Published in Immunity on December 01, 2001
Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity (2008) 1.72
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol (2006) 1.55
ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation. J Exp Med (2004) 1.44
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol (2006) 1.41
Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. J Immunol (2005) 1.38
Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP. EMBO J (2005) 1.36
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. Proc Natl Acad Sci U S A (2009) 1.35
SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Proc Natl Acad Sci U S A (2007) 1.30
Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med (2002) 1.24
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells. Mol Cell Biol (2009) 1.19
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med (2012) 1.07
Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol (2011) 1.07
Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76. Cold Spring Harb Perspect Biol (2010) 1.02
Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol (2006) 1.01
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exp Med (2008) 0.95
Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses. Sci Signal (2011) 0.95
Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol (2003) 0.92
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood (2013) 0.88
Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. Mol Cell Biol (2010) 0.87
A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Proc Natl Acad Sci U S A (2005) 0.85
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation. J Biol Chem (2008) 0.84
Cbl enforces Vav1 dependence and a restricted pathway of T cell development. PLoS One (2011) 0.84
Lymphocyte signaling: beyond knockouts. Nat Immunol (2009) 0.83
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. EMBO J (2011) 0.82
ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development. Mol Cell Biol (2006) 0.81
The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability. Mol Cell Biol (2004) 0.80
Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76. J Immunol (2009) 0.79
The SLP-76 Src homology 2 domain is required for T cell development and activation. J Immunol (2011) 0.78
Understanding signal integration through targeted mutations of an adapter protein. FEBS Lett (2010) 0.78
Development of nanoscale structure in LAT-based signaling complexes. J Cell Sci (2016) 0.75
The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function. Immune Netw (2009) 0.75
CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (1995) 12.24
Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45. Science (1993) 4.47
Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res (1984) 3.94
Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol (1988) 3.60
Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med (2001) 3.47
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science (1998) 3.18
Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J (1999) 2.62
Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol (1992) 2.51
Coupling of the TCR to integrin activation by Slap-130/Fyb. Science (2001) 2.26
Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem (1995) 2.22
Regional patterns of soil organic carbon stocks in China. J Environ Manage (2006) 2.21
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity (1996) 2.18
The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr Biol (1999) 2.10
Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J Biol Chem (1993) 2.02
Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J Biol Chem (1997) 2.00
Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol (1994) 1.91
RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int (2006) 1.88
The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem (1997) 1.78
Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J Exp Med (1996) 1.75
Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. Proc Natl Acad Sci U S A (1982) 1.73
The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res (1998) 1.73
Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem (2001) 1.72
Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur J Immunol (1999) 1.70
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity (2001) 1.68
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J Exp Med (2001) 1.62
Strain dynamics of ultrathin VO₂ film grown on TiO₂ (001) and the associated phase transition modulation. Nano Lett (2014) 1.61
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics (1999) 1.60
Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity (1995) 1.59
Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest (2000) 1.59
Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest (1996) 1.59
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol (1998) 1.57
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. J Clin Invest (1999) 1.56
HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Proc Natl Acad Sci U S A (2000) 1.53
A phorbol ester (TPA) can replace macrophages in human lymphocyte cultures stimulated with a mitogen but not with an antigen. J Immunol (1982) 1.52
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res (2001) 1.50
Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu Rev Immunol (1999) 1.46
The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. J Biol Chem (2000) 1.43
Bilateral Bispectral Index (BIS)-Vista as a measure of physiologic sleep in sleep-deprived anesthesiologists. Minerva Anestesiol (2010) 1.43
Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens (1999) 1.42
Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex. J Biol Chem (1995) 1.42
Epidemiology and ecology of rickettsial diseases in the People's Republic of China. Rev Infect Dis (1988) 1.35
Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution. Eur J Immunol (1998) 1.35
Antigenic diversity of Rickettsia conorii. Am J Trop Med Hyg (1992) 1.35
Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. J Immunol (1996) 1.34
Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells. J Biol Chem (1997) 1.33
Clinical management of brain stem glioma. Arch Dis Child (1999) 1.32
Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. J Biol Chem (1998) 1.31
The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. J Immunol (1998) 1.31
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J Clin Invest (1997) 1.29
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors. Proc Natl Acad Sci U S A (2000) 1.29
Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. J Biol Chem (1999) 1.28
Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem (2000) 1.25
Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem (1996) 1.22
Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res (2001) 1.22
Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem (1994) 1.22
Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling. J Exp Med (2000) 1.21
Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase. J Biol Chem (1996) 1.21
Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J Biol Chem (1999) 1.21
Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity (1997) 1.20
Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. Am J Physiol Renal Physiol (2001) 1.19
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells. Mol Cell Biol (2009) 1.19
Adapter proteins in lymphocyte antigen-receptor signaling. Curr Opin Immunol (2000) 1.19
Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol Cell Biol (1998) 1.18
Compliance with antibiotic prophylaxis in urinary tract infection. Arch Dis Child (1993) 1.16
SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation. J Immunol (1998) 1.16
Management and outcome of severe head injuries in the Trent region 1985-90. Arch Dis Child (1992) 1.16
Functional association between SLAP-130 and SLP-76 in Jurkat T cells. J Biol Chem (2000) 1.15
Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. Am J Physiol (1999) 1.12
Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. J Immunol (1997) 1.11
Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli. J Bacteriol (1983) 1.11
Bacillus Calmette-Guérin therapy alters the progression of superficial bladder cancer. J Clin Oncol (1988) 1.11
Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiol Genomics (2000) 1.11
Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes. J Exp Med (1999) 1.10
Evidence for an interleukin-independent pathway for human lymphocyte activation. Proc Natl Acad Sci U S A (1983) 1.10
Regulation of CD45 engagement by the B-cell receptor CD22. Proc Natl Acad Sci U S A (1995) 1.10
Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. J Biol Chem (1999) 1.09
Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circ Res (2000) 1.08
Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. Blood (1996) 1.06
SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem (1998) 1.06
Three domains of SLP-76 are required for its optimal function in a T cell line. J Immunol (1997) 1.05
Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem (2000) 1.05
Cutting edge: a novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration. J Immunol (2000) 1.04
Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. J Biol Chem (2000) 1.04
SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity. J Biol Chem (1999) 1.04
In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase. J Biol Chem (1994) 1.03
Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide. J Immunol (1999) 1.03
Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol (2010) 1.01
Rickettsial and serologic evidence for prevalent spotted fever rickettsiosis in inner Mongolia. Am J Trop Med Hyg (1987) 1.00