Published in Hypertension on October 01, 2000
Identifying Genes Involved in Abnormal Blood Pressure - Hypertension SCOR | NCT00005325
Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation (2011) 31.98
Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2012) 30.79
Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet (2008) 11.80
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet (2007) 5.64
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81
WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest (2003) 3.67
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet (2007) 3.04
Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation (2017) 2.76
Multiple genes for essential-hypertension susceptibility on chromosome 1q. Am J Hum Genet (2006) 2.34
Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. Am J Hum Genet (2003) 2.23
Genome-wide association studies: contribution of genomics to understanding blood pressure and essential hypertension. Curr Hypertens Rep (2010) 2.03
Genetic Analysis Workshop 13: simulated longitudinal data on families for a system of oligogenic traits. BMC Genet (2003) 2.02
Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. BMC Med Genet (2007) 2.00
Linkage and association analysis of angiotensin I-converting enzyme (ACE)-gene polymorphisms with ACE concentration and blood pressure. Am J Hum Genet (2001) 1.91
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J Clin Invest (2015) 1.89
Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. J Hypertens (2011) 1.81
Genetics of the Framingham Heart Study population. Adv Genet (2008) 1.62
A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals. Hypertension (2013) 1.60
A genome-wide association study of depressive symptoms. Biol Psychiatry (2013) 1.58
Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium. Hum Mol Genet (2011) 1.54
Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet (2014) 1.47
Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. Am J Hum Genet (2004) 1.45
The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med (Berl) (2008) 1.35
Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study. BMC Genet (2003) 1.34
Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. Hypertension (2012) 1.28
An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study. BMC Genet (2007) 1.27
A QTL genome scan of the metabolic syndrome and its component traits. BMC Genet (2003) 1.24
Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Hypertension (2010) 1.22
GOSR2 Lys67Arg is associated with hypertension in whites. Am J Hypertens (2008) 1.20
A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search. Am J Hum Genet (2002) 1.20
Use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits. BMC Genet (2003) 1.18
STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression. BMC Med Genet (2009) 1.17
In hypertension, the kidney is not always the heart of the matter. J Clin Invest (2005) 1.17
Arterial stiffness: a brief review. Acta Pharmacol Sin (2010) 1.15
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes. Hypertension (2014) 1.11
Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis Study. Bone (2006) 1.10
Multiple imputation methods for longitudinal blood pressure measurements from the Framingham Heart Study. BMC Genet (2003) 1.09
Strategy and model building in the fourth dimension: a null model for genotype x age interaction as a Gaussian stationary stochastic process. BMC Genet (2003) 1.08
Genes for blood pressure: an opportunity to understand hypertension. Eur Heart J (2013) 1.07
Genome-wide linkage analysis of systolic blood pressure: a comparison of two approaches to phenotype definition. BMC Genet (2003) 1.07
A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study. Am J Hum Genet (2007) 1.04
Longitudinal association analysis of quantitative traits. Genet Epidemiol (2012) 1.04
Genetic contribution to biological aging: the Framingham Study. J Gerontol A Biol Sci Med Sci (2004) 1.00
Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. Circ Cardiovasc Genet (2010) 1.00
Af17 deficiency increases sodium excretion and decreases blood pressure. J Am Soc Nephrol (2011) 1.00
Multilevel modeling for the analysis of longitudinal blood pressure data in the Framingham Heart Study pedigrees. BMC Genet (2003) 0.99
Genome-wide linkage analysis of systolic blood pressure slope using the Genetic Analysis Workshop 13 data sets. BMC Genet (2003) 0.99
Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results. BMC Proc (2009) 0.98
Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.97
Linkage analysis of longitudinal data and design consideration. BMC Genet (2006) 0.97
Flexible semiparametric analysis of longitudinal genetic studies by reduced rank smoothing. J R Stat Soc Ser C Appl Stat (2011) 0.97
Body mass index in primary and secondary pediatric hypertension. Pediatr Nephrol (2004) 0.95
Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension (2013) 0.95
A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. PLoS One (2012) 0.94
Longitudinal familial analysis of blood pressure involving parametric (co)variance functions. BMC Genet (2003) 0.94
Genome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure. BMC Genet (2003) 0.93
Bivariate linkage study of proximal hip geometry and body size indices: the Framingham study. Calcif Tissue Int (2007) 0.92
Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches. BMC Genet (2003) 0.92
Screening the genome to detect an association with hypertension. BMC Genet (2003) 0.91
WNK kinases, renal ion transport and hypertension. Am J Nephrol (2008) 0.91
Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study. Hypertension (2011) 0.91
A common genetic factor underlies hypertension and other cardiovascular disorders. BMC Cardiovasc Disord (2004) 0.90
Guanylyl cyclase / atrial natriuretic peptide receptor-A: role in the pathophysiology of cardiovascular regulation. Can J Physiol Pharmacol (2011) 0.90
The functional genomics of guanylyl cyclase/natriuretic peptide receptor-A: perspectives and paradigms. FEBS J (2011) 0.90
Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study. J Bone Miner Res (2009) 0.89
Genome-wide profiling of blood pressure in adults and children. Hypertension (2011) 0.89
Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study. J Hypertens (2008) 0.89
EM-random forest and new measures of variable importance for multi-locus quantitative trait linkage analysis. Bioinformatics (2008) 0.88
A genome wide linkage scan of metacarpal size and geometry in the Framingham Study. Am J Hum Biol (2008) 0.88
Comparison of longitudinal variance components and regression-based approaches for linkage detection on chromosome 17 for systolic blood pressure. BMC Genet (2003) 0.88
The genetics of blood pressure and hypertension: the role of rare variation. Cardiovasc Ther (2010) 0.88
Depressive symptoms are associated with visceral adiposity in a community-based sample of middle-aged women and men. Obesity (Silver Spring) (2013) 0.87
Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart Study. Am J Hypertens (2008) 0.87
Angiotensin-converting enzyme gene 2350 G/A polymorphism and susceptibility to atrial fibrillation in Han Chinese patients with essential hypertension. Clinics (Sao Paulo) (2013) 0.86
Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling. BMC Genet (2003) 0.86
A discussion of gene-gene and gene-environment interactions and longitudinal genetic analysis of complex traits. Stat Med (2012) 0.86
Genetic linkage analysis of longitudinal hypertension phenotypes using three summary measures. BMC Genet (2003) 0.86
Susceptibility scoring in family-based association testing. BMC Genet (2003) 0.85
Bivariate association analysis of longitudinal phenotypes in families. BMC Proc (2014) 0.85
Blood pressure and human genetic variation in the general population. Curr Opin Cardiol (2010) 0.85
Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping. J Hypertens (2012) 0.84
Segregation and linkage analysis for longitudinal measurements of a quantitative trait. BMC Genet (2003) 0.84
Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme. J Mol Med (Berl) (2013) 0.84
Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. J Hypertens (2009) 0.84
Genetic admixture, social-behavioural factors and body composition are associated with blood pressure differently by racial-ethnic group among children. J Hum Hypertens (2011) 0.84
Association of genetic variation in the mitochondrial genome with blood pressure and metabolic traits. Hypertension (2012) 0.84
Heritability of blood pressure responses to cold pressor test in a Chinese population. Am J Hypertens (2009) 0.83
Genome scan linkage results for longitudinal systolic blood pressure phenotypes in subjects from the Framingham Heart Study. BMC Genet (2003) 0.83
Transmission ratio distortion in families from the Framingham Heart Study. BMC Genet (2003) 0.82
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure. Hum Genet (2015) 0.82
Endothelial dysfunction in experimental models of arterial hypertension: cause or consequence? Biomed Res Int (2014) 0.82
Progress and future aspects in genetics of human hypertension. Curr Hypertens Rep (2013) 0.82
Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community. Eur J Cardiovasc Prev Rehabil (2011) 0.81
Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension. Am J Hum Genet (2006) 0.81
Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC). PLoS One (2015) 0.81
The association of educational attainment and SBP among older community-living adults: the Maintenance of Balance, Independent Living, Intellect and Zest in the Elderly (MOBILIZE) Boston Study. J Hypertens (2012) 0.80
Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med (2001) 10.54
Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71
Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol (1985) 7.93
The progression from hypertension to congestive heart failure. JAMA (1996) 7.56
Lifetime risk of developing coronary heart disease. Lancet (1999) 7.54
Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation (1997) 7.34
Relation of pooled logistic regression to time dependent Cox regression analysis: the Framingham Heart Study. Stat Med (1990) 7.00
A randomized trial of treatment options for alcohol-abusing workers. N Engl J Med (1991) 6.94
Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med (1999) 6.72
Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation (1996) 6.20
Molecular basis of human hypertension: role of angiotensinogen. Cell (1992) 6.07
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science (1999) 6.04
Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet (1996) 5.95
Accuracy of death certificates for coding coronary heart disease as the cause of death. Ann Intern Med (1998) 5.63
The organization of the histone genes in Drosophila melanogaster: functional and evolutionary implications. Cold Spring Harb Symp Quant Biol (1978) 5.60
Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet (2001) 5.54
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol (1999) 5.43
Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation (2001) 5.11
Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14225 in man. N Engl J Med (1978) 5.04
Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study. Circulation (1999) 5.04
Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med (1999) 5.01
Comparisons of five health status instruments for orthopedic evaluation. Med Care (1990) 4.57
Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation (1994) 4.52
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol (1998) 4.44
Inverse association of dietary fat with development of ischemic stroke in men. JAMA (1998) 4.20
Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J (1987) 4.12
Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum (1989) 4.02
The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings. Ann Intern Med (1990) 4.02
CAG repeat number governs the development rate of pathology in Huntington's disease. Ann Neurol (1997) 4.01
Bone mass and the risk of breast cancer among postmenopausal women. N Engl J Med (1997) 3.96
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89
Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet (1996) 3.84
Predictive testing for Huntington's disease with use of a linked DNA marker. N Engl J Med (1988) 3.82
Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet (1999) 3.73
Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet (1996) 3.71
Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. Int J Obes (Lond) (2006) 3.69
Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. A prospective study. JAMA (1996) 3.68
An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study) Am J Cardiol (1992) 3.66
Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes (2000) 3.60
The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science (1987) 3.59
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet (1997) 3.51
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation (1994) 3.44
A controlled trial of an educational program to prevent low back injuries. N Engl J Med (1997) 3.33
The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study. Ann Intern Med (1994) 3.20
Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation (2001) 3.18
Prevention of childhood injuries: evaluation of the Statewide Childhood Injury Prevention Program (SCIPP). Am J Public Health (1989) 3.17
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology (2012) 3.12
Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res (2000) 3.09
Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation (1996) 3.07
Fish consumption and risk of sudden cardiac death. JAMA (1998) 3.06
Isolation of specific RNA's using DNA covalently linked to diazobenzyloxymethyl cellulose or paper. Methods Enzymol (1979) 3.04
Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency. Kidney Int (1999) 2.95
Modern strategies to prevent coronary sequelae and stroke in hypertensive patients differ from the JNC V Consensus Guidelines. Am J Hypertens (1994) 2.91
A specific orally active inhibitor of angiotensin-converting enzyme in man. Lancet (1977) 2.90
Comparative measurement sensitivity of short and longer health status instruments. Med Care (1992) 2.89
Cardiorespiratory events recorded on home monitors: Comparison of healthy infants with those at increased risk for SIDS. JAMA (2001) 2.87
Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension (1998) 2.86
Comparative measurement efficiency and sensitivity of five health status instruments for arthritis research. Arthritis Rheum (1985) 2.85
Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med (1997) 2.81
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature (1990) 2.80
Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol (1991) 2.70
A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci U S A (1995) 2.69
Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol (2001) 2.57
Regional obesity and risk of cardiovascular disease; the Framingham Study. J Clin Epidemiol (1991) 2.56
Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation (2001) 2.54
Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study) Am J Cardiol (1999) 2.51
Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics (2001) 2.50
Protective effect of fruits and vegetables on development of stroke in men. JAMA (1995) 2.50
Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N Engl J Med (1996) 2.49
Rate of functional decline in Huntington's disease. Huntington Study Group. Neurology (2000) 2.49
New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis (1997) 2.45
Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study. Arthritis Rheum (1998) 2.45
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J (1996) 2.39
Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Nat Genet (2000) 2.38
Head injury and the risk of AD in the MIRAGE study. Neurology (2000) 2.34
Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int (2001) 2.34
Oral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients. Ann Intern Med (1979) 2.31
Increased rate of suicide among patients with Huntington's disease. J Neurol Neurosurg Psychiatry (1984) 2.31
Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol (2000) 2.28
Prognosis after the onset of coronary heart disease. An investigation of differences in outcome between the sexes according to initial coronary disease presentation. Circulation (1993) 2.27
Television viewing and change in body fat from preschool to early adolescence: The Framingham Children's Study. Int J Obes Relat Metab Disord (2003) 2.26
Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science (2000) 2.21
Factors associated with slow progression in Huntington's disease. Arch Neurol (1991) 2.18
Gitelman's syndrome revisited: an evaluation of symptoms and health-related quality of life. Kidney Int (2001) 2.18
A clinical rule to predict preserved left ventricular ejection fraction in patients after myocardial infarction. Ann Intern Med (1994) 2.17