mediated modulation of capacitative calcium entry. Neuron (2000) 2.25

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A (1999) 2.20

A new method for the estimation of the number of motor units in a muscle. I. Control subjects and patients with myasthenia gravis. J Neurol Neurosurg Psychiatry (1974) 2.14

The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res (2001) 2.14

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds. Nat Genet (1995) 2.11

Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. Ann Oncol (2003) 2.08

Is age an independent predictor of early and late mortality in patients with acute myocardial infarction? Am J Med (1992) 2.08

High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature (1989) 2.07

Huntington's chorea. Deficiency of gamma-aminobutyric acid in brain. N Engl J Med (1973) 2.06

Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene (2001) 2.05

Electrophysiological studies in the post-viral fatigue syndrome. J Neurol Neurosurg Psychiatry (1985) 2.05

A clinical neurological, neurophysiological, and neuropsychological study of sheep farmers and dippers exposed to organophosphate pesticides. Occup Environ Med (2002) 2.04

An epidemiological study of the relations between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy and neuropsychological abnormalities in sheep farmers and dippers. Occup Environ Med (2001) 2.03

Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database Syst Rev (2006) 2.03

Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1999) 2.02

Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp Neurol (1997) 1.98

Breast cancer risk by age at birth, time since birth and time intervals between births: exploring interaction effects. Br J Cancer (2005) 1.94

Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1. Genomics (1998) 1.93

Presenilin-1 regulates neuronal differentiation during neurogenesis. Development (2000) 1.90

Treatment of homocystinuria with a low-methionine diet, supplemental cystine, and a methyl donor. Lancet (1968) 1.90

Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci Lett (1982) 1.89

Complex structure and regulation of the P16 (MTS1) locus. Cancer Res (1995) 1.87

A precision measurement of the mass of the top quark. Nature (2004) 1.87

An improved automated method for the measurement of thermal thresholds. 1. Normal subjects. J Neurol Neurosurg Psychiatry (1985) 1.82

Urinary screening tests in the prevention of mental deficiency. Can Med Assoc J (1966) 1.81

Characterisation of breathing and associated central autonomic dysfunction in the Rett disorder. Arch Dis Child (2001) 1.80

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci U S A (2001) 1.80

Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid. Ann Neurol (1990) 1.80

Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem (2000) 1.77

Impact of cabazitaxel on 2-year survival and palliation of tumour-related pain in men with metastatic castration-resistant prostate cancer treated in the TROPIC trial. Ann Oncol (2013) 1.76

Low incidence of BRCA2 mutations in breast carcinoma and other cancers. Nat Genet (1996) 1.74

Intrachromosomal gene mapping in man: assignment of nucleoside phosphorylase to region 14cen leads to 14q21 by interspecific hybridization of cells with a t(X;14) (p22;q21) translocation. Somatic Cell Genet (1976) 1.68

Green fluorescent protein as a scaffold for intracellular presentation of peptides. Nucleic Acids Res (1998) 1.67

Multistability of cognitive maps in the hippocampus of old rats. Nature (1997) 1.65

Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain. Nucleic Acids Res (1983) 1.65

A systematic approach to assessing the clinical significance of genetic variants. Clin Genet (2013) 1.63

Technical pitfalls leading to errors in the quantitation of plasma amino acids. Clin Chim Acta (1969) 1.62

Cbfa1 as a regulator of osteoblast differentiation and function. Bone (1999) 1.58

Stress failure plays a major role in the development of high-altitude pulmonary oedema in rats. Eur Respir J (2009) 1.57

Characterization of susceptible chiasma configurations that increase the risk for maternal nondisjunction of chromosome 21. Hum Mol Genet (1997) 1.57

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry (1998) 1.57

Influence of the terminal complement-complex on reperfusion injury, no-reflow and arrhythmias: a comparison between C6-competent and C6-deficient rabbits. Cardiovasc Res (1996) 1.55

In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during. J Neurochem (2001) 1.55

Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis. Oncogene (2011) 1.54

Bacterial contamination associated with electronic faucets: a new risk for healthcare facilities. Infect Control Hosp Epidemiol (2001) 1.51

Hodgkin's disease: the protective effect of childbearing. Int J Cancer (1993) 1.51

Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma. Oncogene (2011) 1.50

Public reporting of healthcare-associated infection data in Europe. What are the views of infection prevention opinion leaders? J Hosp Infect (2012) 1.49

Induction of lef1 during zebrafish fin regeneration. Dev Dyn (2000) 1.48

Development and characterization of human constitutive proteasome and immunoproteasome subunit-specific monoclonal antibodies. Tissue Antigens (2005) 1.45

Computer method for the analysis of evoked motor unit potentials. I. Control subjects and patients with myasthenia gravis. J Neurol Neurosurg Psychiatry (1974) 1.45

Efficient, automatic detection of heterozygous bases during large-scale DNA sequence screening. Biotechniques (1995) 1.44

Flow cytometry and cell sorting for yeast viability assessment and cell selection. Yeast (1998) 1.44

Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells. Proc Natl Acad Sci U S A (1987) 1.44

Size-dependent positioning of human chromosomes in interphase nuclei. Biophys J (2000) 1.43

Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene (2006) 1.40

Amyotrophic lateral sclerosis: fasting plasma levels of cysteine and inorganic sulfate are normal, as are brain contents of cysteine. Neurology (1991) 1.40

Association between the mammalian 110,000-dalton heat-shock protein and nucleoli. J Cell Biol (1983) 1.40

The Nudix hydrolases of Deinococcus radiodurans. Mol Microbiol (2001) 1.38

Free entropy and property T factors. Proc Natl Acad Sci U S A (2000) 1.38

An improved automated method for the measurement of thermal thresholds. 2. Patients with peripheral neuropathy. J Neurol Neurosurg Psychiatry (1985) 1.37

A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1. Hum Mol Genet (1994) 1.34

Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. J Biol Chem (1999) 1.33

In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philos Trans R Soc Lond B Biol Sci (1999) 1.32

Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett (2000) 1.31

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. Biochemistry (2001) 1.30

The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition. J Neurol Neurosurg Psychiatry (2005) 1.30