Published in Nat Immunol on December 01, 2001
A new description of cellular quiescence. PLoS Biol (2006) 3.56
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat Immunol (2011) 2.81
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nat Immunol (2011) 2.12
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
Metabolism in T cell activation and differentiation. Curr Opin Immunol (2010) 1.97
Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. Mol Cell Biol (2007) 1.85
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med (2007) 1.83
Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nat Immunol (2009) 1.73
Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem (2010) 1.69
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med (2005) 1.64
TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood (2007) 1.43
Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Blood (2009) 1.42
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol (2010) 1.39
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes Dev (2002) 1.36
Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev (2003) 1.31
Cancer vaccines: progress reveals new complexities. J Clin Invest (2002) 1.29
Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc Natl Acad Sci U S A (2008) 1.27
mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol (2007) 1.22
A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity (2004) 1.22
Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance. Blood Cancer J (2013) 1.17
Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression. EMBO J (2005) 1.16
The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Mol Biol Cell (2009) 1.14
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest (2015) 1.09
GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling. Nat Immunol (2013) 1.06
Negative regulators in homeostasis of naïve peripheral T cells. Immunol Res (2008) 1.05
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PLoS One (2012) 1.03
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood (2010) 1.01
Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. EMBO J (2011) 1.00
Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proc Natl Acad Sci U S A (2004) 0.97
GATA3: a master of many trades in immune regulation. Trends Immunol (2014) 0.96
Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med (2013) 0.93
SMAD regulatory networks construct a balanced immune system. Immunology (2013) 0.93
p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling. J Clin Invest (2002) 0.93
Retracted Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation. Mol Cell Biol (2004) 0.92
Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression. Cell Cycle (2009) 0.92
Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation. J Biol Chem (2010) 0.91
Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities. Mol Cell Biol (2012) 0.91
Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1. Mol Immunol (2008) 0.89
Finding unexpected patterns in microarray data. Plant Physiol (2003) 0.89
Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression. Proc Natl Acad Sci U S A (2005) 0.89
HIV restriction in quiescent CD4⁺ T cells. Retrovirology (2013) 0.88
Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway. J Biol Chem (2011) 0.88
Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. J Immunol (2010) 0.87
Induction and stability of the anergic phenotype in T cells. Semin Immunol (2013) 0.87
Quiescent T cells and HIV: an unresolved relationship. Immunol Res (2010) 0.87
Metabolic regulation of T cell differentiation and function. Mol Immunol (2015) 0.85
Quiescent T cells: actively maintaining inactivity. Nat Immunol (2001) 0.85
Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood (2007) 0.85
Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage. Arthritis Res Ther (2005) 0.84
MHC-dependent desensitization of intrinsic anti-self reactivity. Cancer Immunol Immunother (2008) 0.83
Mechanisms that regulate peripheral immune responses to control organ-specific autoimmunity. Clin Dev Immunol (2011) 0.83
Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting β‑catenin signaling. Int J Oncol (2012) 0.83
CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques. J Med Primatol (2011) 0.82
Genomic expression analysis by single-cell mRNA differential display of quiescent CD8 T cells from tumour-infiltrating lymphocytes obtained from in vivo liver tumours. Immunology (2009) 0.82
The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses. Immunity (2013) 0.81
The role of antiproliferative gene Tob1 in the immune system. Clin Exp Neuroimmunol (2014) 0.81
xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development. Dev Biol (2005) 0.81
Cloning and expression analysis of zebrafish tob1 gene. Dev Genes Evol (2004) 0.81
A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes. EMBO Mol Med (2015) 0.80
T-cell tolerance in cancer. Immunotherapy (2013) 0.79
Th17 differentiation is the default program for DPP2-deficient T-cell differentiation. Eur J Immunol (2011) 0.78
Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation. Mol Cell Biol (2012) 0.78
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. PLoS One (2014) 0.77
The role of the TOB1 gene in growth suppression of hepatocellular carcinoma. Oncol Lett (2012) 0.77
Increased expression of Tbet in CD4(+) T cells from clinically isolated syndrome patients at high risk of conversion to clinically definite MS. Springerplus (2016) 0.76
Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL. Oncotarget (2016) 0.76
Molecular characterization of Tob1 in muscle development in pigs. Int J Mol Sci (2011) 0.76
Identification of the genes specifically expressed in orally tolerized T cells. Cytotechnology (2003) 0.75
Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective. Int J Mol Sci (2015) 0.75
Stress-caused anergy of leukocytes towards Staphylococcal enterotoxin B and exposure transcriptome signatures. Genes Immun (2015) 0.75
Transcription Factor Ets-2 Acts as a Pre-induction Repressor of Interleukin-2 (IL-2) Transcription in Naive T Helper Lymphocytes. J Biol Chem (2016) 0.75
Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep (2016) 0.75
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state. Eur J Immunol (2016) 0.75
Slfn2 mutation-induced loss of T cell quiescence leads to elevated de novo sterol synthesis. Immunology (2017) 0.75
The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae. Microb Cell (2017) 0.75
PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol (2001) 12.26
CD4+CD25high regulatory cells in human peripheral blood. J Immunol (2001) 11.25
CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80
Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest (1981) 6.89
The B7 and CD28 receptor families. Immunol Today (1994) 6.38
Characterization of a human B lymphocyte-specific antigen. J Immunol (1980) 5.76
Antigens on human monocytes identified by monoclonal antibodies. J Immunol (1981) 4.67
B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol (1989) 4.61
Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science (1993) 4.45
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol (2001) 4.05
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A (1991) 3.84
Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med (1999) 3.72
ICOS is critical for CD40-mediated antibody class switching. Nature (2001) 3.63
Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture. Arch Gesamte Virusforsch (1974) 3.24
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity (1997) 3.22
IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest (2000) 3.19
Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol (1991) 3.12
B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol (1983) 3.09
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med (1991) 3.08
B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol (1987) 2.92
Characterization of a human B cell-specific antigen (B2) distinct from B1. J Immunol (1981) 2.86
Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci U S A (1993) 2.76
Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation. Blood (1984) 2.74
Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science (1990) 2.69
Characterization of CTLA-4 structure and expression on human T cells. J Immunol (1993) 2.68
BLAST-2 [EBVCS], an early cell surface marker of human B cell activation, is superinduced by Epstein Barr virus. J Immunol (1985) 2.66
Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc Natl Acad Sci U S A (1992) 2.56
Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature (1992) 2.55
Stages of B cell differentiation in human lymphoid tissue. J Exp Med (1981) 2.49
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity (1995) 2.45
CTLA-4 regulates induction of anergy in vivo. Immunity (2001) 2.39
CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy. J Clin Invest (1997) 2.39
Expression of myeloid differentiation antigens on normal and malignant myeloid cells. J Clin Invest (1981) 2.34
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science (1997) 2.33
Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol (2000) 2.16
Analysis of genomic and intracellular viral RNAs of small plaque mutants of mouse hepatitis virus, JHM strain. Virology (1984) 2.13
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science (1994) 2.10
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity (1999) 2.06
rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1988) 2.06
Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A (1993) 2.03
Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med (1989) 2.02
Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity (1999) 2.02
Hairy cell leukemia: splenectomy after alpha 2b-interferon therapy. Blood (1991) 2.01
Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. N Engl J Med (1991) 1.98
Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts. Cell (1982) 1.95
Monoclonal antibodies defining serologically distinct HLA-D/DR related Ia-like antigens in man. Hum Immunol (1981) 1.94
A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest (1981) 1.93
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci U S A (1992) 1.92
Expression of cell surface markers after human B lymphocyte activation. Proc Natl Acad Sci U S A (1981) 1.91
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J Immunol (1998) 1.82
CTLA4 mediates antigen-specific apoptosis of human T cells. Proc Natl Acad Sci U S A (1995) 1.80
Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A (1996) 1.80
Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A (1994) 1.79
The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response. Immunol Rev (1996) 1.76
Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity. Proc Natl Acad Sci U S A (1995) 1.75
p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med (2000) 1.73
Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med (1989) 1.72
Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A (1993) 1.72
Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis. Bone Marrow Transplant (2010) 1.68
Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res (1980) 1.66
Researches on Vaccine Virus in Vitro with Special References to its Affinity for Nerve Tissue. Am J Pathol (1925) 1.65
B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J Exp Med (1993) 1.63
HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes. J Immunol (1986) 1.63
Persistent, tolerant or subacute infection in Borna disease virus-infected rats. J Gen Virol (1983) 1.62
High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission. J Clin Oncol (1998) 1.61
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol (1994) 1.61
The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. Mamm Genome (1997) 1.59
Expression of common acute lymphoblastic leukemia antigen (CALLA) by lymphomas of B-cell and T-cell lineage. Blood (1981) 1.57
Combination chemotherapy followed by an immunotoxin (anti-B4-blocked ricin) in patients with indolent lymphoma: results of a phase II study. Cancer J (2000) 1.55
Influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients. Acta Haematol (1994) 1.55
PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal Immunol (2009) 1.53
B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation. J Clin Invest (1984) 1.51