Published in Am J Physiol Gastrointest Liver Physiol on January 28, 2010
Risk factors for pancreatic cancer: underlying mechanisms and potential targets. Front Physiol (2014) 1.10
Autophagy and pancreatitis. Am J Physiol Gastrointest Liver Physiol (2012) 1.04
Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proc Natl Acad Sci U S A (2016) 0.88
Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.87
Molecular and cellular mechanisms of pancreatic injury. Curr Opin Gastroenterol (2010) 0.86
SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression. Oncogenesis (2015) 0.79
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet (1996) 7.94
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet (2000) 4.83
Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med (1998) 3.91
Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Gastroenterology (2001) 2.36
Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol (2008) 1.85
Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin. Eur J Biochem (1988) 1.62
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest (2001) 1.51
Chronic pancreatitis: genetics and pathogenesis. Annu Rev Genomics Hum Genet (2009) 1.46
Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology (2005) 1.38
Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology (2005) 1.29
Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis. J Med Genet (2000) 1.27
Immunohistochemical localization of pancreatic secretory trypsin inhibitor in fetal and adult pancreatic and extrapancreatic tissues. J Histochem Cytochem (1986) 1.19
A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas. EMBO J (1987) 1.18
Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3. Pancreas (2006) 1.03
Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen activation. Autophagy (2008) 1.03
Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide. Am J Physiol (1989) 1.02
Human pancreatic secretory trypsin inhibitor. Methods Enzymol (1976) 1.02
Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution. Am J Pathol (1996) 1.02
Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. Pancreas (2008) 1.02
The role of trypsin, trypsin inhibitor, and trypsin receptor in the onset and aggravation of pancreatitis. J Gastroenterol (2006) 0.97
Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells. Am J Physiol (1992) 0.95
Trypsin inhibitor from human pancreas and pancreatic juice. J Biol Chem (1974) 0.93
Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. Histochem Cell Biol (2008) 0.88
Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium. Proc Natl Acad Sci U S A (1992) 0.87
Cholecystokinin- and secretin-releasing peptides in the intestine--a new regulatory interendocrine mechanism in the gastrointestinal tract. Regul Pept (1998) 0.87
A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance. Gut (2005) 0.87
Developmental profile of a caltrin-like protease inhibitor, P12, in mouse seminal vesicle and characterization of its binding sites on sperm surface. Biol Reprod (1998) 0.86
Role of genetic disorders in acute recurrent pancreatitis. World J Gastroenterol (2008) 0.85
Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol Metab Clin North Am (2006) 0.85
Androgen regulated expression of a spermine binding protein gene in mouse ventral prostate. Nucleic Acids Res (1987) 0.85
Biochemistry and biology of SPINK-PSTI and monitor peptide. Endocrinol Metab Clin North Am (2006) 0.82
Differences in stimulatory effects between rat pancreatic secretory trypsin inhibitor-61 and -56 on rat pancreas. Jpn J Physiol (1989) 0.80
Susceptibility to pancreatitis related to PSTI/SPINK1 expression. Gastroenterol Clin North Am (2004) 0.77
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40
The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65
Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development (2002) 2.59
Autoimmune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and rapamycin treatment. Gut (2013) 2.28
Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell Stem Cell (2013) 2.23
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest (2011) 2.13
Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J Cell Biol (2008) 1.85
Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest. Am J Physiol Heart Circ Physiol (2009) 1.66
Applicability of disseminated intravascular coagulation parameters in the assessment of the severity of acute pancreatitis. Pancreas (2006) 1.56
Site-directed integration of the cre gene mediated by Cre recombinase using a combination of mutant lox sites. Nucleic Acids Res (2002) 1.54
Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. Gut (2007) 1.53
The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell Signal (2013) 1.52
Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. Am J Physiol Gastrointest Liver Physiol (2010) 1.38
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun (2012) 1.36
Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells. Biol Reprod (2007) 1.34
Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A. Gastroenterology (2012) 1.32
Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice. Dev Dyn (2009) 1.30
Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology (2005) 1.29
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Dev Growth Differ (2005) 1.28
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest (2013) 1.28
LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. Biol Reprod (2006) 1.27
Cholecystokinin. Curr Opin Endocrinol Diabetes Obes (2007) 1.26
Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa. Arch Gen Psychiatry (2007) 1.23
Region-specific gastrointestinal Hox code during murine embryonal gut development. Dev Growth Differ (2002) 1.19
Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol (2011) 1.18
Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). J Pharmacol Exp Ther (2003) 1.17
Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat (2007) 1.17
Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep (2013) 1.12
Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats. Am J Physiol Gastrointest Liver Physiol (2002) 1.12
Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor. Mol Cancer Res (2009) 1.12
SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas. J Clin Invest (2014) 1.10
Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.09
Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut (2012) 1.09
Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells. Blood (2002) 1.09
Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice. Hum Mol Genet (2006) 1.09
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. J Clin Invest (2015) 1.09
Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases. Genes Cells (2006) 1.06
A novel murine gene, Sickle tail, linked to the Danforth's short tail locus, is required for normal development of the intervertebral disc. Genetics (2005) 1.06
BMP signaling in the development of the mouse esophagus and forestomach. Development (2010) 1.06
β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci (2012) 1.05
Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion. J Clin Invest (2013) 1.05
Genetic and cellular mechanisms regulating anterior foregut and esophageal development. Dev Biol (2012) 1.04
Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3. Pancreas (2006) 1.03
Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen activation. Autophagy (2008) 1.03
Expression of Hqk encoding a KH RNA binding protein is altered in human glioma. Jpn J Cancer Res (2002) 1.03
Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. Pancreas (2008) 1.02
International Gene Trap Project: towards gene-driven saturation mutagenesis in mice. Curr Pharm Biotechnol (2009) 1.01
HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer. Am J Pathol (2009) 1.01
c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci Signal (2012) 1.01
CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J (2012) 0.99
The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. Mol Cancer Ther (2007) 0.98
The role of trypsin, trypsin inhibitor, and trypsin receptor in the onset and aggravation of pancreatitis. J Gastroenterol (2006) 0.97
BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis. J Clin Invest (2015) 0.96
Proteome profiling reveals gender differences in the composition of human serum. Proteomics (2010) 0.95
The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol Cell Biol (2010) 0.95
Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats. Am J Physiol Gastrointest Liver Physiol (2006) 0.95
Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. J Mol Histol (2011) 0.94
Misexpression of the eyes absent family triggers the apoptotic program. J Biol Chem (2001) 0.94
Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus. PLoS One (2012) 0.93
Non-O1 Vibrio cholerae septicemia: case report, discussion of literature, and relevance to bioterrorism. Diagn Microbiol Infect Dis (2004) 0.93
Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. Mech Dev (2008) 0.93
The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats. Gastroenterology (2005) 0.92
Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene. Biochem Biophys Res Commun (2005) 0.92
Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation. Endocrinology (2011) 0.92
C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis. Biochem Biophys Res Commun (2007) 0.91
Comparative analysis of right element mutant lox sites on recombination efficiency in embryonic stem cells. BMC Biotechnol (2010) 0.90
Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells. Proc Natl Acad Sci U S A (2014) 0.90
Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart. Dev Biol (2006) 0.90
Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases. Exp Anim (2011) 0.90
Pseudopod-like basal cell processes in intestinal cholecystokinin cells. Cell Tissue Res (2010) 0.89
Further evidence for endothelin as an important mediator of pancreatic and intestinal ischemia in severe acute pancreatitis. Pancreas (2003) 0.89
Proinflammatory role of trypsin and protease-activated receptor-2 in a rat model of acute pancreatitis. Pancreas (2005) 0.89
Establishment of an efficient BAC transgenesis protocol and its application to functional characterization of the mouse Brachyury locus. Exp Anim (2004) 0.89
Role of ornithine decarboxylase antizyme inhibitor in vivo. Genes Cells (2008) 0.89
The gut connectome: making sense of what you eat. J Clin Invest (2015) 0.89
Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins. Proc Natl Acad Sci U S A (2009) 0.88
Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. Pancreas (2010) 0.88
Myopathy phenotype in transgenic mice expressing mutated PABPN1 as a model of oculopharyngeal muscular dystrophy. Hum Mol Genet (2003) 0.88
Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. Histochem Cell Biol (2008) 0.88
Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet (2013) 0.88
Genetic background of pancreatitis. Postgrad Med J (2006) 0.88
Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes. J Neurochem (2006) 0.88
From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene. JOP (2003) 0.87
Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression. Lab Invest (2010) 0.87
IGSF4 is a novel TCR ζ-chain-interacting protein that enhances TCR-mediated signaling. J Exp Med (2011) 0.87
Pancreatic cancer in the remnant pancreas following primary pancreatic resection. Surg Today (2013) 0.87
Axon-like basal processes in enteroendocrine cells: characteristics and potential targets. Clin Transl Sci (2011) 0.86
Screening methods to identify TALEN-mediated knockout mice. Exp Anim (2014) 0.86
Characterization of the AINV gene and the encoded invertase from the dimorphic yeast Arxula adeninivorans. Antonie Van Leeuwenhoek (2004) 0.85
Immunization in familial amyloidotic polyneuropathy: counteracting deposition by immunization with a Y78F TTR mutant. Lab Invest (2006) 0.85