Published in J Biol Chem on November 16, 2001
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest (2003) 3.15
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
Dual mechanism of a natural CaMKII inhibitor. Mol Biol Cell (2007) 1.86
CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67
Molecular mechanisms of microcystin toxicity in animal cells. Int J Mol Sci (2010) 1.30
Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Mol Biol Cell (2003) 1.14
Epithelial cell apoptosis causes acute lung injury masquerading as emphysema. Am J Respir Cell Mol Biol (2009) 1.11
Fortilin binds Ca2+ and blocks Ca2+-dependent apoptosis in vivo. Biochem J (2007) 1.06
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. Biochem J (2005) 1.04
CaMKII in cerebral ischemia. Acta Pharmacol Sin (2011) 1.04
The combination of calmodulin antagonists and interferon-gamma induces apoptosis through caspase-dependent and -independent pathways in cholangiocarcinoma cells. Am J Pathol (2003) 0.95
CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death. J Neurochem (2011) 0.95
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II. BMC Chem Biol (2008) 0.94
Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Br J Pharmacol (2008) 0.92
Glutamate-induced NFkappaB activation in the retina. Invest Ophthalmol Vis Sci (2008) 0.88
Oxidized CaMKII: a "heart stopper" for the sinus node? J Clin Invest (2011) 0.80
Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron. Toxins (Basel) (2014) 0.78
The role of CaMKII in calcium-activated death pathways in bone marrow B cells. Toxicol Sci (2010) 0.77
Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Sci Rep (2016) 0.76
Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. PLoS One (2014) 0.75
Association of genetic variation in calmodulin and left ventricular mass in full-term newborns. Int J Genomics (2013) 0.75
Cell Death Inducing Microbial Protein Phosphatase Inhibitors-Mechanisms of Action. Mar Drugs (2015) 0.75
Nodularin exposure induces SOD1 phosphorylation and disrupts SOD1 co-localization with actin filaments. Toxins (Basel) (2012) 0.75
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. N Engl J Med (2015) 6.48
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Global changes to the ubiquitin system in Huntington's disease. Nature (2007) 3.91
Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. Annu Rev Biochem (2001) 3.64
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42
Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem J (2002) 3.29
CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol (2005) 2.47
Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron (2003) 2.36
Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol (2007) 2.07
Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B. J Neurosci (2006) 2.05
The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem (2001) 1.99
Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods (2008) 1.84
A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci (2005) 1.78
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73
cAMP effector mechanisms. Novel twists for an 'old' signaling system. FEBS Lett (2003) 1.62
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools. Nat Methods (2011) 1.60
An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Proc Natl Acad Sci U S A (2003) 1.57
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell (2011) 1.56
Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin. J Biol Chem (2002) 1.44
Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS One (2010) 1.38
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun (2013) 1.36
Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol (2012) 1.32
Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+/calmodulin-dependent protein kinase II. J Biol Chem (2002) 1.30
Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations. EMBO J (2002) 1.23
Promiscuous protein biotinylation by Escherichia coli biotin protein ligase. Protein Sci (2004) 1.22
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat Struct Mol Biol (2010) 1.21
Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clin Cancer Res (2013) 1.21
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data. Genome Biol (2008) 1.18
Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial. Eur J Cancer (2013) 1.17
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathol (2013) 1.13
cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. J Biol Chem (2004) 1.10
Calcium/calmodulin-dependent protein kinase II (CaMKII) localization acts in concert with substrate targeting to create spatial restriction for phosphorylation. J Biol Chem (2004) 1.08
Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer (2010) 1.06
Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis. Exp Cell Res (2004) 1.05
In search of cellular immunophenotypes in the blood of children with autism. PLoS One (2011) 1.04
Deconvoluting post-transplant immunity: cell subset-specific mapping reveals pathways for activation and expansion of memory T, monocytes and B cells. PLoS One (2010) 1.03
Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. PLoS One (2013) 1.02
Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. Biochim Biophys Acta (2009) 1.02
Genome-wide association study identifies a possible susceptibility locus for endometrial cancer. Cancer Epidemiol Biomarkers Prev (2012) 1.02
The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of steroidogenic factor 1. Mol Endocrinol (2002) 0.98
Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations. Arch Neurol (2012) 0.97
High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. Clin Cancer Res (2013) 0.97
Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife (2013) 0.96
Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. Blood (2008) 0.95
Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. Breast Cancer Res Treat (2013) 0.95
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer (2009) 0.94
Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. J Biol Chem (2011) 0.94
Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study. BMC Surg (2014) 0.90
Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix. Int J Cancer (2004) 0.90
Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II. Curr Opin Struct Biol (2013) 0.90
Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10. Cancer Res (2013) 0.89
cAMP-mediated regulation of HNF-4alpha depends on the level of coactivator PGC-1alpha. Biochim Biophys Acta (2010) 0.89
8OHdG is not a biomarker for Huntington disease state or progression. Neurology (2013) 0.88
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer. Mol Cancer (2014) 0.87
Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue. PLoS One (2013) 0.86
1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism Apa1 influence bone mineral density in primary hyperparathyroidism. PLoS One (2013) 0.86
Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells. PLoS One (2013) 0.85
Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease. Nat Clin Pract Cardiovasc Med (2006) 0.85
Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. Breast Cancer Res Treat (2012) 0.85
Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts. Toxicol Sci (2008) 0.85
Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. Clin Cancer Res (2010) 0.84
Cancer progression is associated with increased expression of basement membrane proteins in three-dimensional in vitro models of human oral cancer. Arch Oral Biol (2009) 0.84
ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas. Mod Pathol (2012) 0.84
Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. Endocrinology (2008) 0.84
Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo. J Neurosci Res (2004) 0.84
COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity (Silver Spring) (2014) 0.83
COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. Endocrinology (2015) 0.83
Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1. Endocrinology (2002) 0.83
Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. PLoS One (2011) 0.83
Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells. Chem Biol (2003) 0.82
Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. Anticancer Res (2005) 0.82
Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1. Mol Pharm (2011) 0.82
Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. Oncotarget (2014) 0.82
Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun (2013) 0.81
Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology (2010) 0.81
Polymorphisms in inflammation pathway genes and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev (2012) 0.81
HPV DNA testing improves CIN2+ risk stratification and detection of CIN2+ in delayed triage of ASCUS and LSIL. A population-based follow-up study from Western Norway. Cancer Med (2013) 0.80
Differential regulation of SF-1-cofactor interactions. Endocr Res (2002) 0.79
Tissue-specific effects of bariatric surgery including mitochondrial function. J Obes (2011) 0.79
Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. J Steroid Biochem Mol Biol (2005) 0.79
Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. Histopathology (2011) 0.79
Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. BMC Cancer (2012) 0.79
The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: the major autoantigen in autoimmune Addison's disease. J Autoimmun (2009) 0.79
The impact of HPV infection on survival in a geographically defined cohort of oropharynx squamous cell carcinoma (OPSCC) patients in whom surgical treatment has been one main treatment. Acta Otolaryngol (2014) 0.79
PI3K pathway in gynecologic malignancies. Am Soc Clin Oncol Educ Book (2013) 0.79
Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. Eur J Oral Sci (2008) 0.79
Predictors for remission of major components of the metabolic syndrome after biliopancreatic diversion with duodenal switch (BPDDS). Obes Surg (2013) 0.79
Annexin-A2 as predictor biomarker of recurrent disease in endometrial cancer. Int J Cancer (2014) 0.78
The impact of HPV infection, smoking history, age and operability of the patient on disease-specific survival in a geographically defined cohort of patients with oropharyngeal squamous cell carcinoma. Acta Otolaryngol (2014) 0.78
The cAMP-dependent protein kinase pathway as therapeutic target: possibilities and pitfalls. Curr Top Med Chem (2011) 0.78
CaMKII structure--an elegant design. Cell (2005) 0.78
Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells. Toxicology (2009) 0.77
Energy intake, nutritional status and weight reduction in patients one year after laparoscopic sleeve gastrectomy. Springerplus (2013) 0.77
Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. Mol Nutr Food Res (2014) 0.77
Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. Mol Endocrinol (2003) 0.77
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation. Biochim Biophys Acta (2009) 0.77
Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. Obesity (Silver Spring) (2013) 0.76
Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. Eur J Endocrinol (2004) 0.76
Peripheral blood monocyte and T-lymphocyte activation levels at diagnosis predict long-term survival in head and neck squamous cell carcinoma patients. APMIS (2015) 0.76
cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. Endocrinology (2013) 0.75