Published in Gut on December 01, 2001
Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut (2004) 2.55
Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence. Ann Surg (2005) 1.33
Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm Genome (2004) 1.20
Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning. World J Gastroenterol (2003) 0.97
Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease. J Gastroenterol (2011) 0.97
Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12. Hum Genet (2006) 0.96
Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease. PLoS One (2011) 0.94
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet (2016) 0.85
Crohn's disease or Crohn's diseases? Gut (2003) 0.81
Change in the diagnosis of inflammatory bowel disease: a hospital-based cohort study from Korea. Intest Res (2016) 0.79
Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives. World J Gastroenterol (2010) 0.76
Optimizing the chances of success in the search for epigenetic biomarkers: Embracing genetic variation. Am J Med Genet B Neuropsychiatr Genet (2017) 0.75
The future of genetic studies of complex human diseases. Science (1996) 64.76
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
Inflammatory bowel disease (1) N Engl J Med (1991) 5.78
Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature (1996) 5.44
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet (1996) 4.09
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet (2000) 3.52
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A (1998) 2.88
A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet (1999) 2.88
Perforating and non-perforating indications for repeated operations in Crohn's disease: evidence for two clinical forms. Gut (1988) 2.51
A genome-wide search identifies potential new susceptibility loci for Crohn's disease. Inflamm Bowel Dis (1999) 1.74
High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12. Am J Hum Genet (2000) 1.52
Histological discrimination of idiopathic inflammatory bowel disease from other types of colitis. J Clin Pathol (1995) 1.43
Mucosal biopsy diagnosis of colitis: acute self-limited colitis and idiopathic inflammatory bowel disease. Gastroenterology (1994) 1.41
The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease. Am J Hum Genet (2000) 1.01
Frequency and clinical evolution of indeterminate colitis: a retrospective multi-centre study in northern Italy. GSMII (Gruppo di Studio per le Malattie Infiammatorie Intestinali). Eur J Gastroenterol Hepatol (1999) 0.98
Preliminary report on the Mount Sinai Hospital Inflammatory Bowel Disease Genetics Project. Dis Colon Rectum (1997) 0.94
Evolutionary changes in the pathologic diagnosis after the ileoanal pouch procedure. Dis Colon Rectum (1997) 0.94
Searching for genes in complex diseases: lessons from systemic lupus erythematosus. J Clin Invest (2000) 0.88
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics (1987) 54.39
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
High-resolution haplotype structure in the human genome. Nat Genet (2001) 20.51
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet (2000) 15.19
A gene map of the human genome. Science (1996) 14.32
A physical map of 30,000 human genes. Science (1998) 12.43
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet (2001) 11.12
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science (1999) 8.01
A comprehensive genetic map of the mouse genome. Nature (1996) 6.94
Whole-genome association study of bipolar disorder. Mol Psychiatry (2008) 6.80
The molecular basis of Turcot's syndrome. N Engl J Med (1995) 6.65
Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet (1995) 6.51
Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum. J Bacteriol (2001) 6.46
Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics. Microbiol Mol Biol Rev (2001) 4.75
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet (2000) 4.66
Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. N Engl J Med (1995) 4.56
Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis. Gut (2010) 4.50
Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol (2000) 4.10
Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet (2008) 3.87
Surgery and the randomised controlled trial: past, present and future. Med J Aust (1998) 3.83
THE ANEMIA OF INFECTION. III. THE UPTAKE OF RADIO-ACTIVE IRON IN IRON-DEFICIENT AND IN PYRIDOXINE-DEFICIENT PIGS BEFORE AND AFTER ACUTE INFLAMMATION. J Clin Invest (1947) 3.73
Whole-genome shotgun optical mapping of Deinococcus radiodurans. Science (1999) 3.56
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet (2000) 3.52
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science (1995) 3.24
ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet (2000) 3.17
Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet (1993) 3.11
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med (1999) 2.81
A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. N Engl J Med (2000) 2.78
A uniform deleting element mediates the loss of kappa genes in human B cells. Nature (1985) 2.65
Efficient multipoint linkage analysis through reduction of inheritance space. Am J Hum Genet (2001) 2.58
Randomized controlled trials in surgery. Surgery (1994) 2.53
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet (2001) 2.50
Meta-analysis of randomized controlled trials comparing open and laparoscopic ventral and incisional hernia repair with mesh. Br J Surg (2009) 2.50
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci U S A (2001) 2.42
Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. Am J Hum Genet (2004) 2.41
Cancer in an ileoanal reservoir: a new late complication? Gut (1990) 2.41
Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. Neurology (2008) 2.41
Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Am J Hum Genet (2000) 2.40
An optimized set of human telomere clones for studying telomere integrity and architecture. Am J Hum Genet (2000) 2.36
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature (1999) 2.32
Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. Mucosal Immunol (2008) 2.28
Radiation hybrid mapping of the zebrafish genome. Proc Natl Acad Sci U S A (1999) 2.27
Comparison of the bronchodilator and cardiovascular actions of salbutamol, isoprenaline and orciprenaline in guinea-pigs and dogs. Br J Pharmacol (1971) 2.27
Severe paediatric ulcerative colitis: incidence, outcomes and optimal timing for second-line therapy. Gut (2007) 2.22
A prospective cohort study to determine the relationship between serum infliximab concentration and efficacy in patients with luminal Crohn's disease. Aliment Pharmacol Ther (2014) 2.18
A simple, direct method for x-ray scatter estimation and correction in digital radiography and cone-beam CT. Med Phys (2006) 2.18
A map of 75 human ribosomal protein genes. Genome Res (1998) 2.15
Genotype-phenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet (1998) 2.12
A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet (1995) 2.10
Engineering a recombinant Deinococcus radiodurans for organopollutant degradation in radioactive mixed waste environments. Nat Biotechnol (1998) 2.10
Comparison of hemorrhoidal treatment modalities. A meta-analysis. Dis Colon Rectum (1995) 2.07
Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir. Lancet (1986) 2.06
Should we be performing more randomized controlled trials evaluating surgical operations? Surgery (1995) 2.03
Familial adenomatous polyposis-associated thyroid cancer: a clinical, pathological, and molecular genetics study. Am J Pathol (1999) 2.02
An unusual intraoperative complication of stapled colorectal anastomosis: report of a case and review of the literature. Can J Surg (1993) 2.00
Characterization of short tandem repeats from thirty-one human telomeres. Genome Res (1997) 1.96
FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Nat Genet (1998) 1.96
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med (1993) 1.95
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am J Hum Genet (2000) 1.93
Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. Immunity (2001) 1.93
Restorative proctocolectomy with ileal reservoir. Int J Colorectal Dis (1986) 1.91
Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology (1995) 1.90
Evidence for a complex regulating the in vivo activities of early enzymes induced by bacteriophage T4. J Biol Chem (1974) 1.87
Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. Am J Hum Genet (2001) 1.82
Changing causes of mortality in patients with familial adenomatous polyposis. Dis Colon Rectum (1996) 1.82
Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet (1997) 1.82
Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol (1981) 1.82
Location score and haplotype analyses of the locus for autosomal recessive spastic ataxia of Charlevoix-Saguenay, in chromosome region 13q11. Am J Hum Genet (1999) 1.78
Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin Immunol (2000) 1.77
Ranitidine (AH 19065): a new potent, selective histamine H2-receptor antagonist [proceedings]. Br J Pharmacol (1979) 1.76
Genome scan of schizophrenia. Am J Psychiatry (1998) 1.74
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med (1995) 1.73
Direct detection of novel expanded trinucleotide repeats in the human genome. Nat Genet (1993) 1.71
Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Circulation (2001) 1.71