Common themes in mechanisms of gene silencing.

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91

The acetate switch. Microbiol Mol Biol Rev (2005) 6.10

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38

Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37

A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol Cell Biol (2003) 3.09

Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A (2003) 3.09

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J (2002) 3.06

Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol (2002) 2.93

Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae. Mol Biol Cell (2002) 2.80

Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev (2003) 2.58

Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast. Mol Cell (2007) 2.38

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell (2007) 2.07

The Heterochromatin Protein 1 family. Genome Biol (2006) 2.05

Role for perinuclear chromosome tethering in maintenance of genome stability. Nature (2008) 2.03

Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev (2006) 1.98

The nuclear envelope in genome organization, expression and stability. Nat Rev Mol Cell Biol (2010) 1.97

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J Cell Biol (2003) 1.92

Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z. Proc Natl Acad Sci U S A (2007) 1.85

Heterochromatin formation involves changes in histone modifications over multiple cell generations. EMBO J (2005) 1.82

Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78

Mechanisms for the inheritance of chromatin states. Cell (2011) 1.78

The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus. Nat Cell Biol (2009) 1.75

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol (2004) 1.73

Esc1, a nuclear periphery protein required for Sir4-based plasmid anchoring and partitioning. Mol Cell Biol (2002) 1.68

Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog (2009) 1.67

A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. PLoS Pathog (2010) 1.55

Variable switching rates of malaria virulence genes are associated with chromosomal position. Mol Microbiol (2007) 1.45

A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin. Mol Cell Biol (2005) 1.42

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J (2010) 1.40

Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications. Genes Dev (2002) 1.40

A molecular link between gene-specific and chromosome-wide transcriptional repression. Genes Dev (2002) 1.38

A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing. EMBO J (2007) 1.37

Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. Mol Cell Biol (2004) 1.37

Groucho oligomerization is required for repression in vivo. Mol Cell Biol (2004) 1.36

Formation of boundaries of transcriptionally silent chromatin by nucleosome-excluding structures. Mol Cell Biol (2004) 1.32

Transcriptional silencing of an amoebapore gene in Entamoeba histolytica: molecular analysis and effect on pathogenicity. Eukaryot Cell (2003) 1.31

Redundant roles for histone H3 N-terminal lysine residues in subtelomeric gene repression in Saccharomyces cerevisiae. Genetics (2004) 1.30

Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Nucleic Acids Res (2002) 1.27

Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression. Nucleic Acids Res (2003) 1.27

Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica. PLoS Pathog (2006) 1.26

Histone H3 N-terminus regulates higher order structure of yeast heterochromatin. Proc Natl Acad Sci U S A (2009) 1.25

Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex. Genetics (2006) 1.25

Heritable chromatin structure: mapping "memory" in histones H3 and H4. Proc Natl Acad Sci U S A (2002) 1.25

Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer. Mol Biol Cell (2006) 1.24

Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit. Proc Natl Acad Sci U S A (2002) 1.24

Protection of repetitive DNA borders from self-induced meiotic instability. Nature (2011) 1.20

The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiae. Mol Cell Biol (2004) 1.17

Reconstitution of heterochromatin-dependent transcriptional gene silencing. Mol Cell (2009) 1.16

Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res (2009) 1.16

SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15

Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae. Mol Cell Biol (2008) 1.14

Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum. Mol Microbiol (2007) 1.12

Sir2 silences gene transcription by targeting the transition between RNA polymerase II initiation and elongation. Mol Cell Biol (2008) 1.12

Bypassing the catalytic activity of SIR2 for SIR protein spreading in Saccharomyces cerevisiae. Mol Biol Cell (2006) 1.10

The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin. Genes Dev (2003) 1.07

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol (2011) 1.06

Involvement of a short interspersed element in epigenetic transcriptional silencing of the amoebapore gene in Entamoeba histolytica. Eukaryot Cell (2005) 1.06

Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution. Chromosoma (2004) 1.04

Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction. Biochim Biophys Acta (2009) 1.02

Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA. Proc Natl Acad Sci U S A (2013) 1.02

Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Mol Cell Biol (2005) 1.01

Histone H3 Lys79 methylation is required for efficient nucleotide excision repair in a silenced locus of Saccharomyces cerevisiae. Nucleic Acids Res (2009) 0.98

Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin. Mol Cell Biol (2006) 0.94

Position effect on the directionality of silencer function in Saccharomyces cerevisiae. Genetics (2006) 0.91

Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. Mol Cell Biol (2003) 0.90

Fission yeast Arp6 is required for telomere silencing, but functions independently of Swi6. Nucleic Acids Res (2004) 0.88

DNA and the chromosome - varied targets for chemotherapy. Cell Chromosome (2004) 0.88

The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Res (2011) 0.87

Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae. Epigenetics Chromatin (2009) 0.86

Uncoupling transcription from covalent histone modification. PLoS Genet (2014) 0.86

Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae. DNA Repair (Amst) (2014) 0.85

Acanthamoeba castellanii : growth on human cell layers reactivates attenuated properties after prolonged axenic culture. FEMS Microbiol Lett (2009) 0.84

Histone chaperone Chz1p regulates H2B ubiquitination and subtelomeric anti-silencing. Nucleic Acids Res (2009) 0.84

Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. BMC Biol (2014) 0.83

Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER. Nucleic Acids Res (2010) 0.82

Analyses of SUM1-1-mediated long-range repression. Genetics (2005) 0.82

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states. PLoS Genet (2012) 0.81

Telomeric heterochromatin in Plasmodium falciparum. J Biomed Biotechnol (2010) 0.81

Chromatin affinity-precipitation using a small metabolic molecule: its application to analysis of O-acetyl-ADP-ribose. Cell Mol Life Sci (2011) 0.81

RNAi hushes heterochromatin. Genome Biol (2002) 0.80

Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance. Genes Dev (2015) 0.80

Transcriptional regulation: a genomic overview. Arabidopsis Book (2002) 0.79

Differential DNA lesion formation and repair in heterochromatin and euchromatin. Carcinogenesis (2015) 0.79

Effects of Perinuclear Chromosome Tethers in the Telomeric URA3/5FOA System Reflect Changes to Gene Silencing and not Nucleotide Metabolism. Front Genet (2012) 0.78

The C-terminus of histone H2B is involved in chromatin compaction specifically at telomeres, independently of its monoubiquitylation at lysine 123. PLoS One (2011) 0.78

Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena. BMC Cell Biol (2011) 0.77

CEN plasmid segregation is destabilized by tethered determinants of Ty 5 integration specificity: a role for double-strand breaks in CEN antagonism. Chromosoma (2003) 0.76

The SCFDia2 ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing. PLoS Genet (2012) 0.76

Changes in the genome-wide localization pattern of Sir3 in Saccharomyces cerevisiae during different growth stages. Comput Struct Biotechnol J (2013) 0.76

Old cells, new tricks: chromatin structure in senescence. Mamm Genome (2016) 0.76

Fueling transcriptional silencing with Gas1. Proc Natl Acad Sci U S A (2009) 0.75

Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes. Elife (2016) 0.75

Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD(+) homeostasis and contributes to longevity. Front Biol (Beijing) (2015) 0.75

The Epigenetic Pathways to Ribosomal DNA Silencing. Microbiol Mol Biol Rev (2016) 0.75

Modulations of SIR-nucleosome interactions of reconstructed yeast silent pre-heterochromatin by O-acetyl-ADP-ribose and magnesium. Mol Biol Cell (2016) 0.75

Mouse chromocenters contain associated telomeric DNA and telomerase activity. Dokl Biol Sci (2002) 0.75