Published in JAMA on December 07, 1994
Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci U S A (2009) 9.19
The role of apolipoprotein E in Alzheimer's disease. Neuron (2009) 5.55
Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease. Mov Disord (2007) 2.24
Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study. Circ Cardiovasc Genet (2010) 1.77
Genetics of the Framingham Heart Study population. Adv Genet (2008) 1.62
Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. Am J Hum Genet (1996) 1.54
Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo. J Bone Miner Res (2013) 1.47
Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. Exp Gerontol (2008) 1.41
Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City. Am J Hum Genet (1996) 1.30
Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review. Alzheimers Res Ther (2012) 1.30
Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study. PLoS One (2012) 1.17
Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis. Am J Hum Genet (1997) 1.11
The apolipoprotein E gene, attention, and brain function. Neuropsychology (2002) 1.05
Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study. BMC Med Genet (2009) 0.96
Impact of APOE gene polymorphisms on the lipid profile in an Algerian population. Lipids Health Dis (2013) 0.94
Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice. J Clin Invest (1997) 0.93
A prospective study of cognitive health in the elderly (Oregon Brain Aging Study): effects of family history and apolipoprotein E genotype. Am J Hum Genet (1997) 0.93
Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism. Hum Genet (2004) 0.91
Molecular genetics of myocardial infarction. Genomic Med (2008) 0.91
Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E. PLoS One (2010) 0.90
Apolipoprotein e gene polymorphism and its effect on plasma lipids in arteriosclerosis. J Clin Diagn Res (2013) 0.90
Apolipoprotein E and change in episodic memory in blacks and whites. Neuroepidemiology (2013) 0.90
Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish women. Circ Cardiovasc Genet (2009) 0.90
Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. J Clin Invest (1996) 0.88
One step closer to fixing association studies: evidence for age- and gender-specific allele frequency variations and deviations from Hardy-Weinberg expectations in controls. Hum Genet (2005) 0.88
Reduced physiological complexity in robust elderly adults with the APOE epsilon4 allele. PLoS One (2009) 0.87
Apolipoprotein E and kidney function in older adults. Clin Nephrol (2012) 0.86
Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants. Biogerontology (2015) 0.86
Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population. BMC Res Notes (2014) 0.86
Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway. PLoS One (2012) 0.85
Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls. PLoS One (2014) 0.84
Effect of apolipoprotein E gene Hha I restricting fragment length polymorphism on serum lipids in cholecystolithiasis. World J Gastroenterol (1999) 0.82
Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk. Mol Neurodegener (2011) 0.82
Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise. Front Physiol (2014) 0.82
Do long-term HDL-C declines associated with a first birth vary by apo E phenotype? The Coronary Artery Risk Development in Young Adults (CARDIA) study. J Womens Health (Larchmt) (2005) 0.81
APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease. Neurol Sci (2014) 0.79
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutr Metab Cardiovasc Dis (2009) 0.79
Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians. J Community Genet (2010) 0.79
Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction. Cardiol Res Pract (2015) 0.78
Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes. J Diabetes Metab Disord (2012) 0.78
APOE gene polymorphism and risk of coronary stenosis in Pakistani population. Biomed Res Int (2015) 0.76
Apolipoprotein ε4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study. Lipids Health Dis (2011) 0.76
Drivers: A Biologically Contextualized, Cross-Inferential View of the Epidemiology of Neurodegenerative Disorders. J Alzheimers Dis (2016) 0.76
Genetic Research and Women's Heart Disease: a Primer. Curr Atheroscler Rep (2016) 0.75
Etiologic Framework for the Study of Neurodegenerative Disorders as Well as Vascular and Metabolic Comorbidities on the Grounds of Shared Epidemiologic and Biologic Features. Front Aging Neurosci (2016) 0.75
[Apolipoprotein E polymorphism in the population of northern Morocco: frequency and effect on lipid parameters]. Pan Afr Med J (2013) 0.75
Establishment of a rat model with diet-induced coronary atherosclerosis. J Biomed Res (2016) 0.75
Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation (1998) 19.93
Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA (1994) 11.63
Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med (2001) 10.54
Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med (1999) 9.83
Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension (2000) 8.84
Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med (1987) 8.09
Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol (1985) 7.93
The progression from hypertension to congestive heart failure. JAMA (1996) 7.56
Lifetime risk of developing coronary heart disease. Lancet (1999) 7.54
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38
Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation (1997) 7.34
Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol (1998) 6.76
Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med (1999) 6.72
Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study. JAMA (1970) 6.42
Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation (1996) 6.20
Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke (1994) 5.83
Accuracy of death certificates for coding coronary heart disease as the cause of death. Ann Intern Med (1998) 5.63
Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet (2001) 5.54
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol (1999) 5.43
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham study. Neurology (1978) 5.37
Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation (2001) 5.11
Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study. Circulation (1999) 5.04
Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med (1999) 5.01
The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort. Arch Neurol (2000) 4.77
Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med (1994) 4.74
Comparisons of five health status instruments for orthopedic evaluation. Med Care (1990) 4.57
Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation (1994) 4.52
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol (1998) 4.44
Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med (1995) 4.36
Inverse association of dietary fat with development of ischemic stroke in men. JAMA (1998) 4.20
Stroke severity in atrial fibrillation. The Framingham Study. Stroke (1996) 4.11
Left atrial size and the risk of stroke and death. The Framingham Heart Study. Circulation (1995) 4.04
The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings. Ann Intern Med (1990) 4.02
Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum (1989) 4.02
CAG repeat number governs the development rate of pathology in Huntington's disease. Ann Neurol (1997) 4.01
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89
Predictive testing for Huntington's disease with use of a linked DNA marker. N Engl J Med (1988) 3.82
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. A prospective study. JAMA (1996) 3.68
An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study) Am J Cardiol (1992) 3.66
The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science (1987) 3.59
Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA (1987) 3.59
Morning increase in onset of ischemic stroke. Stroke (1989) 3.52
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation (1994) 3.44
Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells. Am J Pathol (1986) 3.35
A controlled trial of an educational program to prevent low back injuries. N Engl J Med (1997) 3.33
Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology (2010) 3.27
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study. Int J Obes Relat Metab Disord (2003) 3.23
The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study. Ann Intern Med (1994) 3.20
Infarcts of undetermined cause: the NINCDS Stroke Data Bank. Ann Neurol (1989) 3.13
Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology (2007) 3.12
The Stroke Data Bank: design, methods, and baseline characteristics. Stroke (1988) 3.12
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology (2012) 3.12
Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. JAMA (2001) 3.12
Lipoprotein(a) levels and risk of coronary heart disease in men. The lipid Research Clinics Coronary Primary Prevention Trial. JAMA (1994) 3.11
Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation (1996) 3.07
Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study. Neurology (2004) 2.97
Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency. Kidney Int (1999) 2.95
Systolic blood pressure, arterial rigidity, and risk of stroke. The Framingham study. JAMA (1981) 2.93
Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology (2011) 2.91
The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors. Arch Otolaryngol Head Neck Surg (1993) 2.91
Comparative measurement sensitivity of short and longer health status instruments. Med Care (1992) 2.89
American Heart Association Prevention Conference. IV. Prevention and Rehabilitation of Stroke. Risk factors. Stroke (1997) 2.87
Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension (1998) 2.86
Comparative measurement efficiency and sensitivity of five health status instruments for arthritis research. Arthritis Rheum (1985) 2.85
Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med (1997) 2.81
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature (1990) 2.80
Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med (1992) 2.77
Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke (2001) 2.71
Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol (1991) 2.70
Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions. Clin Chim Acta (1987) 2.70
Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. Am J Epidemiol (1993) 2.67
Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke (2001) 2.65
Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology (1992) 2.64
Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation (2001) 2.54
Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The Practical Incidence Estimators (PIE) macro. Stat Med (2000) 2.54
Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study) Am J Cardiol (1999) 2.51
Protective effect of fruits and vegetables on development of stroke in men. JAMA (1995) 2.50
Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N Engl J Med (1996) 2.49
Rate of functional decline in Huntington's disease. Huntington Study Group. Neurology (2000) 2.49
Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study. Arthritis Rheum (1998) 2.45
Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study. Neurology (1997) 2.43
The 'preclinical phase' of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort. Arch Neurol (1995) 2.42
Predictors of brain morphology for the men of the NHLBI twin study. Stroke (1999) 2.41
Quantification of mRNA by polymerase chain reaction (PCR) using an internal standard and a nonradioactive detection method. Methods Mol Biol (1998) 2.39
Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med (1999) 2.33
Portacaval shunt in patients with familial hypercholesterolemia. Ann Surg (1983) 2.33