Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein.

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Published in J Mol Biol on December 14, 2001

Authors

G Schmitt-Ulms1, G Legname, M A Baldwin, H L Ball, N Bradon, P J Bosque, K L Crossin, G M Edelman, S J DeArmond, F E Cohen, S B Prusiner

Author Affiliations

1: Institute for Neurodegenerative Diseases, Department of Neurology, University of California, San Francisco, 94143, USA.

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Novel proteinaceous infectious particles cause scrapie. Science (1982) 24.09

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Surface modulation in cell recognition and cell growth. Science (1976) 10.33

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A protease-resistant protein is a structural component of the scrapie prion. Cell (1983) 6.72

Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science (1996) 6.71

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet (1994) 6.50

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Cell adhesion molecules. Science (1983) 5.98

Purification and structural studies of a major scrapie prion protein. Cell (1984) 5.98

The covalent structure of an entire gammaG immunoglobulin molecule. Proc Natl Acad Sci U S A (1969) 5.90

Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. J Biol Chem (1982) 5.87

Adhesion among neural cells of the chick embryo. I. An immunological assay for molecules involved in cell-cell binding. J Biol Chem (1977) 5.61

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Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool. J Mol Biol (1997) 4.79

Concanavalin A derivatives with altered biological activities. Proc Natl Acad Sci U S A (1973) 4.75

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Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science (1990) 4.19

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Improvements in protein secondary structure prediction by an enhanced neural network. J Mol Biol (1990) 4.10

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Cell adhesion molecules in the regulation of animal form and tissue pattern. Annu Rev Cell Biol (1986) 4.04

Further purification and characterization of scrapie prions. Biochemistry (1982) 4.01

Cell adhesion molecules in early chicken embryogenesis. Proc Natl Acad Sci U S A (1982) 4.01

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Cell adhesion and the molecular processes of morphogenesis. Annu Rev Biochem (1985) 3.78

Phylogenetic origins of antibody structure. I. Multichain structure of immunoglobulins in the smooth dogfish (Mustelus canis). J Exp Med (1965) 3.76

A transmembrane form of the prion protein in neurodegenerative disease. Science (1998) 3.76

2 -Microglobulin--a free immunoglobulin domain. Proc Natl Acad Sci U S A (1972) 3.74

Linkage of prion protein and scrapie incubation time genes. Cell (1986) 3.69

Measurement of the scrapie agent using an incubation time interval assay. Ann Neurol (1982) 3.68

Regional mapping of prion proteins in brain. Proc Natl Acad Sci U S A (1992) 3.68

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Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies. Proc Natl Acad Sci U S A (1993) 3.56

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54

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Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44

Structural clues to prion replication. Science (1994) 3.43

Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans. Proc Natl Acad Sci U S A (1999) 3.43

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. Proc Natl Acad Sci U S A (1997) 3.42

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Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol (1988) 3.37

Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol (1990) 3.32

Temperature-sensitive changes in surface modulating assemblies of fibroblasts transformed by mutants of Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.29

Mechanisms of adhesion among cells from neural tissues of the chick embryo. Proc Natl Acad Sci U S A (1976) 3.25

Co-evolution of proteins with their interaction partners. J Mol Biol (2000) 3.23

Binding properties of a cell adhesion molecule from neural tissue. Proc Natl Acad Sci U S A (1982) 3.22

Distinct prion proteins in short and long scrapie incubation period mice. Cell (1987) 3.21

Somatic translocation of antibody genes. Nature (1970) 3.20

Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions. Proc Natl Acad Sci U S A (1983) 3.18

Adhesion among neural cells of the chick embryo. IV. Role of the cell surface molecule CAM in the formation of neurite bundles in cultures of spinal ganglia. J Cell Biol (1978) 3.12

Antibodies to a scrapie prion protein. Nature (1984) 3.09

The covalent and three-dimensional structure of concanavalin A. Proc Natl Acad Sci U S A (1972) 3.09

Early epochal maps of two different cell adhesion molecules. Proc Natl Acad Sci U S A (1983) 3.06

Identification of prion amyloid filaments in scrapie-infected brain. Cell (1985) 3.04

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. J Mol Biol (1997) 2.95

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes. Cell (1993) 2.93

Cell fractionation and arrangement on fibers, beads, and surfaces. Proc Natl Acad Sci U S A (1971) 2.93

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol (1999) 2.92