Embryo-derived stem cells: of mice and men.

PubWeight™: 6.76‹?› | Rank: Top 1%

🔗 View Article (PMID 11687496)

Published in Annu Rev Cell Dev Biol on January 01, 2001

Authors

A G Smith1

Author Affiliations

1: Centre for Genome Research, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, Scotland, EH9 3JQ, United Kingdom. austin.smith@ed.ac.uk

Articles citing this

(truncated to the top 100)

lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature (2011) 11.31

Control of the embryonic stem cell state. Cell (2011) 6.89

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res (2008) 6.43

The transcriptional and epigenomic foundations of ground state pluripotency. Cell (2012) 5.87

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79

Germline competent embryonic stem cells derived from rat blastocysts. Cell (2008) 5.52

Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development (2009) 5.49

Capturing pluripotency. Cell (2008) 5.08

An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell (2010) 5.00

Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A (2004) 4.77

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol (2009) 4.60

Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54

Dependence of mouse embryonic stem cells on threonine catabolism. Science (2009) 2.40

Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol (2003) 2.40

Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol (2008) 2.32

Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat. Proc Natl Acad Sci U S A (2005) 2.28

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A (2004) 2.25

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2010) 2.25

Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest (2005) 2.25

Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell (2008) 2.21

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19

Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Genes Dev (2009) 2.18

The RNA-binding protein repertoire of embryonic stem cells. Nat Struct Mol Biol (2013) 2.12

Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell (2009) 2.09

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells. Nat Biotechnol (2014) 2.05

Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med (2007) 1.97

Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation. PLoS Genet (2009) 1.96

Pluripotency in the embryo and in culture. Cold Spring Harb Perspect Biol (2012) 1.93

Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2005) 1.85

Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells. RNA (2009) 1.78

Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67

Technology insight: In vitro culture of spermatogonial stem cells and their potential therapeutic uses. Nat Clin Pract Endocrinol Metab (2006) 1.66

Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62

Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. Dev Biol (2007) 1.61

Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One (2010) 1.60

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends Biotechnol (2009) 1.56

The Rho-Rock-Myosin signaling axis determines cell-cell integrity of self-renewing pluripotent stem cells. PLoS One (2008) 1.52

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol (2010) 1.51

Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair (2010) 1.50

Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. EMBO J (2013) 1.50

The harmonies played by TGF-β in stem cell biology. Cell Stem Cell (2012) 1.47

Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J Cell Biochem (2009) 1.47

Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor. EMBO J (2013) 1.46

Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photoreceptors. Stem Cells (2005) 1.42

Long-term self-renewal of postnatal muscle-derived stem cells. Mol Biol Cell (2005) 1.42

A simple tool to improve pluripotent stem cell differentiation. Nat Methods (2013) 1.42

Vitrification of mouse embryo-derived ICM cells: a tool for preserving embryonic stem cell potential? J Assist Reprod Genet (2010) 1.42

Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor. Biochem J (2011) 1.41

Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity. Genome Biol (2007) 1.41

Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. Tissue Eng Part A (2010) 1.38

Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model. PLoS One (2008) 1.37

Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2006) 1.35

Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev (2012) 1.34

Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition. Stem Cell Reports (2013) 1.31

A PiggyBac-based recessive screening method to identify pluripotency regulators. PLoS One (2011) 1.30

Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis. PLoS One (2010) 1.29

Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. Stem Cells (2013) 1.28

A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells. Development (2013) 1.26

E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells. Mol Biol Cell (2007) 1.26

Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem (2008) 1.26

Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour. Nat Commun (2011) 1.26

Pluripotent stem cells: private obsession and public expectation. EMBO Mol Med (2010) 1.24

Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnol Bioeng (2010) 1.22

Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proc Natl Acad Sci U S A (2008) 1.22

Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells (2005) 1.22

Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol (2007) 1.21

The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood (2005) 1.21

Dissecting the first transcriptional divergence during human embryonic development. Stem Cell Rev (2012) 1.20

Simultaneous detection of mRNA and protein stem cell markers in live cells. BMC Biotechnol (2009) 1.20

A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. Sci Rep (2012) 1.18

Concise review: The Sox2-Oct4 connection: critical players in a much larger interdependent network integrated at multiple levels. Stem Cells (2013) 1.17

Non-muscle myosin II regulates survival threshold of pluripotent stem cells. Nat Commun (2010) 1.16

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One (2009) 1.15

Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.15

Establishment of rat embryonic stem cells and making of chimera rats. PLoS One (2008) 1.14

Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med (Berl) (2008) 1.12

Marker succession during the development of keratinocytes from cultured human embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.11

ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. Stem Cells (2012) 1.09

The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency. EMBO Rep (2010) 1.08

Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming. Hum Mol Genet (2012) 1.07

Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development (2010) 1.07

A conserved organization of transcription during embryonic stem cell differentiation and in cells with high C value. Mol Biol Cell (2006) 1.06

Instructing an embryonic stem cell-derived oocyte fate: lessons from endogenous oogenesis. Endocr Rev (2009) 1.06

Chemokine-mobilized adult stem cells; defining a better hematopoietic graft. Leukemia (2007) 1.04

Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming. Stem Cells Int (2012) 1.02

HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway. J Cell Biochem (2011) 1.02

Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. Blood (2010) 1.02

Developing defined culture systems for human pluripotent stem cells. Regen Med (2011) 1.01

Alterations of proliferative and differentiation potentials of human embryonic stem cells during long-term culture. Exp Mol Med (2008) 1.00

Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology. Dev Cell (2016) 0.99

Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells. Mol Cell (2016) 0.99

Gene expression profiles during early differentiation of mouse embryonic stem cells. BMC Dev Biol (2009) 0.99

Mesodermal fate decisions of a stem cell: the Wnt switch. Cell Mol Life Sci (2008) 0.99

Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells. Exp Cell Res (2012) 0.99

Pituitary stem cell update and potential implications for treating hypopituitarism. Endocr Rev (2011) 0.99

Probing embryonic stem cell autocrine and paracrine signaling using microfluidics. Annu Rev Anal Chem (Palo Alto Calif) (2012) 0.98

Do all roads lead to Oct4? the emerging concepts of induced pluripotency. Trends Cell Biol (2013) 0.98

RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells. J Cell Sci (2012) 0.98

LIF-dependent signaling: new pieces in the Lego. Stem Cell Rev (2012) 0.98