Published in Am J Physiol Renal Physiol on January 01, 2001
Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production. Kidney Int (2002) 3.23
Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. Am J Physiol Renal Physiol (2007) 1.87
Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice. Am J Hypertens (2012) 1.74
New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II. Peptides (2011) 1.32
Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring. Am J Physiol Regul Integr Comp Physiol (2007) 1.20
Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. Am J Physiol Regul Integr Comp Physiol (2011) 1.12
Intrarenal angiotensin II and hypertension. Curr Hypertens Rep (2003) 1.10
Renal renin-angiotensin system. Contrib Nephrol (2004) 1.09
Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. Am J Physiol Renal Physiol (2011) 0.97
An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol (2008) 0.92
Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice. Am J Physiol Renal Physiol (2013) 0.87
Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice. Diabetes (2014) 0.85
Proximal tubule angiotensinogen modulation of arterial pressure. Curr Opin Nephrol Hypertens (2013) 0.85
Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol (2011) 0.84
Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension. Physiol Rep (2016) 0.81
Angiotensin receptor-associated proteins: local modulators of the renin-angiotensin system. Pflugers Arch (2012) 0.80
Tubular overexpression of gremlin induces renal damage susceptibility in mice. PLoS One (2014) 0.80
UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting duct. Am J Physiol Renal Physiol (2005) 0.79
Augmentation of angiotensinogen expression in the proximal tubule by intracellular angiotensin II via AT1a/MAPK/NF-кB signaling pathways. Am J Physiol Renal Physiol (2016) 0.78
The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models. Toxicol Appl Pharmacol (2013) 0.75
Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res (1984) 3.94
Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol (1988) 3.60
Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol (1992) 2.51
Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol (1994) 1.91
RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int (2006) 1.88
The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem (1997) 1.78
Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. Proc Natl Acad Sci U S A (1982) 1.73
The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res (1998) 1.73
Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem (2001) 1.72
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics (1999) 1.60
Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest (2000) 1.59
Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest (1996) 1.59
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol (1998) 1.57
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res (2001) 1.50
Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens (1999) 1.42
Differential requirement for SLP-76 domains in T cell development and function. Immunity (2001) 1.36
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J Clin Invest (1997) 1.29
Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. J Biol Chem (1999) 1.28
Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem (2000) 1.25
Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem (1996) 1.22
Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res (2001) 1.22
Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem (1994) 1.22
Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. Am J Physiol (1999) 1.12
Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli. J Bacteriol (1983) 1.11
Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiol Genomics (2000) 1.11
Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. J Biol Chem (1999) 1.09
Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circ Res (2000) 1.08
Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem (2000) 1.05
Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. J Biol Chem (2000) 1.04
Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol (2010) 1.01
Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. J Biol Chem (1997) 0.99
The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Res (1999) 0.98
NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension (2001) 0.97
Expression of murine renin genes during fetal development. Mol Endocrinol (1990) 0.97
Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. Biotechniques (2001) 0.96
Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arterioscler Thromb Vasc Biol (2001) 0.95
Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circ Res (1999) 0.94
Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. Stroke (2000) 0.93
Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res (1997) 0.92
Allele-specific expression of the murine Ren-1 genes. J Biol Chem (1989) 0.91
Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. Hypertension (1995) 0.91
Vascular biology in genetically altered mice : smaller vessels, bigger insight. Circ Res (2000) 0.89
Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. J Biol Chem (2000) 0.89
Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. EMBO J (1989) 0.88
Biosynthesis of renin in mouse kidney tumor As4.1 cells. Eur J Biochem (1997) 0.87
JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am J Physiol (1999) 0.87
Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. Am J Physiol (1996) 0.85
Regulation of human renin mRNA expression and protein release in transgenic mice. Hypertension (1996) 0.83
Understanding hypertension through genetic manipulation in mice. Kidney Int (2000) 0.83
Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. Exp Nephrol (1999) 0.82
Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. Hypertension (1999) 0.82
Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice. Circ Res (1999) 0.82
Transgenic mice for studies of the renin-angiotensin system in hypertension. Acta Physiol Scand (2004) 0.81
Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology (1995) 0.80
Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. Hypertension (1998) 0.80
Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. Curr Hypertens Rep (2000) 0.79
Studies on the regulation of renin genes using transgenic mice. Clin Exp Hypertens A (1988) 0.78
Developmental expression of human angiotensinogen in transgenic mice. Am J Physiol (1998) 0.78
Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. Hypertension (1991) 0.78
Transgenic models as tools for studying the regulation of human renin expression. Regul Pept (2000) 0.77
Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice. Cancer Res (1994) 0.76
Downregulation of renin gene expression by interleukin-1. Hypertension (1997) 0.76
Paradoxical regulation of short promoter human renin transgene by angiotensin ii. Hypertension (2001) 0.76
Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic Acids Res (1996) 0.75
Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders. Proc Assoc Am Physicians (1997) 0.75
Physiological insights from genetic manipulation of the renin-angiotensin system. News Physiol Sci (2001) 0.75
Transgenic animals in the study of blood pressure regulation and hypertension. Am J Physiol (1995) 0.75
Human renin 5'-flanking DNA to nucleotide-2750. DNA Seq (1995) 0.75
Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension. Trends Cardiovasc Med (1998) 0.75
Transgenic animals as tools in hypertension research. Proc Soc Exp Biol Med (1994) 0.75
Transgenic animal models as tools for studying renal developmental physiology. Pediatr Nephrol (1996) 0.75