Published in Crit Care Med on April 01, 2004
Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhage. Stroke (2006) 2.68
High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy. Circulation (2012) 1.85
Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg (2009) 1.77
Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Sci Signal (2009) 1.66
Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol (2007) 1.19
Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Crit Care (2009) 1.18
Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 1.17
Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression. Crit Care (2008) 1.09
Testosterone protects rat hearts against ischaemic insults by enhancing the effects of alpha(1)-adrenoceptor stimulation. Br J Pharmacol (2007) 0.96
GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility. Cell Commun Signal (2013) 0.95
Adrenergic signaling in heart failure: a balance of toxic and protective effects. Pflugers Arch (2014) 0.94
Deletion of the β2-adrenergic receptor prevents the development of cardiomyopathy in mice. J Mol Cell Cardiol (2013) 0.93
Selective β2-adrenoreceptor stimulation attenuates myocardial cell death and preserves cardiac function after ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol (2012) 0.86
RGS Proteins in Heart: Brakes on the Vagus. Front Physiol (2012) 0.86
Beta-adrenergic receptor desensitization in man: insight into post-exercise attenuation of cardiac function. J Physiol (2006) 0.86
Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both? Curr Heart Fail Rep (2015) 0.84
Total beta-adrenoceptor knockout slows conduction and reduces inducible arrhythmias in the mouse heart. PLoS One (2012) 0.82
Biased β2 -adrenoceptor signalling in heart failure: pathophysiology and drug discovery. Br J Pharmacol (2014) 0.82
Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Giα-coupled β2-adrenoceptor signaling pathway. PLoS One (2014) 0.81
Pathological hypertrophy reverses β2-adrenergic receptor-induced angiogenesis in mouse heart. Physiol Rep (2015) 0.80
Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway. Am J Physiol Heart Circ Physiol (2012) 0.80
Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways. Cardiovasc Res (2015) 0.79
β-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. J Appl Physiol (1985) (2013) 0.77
Carvedilol in the treatment of elderly patients with chronic heart failure. Clin Interv Aging (2008) 0.77
Sarco"MiR" friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy. Ann Transl Med (2016) 0.75
The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development. Pharmacol Res (2016) 0.75
Suppression of microRNA-16 protects against acute myocardial infarction by reversing beta2-adrenergic receptor down-regulation in rats. Oncotarget (2017) 0.75
Dose-effects of aorta-infused clenbuterol on spinal cord ischemia-reperfusion injury in rabbits. PLoS One (2013) 0.75
Regulation of G protein subunit composition in cardiomyocytes: pharmacological implications. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.75
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proc Natl Acad Sci U S A (2007) 6.04
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Nat Chem Biol (2006) 3.76
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res (2006) 3.42
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc Natl Acad Sci U S A (2009) 2.86
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77
Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J Biol Chem (2005) 2.64
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A (2005) 2.58
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50
Quantitative and dynamic assessment of the contribution of the ER to phagosome formation. Cell (2005) 2.35
The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res (2005) 2.24
Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem (2002) 2.06
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest (2008) 1.89
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med (2011) 1.88
Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ Res (2004) 1.85
Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies. J Biol Chem (2007) 1.85
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. Mol Pharmacol (2008) 1.78
Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg (2009) 1.77
Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem (2007) 1.77
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases. Circ Res (2008) 1.68
Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A (2005) 1.65
Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart. Trends Pharmacol Sci (2006) 1.65
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation (2003) 1.55
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50
Using synthetic lipids to stabilize purified beta2 adrenoceptor in detergent micelles. Anal Biochem (2005) 1.49
Gene expression profiling: classification of mice with left ventricle systolic dysfunction using microarray analysis. Crit Care Med (2010) 1.45
Microarray analysis of gene expression after transverse aortic constriction in mice. Physiol Genomics (2004) 1.44
A new era of GPCR structural and chemical biology. Nat Chem Biol (2012) 1.41
De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J Transl Med (2012) 1.40
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications. Trends Pharmacol Sci (2004) 1.38
Abundance, distribution, and mutation rates of homopolymeric nucleotide runs in the genome of Caenorhabditis elegans. J Mol Evol (2004) 1.36
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. J Clin Invest (2011) 1.35
Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry (2005) 1.34
Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor. Biochemistry (2004) 1.32
The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc Natl Acad Sci U S A (2003) 1.32
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling. Pharmacol Ther (2005) 1.32
Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circ Res (2011) 1.31
PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction. Neuron (2007) 1.31
Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol (2011) 1.30
Allosteric modulation of beta2-adrenergic receptor by Zn(2+). Mol Pharmacol (2002) 1.25
The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A (2006) 1.22
Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction. J Pharmacol Exp Ther (2008) 1.20
Activation of G protein-coupled receptors. Adv Protein Chem (2007) 1.20
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70. Circ Res (2009) 1.18
The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J Biol Chem (2002) 1.15
The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly. Circ Res (2005) 1.15
Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality (2006) 1.14
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice. Am J Physiol Heart Circ Physiol (2002) 1.12
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med (2011) 1.08
Tandem facial amphiphiles for membrane protein stabilization. J Am Chem Soc (2010) 1.05
RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol (2011) 0.98
Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload. PLoS One (2012) 0.95
Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy. J Cell Physiol (2014) 0.94
Toward understanding GPCR dimers. Nat Struct Mol Biol (2004) 0.93
Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chem Commun (Camb) (2013) 0.93
Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal. Traffic (2010) 0.92
Deregulation of RGS2 in cardiovascular diseases. Front Biosci (Schol Ed) (2010) 0.92
Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications. J Clin Invest (2014) 0.92
Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells. Eur J Pharmacol (2005) 0.91
Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor. J Biol Chem (2002) 0.90
Activation of (Na+ + K+)-ATPase modulates cardiac L-type Ca2+ channel function. Mol Pharmacol (2009) 0.90
Depression, negative self-image, and suicidal attempts as effects of substance use and substance dependence. J Addict Dis (2004) 0.89
A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. J Biol Chem (2009) 0.87
Serine496 of β2 subunit of L-type Ca2+ channel participates in molecular crosstalk between activation of (Na++K+)-ATPase and the channel. Biochem Biophys Res Commun (2010) 0.84
Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery. Methods Mol Biol (2009) 0.83
FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. PLoS One (2013) 0.83
Nuclear translocation of type I transforming growth factor β receptor confers a novel function in RNA processing. Mol Cell Biol (2012) 0.83
2,3,4',5-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits angiotensin II-induced cardiac fibroblast proliferation via suppression of the reactive oxygen species-extracellular signal-regulated kinase 1/2 pathway. Clin Exp Pharmacol Physiol (2012) 0.83
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? J Recept Signal Transduct Res (2010) 0.82
The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors. J Biol Chem (2001) 0.82
Cartilage tissue engineering using cryogenic chondrocytes. Arch Otolaryngol Head Neck Surg (2003) 0.79
PDZ-domain arrays for identifying components of GPCR signaling complexes. Trends Pharmacol Sci (2006) 0.79
Infarction induced myocardial apoptosis and ARC activation. J Surg Res (2009) 0.79
AMPK and TNF-alpha at the crossroad of cell survival and death in ischaemic heart. Cardiovasc Res (2009) 0.78
Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes. Biochem Biophys Res Commun (2011) 0.78
Q&A: Brian Kobilka. Stuck on structure. Nature (2014) 0.77
PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF. Am J Physiol Cell Physiol (2013) 0.77
Solitary metastatic clear cell carcinoma to the spleen. Rare Tumors (2011) 0.75
Brian Kobilka: chipping away at the β2-adrenergic receptor. Interview by Ruth Williams. Circ Res (2013) 0.75
Chromhidrosis: a rare diagnosis requiring clinicopathologic correlation. Am J Dermatopathol (2014) 0.75
Emotional Flexibility: Development and Application of a Scale in Adolescent Earthquake Survivors. Psychol Trauma (2017) 0.75
A visual analytics system for breast tumor evaluation. Anal Quant Cytol Histol (2008) 0.75