An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

PubWeight™: 1.39‹?› | Rank: Top 5%

🔗 View Article (PMC 2861894)

Published in Nat Immunol on February 28, 2010

Authors

Michael Berger1, Philippe Krebs, Karine Crozat, Xiaohong Li, Ben A Croker, Owen M Siggs, Daniel Popkin, Xin Du, Brian R Lawson, Argyrios N Theofilopoulos, Yu Xia, Kevin Khovananth, Eva Marie Moresco, Takashi Satoh, Osamu Takeuchi, Shizuo Akira, Bruce Beutler

Author Affiliations

1: Department of Genetics, The Scripps Research Institute, La Jolla, California, USA.

Articles citing this

Regulation of immune responses by mTOR. Annu Rev Immunol (2011) 3.08

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol (2011) 3.03

Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature (2012) 2.98

The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity (2010) 2.85

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat Immunol (2011) 2.81

Decision checkpoints in the thymus. Nat Immunol (2010) 1.75

Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells. J Biol Chem (2010) 1.12

CD8 T cell quiescence revisited. Trends Immunol (2012) 1.11

Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One (2011) 1.08

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One (2013) 1.06

The schlafen family of proteins and their regulation by interferons. J Interferon Cytokine Res (2013) 0.99

After GWAS: mice to the rescue? Curr Opin Immunol (2012) 0.91

Schlafen 3 changes during rat intestinal maturation. Am J Surg (2012) 0.89

Resisting viral infection: the gene by gene approach. Curr Opin Virol (2011) 0.85

Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma. J Biol Chem (2013) 0.83

Characterization of Novel Ribosome-Associated Endoribonuclease SLFN14 from Rabbit Reticulocytes. Biochemistry (2015) 0.81

Quieting T cells with Slfn2. Nat Immunol (2010) 0.81

Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells. Results Immunol (2015) 0.80

Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. J Clin Invest (2016) 0.79

Multi-omic data integration links deleted in breast cancer 1 (DBC1) degradation to chromatin remodeling in inflammatory response. Mol Cell Proteomics (2013) 0.78

The P-loop region of Schlafen 3 acts within the cytosol to induce differentiation of human Caco-2 intestinal epithelial cells. Biochim Biophys Acta (2014) 0.77

Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL. Oncotarget (2016) 0.76

Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives. Genes (Basel) (2014) 0.76

Innate immunity and the new forward genetics. Best Pract Res Clin Haematol (2016) 0.75

A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS. Nat Immunol (2011) 0.75

The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state. Eur J Immunol (2016) 0.75

Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence. Oncotarget (2016) 0.75

Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1. Int J Mol Sci (2016) 0.75

Slfn2 mutation-induced loss of T cell quiescence leads to elevated de novo sterol synthesis. Immunology (2017) 0.75

Articles cited by this

NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell (2007) 12.33

AAA+ proteins: have engine, will work. Nat Rev Mol Cell Biol (2005) 7.73

NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25

Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med (2000) 5.07

Mitogen-activated protein kinases in apoptosis regulation. Oncogene (2004) 4.76

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61

Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med (2000) 4.54

Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature (2006) 4.51

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31

LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science (1997) 3.77

Life and death in peripheral T cells. Nat Rev Immunol (2007) 3.67

A new description of cellular quiescence. PLoS Biol (2006) 3.56

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands. Proc Natl Acad Sci U S A (1999) 3.06

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol (2001) 2.97

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A (2003) 2.91

Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J Immunol (1998) 2.73

Regulation of quiescence in lymphocytes. Trends Immunol (2003) 2.58

Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Nat Immunol (2001) 2.36

Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. Immunity (2003) 2.20

Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription. J Immunol (2007) 2.18

AAA+ ATPases: achieving diversity of function with conserved machinery. Traffic (2007) 2.12

Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity (1998) 2.04

B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunol Rev (2000) 1.89

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A (2006) 1.88

Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci U S A (1999) 1.84

Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int Immunol (2004) 1.76

Lymphocide: cytokines and the control of lymphoid homeostasis. Nat Rev Immunol (2002) 1.70

Mechanisms of L-selectin regulation by activated T cells. J Immunol (1997) 1.64

Genetic control of innate immune responses against cytomegalovirus: MCMV meets its match. Genes Immun (2002) 1.59

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res (2003) 1.38

IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol (2008) 1.38

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem (2005) 1.37

Critical roles of the PI3K/Akt signaling pathway in T cell development. Immunol Lett (2008) 1.37

NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses. Blood (2009) 1.29

JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Immunol Rev (2003) 1.24

Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome (2006) 1.23

A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med (2006) 1.15

Defense against influenza A virus infection: essential role of the chemokine system. Immunobiology (2001) 1.07

Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen. J Immunol (1998) 0.97

Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence. J Gen Virol (2007) 0.93

eXPRESSION: an in silico tool to predict patterns of gene expression. Gene Expr Patterns (2005) 0.93

PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development. J Immunol (2006) 0.88

Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal. BMC Genomics (2009) 0.87

Removal of lymphoid organs. Curr Protoc Immunol (2001) 0.82

Articles by these authors

Pathogen recognition and innate immunity. Cell (2006) 44.14

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12

Toll-like receptors. Annu Rev Immunol (2001) 26.06

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

A draft sequence of the rice genome (Oryza sativa L. ssp. japonica). Science (2002) 21.26

Pattern recognition receptors and inflammation. Cell (2010) 21.05

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10

Toll-like receptors in innate immunity. Int Immunol (2005) 12.24

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

Innate immune recognition of viral infection. Nat Immunol (2006) 9.59

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40

Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17

TLR signaling pathways. Semin Immunol (2004) 9.08

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27

TLR signaling. Semin Immunol (2007) 8.16

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol (2005) 7.74

Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (2005) 7.72

ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med (2005) 7.18

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07

Innate immunity to virus infection. Immunol Rev (2009) 7.04

Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet (2006) 6.71

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62

Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (2006) 6.47

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature (2008) 6.40

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98

Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83

Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol (2006) 5.51

Relating three-dimensional structures to protein networks provides evolutionary insights. Science (2006) 5.50

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol (2006) 5.35

Annotation transfer between genomes: protein-protein interologs and protein-DNA regulogs. Genome Res (2004) 5.26

The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21

CD14 is required for MyD88-independent LPS signaling. Nat Immunol (2005) 5.20

CD36 is a sensor of diacylglycerides. Nature (2005) 5.20

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10

Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med (2006) 5.01

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 4.92

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol (2005) 4.91

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A (2004) 4.88