Published in Nature on February 29, 1996
Genetic Markers as Predictors of Phenotypes in Pediatric Onset Crohn's Disease | NCT00783575
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31
Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet (2001) 3.70
Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet (2008) 3.54
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet (2000) 3.52
Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. Proc Natl Acad Sci U S A (1998) 3.35
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A (1998) 2.88
A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet (1999) 2.88
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest (2001) 2.67
Recent advances in the genetics of autoimmune disease. Annu Rev Immunol (2009) 2.41
A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci U S A (1998) 2.31
Genetic analyses of chromosome 12 loci in Crohn's disease. Gut (2000) 2.30
Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev (2002) 2.29
Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. Mucosal Immunol (2008) 2.28
National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening. J Am Acad Dermatol (2008) 2.19
A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews. Am J Hum Genet (2003) 2.17
IBD-what role do Proteobacteria play? Nat Rev Gastroenterol Hepatol (2012) 2.03
Factors affecting statistical power in the detection of genetic association. J Clin Invest (2005) 2.02
Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol (2011) 2.00
HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis. Gut (1999) 1.94
Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet (2012) 1.88
CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease. Gut (2003) 1.87
The genetics of inflammatory bowel disease. Gut (1997) 1.83
CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. Am J Hum Genet (2002) 1.74
Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Am J Hum Genet (2000) 1.72
NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease. J Gastroenterol (2006) 1.71
Genetics and pulmonary medicine. 3. Genetic susceptibility to tuberculosis in human populations. Thorax (1998) 1.59
International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Am J Hum Genet (2001) 1.58
Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet (2007) 1.55
Why children with inflammatory bowel disease are diagnosed at a younger age than their affected parent. Gut (1999) 1.53
High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12. Am J Hum Genet (2000) 1.52
Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31. Gut (2003) 1.42
Identification of the most active interleukin-32 isoform. Immunology (2008) 1.41
Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon. Gut (2003) 1.38
Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ? World J Gastroenterol (2006) 1.35
Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease. Am J Hum Genet (2003) 1.32
Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13. Am J Hum Genet (2000) 1.30
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci U S A (2001) 1.30
Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease. Infect Immun (1999) 1.28
The role of infection in the aetiology of inflammatory bowel disease. J Gastroenterol (2010) 1.26
MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet (2003) 1.26
Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. Gut (2001) 1.23
The genetic jigsaw of inflammatory bowel disease. Gut (2002) 1.20
Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: phenotype-genotype correlations. World J Gastroenterol (2005) 1.19
NOD2 (CARD15), the first susceptibility gene for Crohn's disease. Gut (2001) 1.19
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p. Proc Natl Acad Sci U S A (2001) 1.17
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. Gut (2004) 1.17
Evidence of linkage of the inflammatory bowel disease susceptibility locus on chromosome 16 (IBD1) to ulcerative colitis. J Med Genet (1998) 1.17
Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families. Am J Hum Genet (2004) 1.17
Emerging roles for XBP1, a sUPeR transcription factor. Gene Expr (2010) 1.17
Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli. Immunology (2007) 1.12
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease. World J Gastroenterol (2007) 1.12
A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31. Am J Hum Genet (2002) 1.10
Crohn's disease: an immune deficiency state. Clin Rev Allergy Immunol (2010) 1.10
Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses. Gut (1999) 1.09
Mapping of a first locus for autosomal dominant myxomatous mitral-valve prolapse to chromosome 16p11.2-p12.1. Am J Hum Genet (1999) 1.07
Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population. Gut (2003) 1.06
Tumour necrosis factor (TNF) gene polymorphism in Crohn's disease (CD): influence on disease behaviour? Clin Exp Immunol (2000) 1.06
Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease. Gut (1998) 1.05
IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease. J Clin Immunol (2000) 1.05
Anticipation in familial Crohn's disease. Gut (1998) 1.04
Strategies for mapping heterogeneous recessive traits by allele-sharing methods. Am J Hum Genet (1997) 1.02
NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality. World J Gastroenterol (2004) 1.02
Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol (2012) 1.01
The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease. Am J Hum Genet (2000) 1.01
Genetic markers in clinically well defined patients with ulcerative colitis (UC). Clin Exp Immunol (1999) 1.01
Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. Ann Hum Genet (2010) 1.01
Novel genetic markers in inflammatory bowel disease. World J Gastroenterol (2007) 0.99
Consistently replicating locus linked to migraine on 10q22-q23. Am J Hum Genet (2008) 0.99
Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies. Gut (2001) 0.99
Inflammatory bowel disease: definition, epidemiology, etiologic aspects, and immunogenetic studies. World J Gastroenterol (1998) 0.98
Association of HLA class II genes with susceptibility to Crohn's disease. Gut (1996) 0.97
Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning. World J Gastroenterol (2003) 0.97
HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations. Hum Immunol (2000) 0.96
OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease. World J Gastroenterol (2008) 0.95
Genetic studies of Crohn's disease: past, present and future. Best Pract Res Clin Gastroenterol (2014) 0.94
Association of inflammatory bowel disease with indicators for childhood antigen and infection exposure. Int J Colorectal Dis (2003) 0.94
Emerging prognostic markers to determine Crohn's disease natural history and improve management strategies: a review of recent literature. Gastroenterol Hepatol (N Y) (2010) 0.93
Complex traits on the map. Nature (1996) 0.93
NOD-like receptor (NLR) signaling beyond the inflammasome. Eur J Immunol (2010) 0.92
The history of genetics in inflammatory bowel disease. Ann Gastroenterol (2014) 0.92
International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92
Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet? World J Gastroenterol (2006) 0.92
Crohn's disease severity in familial and sporadic cases. Gut (1999) 0.91
Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform. Biochim Biophys Acta (2007) 0.91
Five genetic markers in the interleukin 1 family in relation to inflammatory bowel disease. Gut (1998) 0.89
Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Inflamm Bowel Dis (2014) 0.89
NOD2 Polymorphisms and Their Impact on Haematopoietic Stem Cell Transplant Outcome. Bone Marrow Res (2012) 0.89
Association of the interleukin 1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians. Gut (2001) 0.88
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. World J Gastroenterol (2005) 0.88
Impact of exome sequencing in inflammatory bowel disease. World J Gastroenterol (2013) 0.88
A review of study designs and statistical methods for genomic epidemiology studies using next generation sequencing. Front Genet (2015) 0.88
Intestinal stricture in Crohn's disease. Intest Res (2015) 0.87
The genomics of autoimmune disease in the era of genome-wide association studies and beyond. Autoimmun Rev (2011) 0.87
Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn's disease. World J Gastroenterol (2006) 0.87
Matrix metalloproteinases in inflammatory bowel disease: an update. Mediators Inflamm (2015) 0.87
Respiratory involvement in inflammatory bowel diseases. Multidiscip Respir Med (2010) 0.86
Anti-Saccharomyces cerevisiae antibodies associate with phenotypes and higher risk for surgery in Crohn's disease: a meta-analysis. Dig Dis Sci (2012) 0.85
Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations. PLoS One (2010) 0.85
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature (1996) 27.61
Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22
The transcriptional program in the response of human fibroblasts to serum. Science (1999) 19.19
An STS-based map of the human genome. Science (1995) 17.72
The 1993-94 Généthon human genetic linkage map. Nat Genet (1994) 17.64
Estimate of human gene number provided by genome-wide analysis using Tetraodon nigroviridis DNA sequence. Nat Genet (2000) 14.51
A gene map of the human genome. Science (1996) 14.32
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A (1999) 14.16
A physical map of 30,000 human genes. Science (1998) 12.43
A physical map of the human genome. Nature (2001) 12.39
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett (1995) 9.62
A ne method for studying gut transit times using radioopaque markers. Gut (1969) 8.97
The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403. Genome Res (2001) 8.63
Identification of a chromosome 18q gene that is altered in colorectal cancers. Science (1990) 8.32
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature (1996) 8.02
Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi. Nature (2001) 7.53
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature (1994) 7.30
Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet (2001) 7.27
Haseman and Elston revisited. Genet Epidemiol (2000) 7.23
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A (2001) 6.99
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management. J Crohns Colitis (2010) 6.75
Phosphorylation and activation of p70s6k by PDK1. Science (1998) 6.53
Mammalian TOR: a homeostatic ATP sensor. Science (2001) 6.41
Genome sequence of the plant pathogen Ralstonia solanacearum. Nature (2002) 6.23
CARD15 mutations in Blau syndrome. Nat Genet (2001) 5.79
Variation of bowel habit in two population samples. Br Med J (1965) 5.78
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO J (1997) 5.57
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J (1998) 5.34
Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science (2001) 5.32
An interspersed repeated sequence specific for human subtelomeric regions. EMBO J (1990) 5.30
Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Nature (1983) 5.14
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease. EMBO J (1992) 5.05
Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology (1998) 5.02
Dysbiosis in inflammatory bowel disease. Gut (2004) 5.01
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc Natl Acad Sci U S A (1992) 4.91
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem (1992) 4.87
Polymersomes: tough vesicles made from diblock copolymers. Science (1999) 4.76
A radiation hybrid map of the human genome. Hum Mol Genet (1996) 4.75
Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat Genet (1999) 4.74
Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis (2009) 4.72
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J (1994) 4.46
The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J (1995) 4.26
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci U S A (1994) 4.16
Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science (1999) 4.08
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev (2000) 4.05
Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res (1999) 4.04
Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development (2000) 3.96
Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci U S A (1998) 3.89
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem (1998) 3.88
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell (1998) 3.79
Genomic exploration of the hemiascomycetous yeasts: 1. A set of yeast species for molecular evolution studies. FEBS Lett (2000) 3.71
Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients. Lancet (1997) 3.68
Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature (1994) 3.67
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature (2001) 3.65
Interstitial cells of Cajal generate a rhythmic pacemaker current. Nat Med (1998) 3.62
European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut (2006) 3.59
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet (2001) 3.50
Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis. Trends Cell Biol (1999) 3.50
Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis. Gastroenterology (1994) 3.44
A first-generation physical map of the human genome. Nature (1993) 3.40
Preparation of tubulin from brain. Methods Enzymol (1982) 3.39
The stabilization of proteins by sucrose. J Biol Chem (1981) 3.34
Concurrent cisplatin-based chemotherapy plus radiotherapy for cervical cancer--a meta-analysis. Clin Oncol (R Coll Radiol) (2002) 3.33
Prognosis after resection of chronic regional ileitis. Gut (1967) 3.27
European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis (2009) 3.22
Clinical and pathological differentiation of Crohn's disease and proctocolitis. Gastroenterology (1968) 3.20
A method for constructing radiation hybrid maps of whole genomes. Nat Genet (1994) 3.19
Anismus in chronic constipation. Dig Dis Sci (1985) 3.16
New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci U S A (1998) 3.14
Experience in the treatment of Crohn's disease of the large intestine. Gut (1966) 3.14
The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution. Proc Natl Acad Sci U S A (2006) 3.11
A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes. Nature (1986) 3.09
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1996) 3.09
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science (2000) 3.07
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet (2000) 3.07
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A (1993) 3.07
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy. Nat Genet (1995) 3.05
A deletion map of the human Y chromosome based on DNA hybridization. Am J Hum Genet (1986) 3.03
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03
Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae. Antimicrob Agents Chemother (1977) 3.02
A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat Genet (1996) 2.98
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol (2000) 2.95
Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus. Int J Cancer (1999) 2.95
Mycobacteria as a possible cause of inflammatory bowel disease. Lancet (1978) 2.94