Published in Science on March 21, 1975
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Chemical carcinogens transform BHK cells by inducing a recessive mutation. Mol Cell Biol (1982) 0.94
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Amplification of hypoxanthine-guanine phosphoribosyltransferase genes in chromosome-mediated gene transferents. Mol Cell Biol (1984) 0.77
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity. Proc Natl Acad Sci U S A (1980) 7.84
Nonsense mutations in the dihydrofolate reductase gene affect RNA processing. Mol Cell Biol (1989) 5.19
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Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells. Cell (1983) 2.97
Multiple splicing defects in an intronic false exon. Mol Cell Biol (2000) 2.97
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Transformation of the gene for hypoxanthine phosphoribosyltransferase. Somatic Cell Genet (1979) 2.42
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Point mutation analysis in a mammalian gene: rapid preparation of total RNA, PCR amplification of cDNA, and Taq sequencing by a novel method. Biotechniques (1989) 2.17
Separation of linked markers in Chinese hamster cell hybrids: mitotic recombination is not involved. Genetics (1978) 2.11
Effect of gamma rays at the dihydrofolate reductase locus: deletions and inversions. Somat Cell Mol Genet (1986) 2.03
Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol (1993) 1.85
Human genomic sequences that inhibit splicing. Mol Cell Biol (2000) 1.73
Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells. Nucleic Acids Res (1983) 1.68
Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol (1993) 1.58
Direct selection for mutations affecting specific splice sites in a hamster dihydrofolate reductase minigene. Mol Cell Biol (1993) 1.57
Control of 3' splice site choice in vivo by ASF/SF2 and hnRNP A1. Nucleic Acids Res (1999) 1.52
Isolation of mammalian cell mutants deficient in glucose-6-phosphate dehydrogenase activity: linkage to hypoxanthine phosphoribosyl transferase. Proc Natl Acad Sci U S A (1975) 1.48
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The effect of ploidy on chemical mutagenesis in cultured Chinese hamster cells. J Cell Physiol (1973) 1.36
Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA. Mol Cell Biol (1996) 1.31
Non-linkage of induced mutations in Chinese hamster cells. Nat New Biol (1972) 1.20
Deletion analysis of the Chinese hamster dihydrofolate reductase gene promoter. J Biol Chem (1988) 1.14
Large exon size does not limit splicing in vivo. Mol Cell Biol (1994) 1.11
Reversion of a Chinese hamster cell auxotrophic mutant. Proc Natl Acad Sci U S A (1974) 1.11
A domain of methylation change at the albumin locus in rat hepatoma cell variants. Mol Cell Biol (1985) 1.09
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation. Mol Cell Biol (1982) 1.06
Mapping and characterization of mutations induced by benzo[a]pyrene diol epoxide at dihydrofolate reductase locus in CHO cells. Somat Cell Mol Genet (1988) 1.00
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Polyadenylation of Chinese hamster dihydrofolate reductase genomic genes and minigenes after gene transfer. Somat Cell Mol Genet (1987) 0.95
Cointegration of DNA molecules introduced into mammalian cells by electroporation. Somat Cell Mol Genet (1998) 0.95
Selective killing of methotrexate-resistant cells carrying amplified dihydrofolate reductase genes. Cancer Res (1981) 0.93
DNA base changes and RNA levels in N-acetoxy-2-acetylaminofluorene-induced dihydrofolate reductase mutants of Chinese hamster ovary cells. J Mol Biol (1989) 0.90
Gene expression after transformation of Bacillus subtilis. J Bacteriol (1970) 0.90
Effect of differential polyadenylation and cell growth phase on dihydrofolate reductase mRNA stability. J Biol Chem (1999) 0.89
Immortalization of normal liver functions in cell culture: rat hepatocyte-hepatoma cell hybrids expressing ornithine carbamoyltransferase activity. J Cell Physiol (1979) 0.89
Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate reductase promoter. Oncogene (1998) 0.88
RNA processing mutants at the dihydrofolate reductase locus in Chinese hamster ovary cells. Prog Clin Biol Res (1990) 0.87
Characterization of mutations induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the dihydrofolate reductase gene of cultured hamster cells. Proc Natl Acad Sci U S A (1986) 0.86
An alternatively spliced Pit-1 isoform altered in its ability to trans-activate. Nucleic Acids Res (1992) 0.85
Mutants of Chinese hamster ovary cells with altered glucose-6-phosphate dehydrogenase activity. Somatic Cell Genet (1977) 0.84
Cell-growth regulation of the hamster dihydrofolate reductase gene promoter by transcription factor Sp1. Eur J Biochem (1997) 0.84
Multihormonal induction of alpha 2u-globulin in an established rat hepatoma cell line. J Cell Physiol (1982) 0.83
Point mutational analysis of the hamster dihydrofolate reductase minimum promoter. J Biol Chem (1992) 0.81
Use of fluorescence-activated cell sorter to isolate mutant mammalian cells deficient in an internal protein, dihydrofolate reductase. Somat Cell Mol Genet (1985) 0.81
Repetitive cloning of mutant genes using locus-specific sticky ends. Methods Enzymol (1987) 0.80
The rat albumin gene promoter is appropriately regulated in transient but not in stable transfections. Nucleic Acids Res (1988) 0.79
Use of a selectable reporter for the isolation of mammalian regulatory genes. Gene (1990) 0.79
Rat serum albumin synthesis in variant rat hepatoma cells. J Cell Physiol (1983) 0.79
A mutational hot spot induced by N-hydroxy-aminofluorene in dihydrofolate reductase mutants of Chinese hamster ovary cells. Carcinogenesis (1993) 0.75
In vivo photoreaction of a chiral cobalt complex: DNA cleavage by Co(DIP)3(3+) in mammalian cells. Mutat Res (1988) 0.75