Published in Health Technol Assess on January 01, 2001
Operative versus non-operative treatment for closed, displaced, intra-articular fractures of the calcaneus: randomised controlled trial. BMJ (2014) 3.80
Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45
Subgroup identification from randomized clinical trial data. Stat Med (2011) 3.22
Discrepancies in sample size calculations and data analyses reported in randomised trials: comparison of publications with protocols. BMJ (2008) 2.56
Case-mix adjustment in non-randomised observational evaluations: the constant risk fallacy. J Epidemiol Community Health (2007) 2.38
Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysis. BMC Med Res Methodol (2006) 2.27
Design, analysis and presentation of factorial randomised controlled trials. BMC Med Res Methodol (2003) 2.10
SUPPORT Tools for evidence-informed health Policymaking (STP) 10: Taking equity into consideration when assessing the findings of a systematic review. Health Res Policy Syst (2009) 2.03
Clinical outcomes of single-visit oral prophylaxis: a practice-based randomised controlled trial. BMC Oral Health (2011) 1.49
The exclusion of patients with chronic kidney disease from clinical trials in coronary artery disease. Kidney Int (2006) 1.47
Improving the use of research evidence in guideline development: 12. Incorporating considerations of equity. Health Res Policy Syst (2006) 1.46
A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers. J Clin Periodontol (2007) 1.44
Three simple rules to ensure reasonably credible subgroup analyses. BMJ (2015) 1.40
Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research. J Med Genet (2014) 1.34
Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. Psychopharmacology (Berl) (2011) 1.30
Independent evaluation of a clinical prediction rule for spinal manipulative therapy: a randomised controlled trial. Eur Spine J (2008) 1.27
A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids. J Pediatr Gastroenterol Nutr (2009) 1.20
Multimorbidity and evidence generation. J Gen Intern Med (2014) 1.17
Motor control or graded activity exercises for chronic low back pain? A randomised controlled trial. BMC Musculoskelet Disord (2008) 1.05
From nature versus nurture, via nature and nurture, to gene x environment interaction in mental disorders. Eur Child Adolesc Psychiatry (2009) 1.02
The three stages of building and testing mid-level theories in a realist RCT: a theoretical and methodological case-example. Trials (2015) 1.02
Competing risk and heterogeneity of treatment effect in clinical trials. Trials (2008) 1.01
Evaluation of heterogeneity in pharmacotherapy trials for drug dependence: a Bayesian approach. Am J Drug Alcohol Abuse (2009) 1.01
Methodological criteria for the assessment of moderators in systematic reviews of randomised controlled trials: a consensus study. BMC Med Res Methodol (2011) 0.99
Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med (2013) 0.96
Osteoarthritis subpopulations and implications for clinical trial design. Arthritis Res Ther (2011) 0.93
Managing Injuries of the Neck Trial (MINT): design of a randomised controlled trial of treatments for whiplash associated disorders. BMC Musculoskelet Disord (2007) 0.92
Aggregate-data estimation of an individual patient data linear random effects meta-analysis with a patient covariate-treatment interaction term. Biostatistics (2012) 0.90
From Protocols to Publications: A Study in Selective Reporting of Outcomes in Randomized Trials in Oncology. J Clin Oncol (2015) 0.89
The CARDia trial protocol. Heart (2003) 0.88
How to work with a subgroup analysis. Can J Surg (2009) 0.86
GENetic and clinical predictors of treatment response in depression: the GenPod randomised trial protocol. Trials (2008) 0.86
Sex- and age-interacting eQTLs in human complex diseases. Hum Mol Genet (2013) 0.86
Pain location and functioning in persons with spinal cord injury. PM R (2014) 0.85
Assessing Heterogeneity of Treatment Effects: Are Authors Misinterpreting Their Results? Health Serv Res (2010) 0.85
Variation in the sustained effects of the communities that care prevention system on adolescent smoking, delinquency, and violence. Prev Sci (2014) 0.85
Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers. Food Sci Nutr (2013) 0.84
Targeting targeted agents: open issues for clinical trial design. J Exp Clin Cancer Res (2009) 0.83
Antioxidant activity of noni juice in heavy smokers. Chem Cent J (2009) 0.83
Design considerations in a clinical trial of a cognitive behavioural intervention for the management of low back pain in primary care: Back Skills Training Trial. BMC Musculoskelet Disord (2007) 0.83
A multicentre randomised controlled trial evaluating lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea in older people admitted to hospital: the PLACIDE study protocol. BMC Infect Dis (2012) 0.82
A randomized controlled trial of tai chi for long-term low back pain (TAI CHI): study rationale, design, and methods. BMC Musculoskelet Disord (2009) 0.81
A systematic review of individual patient data meta-analyses on surgical interventions. Syst Rev (2013) 0.81
Assessing the impact of human trampling on vegetation: a systematic review and meta-analysis of experimental evidence. PeerJ (2014) 0.80
Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study. JMIR Res Protoc (2016) 0.78
Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting. Osteoporos Int (2017) 0.78
Hidden decay of impact after education for self-management of chronic illnesses: hypotheses. Chronic Illn (2012) 0.78
Exploring equity in primary-care-based physical activity interventions using PROGRESS-Plus: a systematic review and evidence synthesis. Int J Behav Nutr Phys Act (2016) 0.78
The influence of baseline marijuana use on treatment of cocaine dependence: application of an informative-priors bayesian approach. Front Psychiatry (2012) 0.77
Low-dose nonlinear effects of smoking on coronary heart disease risk. Dose Response (2011) 0.77
Tamoxifen is not effective in good prognosis patients with hepatocellular carcinoma. BMC Cancer (2006) 0.76
The effect of active video games by ethnicity, sex and fitness: subgroup analysis from a randomised controlled trial. Int J Behav Nutr Phys Act (2014) 0.76
Can we predict response to the McKenzie method in patients with acute low back pain? A secondary analysis of a randomized controlled trial. Eur Spine J (2011) 0.76
Fear of negative evaluation biases social evaluation inference: evidence from a probabilistic learning task. PLoS One (2015) 0.76
Designing cost-efficient randomized trials by using flexible recruitment strategies. BMC Med Res Methodol (2012) 0.75
Moderators of treatment response to trauma-focused cognitive behavioral therapy among youth in Zambia. J Child Psychol Psychiatry (2016) 0.75
Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder. J Subst Abuse Treat (2016) 0.75
Identifying subgroups of enhanced predictive accuracy from longitudinal biomarker data using tree-based approaches: applications to fetal growth. J R Stat Soc Ser A Stat Soc (2016) 0.75
Bayesian variable selection in cost-effectiveness analysis. Int J Environ Res Public Health (2010) 0.75
Statistical results on restorative dentistry experiments: effect of the interaction between main variables. J Appl Oral Sci (2010) 0.75
Effects of yoga, strength training and advice on back pain: a randomized controlled trial. BMC Musculoskelet Disord (2017) 0.75
Noni juice improves serum lipid profiles and other risk markers in cigarette smokers. ScientificWorldJournal (2012) 0.75
Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients. BMC Nephrol (2017) 0.75
Examining the Efficacy of HIV Risk-Reduction Counseling on the Sexual Risk Behaviors of a National Sample of Drug Abuse Treatment Clients: Analysis of Subgroups. AIDS Behav (2016) 0.75
Permutation Testing for Treatment-Covariate Interactions and Subgroup Identification. Stat Biosci (2015) 0.75
Impact of misspecifying the distribution of a prognostic factor on power and sample size for testing treatment interactions in clinical trials. BMC Med Res Methodol (2013) 0.75
No Differences in Outcomes in People with Low Back Pain Who Met the Clinical Prediction Rule for Lumbar Spine Manipulation When a Pragmatic Non-thrust Manipulation Was Used as the Comparator. Physiother Can (2014) 0.75
The effect of abaloparatide-SC on fracture risk is independent of baseline FRAX fracture probability: A post hoc analysis of the ACTIVE study. J Bone Miner Res (2017) 0.75
Equity effects of children's physical activity interventions: a systematic scoping review. Int J Behav Nutr Phys Act (2017) 0.75
Bias in meta-analysis detected by a simple, graphical test. BMJ (1997) 122.24
The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med (2001) 37.70
Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ (2001) 20.65
The hazards of scoring the quality of clinical trials for meta-analysis. JAMA (1999) 17.00
Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol (2001) 12.72
Misleading meta-analysis. BMJ (1995) 11.94
Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ (2000) 11.35
Sifting the evidence-what's wrong with significance tests? BMJ (2001) 9.50
Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol (2000) 7.95
Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis. BMJ (2001) 7.13
Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ (2004) 6.48
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Who benefits from medical interventions? BMJ (1994) 5.58
Spurious precision? Meta-analysis of observational studies. BMJ (1998) 5.45
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell (2000) 5.31
Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Swiss HIV Cohort Study. Lancet (1999) 4.83
Evidence based purchasing: understanding results of clinical trials and systematic reviews. BMJ (1995) 4.75
The patient-centredness of consultations and outcome in primary care. Br J Gen Pract (1999) 4.67
Early enteral feeding versus "nil by mouth" after gastrointestinal surgery: systematic review and meta-analysis of controlled trials. BMJ (2001) 4.47
Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial. Lancet (2011) 4.35
Socioeconomic differentials in wealth and health. BMJ (1993) 4.32
Population requirement for primary hip-replacement surgery: a cross-sectional study. Lancet (1999) 4.29
Risk of lung cancer associated with residential radon exposure in south-west England: a case-control study. Br J Cancer (1998) 4.24
Clinical features of colorectal cancer before diagnosis: a population-based case-control study. Br J Cancer (2005) 4.19
A randomized controlled trial of antibiotics on symptom resolution in patients presenting to their general practitioner with a sore throat. Br J Gen Pract (1997) 4.18
What constitutes controlled hypertension? Patient based comparison of hypertension guidelines. BMJ (1996) 4.11
The limits to demand for health care. BMJ (2000) 4.00
The impact of patients' preferences on the treatment of atrial fibrillation: observational study of patient based decision analysis. BMJ (2000) 3.93
A randomized controlled trial and economic evaluation of counselling in primary care. Br J Gen Pract (1998) 3.84
Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe. J Natl Cancer Inst (1998) 3.74
Magnesium and myocardial infarction. Lancet (1994) 3.74
Lysosomes of the arterial wall. I. Isolation and subcellular fractionation of cells from normal rabbit aorta. J Exp Med (1972) 3.73
What are the clinical features of lung cancer before the diagnosis is made? A population based case-control study. Thorax (2005) 3.66
Grey literature in meta-analyses of randomized trials of health care interventions. Cochrane Database Syst Rev (2007) 3.51
HIV and male circumcision--a systematic review with assessment of the quality of studies. Lancet Infect Dis (2005) 3.49
Reporting on quality of life in randomised controlled trials: bibliographic study. BMJ (1998) 3.37
AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study. JAMA (1999) 3.34
Hospital at home or acute hospital care? A cost minimisation analysis. BMJ (1998) 3.33
Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort. Am J Clin Nutr (1998) 3.21
Smoking and health promotion in Nazi Germany. J Epidemiol Community Health (1994) 3.20
Randomised controlled trial comparing effectiveness and acceptability of an early discharge, hospital at home scheme with acute hospital care. BMJ (1998) 3.15
Childhood social circumstances and psychosocial and behavioural factors as determinants of plasma fibrinogen. Lancet (1996) 3.11
How policy informs the evidence. BMJ (2001) 3.06
Childhood leg length and adult mortality: follow up of the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-war Britain. J Epidemiol Community Health (1998) 2.95
A general practice-based study examining the absolute risk of cardiovascular disease in treated hypertensive patients. Br J Gen Pract (1996) 2.94
Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol (2005) 2.94
An iron-regulated ferric reductase associated with the absorption of dietary iron. Science (2001) 2.90
Non-communicable diseases in low- and middle-income countries: context, determinants and health policy. Trop Med Int Health (2008) 2.86
Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs. Lancet (1984) 2.83
Relation between parasuicide, suicide, psychiatric admissions, and socioeconomic deprivation. BMJ (1995) 2.83
Do all men attending departments of genitourinary medicine need to be screened for non-gonococcal urethritis? Int J STD AIDS (2002) 2.81
Socioeconomic differentials in mortality among men within Great Britain: time trends and contributory causes. J Epidemiol Community Health (1998) 2.65
Funding clinical research. Lancet (1999) 2.63
A persistent defect in intestinal permeability in coeliac disease demonstrated by a 51Cr-labelled EDTA absorption test. Lancet (1983) 2.62
Childhood energy intake and adult mortality from cancer: the Boyd Orr Cohort Study. BMJ (1998) 2.60
Psychosocial factors and public health: a suitable case for treatment? J Epidemiol Community Health (2003) 2.53
Childhood housing conditions and later mortality in the Boyd Orr cohort. J Epidemiol Community Health (2001) 2.47
The causes and effects of socio-demographic exclusions from clinical trials. Health Technol Assess (2005) 2.38
The Bristol shared care glaucoma study: outcome at follow up at 2 years. Br J Ophthalmol (2000) 2.38
Impact of childhood and adulthood socioeconomic position on cause specific mortality: the Oslo Mortality Study. J Epidemiol Community Health (2003) 2.38
The Swiss HIV Cohort Study: rationale, organization and selected baseline characteristics. Soz Praventivmed (1994) 2.38
Genital Chlamydia trachomatis infections in Uppsala County, Sweden, 1985-1993: declining rates for how much longer? Sex Transm Dis (1995) 2.36
Immunoglobulin structure: partial amino acid sequence of a Bence Jones protein. Science (1965) 2.36
Commentary: understanding it all--health, meta-theories, and mortality trends. BMJ (1997) 2.35
Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst Rev (2003) 2.32
Case definition in childhood accident studies: a vital factor in determining results. Int J Epidemiol (1986) 2.32
The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet (1984) 2.30
Are randomised controlled trials in the BMJ different? BMJ (2001) 2.26
Relation between number of siblings and adult mortality and stroke risk: 25 year follow up of men in the Collaborative study. J Epidemiol Community Health (2003) 2.25
Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study. Clin Infect Dis (2001) 2.24
Absorption of 51chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease. Gastroenterology (1983) 2.23
Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection. Health Technol Assess (2007) 2.23
The association between components of adult height and Type II diabetes and insulin resistance: British Women's Heart and Health Study. Diabetologia (2002) 2.22
The Bristol Shared Care Glaucoma Study--validity of measurements and patient satisfaction. J Public Health Med (1997) 2.21
Localisation of enzymic defect in propionicacidaemia. Lancet (1970) 2.19
Treatment of acute paracetamol poisoning. Lancet (1968) 2.18
Discontinuation of primary prophylaxis against Pneumocystis carinii pneumonia in HIV-1-infected adults treated with combination antiretroviral therapy. Swiss HIV Cohort Study. N Engl J Med (1999) 2.17
Pre-existing ischaemic heart disease and ischaemic heart disease mortality in women compared with men. Int J Epidemiol (1997) 2.16
Tuberculosis in HIV programmes in lower-income countries: practices and risk factors. Int J Tuberc Lung Dis (2011) 2.15
Hip fractures and fluoridation in Utah's elderly population. JAMA (1992) 2.13
Infant mortality, stomach cancer, stroke, and coronary heart disease: ecological analysis. BMJ (2000) 2.13
Epidemiology--is it time to call it a day? Int J Epidemiol (2001) 2.12
Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine. Gut (1986) 2.10
Caring for elderly dependents: effects on the carers' quality of life. Age Ageing (1992) 2.09
King's model for allocating service increment for teaching and research (SIFTR). BMJ (1992) 2.08
Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev (2004) 2.05
Immobilized proteins in buffer imaged at molecular resolution by atomic force microscopy. Biophys J (1990) 2.04
Multiple risk factor interventions for primary prevention of coronary heart disease. Cochrane Database Syst Rev (2006) 2.04
The importance of anaemia in diagnosing colorectal cancer: a case-control study using electronic primary care records. Br J Cancer (2008) 2.04
Secular trends in antidepressant prescribing in the UK, 1975-1998. J Public Health Med (2001) 2.04
The mortality of colorectal cancer in relation to the initial symptom at presentation to primary care and to the duration of symptoms: a cohort study using medical records. Br J Cancer (2006) 2.01
An additional dimension to health inequalities: disease severity and socioeconomic position. J Epidemiol Community Health (1999) 2.01
Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia (2009) 1.99