Published in Proc Natl Acad Sci U S A on May 01, 1992
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity (2007) 8.94
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med (1995) 8.31
CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med (1996) 4.97
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med (1992) 3.77
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med (1994) 3.66
Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med (1994) 3.24
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood (2010) 3.21
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A (1996) 2.40
Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proc Natl Acad Sci U S A (1998) 2.29
Expression and functional significance of an additional ligand for CTLA-4. Proc Natl Acad Sci U S A (1993) 2.03
CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help. J Exp Med (1993) 1.93
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest (2001) 1.82
Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J Exp Med (1993) 1.81
Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A (1993) 1.72
T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells. J Exp Med (1994) 1.43
Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc Natl Acad Sci U S A (1994) 1.43
Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy. J Exp Med (1993) 1.30
A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation. J Exp Med (1994) 1.25
Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. J Exp Med (1995) 1.17
Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate. J Exp Med (1996) 1.15
B cells are not essential for peripheral T-cell tolerance. Proc Natl Acad Sci U S A (1996) 1.15
Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia. Hepatology (2012) 1.14
CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion. J Exp Med (1997) 1.13
Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma. J Clin Invest (1995) 1.11
CD28, CTLA-4 and their ligands: who does what and to whom? Immunology (2000) 1.10
A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7. J Exp Med (1993) 1.10
Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor. Proc Natl Acad Sci U S A (1993) 1.03
Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms. Immunology (2002) 1.00
Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation. Proc Natl Acad Sci U S A (2001) 0.98
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. J Exp Med (1995) 0.97
Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain. J Exp Med (1995) 0.92
Enhancement of B7-1 (CD80) expression on B-lymphoma cells by irradiation. Immunology (1999) 0.87
Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules. Proc Natl Acad Sci U S A (1996) 0.86
FcRn overexpression in transgenic mice results in augmented APC activity and robust immune response with increased diversity of induced antibodies. PLoS One (2012) 0.86
B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge. Proc Natl Acad Sci U S A (1998) 0.84
The costimulatory molecule B7 is expressed in the medullary region of the murine thymus. Immunology (1994) 0.83
Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cells. Immunology (2004) 0.83
Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol Med (1998) 0.83
Expression of B7 co-stimulatory molecules by B16 melanoma results in a natural killer cell-dependent local anti-tumour response, but induces T-cell-dependent systemic immunity only against B7-expressing tumours. Br J Cancer (1998) 0.83
Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48. Proc Natl Acad Sci U S A (1993) 0.82
Irradiation up-regulates CD80 expression through induction of tumour necrosis factor-alpha and CD40 ligand expression on B lymphoma cells. Immunology (2002) 0.81
Superantigen-induced peripheral T-cell deletion: the effects of chemical modification of antigen-presenting cells, interleukin-4 and glucocorticoid hormones. Immunology (1995) 0.80
A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice. Proc Natl Acad Sci U S A (1997) 0.79
Cytokines, IgG subclasses and costimulation in a mouse model of thyroid autoimmunity induced by injection of fibroblasts co-expressing MHC class II and thyroid autoantigens. Clin Exp Immunol (2000) 0.78
Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters. Mol Cell Proteomics (2013) 0.78
Costimulatory protein B7-1 enhances the cytotoxic T cell response and antibody response to hepatitis B surface antigen. Proc Natl Acad Sci U S A (1996) 0.78
A lay doctor's guide to the inflammatory process in the gastrointestinal tract. Postgrad Med J (2000) 0.76
Major histocompatibility complex class II- fetal skin dendritic cells are potent accessory cells of polyclonal T-cell responses. Immunology (2000) 0.76
Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase. PLoS One (2014) 0.75
A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol (1973) 45.44
A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J Immunol (1979) 16.56
Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A (1987) 14.24
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med (1991) 8.78
Properties and applications of monoclonal antibodies directed against determinants of they Thy-1 locus. J Immunol (1979) 7.79
Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol (1989) 7.69
Establishment and characterization of BALB/c lymphoma lines with B cell properties. J Immunol (1979) 6.70
T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci U S A (1990) 6.19
A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J Immunol (1981) 5.85
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci U S A (1989) 5.07
B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A (1991) 3.84
Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol (1991) 3.12
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med (1991) 3.08
Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J (1991) 2.97
B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol (1987) 2.92
The costimulatory function of antigen-presenting cells. Immunol Today (1990) 2.71
Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer. J Immunol (1983) 2.45
A mouse IgM allotypic determinant (Igh-6.5) recognized by a monoclonal rat antibody. J Immunol (1981) 2.27
T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc Natl Acad Sci U S A (1988) 2.21
Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells. J Immunol (1988) 2.12
A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol (1986) 1.95
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci U S A (1992) 1.92
Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. J Immunol (1991) 1.90
Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Cell (1986) 1.77
Characterization of an anti-H-2 monoclonal antibody and its use in large-scale antigen purification. J Immunol (1981) 1.70
Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes. J Exp Med (1984) 1.65
The murine IL 2 receptor. III. Cellular requirements for the induction of IL 2 receptor expression on T cell subpopulations. J Immunol (1985) 1.40
Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone. Nature (1987) 1.34
The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes. Eur J Immunol (1985) 1.24
Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. J Immunol (1978) 1.11
sgp-60, a signal-transducing glycoprotein concerned with T cell activation through the T cell receptor/CD3 complex. J Immunol (1990) 1.06
Costimulatory signal provided by a B-lymphoblastoid cell line and its Ia-negative variant. Proc Natl Acad Sci U S A (1989) 1.03
Histocompatibility-linked immune response genes. Science (1972) 16.79
PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol (2001) 12.26
CD4+CD25high regulatory cells in human peripheral blood. J Immunol (2001) 11.25
CTLA-4 can function as a negative regulator of T cell activation. Immunity (1994) 9.80
The regulatory influence of activated T cells on B cell responses to antigen. Adv Immunol (1972) 9.43
Genetic control of specific immune responses. Adv Immunol (1969) 8.81
Properties of antibodies cytophilic for macrophages. J Exp Med (1966) 8.64
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex. J Exp Med (1975) 7.64
Cell selection by antigen in the immune response. Adv Immunol (1969) 6.05
The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products. Transplant Rev (1975) 5.88
Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J Exp Med (1970) 5.71
Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT). J Exp Med (1974) 5.55
A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes. J Immunol (1978) 5.07
Role of MHC gene products in immune regulation. Science (1981) 4.84
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med (1966) 4.58
Functional specificity of thymus- dependent lymphocytes. Science (1977) 4.31
Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med (1971) 4.29
Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions. Proc Natl Acad Sci U S A (1973) 4.12
Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene. J Exp Med (1973) 4.05
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol (2001) 4.05
A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression. Scand J Immunol (1981) 3.85
B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A (1991) 3.84
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). J Immunol (1976) 3.64
ICOS is critical for CD40-mediated antibody class switching. Nature (2001) 3.63
The immune response genes of the major histocompatibility complex. Immunol Rev (1978) 3.61
The effect of the amount of mycobacterial adjuvants on the immune response of strain 2, strain 13 and Hartley strain guinea pigs to DNP-PLL and DNP-GL. J Immunol (1969) 3.53
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med (1984) 3.36
Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A (1993) 3.27
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity (1997) 3.22
Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors. J Exp Med (1980) 3.21
Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT). J Exp Med (1975) 3.17
Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol (1991) 3.12
Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro. J Exp Med (1976) 3.10
Secondary antibody responses in haptenic systems: cell population selection by antigen. J Immunol (1967) 3.01
Genetic control of immune responses in vitro. 3. Tolerogenic properties of the terpolymer L-glutamic acid 60-L-alanine30-L-tyrosine10 (GAT) for spleen cells from nonresponder (H-2s and H-2q) mice. J Exp Med (1974) 3.01
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol (2001) 2.97
Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs. Proc Natl Acad Sci U S A (1970) 2.89
Complementation of H-2-linked Ir genes in the mouse. Proc Natl Acad Sci U S A (1975) 2.88
Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science (1993) 2.78
Genetic control of specific immune suppression. I. Experimental conditions for the stimulation of suppressor cells by the copolymer L-glutamic acid50-L-tyrosine50 (GT) in nonresponder BALB/c mice. J Exp Med (1975) 2.78
Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci U S A (1993) 2.76
Characterization of CTLA-4 structure and expression on human T cells. J Immunol (1993) 2.68
The histocompatibility-linked immune response genes. Adv Cancer Res (1975) 2.64
Suppressor cells and immunoregulation. Annu Rev Immunol (1984) 2.63
Genetic control of immune responsiveness to a glutamic acid, alanine, tyrosine copolymer in mice. I. Linkage of responsiveness to H-2 genotype. J Immunol (1971) 2.60
Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature (1992) 2.55
Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses. J Exp Med (1970) 2.54
Mechanisms of regulation of cell-mediated immunity. II. Induction and suppression of delayed-type hypersensitivity to azobenzenearsonate-coupled syngeneic cells. J Immunol (1978) 2.52
Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10. J Exp Med (1979) 2.51
The distribution of antigenic and nonantigenic compounds within draining lymph nodes. Lab Invest (1966) 2.49
Biological behavior of human breast carcinoma-associated antigens expressed during cellular proliferation. Cancer Res (1983) 2.46
Antigen binding and capping by lymphocytes of genetic nonresponder mice. J Exp Med (1972) 2.46
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. J Exp Med (1979) 2.40
The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice. J Immunol (1988) 2.39
Genetic control of specific immune suppression. IV. Responsiveness to the random copolymer L-glutamic acid50-L-tyrosine50 induced in BALB/c mice by cyclophosphamide. J Exp Med (1976) 2.39
Radioresistance of carrier-specific helper thymus-derived lymphocytes in mice. Proc Natl Acad Sci U S A (1972) 2.35
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science (1997) 2.33
Antihapten antibody specificity and L chain type. J Exp Med (1967) 2.33
Identification of the membrane receptor for the complement fragment C3d by means of a monoclonal antibody. J Exp Med (1983) 2.31
The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens. J Exp Med (1978) 2.20
Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol (2000) 2.16
Studies on the effect of the carrier molecule on antihapten antibody synthesis. I. Effect of carrier on the nature of the antibody synthesized. J Exp Med (1966) 2.16
A sonographic screening method for Down syndrome. Am J Obstet Gynecol (1987) 2.16
Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. I. Genetic control of delayed-type hypersensitivity by VH and I-A-region genes. J Exp Med (1979) 2.14
Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT) II. Presence of I-J determinants on the GT-suppressive factor. J Exp Med (1977) 2.12
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway. J Exp Med (1980) 2.11
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science (1994) 2.10
Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT). III. Generation of suppressor T cells by a suppressive extract derived from GT-primed lymphoid cells. J Exp Med (1977) 2.08
The I-J subregion codes for determinats on suppressor factor(s) which limit the contact sensitivity response to picryl chloride. J Exp Med (1977) 2.07
Properties of macrophage receptors for cytophilic antibodies. Br J Exp Pathol (1966) 2.07
Mapping the H-2-linked genes governing, respectively, the immune responses to a glutamic acid-alanine-tyrosine copolymer and to limiting doses of ovalbumin. J Immunol (1973) 2.07
rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1988) 2.06
Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A (1993) 2.03
Radioresistance of cooperative function of carrier-specific lymphocytes in antihapten antibody responses. Science (1970) 2.03
Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J Exp Med (1989) 2.02
Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity (1999) 2.02
Mechanisms of regulation of cell-mediated immunity. III. The characterization of azobenzenearsonate-specific suppressor T-cell-derived-suppressor factors. J Exp Med (1979) 1.99
Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. N Engl J Med (1991) 1.98
A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and DNP-GL in responder and nonresponder guinea pigs. J Exp Med (1967) 1.94
Studies on the effect of the carrier molecule on antihapten antibody synthesis. II. Carrier specificity of anti-2,4-dinitrophenyl-poly-l-lysine antibodies. J Exp Med (1966) 1.94
Serum concentrations and allotypes of immunoglobulins in two lines of mice genetically selected for "high" or "low" antibody synthesis. J Exp Med (1970) 1.93
Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum. Proc Natl Acad Sci U S A (1977) 1.93
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci U S A (1992) 1.92
Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation. J Exp Med (1983) 1.92
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J Immunol (1992) 1.91
Histocompatibility type and immune responsiveness in random bred Hartley strain guinea pigs. J Exp Med (1970) 1.90
Hapten-specific IgE antibody responses in mice. I. Secondary IgE responses in irradiated recipients of syngeneic primed spleen cells. J Exp Med (1973) 1.87
Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells. J Exp Med (1972) 1.86
Inhibition of T-lymphocyte-mediated tumor-specific lysis by alloantisera directed against the H-2 serological specificities of the tumor. J Exp Med (1975) 1.86