| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
|
JAMA
|
1997
|
17.88
|
|
2
|
Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study.
|
Hypertension
|
2000
|
8.84
|
|
3
|
Neuropathological classification of Huntington's disease.
|
J Neuropathol Exp Neurol
|
1985
|
7.93
|
|
4
|
CAG repeat number governs the development rate of pathology in Huntington's disease.
|
Ann Neurol
|
1997
|
4.01
|
|
5
|
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study.
|
Circulation
|
1998
|
3.89
|
|
6
|
Predictive testing for Huntington's disease with use of a linked DNA marker.
|
N Engl J Med
|
1988
|
3.82
|
|
7
|
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.
|
Science
|
1987
|
3.59
|
|
8
|
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
|
Neurology
|
2012
|
3.12
|
|
9
|
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
|
Nature
|
1990
|
2.80
|
|
10
|
Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study.
|
Ann Neurol
|
1991
|
2.70
|
|
11
|
Genetic and environmental contributions to platelet aggregation: the Framingham heart study.
|
Circulation
|
2001
|
2.54
|
|
12
|
Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass.
|
N Engl J Med
|
1996
|
2.49
|
|
13
|
Rate of functional decline in Huntington's disease. Huntington Study Group.
|
Neurology
|
2000
|
2.49
|
|
14
|
Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study.
|
Arthritis Rheum
|
1998
|
2.45
|
|
15
|
Increased rate of suicide among patients with Huntington's disease.
|
J Neurol Neurosurg Psychiatry
|
1984
|
2.31
|
|
16
|
Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study.
|
Neurology
|
2008
|
2.16
|
|
17
|
Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease.
|
Am J Med Genet A
|
2003
|
2.15
|
|
18
|
Genetic associations in age-related hearing thresholds.
|
Arch Otolaryngol Head Neck Surg
|
1999
|
1.94
|
|
19
|
Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study.
|
Hum Mol Genet
|
2000
|
1.94
|
|
20
|
Factors related to onset age of Huntington disease.
|
Am J Hum Genet
|
1982
|
1.93
|
|
21
|
Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study.
|
Neurology
|
2002
|
1.90
|
|
22
|
Factors associated with HD CAG repeat instability in Huntington disease.
|
J Med Genet
|
2007
|
1.86
|
|
23
|
Familial lipoprotein disorders in patients with premature coronary artery disease.
|
Circulation
|
1992
|
1.84
|
|
24
|
Weight loss in early stage of Huntington's disease.
|
Neurology
|
2002
|
1.79
|
|
25
|
Parental age at child's birth and son's risk of prostate cancer. The Framingham Study.
|
Am J Epidemiol
|
1999
|
1.77
|
|
26
|
Attitudes toward presymptomatic testing in Huntington disease.
|
Am J Med Genet
|
1987
|
1.75
|
|
27
|
A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study.
|
Diabetologia
|
2003
|
1.72
|
|
28
|
Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study.
|
JAMA
|
1994
|
1.71
|
|
29
|
Huntington disease: no evidence for locus heterogeneity.
|
Genomics
|
1989
|
1.70
|
|
30
|
Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum.
|
Hum Mol Genet
|
1995
|
1.67
|
|
31
|
Coronary risk associated with age and sex of parental heart disease in the Framingham Study.
|
Am J Cardiol
|
1989
|
1.65
|
|
32
|
Maternal transmission in Huntington's disease.
|
Lancet
|
1983
|
1.64
|
|
33
|
Heritability of left ventricular mass: the Framingham Heart Study.
|
Hypertension
|
1997
|
1.63
|
|
34
|
Evidence for the GluR6 gene associated with younger onset age of Huntington's disease.
|
Neurology
|
1999
|
1.60
|
|
35
|
Heritability of longitudinal change in lung function. The Framingham study.
|
Am J Respir Crit Care Med
|
2001
|
1.60
|
|
36
|
Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham Study.
|
J Bone Miner Res
|
2002
|
1.58
|
|
37
|
Estimation of morbid risk and age at onset with missing information.
|
Am J Hum Genet
|
1991
|
1.56
|
|
38
|
The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD.
|
Am J Hum Genet
|
1993
|
1.55
|
|
39
|
Evidence for major genes influencing pulmonary function in the NHLBI family heart study.
|
Genet Epidemiol
|
2000
|
1.54
|
|
40
|
Beta-glucocerebrosidase gene locus as a link for Gaucher's disease and familial hypo-alpha-lipoproteinaemia.
|
Lancet
|
1998
|
1.44
|
|
41
|
Quantitative neuropathological changes in presymptomatic Huntington's disease.
|
Ann Neurol
|
2001
|
1.44
|
|
42
|
Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study.
|
Am J Med Genet
|
1999
|
1.42
|
|
43
|
Maternal factors in onset of Huntington disease.
|
Am J Hum Genet
|
1985
|
1.39
|
|
44
|
Familial aggregation of stroke. The Framingham Study.
|
Stroke
|
1993
|
1.36
|
|
45
|
Segregation analysis of pulmonary function among families in the Framingham Study.
|
Am J Respir Crit Care Med
|
1998
|
1.35
|
|
46
|
Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study.
|
Arterioscler Thromb Vasc Biol
|
1999
|
1.33
|
|
47
|
Morphometric analysis of the prefrontal cortex in Huntington's disease.
|
Neurology
|
1991
|
1.30
|
|
48
|
Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.
|
Am J Hum Genet
|
2004
|
1.27
|
|
49
|
Evidence of presymptomatic cognitive decline in Huntington's disease.
|
J Clin Exp Neuropsychol
|
1992
|
1.27
|
|
50
|
Huntington's disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains.
|
Neurobiol Dis
|
1994
|
1.25
|
|
51
|
Genome-wide scan for Parkinson's disease: the GenePD Study.
|
Neurology
|
2001
|
1.25
|
|
52
|
Segregation analysis reveals evidence of a major gene for Alzheimer disease.
|
Am J Hum Genet
|
1991
|
1.25
|
|
53
|
Reduced penetrance of the Huntington's disease mutation.
|
Hum Mol Genet
|
1997
|
1.25
|
|
54
|
Segregation analysis of serum uric acid in the NHLBI Family Heart Study.
|
Hum Genet
|
2000
|
1.19
|
|
55
|
Juvenile onset Huntington's disease--clinical and research perspectives.
|
Ment Retard Dev Disabil Res Rev
|
2001
|
1.18
|
|
56
|
Late onset of Huntington's disease.
|
J Neurol Neurosurg Psychiatry
|
1985
|
1.18
|
|
57
|
Assessment of genetic risk for Alzheimer's disease among first-degree relatives.
|
Ann Neurol
|
1989
|
1.17
|
|
58
|
Gametic but not somatic instability of CAG repeat length in Huntington's disease.
|
J Med Genet
|
1993
|
1.15
|
|
59
|
Kynurenine pathway abnormalities in Parkinson's disease.
|
Neurology
|
1992
|
1.14
|
|
60
|
Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.
|
Neurology
|
1990
|
1.13
|
|
61
|
Genome-wide linkage analysis of lipids in the Hypertension Genetic Epidemiology Network (HyperGEN) Blood Pressure Study.
|
Arterioscler Thromb Vasc Biol
|
2001
|
1.13
|
|
62
|
Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting.
|
Am J Hum Genet
|
1992
|
1.12
|
|
63
|
Predictors of nursing home placement in Huntington disease.
|
Neurology
|
2003
|
1.11
|
|
64
|
Potential impact of a predictive test on the gene frequency of Huntington disease.
|
Am J Med Genet
|
1984
|
1.10
|
|
65
|
Family patterns of coronary heart disease mortality: the Framingham Longevity Study.
|
J Clin Epidemiol
|
1992
|
1.09
|
|
66
|
The BsmI vitamin D receptor restriction fragment length polymorphism (bb) influences the effect of calcium intake on bone mineral density.
|
J Bone Miner Res
|
1997
|
1.07
|
|
67
|
Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study.
|
Atherosclerosis
|
2001
|
1.06
|
|
68
|
A clinical genetic study of Parkinson's disease: evidence for dominant transmission.
|
Neurology
|
1994
|
1.04
|
|
69
|
Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease: a quantitative Golgi study.
|
Neurology
|
1993
|
1.03
|
|
70
|
Huntington's disease.
|
Cold Spring Harb Symp Quant Biol
|
1996
|
1.02
|
|
71
|
Segregation analysis of Parkinson disease revealing evidence for a major causative gene.
|
Am J Med Genet
|
2002
|
1.01
|
|
72
|
Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study.
|
Mov Disord
|
2005
|
1.01
|
|
73
|
Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study.
|
Ann Hum Genet
|
2006
|
1.01
|
|
74
|
Multiple sclerosis sibling pairs: clustered onset and familial predisposition.
|
Neurology
|
1990
|
0.98
|
|
75
|
Using survival methods to estimate age-at-onset distributions for genetic diseases with an application to Huntington disease.
|
Genet Epidemiol
|
1989
|
0.97
|
|
76
|
Genome scan for quantitative trait loci linked to high-density lipoprotein cholesterol: The NHLBI Family Heart Study.
|
Arterioscler Thromb Vasc Biol
|
2001
|
0.97
|
|
77
|
Neocortical dendritic pathology in human partial epilepsy: a quantitative Golgi study.
|
Epilepsia
|
1994
|
0.97
|
|
78
|
Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.
|
Science
|
1987
|
0.96
|
|
79
|
Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis.
|
Osteoporos Int
|
2002
|
0.96
|
|
80
|
Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus. The NHLBI Family Heart Study.
|
Arterioscler Thromb Vasc Biol
|
2000
|
0.96
|
|
81
|
Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination.
|
Genes Immun
|
2007
|
0.95
|
|
82
|
Understanding the decision to take the predictive test for Huntington disease.
|
Am J Med Genet
|
1991
|
0.94
|
|
83
|
Familial Alzheimer's disease: progress and problems.
|
Neurobiol Aging
|
1989
|
0.92
|
|
84
|
Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI Family Heart Study).
|
Am J Cardiol
|
1999
|
0.91
|
|
85
|
A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study.
|
Neurology
|
2003
|
0.90
|
|
86
|
BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study.
|
Neurology
|
2005
|
0.90
|
|
87
|
Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.
|
Hypertension
|
2001
|
0.89
|
|
88
|
Evidence of cortical metabolic dysfunction in early Huntington's disease by single-photon-emission computed tomography.
|
Mov Disord
|
1996
|
0.86
|
|
89
|
Long-term impact of Huntington disease linkage testing.
|
Am J Med Genet
|
1997
|
0.86
|
|
90
|
Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart study.
|
J Intern Med
|
2000
|
0.86
|
|
91
|
Huntington's disease in monozygotic twins reared apart.
|
J Med Genet
|
1983
|
0.86
|
|
92
|
Phenotypic variation in 2 Huntington's disease families with linkage to chromosome 4.
|
Neurology
|
1989
|
0.86
|
|
93
|
Hybrid ape offspring of a mating of gibbon and siamang.
|
Science
|
1979
|
0.85
|
|
94
|
Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study.
|
Neurology
|
2006
|
0.83
|
|
95
|
Considerations in using linkage analysis as a presymptomatic test for Huntington's disease.
|
J Med Genet
|
1988
|
0.83
|
|
96
|
Effects of similarities in lifestyle habits on familial aggregation of high density lipoprotein and low density lipoprotein cholesterol: the NHLBI Family Heart Study.
|
Am J Epidemiol
|
1999
|
0.83
|
|
97
|
Estimation of fertility and fitness in Huntington disease in New England.
|
Am J Med Genet
|
1989
|
0.82
|
|
98
|
Huntington's disease: genetics, chemical pathology, and management.
|
Prog Med Genet
|
1985
|
0.81
|
|
99
|
Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data.
|
Genet Epidemiol
|
2001
|
0.80
|
|
100
|
NYD-SP18 is associated with obesity in the NHLBI Family Heart Study.
|
Int J Obes (Lond)
|
2008
|
0.79
|
|
101
|
Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants.
|
Diabetologia
|
2006
|
0.79
|
|
102
|
Change in attitudes toward presymptomatic testing in Huntington disease.
|
Am J Med Genet
|
1986
|
0.77
|
|
103
|
Evidence for a major gene accounting for mild elevation in LDL cholesterol: the NHLBI Family Heart Study.
|
Ann Hum Genet
|
1999
|
0.77
|
|
104
|
Absence of linkage for bone mineral density to chromosome 12q12-14 in the region of the vitamin D receptor gene.
|
Calcif Tissue Int
|
2000
|
0.77
|
|
105
|
Discrepancy resolved.
|
Nat Genet
|
1993
|
0.77
|
|
106
|
False-negative results with levodopa for early detection of Huntington's disease.
|
N Engl J Med
|
1982
|
0.77
|
|
107
|
Segregation analysis for high density lipoprotein in the Berkeley data.
|
Genet Epidemiol
|
1993
|
0.77
|
|
108
|
Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease.
|
Mov Disord
|
1999
|
0.76
|
|
109
|
Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136-->Ser) variant in multigenerational pedigree studies.
|
Atherosclerosis
|
1996
|
0.76
|
|
110
|
[Huntington disease: 7 cases with relatively preserved neostriatal islets].
|
Rev Neurol (Paris)
|
1992
|
0.76
|
|
111
|
Molecular genetics of familial Alzheimer's disease.
|
Eur Neurol
|
1989
|
0.75
|
|
112
|
Interpreting plots of a multidimensional dose-response surface in a parallel coordinate system.
|
Biometrics
|
1990
|
0.75
|
|
113
|
Smoking influences the association between apolipoprotein E and lipids: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Lipids
|
2000
|
0.75
|
|
114
|
Two-stage designs for the logistic regression model in single-agent bioassays.
|
J Biopharm Stat
|
1996
|
0.75
|
|
115
|
Robust analysis of covariance.
|
Biometrics
|
1982
|
0.75
|
|
116
|
Linkage map of anonymous loci near the CF gene.
|
Prog Clin Biol Res
|
1989
|
0.75
|
|
117
|
Molecular genetics of familial Alzheimer's disease.
|
Can J Neurol Sci
|
1989
|
0.75
|
|
118
|
Influence of marker heterozygosity and genetic heterogeneity on fine mapping.
|
Genet Epidemiol
|
2001
|
0.75
|
|
119
|
Experimental designs for estimating effective doses.
|
Clin Pharmacol Ther
|
1969
|
0.75
|
|
120
|
Alzheimer's disease, Down's syndrome, and aging: the genetic approach.
|
Ann N Y Acad Sci
|
1982
|
0.75
|
|
121
|
Quantification of muscle tremor of Huntington's disease patients and their offspring in an early detection study.
|
Biol Psychiatry
|
1979
|
0.75
|
|
122
|
No evidence of linkage between the very-low-density lipoprotein receptor gene and fasting serum insulin or homeostasis model assessment insulin resistance index: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Metabolism
|
2000
|
0.75
|
|
123
|
Attitudes toward marriage and childbearing of individuals at risk for Huntington's disease.
|
Soc Work Health Care
|
1984
|
0.75
|
|
124
|
Stratification techniques to explore genotype environment interactions.
|
Genet Epidemiol
|
1999
|
0.75
|
|
125
|
Detecting linkage for a complex disease using simulated extended pedigrees.
|
Genet Epidemiol
|
1997
|
0.75
|
|
126
|
An unusual cause of ocular pain.
|
J Tenn Med Assoc
|
1967
|
0.75
|
|
127
|
Insulin and hypertension in the NHLBI Family Heart Study: a sibpair approach to a controversial issue.
|
Am J Hypertens
|
2000
|
0.75
|
|
128
|
The speakers' platform: neglected medium.
|
Natl Conf Dent Public Relat
|
1967
|
0.75
|
|
129
|
Learned aversions to intracerebral carbachol.
|
Physiol Behav
|
1977
|
0.75
|
|
130
|
Segregation analysis of total nevus density and estimation of lifetime risk and average onset age of melanoma.
|
Cytogenet Cell Genet
|
1992
|
0.75
|