Published in Nucleic Acids Res on December 23, 1988
Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene. Mol Cell Biol (1990) 1.02
Activity of U-snRNA genes with modified placement of promoter elements in transfected protoplasts and stably transformed tobacco. Nucleic Acids Res (1993) 0.77
Transient gene delivery for functional enrichment of differentiating embryonic stem cells. Biotechnol Bioeng (2008) 0.76
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
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DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell (1986) 20.08
Regulation of inducible and tissue-specific gene expression. Science (1987) 15.04
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73
Deletion mapping of DNA regions required for SV40 early region promoter function in vivo. J Mol Appl Genet (1982) 10.71
Tissue-specific in vitro transcription from the mouse albumin promoter. Cell (1986) 10.54
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science (1985) 9.73
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The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell (1987) 6.14
The rat serum albumin gene: analysis of cloned sequences. Proc Natl Acad Sci U S A (1979) 5.17
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
Characterization of the bovine papilloma virus plasmid maintenance sequences. Cell (1984) 5.01
DNA methylation affects the formation of active chromatin. Cell (1986) 4.65
An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev (1987) 4.48
Sequence-specific interactions of nuclear factors with the insulin gene enhancer. Cell (1986) 4.42
Factors involved in control of tissue-specific expression of albumin gene. Cell (1987) 4.39
Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence. Cell (1985) 4.38
Normal rat cell lines deficient in nuclear thymidine kinase. Virology (1981) 4.13
Transforming DNA integrates into the host chromosome. Cell (1981) 3.98
Cell-type-specific contacts to immunoglobulin enhancers in nuclei. Nature (1985) 3.94
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High-sensitivity S1 mapping with single-stranded [32P]DNA probes synthesized from bacteriophage M13mp templates. Gene (1984) 3.81
A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin. Cell (1983) 3.33
Tissue-specific expression is conferred by a sequence from the 5' end of the rat albumin gene. EMBO J (1984) 3.07
Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochimie (1974) 2.75
Factors governing the expression of a bacterial gene in mammalian cells. Mol Cell Biol (1981) 2.74
Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J (1985) 2.70
Regulated expression of human growth hormone genes in mouse cells. Cell (1982) 2.58
Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system. Mol Cell Biol (1987) 2.52
Transformation of the gene for hypoxanthine phosphoribosyltransferase. Somatic Cell Genet (1979) 2.42
Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. EMBO J (1987) 2.02
Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types. Genes Dev (1987) 1.76
Cell-specified expression of a selectable hybrid gene. Proc Natl Acad Sci U S A (1984) 1.74
Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression. Mol Cell Biol (1986) 1.73
Structure of mutant alleles at the aprt locus of Chinese hamster ovary cells. J Mol Biol (1983) 1.45
Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids. Proc Natl Acad Sci U S A (1986) 1.36
Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells. Mol Cell Biol (1987) 1.35
Expression of the albumin gene in rat hepatoma cells and their dedifferentiated variants. Cell (1981) 1.30
Tissue-specific transcription enhancement of the fibroin gene characterized by cell-free systems. Proc Natl Acad Sci U S A (1986) 1.07
Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line. Mol Cell Biol (1988) 1.06
Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters. Mol Cell Biol (1986) 0.99
Isolation of thymidine kinase-deficient rat hepatoma cells by selection with bromodeoxyuridine, Hoechst 33258, and visible light. Biochem Genet (1984) 0.93
Comparison of phenotypic expression with genotypic transformation by using cloned, selectable markers. Mol Cell Biol (1982) 0.92
Rat serum albumin synthesis in variant rat hepatoma cells. J Cell Physiol (1983) 0.79
Expression of the mouse serum albumin gene introduced into differentiated and dedifferentiated rat hepatoma cells. Proc Natl Acad Sci U S A (1985) 0.78
Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity. Proc Natl Acad Sci U S A (1980) 7.84
Nonsense mutations in the dihydrofolate reductase gene affect RNA processing. Mol Cell Biol (1989) 5.19
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. Proc Natl Acad Sci U S A (1978) 4.60
Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells. Cell (1974) 3.61
Mutant alleles for hypoxanthine phosphoriboxyltransferase: codominant expression, complementation, and segregation in hybrid Chinese hamster cells. Somatic Cell Genet (1976) 3.38
Induction and repression of the histidine-degrading enzymes of Bacillus subtilis. J Biol Chem (1968) 3.36
Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells. Cell (1983) 2.97
Multiple splicing defects in an intronic false exon. Mol Cell Biol (2000) 2.97
Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene. Mol Cell Biol (1986) 2.82
Transformation of the gene for hypoxanthine phosphoribosyltransferase. Somatic Cell Genet (1979) 2.42
Point mutation analysis in a mammalian gene: rapid preparation of total RNA, PCR amplification of cDNA, and Taq sequencing by a novel method. Biotechniques (1989) 2.17
Separation of linked markers in Chinese hamster cell hybrids: mitotic recombination is not involved. Genetics (1978) 2.11
Effect of gamma rays at the dihydrofolate reductase locus: deletions and inversions. Somat Cell Mol Genet (1986) 2.03
Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol (1993) 1.85
Human genomic sequences that inhibit splicing. Mol Cell Biol (2000) 1.73
Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells. Nucleic Acids Res (1983) 1.68
Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol (1993) 1.58
Direct selection for mutations affecting specific splice sites in a hamster dihydrofolate reductase minigene. Mol Cell Biol (1993) 1.57
Control of 3' splice site choice in vivo by ASF/SF2 and hnRNP A1. Nucleic Acids Res (1999) 1.52
Anchorage of the Chinese hamster dihydrofolate reductase gene to the nuclear scaffold occurs in an intragenic region. J Mol Biol (1987) 1.48
Isolation of mammalian cell mutants deficient in glucose-6-phosphate dehydrogenase activity: linkage to hypoxanthine phosphoribosyl transferase. Proc Natl Acad Sci U S A (1975) 1.48
Biosynthesis of dipicolinic acid in Bacillus subtilis. Biochem Biophys Res Commun (1967) 1.43
The effect of ploidy on chemical mutagenesis in cultured Chinese hamster cells. J Cell Physiol (1973) 1.36
Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA. Mol Cell Biol (1996) 1.31
Non-linkage of induced mutations in Chinese hamster cells. Nat New Biol (1972) 1.20
Deletion analysis of the Chinese hamster dihydrofolate reductase gene promoter. J Biol Chem (1988) 1.14
Large exon size does not limit splicing in vivo. Mol Cell Biol (1994) 1.11
Reversion of a Chinese hamster cell auxotrophic mutant. Proc Natl Acad Sci U S A (1974) 1.11
A domain of methylation change at the albumin locus in rat hepatoma cell variants. Mol Cell Biol (1985) 1.09
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation. Mol Cell Biol (1982) 1.06
Mapping and characterization of mutations induced by benzo[a]pyrene diol epoxide at dihydrofolate reductase locus in CHO cells. Somat Cell Mol Genet (1988) 1.00
Splicing mutations in the CHO DHFR gene preferentially induced by (+/-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene. Proc Natl Acad Sci U S A (1990) 1.00
Efficient cloning of single-copy genes using specialized cosmid vectors: isolation of mutant dihydrofolate reductase genes. Proc Natl Acad Sci U S A (1985) 0.96
Cointegration of DNA molecules introduced into mammalian cells by electroporation. Somat Cell Mol Genet (1998) 0.95
Polyadenylation of Chinese hamster dihydrofolate reductase genomic genes and minigenes after gene transfer. Somat Cell Mol Genet (1987) 0.95
Selective killing of methotrexate-resistant cells carrying amplified dihydrofolate reductase genes. Cancer Res (1981) 0.93
DNA base changes and RNA levels in N-acetoxy-2-acetylaminofluorene-induced dihydrofolate reductase mutants of Chinese hamster ovary cells. J Mol Biol (1989) 0.90
Gene expression after transformation of Bacillus subtilis. J Bacteriol (1970) 0.90
Immortalization of normal liver functions in cell culture: rat hepatocyte-hepatoma cell hybrids expressing ornithine carbamoyltransferase activity. J Cell Physiol (1979) 0.89
Effect of differential polyadenylation and cell growth phase on dihydrofolate reductase mRNA stability. J Biol Chem (1999) 0.89
Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate reductase promoter. Oncogene (1998) 0.88
Characterization of mutations induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the dihydrofolate reductase gene of cultured hamster cells. Proc Natl Acad Sci U S A (1986) 0.86
Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells. Science (1975) 0.86
An alternatively spliced Pit-1 isoform altered in its ability to trans-activate. Nucleic Acids Res (1992) 0.85
Mutants of Chinese hamster ovary cells with altered glucose-6-phosphate dehydrogenase activity. Somatic Cell Genet (1977) 0.84
Cell-growth regulation of the hamster dihydrofolate reductase gene promoter by transcription factor Sp1. Eur J Biochem (1997) 0.84
Multihormonal induction of alpha 2u-globulin in an established rat hepatoma cell line. J Cell Physiol (1982) 0.83
Use of fluorescence-activated cell sorter to isolate mutant mammalian cells deficient in an internal protein, dihydrofolate reductase. Somat Cell Mol Genet (1985) 0.81
Point mutational analysis of the hamster dihydrofolate reductase minimum promoter. J Biol Chem (1992) 0.81
Repetitive cloning of mutant genes using locus-specific sticky ends. Methods Enzymol (1987) 0.80
Use of a selectable reporter for the isolation of mammalian regulatory genes. Gene (1990) 0.79
Rat serum albumin synthesis in variant rat hepatoma cells. J Cell Physiol (1983) 0.79
A mutational hot spot induced by N-hydroxy-aminofluorene in dihydrofolate reductase mutants of Chinese hamster ovary cells. Carcinogenesis (1993) 0.75
In vivo photoreaction of a chiral cobalt complex: DNA cleavage by Co(DIP)3(3+) in mammalian cells. Mutat Res (1988) 0.75