PubRank

Morris F White

Author PubWeight™ 134.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002 9.76
2 Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2001 5.12
3 SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 2002 4.84
4 Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 2005 4.81
5 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 2007 4.80
6 The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002 4.05
7 Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol 2005 3.50
8 Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 2008 3.22
9 c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 2002 2.45
10 Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med 2011 2.40
11 Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 2004 2.34
12 RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem 2005 2.32
13 Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med 2005 2.18
14 Insulin-like signaling, nutrient homeostasis, and life span. Annu Rev Physiol 2008 2.07
15 Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003 2.03
16 Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest 2002 1.95
17 Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest 2002 1.93
18 Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 2009 1.85
19 Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 2003 1.83
20 Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 2005 1.80
21 Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab 2010 1.77
22 The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol 2009 1.69
23 Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol 2008 1.67
24 Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab 2010 1.67
25 Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol 2004 1.65
26 Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun 2004 1.59
27 Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal 2010 1.59
28 Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol 2004 1.55
29 Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem 2005 1.51
30 Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes 2003 1.51
31 Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem 2003 1.47
32 Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol 2008 1.40
33 Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem 2002 1.34
34 Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes 2012 1.32
35 Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Res 2002 1.32
36 Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem 2009 1.31
37 Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol 2002 1.21
38 Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Mol Cell Biol 2006 1.19
39 Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes 2004 1.18
40 Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. Am J Physiol Cell Physiol 2004 1.16
41 The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes 2007 1.15
42 Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes 2013 1.14
43 IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J Clin Invest 2011 1.14
44 Chronic activation of a designer G(q)-coupled receptor improves β cell function. J Clin Invest 2013 1.13
45 Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect 2012 1.13
46 Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol 2010 1.13
47 Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes 2013 1.12
48 Insulin receptor substrate proteins and diabetes. Arch Pharm Res 2004 1.12
49 The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Mol Endocrinol 2006 1.08
50 Signaling pathways: the benefits of good communication. Curr Biol 2004 1.04
51 Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem 2005 1.00
52 Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci 2005 1.00
53 Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol 2007 0.98
54 IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology 2004 0.98
55 Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest 2013 0.97
56 IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab 2012 0.95
57 The AKTion in non-canonical insulin signaling. Nat Med 2012 0.94
58 Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem 2011 0.93
59 Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. Am J Physiol Endocrinol Metab 2010 0.93
60 Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol 2013 0.92
61 Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes 2002 0.92
62 Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem 2014 0.92
63 Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology 2009 0.90
64 Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. J Biol Chem 2013 0.88
65 Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes 2012 0.88
66 Foxo1 in hepatic lipid metabolism. Cell Cycle 2010 0.87
67 Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab 2005 0.87
68 Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS One 2013 0.87
69 IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation. Cereb Cortex 2011 0.87
70 Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. J Biol Chem 2005 0.85
71 Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal 2013 0.85
72 Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Front Biosci 2007 0.84
73 Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? BMC Dev Biol 2010 0.84
74 The IRS2 Gly1057Asp variant is associated with human longevity. J Gerontol A Biol Sci Med Sci 2009 0.83
75 Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol 2008 0.83
76 Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E. J Histochem Cytochem 2005 0.82
77 Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology. J Cell Physiol 2007 0.82
78 Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 2009 0.82
79 Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2. Am J Physiol Endocrinol Metab 2007 0.80
80 Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem 2002 0.80
81 Diabetes forum: Extreme makeover of pancreatic alpha-cells. Nature 2010 0.79
82 Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am 2012 0.78
83 Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. FEBS J 2013 0.77
84 Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance. Diabetes 2009 0.75
85 kNOXing on the door of selective insulin resistance. Arterioscler Thromb Vasc Biol 2012 0.75
86 Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. FEBS Lett 2003 0.75