A simple tool to improve pluripotent stem cell differentiation.

Generation of functional human pancreatic β cells in vitro. Cell (2014) 5.90

Differentiated human stem cells resemble fetal, not adult, β cells. Proc Natl Acad Sci U S A (2014) 1.44

Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports (2013) 1.33

Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations. Cell Stem Cell (2014) 1.30

Protein post-translational modifications and regulation of pluripotency in human stem cells. Cell Res (2013) 1.12

Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J Comp Neurol (2014) 1.09

Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports (2014) 1.00

Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports (2015) 0.93

Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells. PLoS One (2013) 0.92

Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. J Neurogenet (2014) 0.91

Back to the future: how human induced pluripotent stem cells will transform regenerative medicine. Hum Mol Genet (2013) 0.89

Pancreatic stem cells remain unresolved. Stem Cells Dev (2014) 0.89

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. Front Cell Neurosci (2014) 0.89

How the cell cycle impacts chromatin architecture and influences cell fate. Front Genet (2015) 0.87

Linking the Cell Cycle to Cell Fate Decisions. Trends Cell Biol (2015) 0.85

Nanoparticle-mediated intracellular delivery enables cryopreservation of human adipose-derived stem cells using trehalose as the sole cryoprotectant. ACS Appl Mater Interfaces (2015) 0.82

Cell Cycle-Driven Heterogeneity: On the Road to Demystifying the Transitions between "Poised" and "Restricted" Pluripotent Cell States. Stem Cells Int (2015) 0.81

Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells. Sci Rep (2015) 0.81

DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS One (2015) 0.81

Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling. J Thromb Haemost (2014) 0.81

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Gut (2016) 0.80

Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation (2016) 0.79

Assessment of the Potential of CDK2 Inhibitor NU6140 to Influence the Expression of Pluripotency Markers NANOG, OCT4, and SOX2 in 2102Ep and H9 Cells. Int J Cell Biol (2014) 0.79

Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells. PLoS One (2015) 0.79

Improvement of Cell Survival During Human Pluripotent Stem Cell Definitive Endoderm Differentiation. Stem Cells Dev (2015) 0.78

Investigation of Rett syndrome using pluripotent stem cells. J Cell Biochem (2013) 0.78

Transcriptional control of stem cell fate by E2Fs and pocket proteins. Front Genet (2015) 0.77

Retinoic Acid Specifically Enhances Embryonic Stem Cell Metastate Marked by Zscan4. PLoS One (2016) 0.77

A cost-effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells. Sci Rep (2015) 0.77

Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases. Sci Rep (2016) 0.77

Pluripotent stem cells as a platform for cardiac arrhythmia drug screening. Curr Treat Options Cardiovasc Med (2014) 0.76

A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation. J Cell Biol (2015) 0.76

Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells. Stem Cells Dev (2014) 0.76

Advances in reprogramming-based study of neurologic disorders. Stem Cells Dev (2015) 0.76

Two novel DXZ4-associated long noncoding RNAs show developmental changes in expression coincident with heterochromatin formation at the human (Homo sapiens) macrosatellite repeat. Chromosome Res (2015) 0.76

A low absolute number of expanded transcripts is involved in myotonic dystrophy type 1 manifestation in muscle. Hum Mol Genet (2016) 0.75

H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro. Stem Cell Reports (2016) 0.75

Marmoset induced pluripotent stem cells: Robust neural differentiation following pretreatment with dimethyl sulfoxide. Stem Cell Res (2015) 0.75

Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide. Cold Spring Harb Mol Case Stud (2017) 0.75

PTF1a Activity in Enriched Posterior Foregut Endoderm, but Not Definitive Endoderm, Leads to Enhanced Pancreatic Differentiation in an In Vitro Mouse ESC-Based Model. Stem Cells Int (2016) 0.75

Utilizing FUCCI reporters to understand pluripotent stem cell biology. Methods (2015) 0.75

Influence of in vitro and in vivo oxygen modulation on β cell differentiation from human embryonic stem cells. Stem Cells Transl Med (2013) 0.75

Ethnicity-Dependent and -Independent Heterogeneity in Healthy Normal Breast Hierarchy Impacts Tumor Characterization. Sci Rep (2015) 0.75

A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes. Stem Cells Transl Med (2016) 0.75

Insulin-secreting β cells require a post-genomic concept. World J Diabetes (2016) 0.75

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42

Checkpoints: controls that ensure the order of cell cycle events. Science (1989) 21.01

The retinoblastoma protein and cell cycle control. Cell (1995) 20.21

A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol (2007) 13.56

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol (2009) 13.16

Effects of an Rb mutation in the mouse. Nature (1992) 11.06

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol (2006) 10.95

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol (2008) 10.60

G1 events and regulation of cell proliferation. Science (1989) 9.73

Cyclin synthesis drives the early embryonic cell cycle. Nature (1989) 9.73

Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell (2011) 8.21

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet (2008) 7.30

Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol (2001) 6.76

Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell (2011) 6.71

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell (1989) 6.46

Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19

A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol (2011) 4.95

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A (2012) 4.85

Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43

The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer (2011) 3.42

A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol (2009) 3.15

Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82

A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32

Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood (2007) 2.18

Production of functional glucagon-secreting α-cells from human embryonic stem cells. Diabetes (2010) 1.73

How to make beta cells? Curr Opin Cell Biol (2009) 1.31

Human embryonic stem cells exhibit increased propensity to differentiate during the G1 phase prior to phosphorylation of retinoblastoma protein. Stem Cells (2012) 1.29

Acetylation regulates the differentiation-specific functions of the retinoblastoma protein. EMBO J (2004) 1.27

Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. J Cell Biol (1995) 1.16

A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One (2010) 1.02

Keeping an eye on retinoblastoma control of human embryonic stem cells. J Cell Biochem (2009) 1.01

Dimethyl sulfoxide restores contact inhibition-induced growth arrest and inhibits cell density-dependent apoptosis in hamster cells. Exp Cell Res (1999) 0.98

Early G1 growth arrest of hybridoma B cells by DMSO involves cyclin D2 inhibition and p21[CIP1] induction. Oncogene (1998) 0.92

Reversible G1 arrest in the cell cycle of human lymphoid cell lines by dimethyl sulfoxide. Exp Cell Res (1990) 0.91

Reversible G1 arrest induced by dimethyl sulfoxide in human lymphoid cell lines: dimethyl sulfoxide inhibits IL-6-induced differentiation of SKW6-CL4 into IgM-secreting plasma cells. Exp Cell Res (1996) 0.87

Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93

Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21

"Stemness": transcriptional profiling of embryonic and adult stem cells. Science (2002) 15.55

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29

Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89

Retracted Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell (2013) 6.86

Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55

Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (2005) 6.14

Recovery from diabetes in mice by beta cell regeneration. J Clin Invest (2007) 4.32

A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell (2007) 4.13

Extreme makeover: converting one cell into another. Cell Stem Cell (2008) 3.60

Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell (2009) 3.31

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15

Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature (2007) 3.11

The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell (2006) 3.10

A gene regulatory network in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 2.94

Endothelial signaling during development. Nat Med (2003) 2.83

Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev (2003) 2.58

Role of VEGF-A in vascularization of pancreatic islets. Curr Biol (2003) 2.56

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50

Insulin staining of ES cell progeny from insulin uptake. Science (2003) 2.46

Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A (2005) 2.41

Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development (2003) 2.39

Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell (2009) 2.31

Single-cell transcript analysis of pancreas development. Dev Cell (2003) 2.11

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol (2012) 1.90

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90

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Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol (2007) 1.75

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature (2012) 1.64

How to make a functional β-cell. Development (2013) 1.58

Transcriptional dynamics of endodermal organ formation. Dev Dyn (2009) 1.58

Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49

Differentiated human stem cells resemble fetal, not adult, β cells. Proc Natl Acad Sci U S A (2014) 1.44

The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J Biol Chem (2004) 1.31

How to make beta cells? Curr Opin Cell Biol (2009) 1.31

Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes (2002) 1.23

A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation. J Biol Chem (2010) 1.23

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc Natl Acad Sci U S A (2012) 1.21

Facultative endocrine progenitor cells in the adult pancreas. Cell (2008) 1.21

How important are adult stem cells for tissue maintenance? Cell Cycle (2004) 1.17

Wnt signaling specifies and patterns intestinal endoderm. Mech Dev (2011) 1.14

Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev (2006) 1.13

Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn (2008) 1.11

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife (2014) 1.08

Development of an ectopic site for islet transplantation, using biodegradable scaffolds. Tissue Eng (2005) 1.06

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice. Diabetologia (2013) 0.99

Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP. J Leukoc Biol (2009) 0.97

Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96

Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development (2013) 0.96

Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int J Dev Biol (2002) 0.86

Derivation of human embryonic stem cells by immunosurgery. J Vis Exp (2007) 0.82

Cellular reprogramming of human amniotic fluid cells to express insulin. Differentiation (2010) 0.81

Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med (2016) 0.81

The molecular biography of the cell. Cell (2005) 0.81

Generating β-cells in vitro: progress towards a Holy Grail. Curr Opin Endocrinol Diabetes Obes (2013) 0.78

New findings in pancreatic and intestinal endocrine development to advance regenerative medicine. Curr Opin Endocrinol Diabetes Obes (2013) 0.78

Coordinating cell cycle progression via cyclin specificity. Cell Cycle (2011) 0.78

Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells (2013) 0.77

Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes. Nat Commun (2016) 0.75