Published in Mol Pharmacol on January 01, 2002
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. J Med Chem (2012) 2.10
N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One (2012) 1.17
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol Pharmacol (2012) 1.00
Conserved rhodopsin intradiscal structural motifs mediate stabilization: effects of zinc. Biochemistry (2009) 0.81
G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity. PLoS One (2013) 0.81
Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. J Am Chem Soc (2016) 0.80
Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies. Mol Neurobiol (2015) 0.78
The Effects of Leucine, Zinc, and Chromium Supplements on Inflammatory Events of the Respiratory System in Type 2 Diabetic Rats. PLoS One (2015) 0.75
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity. Neural Plast (2017) 0.75
Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc. Mol Pharmacol (2016) 0.75
Zinc Methionine Supplementation Impacts Gene and Protein Expression in Calf-Fed Holstein Steers with Minimal Impact on Feedlot Performance. Biol Trace Elem Res (2015) 0.75
Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region. Chem Sci (2016) 0.75
Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor. In Silico Pharmacol (2014) 0.75
Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Nat Chem Biol (2006) 3.76
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc Natl Acad Sci U S A (2009) 2.86
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77
Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem (2003) 2.68
Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J Biol Chem (2005) 2.64
Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem (2002) 2.06
Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies. J Biol Chem (2007) 1.85
Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A (2005) 1.65
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50
Using synthetic lipids to stabilize purified beta2 adrenoceptor in detergent micelles. Anal Biochem (2005) 1.49
A new era of GPCR structural and chemical biology. Nat Chem Biol (2012) 1.41
Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry (2005) 1.34
Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor. Biochemistry (2004) 1.32
The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc Natl Acad Sci U S A (2003) 1.32
Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart. Crit Care Med (2004) 1.28
Activation of G protein-coupled receptors. Adv Protein Chem (2007) 1.20
The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J Biol Chem (2002) 1.15
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice. Am J Physiol Heart Circ Physiol (2002) 1.12
Tandem facial amphiphiles for membrane protein stabilization. J Am Chem Soc (2010) 1.05
Toward understanding GPCR dimers. Nat Struct Mol Biol (2004) 0.93
Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chem Commun (Camb) (2013) 0.93
Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal. Traffic (2010) 0.92
Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor. J Biol Chem (2002) 0.90
Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery. Methods Mol Biol (2009) 0.83
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? J Recept Signal Transduct Res (2010) 0.82
The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors. J Biol Chem (2001) 0.82
PDZ-domain arrays for identifying components of GPCR signaling complexes. Trends Pharmacol Sci (2006) 0.79
Q&A: Brian Kobilka. Stuck on structure. Nature (2014) 0.77
Brian Kobilka: chipping away at the β2-adrenergic receptor. Interview by Ruth Williams. Circ Res (2013) 0.75
Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules. Bioorg Med Chem Lett (2011) 0.75