Published in Nature on January 11, 2001
The primary transcriptome of the major human pathogen Helicobacter pylori. Nature (2010) 7.70
Conserved patterns of protein interaction in multiple species. Proc Natl Acad Sci U S A (2005) 7.48
Protein networks in disease. Genome Res (2008) 5.65
A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol (2005) 5.43
Systematic interpretation of genetic interactions using protein networks. Nat Biotechnol (2005) 5.38
Annotation transfer between genomes: protein-protein interologs and protein-DNA regulogs. Genome Res (2004) 5.26
Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Genome Res (2001) 5.10
Conserved pathways within bacteria and yeast as revealed by global protein network alignment. Proc Natl Acad Sci U S A (2003) 4.68
Inferring domain-domain interactions from protein-protein interactions. Genome Res (2002) 4.36
Protein interaction mapping: a Drosophila case study. Genome Res (2005) 4.15
The Gaggle: an open-source software system for integrating bioinformatics software and data sources. BMC Bioinformatics (2006) 4.05
Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network. Genome Biol (2003) 3.80
HomoMINT: an inferred human network based on orthology mapping of protein interactions discovered in model organisms. BMC Bioinformatics (2005) 3.75
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J (2002) 3.53
Predictome: a database of putative functional links between proteins. Nucleic Acids Res (2002) 3.32
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol (2006) 3.23
PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Res (2004) 3.20
Protein interaction data curation: the International Molecular Exchange (IMEx) consortium. Nat Methods (2012) 3.17
No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly. BMC Evol Biol (2003) 3.07
Functional proteomics mapping of a human signaling pathway. Genome Res (2004) 3.04
Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol (2009) 3.03
How the global structure of protein interaction networks evolves. Proc Biol Sci (2003) 2.96
A Drosophila protein-interaction map centered on cell-cycle regulators. Genome Biol (2004) 2.95
Topological structure analysis of the protein-protein interaction network in budding yeast. Nucleic Acids Res (2003) 2.90
Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networks. BMC Bioinformatics (2006) 2.57
The structural biology of type IV secretion systems. Nat Rev Microbiol (2009) 2.54
A simple dependence between protein evolution rate and the number of protein-protein interactions. BMC Evol Biol (2003) 2.38
VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion. EMBO J (2003) 2.23
Can bibliographic pointers for known biological data be found automatically? Protein interactions as a case study. Comp Funct Genomics (2001) 2.21
3did: interacting protein domains of known three-dimensional structure. Nucleic Acids Res (2005) 2.18
Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR). Nat Methods (2006) 2.15
A proteome-wide protein interaction map for Campylobacter jejuni. Genome Biol (2007) 2.13
Evolution of biomolecular networks: lessons from metabolic and protein interactions. Nat Rev Mol Cell Biol (2009) 2.09
SCOPPI: a structural classification of protein-protein interfaces. Nucleic Acids Res (2006) 2.06
Structure and evolution of protein interaction networks: a statistical model for link dynamics and gene duplications. BMC Evol Biol (2004) 2.01
Filtering high-throughput protein-protein interaction data using a combination of genomic features. BMC Bioinformatics (2005) 1.96
Recognizing the pseudogenes in bacterial genomes. Nucleic Acids Res (2005) 1.96
An expanded view of bacterial DNA replication. Proc Natl Acad Sci U S A (2002) 1.95
Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proc Natl Acad Sci U S A (2006) 1.95
Prediction of yeast protein-protein interaction network: insights from the Gene Ontology and annotations. Nucleic Acids Res (2006) 1.93
A large-scale protein protein interaction analysis in Synechocystis sp. PCC6803. DNA Res (2007) 1.93
Toward the dynamic interactome: it's about time. Brief Bioinform (2010) 1.91
Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 1.90
Apparent dependence of protein evolutionary rate on number of interactions is linked to biases in protein-protein interactions data sets. BMC Evol Biol (2003) 1.90
Model criticism based on likelihood-free inference, with an application to protein network evolution. Proc Natl Acad Sci U S A (2009) 1.89
A dual mechanism controlling the localization and function of exocytic v-SNAREs. Proc Natl Acad Sci U S A (2003) 1.86
Where have all the interactions gone? Estimating the coverage of two-hybrid protein interaction maps. PLoS Comput Biol (2007) 1.81
A simple physical model for scaling in protein-protein interaction networks. Proc Natl Acad Sci U S A (2005) 1.78
Large-scale analysis of the meningococcus genome by gene disruption: resistance to complement-mediated lysis. Genome Res (2003) 1.78
Unraveling protein networks with power graph analysis. PLoS Comput Biol (2008) 1.77
The Plasmodium protein network diverges from those of other eukaryotes. Nature (2005) 1.76
The tomato MADS-box transcription factor RIPENING INHIBITOR interacts with promoters involved in numerous ripening processes in a COLORLESS NONRIPENING-dependent manner. Plant Physiol (2011) 1.75
Systems level insights into the stress response to UV radiation in the halophilic archaeon Halobacterium NRC-1. Genome Res (2004) 1.74
Networking proteins in yeast. Proc Natl Acad Sci U S A (2001) 1.70
Proteome analysis of secreted proteins of the gastric pathogen Helicobacter pylori. Infect Immun (2002) 1.70
hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer (2003) 1.65
Role for erbin in bacterial activation of Nod2. Infect Immun (2006) 1.63
A revised annotation and comparative analysis of Helicobacter pylori genomes. Nucleic Acids Res (2003) 1.59
The binary protein interactome of Treponema pallidum--the syphilis spirochete. PLoS One (2008) 1.59
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci (2009) 1.58
The society of genes: networks of functional links between genes from comparative genomics. Genome Biol (2002) 1.55
DOMINE: a database of protein domain interactions. Nucleic Acids Res (2007) 1.54
An integrated approach to the prediction of domain-domain interactions. BMC Bioinformatics (2006) 1.52
Interplay of metal ions and urease. Metallomics (2009) 1.48
Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment. BMC Bioinformatics (2007) 1.47
Characterization of Helicobacter pylori nickel metabolism accessory proteins needed for maturation of both urease and hydrogenase. J Bacteriol (2003) 1.46
The protein network of bacterial motility. Mol Syst Biol (2007) 1.45
Stable evolutionary signal in a yeast protein interaction network. BMC Evol Biol (2006) 1.45
Molecular biologist's guide to proteomics. Microbiol Mol Biol Rev (2002) 1.45
Protein subassemblies of the Helicobacter pylori Cag type IV secretion system revealed by localization and interaction studies. J Bacteriol (2008) 1.38
Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. Proc Natl Acad Sci U S A (2008) 1.37
Coevolution of an aminoacyl-tRNA synthetase with its tRNA substrates. Proc Natl Acad Sci U S A (2003) 1.36
Upstream plasticity and downstream robustness in evolution of molecular networks. BMC Evol Biol (2004) 1.36
A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet (2009) 1.29
A rice kinase-protein interaction map. Plant Physiol (2008) 1.28
iPfam: a database of protein family and domain interactions found in the Protein Data Bank. Nucleic Acids Res (2013) 1.26
Cost-effective strategies for completing the interactome. Nat Methods (2008) 1.25
Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1. Genome Biol (2004) 1.25
Inferring genome-wide functional linkages in E. coli by combining improved genome context methods: comparison with high-throughput experimental data. Genome Res (2007) 1.23
Characterization of two cryptic Helicobacter pylori plasmids: a putative source for horizontal gene transfer and gene shuffling. J Bacteriol (2002) 1.23
Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori. Appl Environ Microbiol (2008) 1.21
The Modular Organization of Protein Interactions in Escherichia coli. PLoS Comput Biol (2009) 1.20
A large scale analysis of protein-protein interactions in the nitrogen-fixing bacterium Mesorhizobium loti. DNA Res (2008) 1.20
Identifying hubs in protein interaction networks. PLoS One (2009) 1.20
Dominating biological networks. PLoS One (2011) 1.19
RNA polymerase mutants defective in the initiation of transcription-coupled DNA repair. Nucleic Acids Res (2005) 1.19
Network of hydrogenase maturation in Escherichia coli: role of accessory proteins HypA and HybF. J Bacteriol (2002) 1.17
A truer measure of our ignorance. Proc Natl Acad Sci U S A (2008) 1.16
Computational inference and experimental validation of the nitrogen assimilation regulatory network in cyanobacterium Synechococcus sp. WH 8102. Nucleic Acids Res (2006) 1.14
Protein-protein interactions among Helicobacter pylori cag proteins. J Bacteriol (2006) 1.14
A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Genome Res (2003) 1.13
The human protein coevolution network. Genome Res (2009) 1.13
Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1. J Bacteriol (2010) 1.12
The nuclear interactor PYL8/RCAR3 of Fagus sylvatica FsPP2C1 is a positive regulator of abscisic acid signaling in seeds and stress. Plant Physiol (2009) 1.11
The organization of the microbial biodegradation network from a systems-biology perspective. EMBO Rep (2003) 1.11
Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system. Microbiol Mol Biol Rev (2012) 1.11
Infection Strategies of Bacterial and Viral Pathogens through Pathogen-Human Protein-Protein Interactions. Front Microbiol (2012) 1.09
Template-based structure modeling of protein-protein interactions. Curr Opin Struct Biol (2013) 1.08
Yeast two hybrid analyses reveal novel binary interactions between human cytomegalovirus-encoded virion proteins. PLoS One (2011) 1.08
M-TASSER: an algorithm for protein quaternary structure prediction. Biophys J (2007) 1.08
Massive gene decay in the leprosy bacillus. Nature (2001) 11.98
Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat Genet (1997) 9.60
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol Cell (1998) 5.89
Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain. Cell (1987) 4.63
Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions. J Bacteriol (1992) 4.02
Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Yeast (2000) 3.85
Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchange. J Bacteriol (1992) 3.75
Complete DNA sequence of yeast chromosome XI. Nature (1994) 3.51
Characterization of Sm-like proteins in yeast and their association with U6 snRNA. EMBO J (1999) 3.49
Genome-wide protein interaction maps using two-hybrid systems. FEBS Lett (2000) 3.13
Diphtheria in the Manchester area 1967-1971. Lancet (1974) 2.70
Chemically distinct transition states govern rapid dissociation of single L-selectin bonds under force. Proc Natl Acad Sci U S A (2001) 2.66
Rapid and specific detection of the pap, afa, and sfa adhesin-encoding operons in uropathogenic Escherichia coli strains by polymerase chain reaction. J Clin Microbiol (1992) 2.65
Yeast RNase III as a key processing enzyme in small nucleolar RNAs metabolism. J Mol Biol (1998) 2.65
The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II. EMBO J (1990) 2.38
Processing of a dicistronic small nucleolar RNA precursor by the RNA endonuclease Rnt1. EMBO J (1998) 2.20
Latent tuberculosis infection among undergraduate medical students in Rio de Janeiro State, Brazil. Int J Tuberc Lung Dis (2005) 2.16
Helicobacter pylori requires an acidic environment to survive in the presence of urea. Infect Immun (1995) 2.15
Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species. J Bacteriol (1995) 2.15
The Dr hemagglutinin, afimbrial adhesins AFA-I and AFA-III, and F1845 fimbriae of uropathogenic and diarrhea-associated Escherichia coli belong to a family of hemagglutinins with Dr receptor recognition. Infect Immun (1990) 2.14
Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers. Proc Natl Acad Sci U S A (1994) 2.11
Genotyping of Helicobacter pylori isolates by sequencing of PCR products and comparison with the RAPD technique. Res Microbiol (1996) 2.11
Protein--protein interaction maps: a lead towards cellular functions. Trends Genet (2001) 2.10
The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding. Mol Cell Biol (1990) 2.06
The Helicobacter pylori UreI protein is not involved in urease activity but is essential for bacterial survival in vivo. Infect Immun (1998) 2.05
The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proc Natl Acad Sci U S A (1995) 1.99
Formation of planar bilayer membranes from lipid monolayers. A critique. Biophys J (1976) 1.95
Essential role of Helicobacter pylori gamma-glutamyltranspeptidase for the colonization of the gastric mucosa of mice. Mol Microbiol (1999) 1.91
Allergenic materials in the house dust of allergy clinic patients. Ann Allergy Asthma Immunol (2001) 1.82
The interaction of vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 In vivo mutation rate. J Virol (2000) 1.79
Recombinant antigens prepared from the urease subunits of Helicobacter spp.: evidence of protection in a mouse model of gastric infection. Infect Immun (1994) 1.77
Molecular characterization of a 23-kilodalton major antigen secreted by Toxoplasma gondii. Proc Natl Acad Sci U S A (1989) 1.73
A genomic approach of the hepatitis C virus generates a protein interaction map. Gene (2000) 1.72
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer (2003) 1.65
Adhesion to and invasion of HeLa cells by pathogenic Escherichia coli carrying the afa-3 gene cluster are mediated by the AfaE and AfaD proteins, respectively. Infect Immun (1997) 1.65
Hereditary multiple exostoses. Anthropometric, roentgenographic, and clinical aspects. J Bone Joint Surg Am (1979) 1.65
Pharmacokinetics and fibrin specificity of alteplase during accelerated infusions in acute myocardial infarction. J Am Coll Cardiol (1992) 1.63
PrPSc accumulation in myocytes from sheep incubating natural scrapie. Nat Med (2004) 1.63
Yeast forward and reverse 'n'-hybrid systems. Nucleic Acids Res (1999) 1.63
Immune responses of specific-pathogen-free mice to chronic Helicobacter pylori (strain SS1) infection. Infect Immun (1998) 1.61
Frequency of complications of cardiopulmonary resuscitation after thrombolysis during acute myocardial infarction. Am J Cardiol (1992) 1.61
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Nucleotide sequence of the afimbrial-adhesin-encoding afa-3 gene cluster and its translocation via flanking IS1 insertion sequences. J Bacteriol (1994) 1.60
Characterization of plasmid-borne afa-3 gene clusters encoding afimbrial adhesins expressed by Escherichia coli strains associated with intestinal or urinary tract infections. Infect Immun (1993) 1.58
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Protein-protein interaction map inference using interacting domain profile pairs. Bioinformatics (2001) 1.52
The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase. J Bacteriol (1997) 1.49
Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 1.48
In vivo commitment to splicing in yeast involves the nucleotide upstream from the branch site conserved sequence and the Mud2 protein. EMBO J (1997) 1.47
Evidence that the 60-kDa protein of 17S U2 small nuclear ribonucleoprotein is immunologically and functionally related to the yeast PRP9 splicing factor and is required for the efficient formation of prespliceosomes. Proc Natl Acad Sci U S A (1993) 1.46
The afimbrial adhesive sheath encoded by the afa-3 gene cluster of pathogenic Escherichia coli is composed of two adhesins. Mol Microbiol (1996) 1.43
Evidence for specific secretion rather than autolysis in the release of some Helicobacter pylori proteins. Infect Immun (1998) 1.43
STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis (2008) 1.42
Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41
Helicobacter pylori hspA-hspB heat-shock gene cluster: nucleotide sequence, expression, putative function and immunogenicity. Mol Microbiol (1994) 1.41
Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7 TeV. Phys Rev Lett (2011) 1.39
Inferring regulatory elements from a whole genome. An analysis of Helicobacter pylori sigma(80) family of promoter signals. J Mol Biol (2000) 1.37
Identification and characterization of an aliphatic amidase in Helicobacter pylori. Mol Microbiol (1997) 1.36
The two-hybrid: an in vivo protein-protein interaction assay. Mol Biol Rep (1995) 1.36
The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pylori. J Antimicrob Chemother (1999) 1.35
Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32
Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions. J Biol Chem (1997) 1.32
The peopling of modern Bosnia-Herzegovina: Y-chromosome haplogroups in the three main ethnic groups. Ann Hum Genet (2005) 1.31
Frequent association between alteration of the rdxA gene and metronidazole resistance in French and North African isolates of Helicobacter pylori. Antimicrob Agents Chemother (2000) 1.31
A novel gene, spp91-1, suppresses the splicing defect and the pre-mRNA nuclear export in the prp9-1 mutant. EMBO J (1992) 1.31
Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA. Eur J Immunol (1993) 1.29
Analysis of the lacZ sequences from two Streptococcus thermophilus strains: comparison with the Escherichia coli and Lactobacillus bulgaricus beta-galactosidase sequences. J Gen Microbiol (1991) 1.29
Monoclonal antibodies to rabbit progesterone receptor: crossreaction with other mammalian progesterone receptors. Proc Natl Acad Sci U S A (1983) 1.29
High-frequency S-layer protein variation in Campylobacter fetus revealed by sapA mutagenesis. Mol Microbiol (1994) 1.29
Observation of associated near-side and away-side long-range correlations in sqrt[s(NN)]=5.02 TeV proton-lead collisions with the ATLAS detector. Phys Rev Lett (2013) 1.27
Cloning and allelic exchange mutagenesis of two flagellin genes of Helicobacter felis. Mol Microbiol (1999) 1.26
Identification of nonessential Helicobacter pylori genes using random mutagenesis and loop amplification. Res Microbiol (2001) 1.25
Local immunoglobulin G antibodies in the stomach may contribute to immunity against Helicobacter infection in mice. Gastroenterology (1997) 1.24
Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7 TeV. Phys Rev Lett (2012) 1.23
GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'. Allergy (2009) 1.22
The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. Nucleic Acids Res (1993) 1.21
Interaction between the first and last nucleotides of pre-mRNA introns is a determinant of 3' splice site selection in S. cerevisiae. Nucleic Acids Res (1994) 1.21
What Affects Clinicians' Usage of Health Information Exchange? Appl Clin Inform (2011) 1.20
Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19
Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector. Phys Rev Lett (2013) 1.19
Identification of the Helicobacter pylori anti-sigma28 factor. Mol Microbiol (2001) 1.19
Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76 TeV. Phys Rev Lett (2012) 1.19
Cloning, expression and sequencing of Helicobacter felis urease genes. Mol Microbiol (1993) 1.17
The Helicobacter pylori UreI protein: role in adaptation to acidity and identification of residues essential for its activity and for acid activation. Mol Microbiol (2001) 1.17
Functional conservation of the transportin nuclear import pathway in divergent organisms. Mol Cell Biol (1998) 1.16
Mechanics of electrocompression of lipid bilayer membranes. Biophys J (1975) 1.16
Analysis of the ptsH-ptsI-crr region in Escherichia coli K-12: nucleotide sequence of the ptsH gene. Gene (1985) 1.15
Characterization of the interaction partners of secreted proteins and chaperones of Shigella flexneri. Mol Microbiol (2001) 1.15