Published in Mamm Genome on November 01, 2004
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol (2015) 2.42
Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training. Mamm Genome (2008) 1.62
Principles for valid histopathologic scoring in research. Vet Pathol (2013) 1.18
Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflamm Bowel Dis (2013) 1.05
Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis (2010) 0.93
Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in mice. Am J Physiol Gastrointest Liver Physiol (2009) 0.92
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol (2008) 0.91
Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease. Genes Immun (2010) 0.89
Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis. Pflugers Arch (2014) 0.88
A Multihit Model: Colitis Lessons from the Interleukin-10-deficient Mouse. Inflamm Bowel Dis (2015) 0.86
Colitis-induced bone loss is gender dependent and associated with increased inflammation. Inflamm Bowel Dis (2013) 0.84
The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. PLoS One (2013) 0.84
A protective role for human IL-10-expressing CD4+ T cells in colitis. J Immunol (2012) 0.82
Genetic dissection of granulomatous enterocolitis and arthritis in the intramural peptidoglycan-polysaccharide-treated rat model of IBD. Inflamm Bowel Dis (2009) 0.80
Growth hormone secretagogue receptor is important in the development of experimental colitis. Cell Biosci (2015) 0.79
The Mongolian gerbil as a model for inflammatory bowel disease. Int J Exp Pathol (2010) 0.78
Enhanced production of early lineages of monocytic and granulocytic cells in mice with colitis. Proc Natl Acad Sci U S A (2012) 0.78
Microbial and histopathologic considerations in the use of mouse models of inflammatory bowel diseases. Inflamm Bowel Dis (2012) 0.77
Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury. Am J Physiol Regul Integr Comp Physiol (2016) 0.75
CREM Alpha Enhances IL-21 Production in T Cells In Vivo and In Vitro. Front Immunol (2016) 0.75
FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Nat Commun (2016) 0.75
Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening. Methods Mol Biol (2016) 0.75
Time to Integrate to Nest Test Evaluation in a Mouse DSS-Colitis Model. PLoS One (2015) 0.75
Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance. PLoS One (2015) 0.75
Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice. Front Pharmacol (2017) 0.75
Empirical threshold values for quantitative trait mapping. Genetics (1994) 46.95
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun (1998) 7.86
A statistical framework for quantitative trait mapping. Genetics (2001) 7.55
Experimental models of inflammatory bowel disease. Gastroenterology (1995) 6.28
Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology (1999) 5.03
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun (1998) 3.80
The "Swiss roll": a simple technique for histological studies of the rodent intestine. Lab Anim (1981) 2.90
Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim (2002) 2.84
Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology (1994) 1.56
Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. Genomics (2002) 1.35
Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. Infect Immun (2000) 1.33
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci U S A (2001) 1.30
Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice. Genomics (1999) 1.29
Animal models of inflammatory bowel disease. J Gastroenterol (2002) 1.23
Heritable susceptibility for colitis in mice induced by IL-10 deficiency. Inflamm Bowel Dis (2000) 1.17
Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies. Gut (2001) 0.99
Crohn's disease or Crohn's diseases? Gut (2003) 0.81
Amelioration of murine colitis by feeding a solution of lysed Escherichia coli. Scand J Gastroenterol (2003) 0.78
Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 25.91
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med (2008) 13.02
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Late developmental plasticity in the T helper 17 lineage. Immunity (2009) 8.81
Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med (2004) 7.93
Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest (2004) 5.39
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature (2006) 5.07
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med (2010) 4.76
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
Reciprocal interactions of the intestinal microbiota and immune system. Nature (2012) 4.42
The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse. Cancer Res (2002) 4.31
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Development (2003) 3.84
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity (2007) 3.84
Mouse models of diabetic nephropathy. J Am Soc Nephrol (2009) 3.74
Role of COL4A1 in small-vessel disease and hemorrhagic stroke. N Engl J Med (2006) 3.58
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science (2005) 3.58
Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology (2005) 3.41
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood (2011) 3.32
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature (2013) 3.21
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol (2011) 3.17
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell (2009) 3.16
Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-α in newly diagnosed chronic myeloid leukemia. J Clin Oncol (2011) 3.09
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet (2009) 2.96
TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. J Clin Oncol (2011) 2.88
High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Blood (2006) 2.87
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A (2009) 2.77
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Blood (2012) 2.69
Pathbase: a database of mutant mouse pathology. Nucleic Acids Res (2004) 2.66
Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol (2005) 2.64
Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. J Clin Oncol (2010) 2.38
Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone. J Lipid Res (2002) 2.30
Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes. J Clin Oncol (2011) 2.26
Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia. J Clin Oncol (2009) 2.23
p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ. Gut (2009) 2.20
The Mouse Tumor Biology database. Nat Rev Cancer (2008) 2.15
Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression. Am J Gastroenterol (2006) 2.14
RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group. J Clin Oncol (2011) 2.11
Persistent malignant stem cells in del(5q) myelodysplasia in remission. N Engl J Med (2010) 2.11
Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell (2003) 2.06
Breast carcinoma during pregnancy. International recommendations from an expert meeting. Cancer (2006) 2.04
SHARPIN is an endogenous inhibitor of β1-integrin activation. Nat Cell Biol (2011) 2.01
Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science (2012) 2.01
Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity. Sci Transl Med (2014) 2.00
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell (2007) 1.96
The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML. Blood (2010) 1.96
Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response. Blood (2006) 1.93
Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med (2010) 1.86
The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res (2005) 1.84
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 1.84
Breast cancer susceptibility: current knowledge and implications for genetic counselling. Eur J Hum Genet (2008) 1.82
Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis. Blood (2005) 1.82
Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology (2005) 1.81
The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol (2012) 1.80
Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group. J Clin Oncol (2011) 1.79
Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production. J Immunol (2006) 1.77
Ancient papillomavirus-host co-speciation in Felidae. Genome Biol (2007) 1.75
Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J Immunol (2004) 1.71
'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development (2003) 1.70
T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J Exp Med (2002) 1.69
Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and -5/5q-. Blood (2012) 1.68
TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol (2009) 1.66
Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. Blood (2011) 1.65
High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities. J Clin Oncol (2010) 1.64
Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice. Dis Model Mech (2011) 1.62
Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. Blood (2013) 1.62
Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet (2003) 1.58
Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia. J Immunol (2007) 1.58
Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry. Rapid Commun Mass Spectrom (2004) 1.57
Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood (2010) 1.56
Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol (2007) 1.54
Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity (2011) 1.53
Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis. Carcinogenesis (2002) 1.52
Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol (2009) 1.52
Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J Immunol (2002) 1.49
Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia. J Clin Oncol (2010) 1.46
Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor. Toxicol Pathol (2004) 1.43
Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm Bowel Dis (2007) 1.40
Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia. Blood (2004) 1.39
Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production. J Immunol (2011) 1.39
Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice. Inflamm Bowel Dis (2014) 1.38
Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. Obesity (Silver Spring) (2010) 1.38
Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. Blood (2002) 1.38
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood (2007) 1.37
Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology (2012) 1.37
Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. Genomics (2002) 1.35
Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis. Gastroenterology (2011) 1.35
Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. J Immunol (2012) 1.34
Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation. J Biol Chem (2006) 1.34
Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations. Inflamm Bowel Dis (2007) 1.33
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG). Blood (2013) 1.33
IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis. Haematologica (2010) 1.32
Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression. Haematologica (2009) 1.31