Published in J Biol Chem on November 07, 2001
Genome-wide analysis of survival in early-stage non-small-cell lung cancer. J Clin Oncol (2009) 1.52
The Eyes Absent proteins in development and disease. Cell Mol Life Sci (2012) 1.16
Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 0.96
EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene (2013) 0.95
The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opin Ther Targets (2015) 0.94
Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection. Nucleic Acids Res (2006) 0.94
Drosophila nemo promotes eye specification directed by the retinal determination gene network. Genetics (2008) 0.92
Identification of I411K, a novel missense EYA4 mutation causing autosomal dominant non‑syndromic hearing loss. Int J Mol Med (2014) 0.87
Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth. Oncotarget (2014) 0.85
Eya2, a target activated by Plzf, is critical for PLZF-RARA-induced leukemogenesis. Mol Cell Biol (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell (2003) 7.60
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature (2007) 7.21
NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature (2005) 4.97
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood (2007) 4.91
Myc pathways provoking cell suicide and cancer. Oncogene (2003) 3.49
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev (2002) 3.16
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest (2008) 2.83
Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest (2002) 2.50
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood (2009) 2.39
Targeting lactate metabolism for cancer therapeutics. J Clin Invest (2013) 2.14
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc Natl Acad Sci U S A (2003) 2.07
Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell (2005) 1.95
Mitochondrial dysfunction in ataxia-telangiectasia. Blood (2011) 1.93
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell (2011) 1.91
Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J (2003) 1.85
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood (2010) 1.76
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol (2008) 1.72
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68
c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol Cell Biol (2003) 1.59
Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation. PLoS One (2011) 1.53
Retracted FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma. J Cell Biol (2005) 1.51
Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Mol Cell (2003) 1.47
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Res (2013) 1.46
Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. Am J Physiol Gastrointest Liver Physiol (2010) 1.38
Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood (2008) 1.31
Modulating autophagy for therapeutic benefit. Autophagy (2007) 1.30
Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J (2007) 1.29
Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state. Cell (2012) 1.29
Mapping the phosphorylation sites of Ulk1. J Proteome Res (2009) 1.21
Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Mol Cancer Res (2007) 1.16
Clearing the TRAIL for Cancer Therapy. Cancer Cell (2007) 1.13
Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Mol Cell Biol (2004) 1.13
Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma. Cancer Res (2009) 1.09
Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. Cancer Res (2007) 1.09
Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. Cancer Res (2002) 1.05
A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular development. Development (2008) 1.05
The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. Mol Cell Biol (2005) 1.04
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. Mol Cell Biol (2006) 1.01
Chlamydia species-dependent differences in the growth requirement for lysosomes. PLoS One (2011) 1.01
The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. Mol Cancer Ther (2007) 0.98
Nfkb 1 is dispensable for Myc-induced lymphomagenesis. Oncogene (2005) 0.97
Mechanisms of group B streptococcal-induced apoptosis of murine macrophages. J Immunol (2005) 0.97
Myc suppression of Nfkb2 accelerates lymphomagenesis. BMC Cancer (2010) 0.96
Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. Mol Cancer Res (2010) 0.95
Haploinsufficiency for odc modifies mouse skin tumor susceptibility. Cancer Res (2005) 0.94
The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib. Cancer Res (2008) 0.94
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett (2013) 0.93
FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion. Mol Cell Biol (2005) 0.93
Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J Med Chem (2014) 0.90
FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma. J Cell Biol (2007) 0.88
Targeting the autophagy pathway for cancer chemoprevention. Curr Opin Cell Biol (2010) 0.87
Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance. Biologics (2008) 0.86
Monitoring the autophagy pathway in cancer. Methods Enzymol (2009) 0.84
The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia. J Biol Chem (2005) 0.84
Id2 is dispensable for myc-induced lymphomagenesis. Cancer Res (2004) 0.82
Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype. Am J Physiol Gastrointest Liver Physiol (2010) 0.81
AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. CNS Neurosci Ther (2014) 0.81
Synthesis and SAR of Lehualide B: a marine-derived natural product with potent anti-multiple myeloma activity. ACS Chem Biol (2013) 0.80
Novel extranuclear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis. Mol Cancer Ther (2002) 0.79
Mnt: master regulator of the Max network. Cell Cycle (2004) 0.79
A new piece of the ALS puzzle. Nat Genet (2003) 0.78
A novel Eyes Absent 2 protein is expressed in the human eye. Gene (2002) 0.76
CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis. J Clin Invest (2014) 0.76
Endogenous elevation of plasma cholecystokinin does not prevent gallstones. Eur J Clin Invest (2015) 0.76
Embryonic Expression and Function of the Xenopus Ink4d Cyclin D-Dependent Kinase Inhibitor. Cell Dev Biol (2014) 0.75