Published in Diabetes on January 01, 2002
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol (2009) 2.94
Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab (2007) 1.68
Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes. Cytokine (2012) 1.38
Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes. Diabetes (2008) 1.31
Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition? Trends Immunol (2010) 1.28
Challenges and emerging technologies in the immunoisolation of cells and tissues. Adv Drug Deliv Rev (2007) 1.24
CCR2 regulates monocyte recruitment as well as CD4 T1 allorecognition after lung transplantation. Am J Transplant (2010) 1.17
Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture. PLoS One (2012) 1.13
Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev (2008) 1.12
Portal vein thrombosis is a potentially preventable complication in clinical islet transplantation. Am J Transplant (2011) 1.10
Insulin resistance, inflammation, and obesity: role of monocyte chemoattractant protein-1 (or CCL2) in the regulation of metabolism. Mediators Inflamm (2010) 1.09
Current status of islet cell transplantation. J Hepatobiliary Pancreat Surg (2008) 1.07
CXCR1/2 inhibition enhances pancreatic islet survival after transplantation. J Clin Invest (2012) 1.05
Association between plasma monocyte chemoattractant protein-1 concentration and cardiovascular disease mortality in middle-aged diabetic and nondiabetic individuals. Diabetes Care (2009) 1.05
Regulating MCP-1 diffusion in affinity hydrogels for enhancing immuno-isolation. J Control Release (2009) 1.04
A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor. Br J Pharmacol (2003) 1.01
Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood. Clin Exp Immunol (2005) 1.01
Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation (2008) 1.00
Islet transplantation and encapsulation: an update on recent developments. Rev Diabet Stud (2011) 0.98
Islet transplantation and antioxidant management: a comprehensive review. World J Gastroenterol (2009) 0.97
Low expression of ARHI is associated with shorter progression-free survival in pancreatic endocrine tumors. Neoplasia (2007) 0.93
α-1-antitrypsin gene delivery reduces inflammation, increases T-regulatory cell population size and prevents islet allograft rejection. Mol Med (2011) 0.93
Anti-proinflammatory effects of sirolimus on human islet preparations. Transplantation (2008) 0.87
Regulation of the CCL2 gene in pancreatic β-cells by IL-1β and glucocorticoids: role of MKP-1. PLoS One (2012) 0.87
Characterization of pancreatic ductal cells in human islet preparations. Lab Invest (2008) 0.87
Prolactin supplementation to culture medium improves beta-cell survival. Transplantation (2010) 0.87
Innate immunity and heat shock response in islet transplantation. Clin Exp Immunol (2009) 0.86
Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation. Eur J Immunol (2010) 0.85
Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation. J Transplant (2011) 0.85
Toward engineering a novel transplantation site for human pancreatic islets. Diabetes (2013) 0.84
Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways. PLoS One (2014) 0.84
A novel method for quantitative monitoring of transplanted islets of langerhans by positive contrast magnetic resonance imaging. Am J Transplant (2011) 0.83
Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation. J Transplant (2011) 0.83
Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes. EMBO Mol Med (2014) 0.82
Thrombosis and inflammation in intraportal islet transplantation: a review of pathophysiology and emerging therapeutics. J Diabetes Sci Technol (2008) 0.82
Antiproinflammatory effects of iodixanol (OptiPrep)-based density gradient purification on human islet preparations. Cell Transplant (2010) 0.82
The humanized NOD/SCID mouse as a preclinical model to study the fate of encapsulated human islets. Rev Diabet Stud (2010) 0.79
The therapeutic role of monocyte chemoattractant protein-1 in a renal tissue engineering strategy for diabetic patients. PLoS One (2013) 0.79
Alpha E: no more rejection? J Exp Med (2002) 0.79
Anti-apoptotic Effects of Bone Marrow on Human Islets: A Preliminary Report. J Stem Cell Res Ther (2015) 0.78
Altered phenotype of peripheral blood dendritic cells in pediatric type 1 diabetes. Diabetes Care (2012) 0.78
Big mac attack: does it play a direct role for monocytes/macrophages in type 1 diabetes? Diabetes (2008) 0.78
Effect of nicotinamide on early graft failure following intraportal islet transplantation. Exp Mol Med (2009) 0.78
Thiobenzothiazole-modified Hydrocortisones Display Anti-inflammatory Activity with Reduced Impact on Islet β-Cell Function. J Biol Chem (2015) 0.77
The therapeutic effect of monocyte chemoattractant protein-1 delivered by an electrospun scaffold for hyperglycemia and nephrotic disorders. Int J Nanomedicine (2014) 0.77
Immunohistochemical study of monocyte chemoattractant protein-1 in the pancreas of NOD mice following cyclophosphamide administration and during spontaneous diabetes. J Mol Histol (2006) 0.76
Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type-2 Diabetes. Diabetes (2017) 0.76
NFAT targets signaling molecules to gene promoters in pancreatic β-cells. Mol Endocrinol (2014) 0.76
Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression. Sci Rep (2017) 0.75
Improvement of islet graft function using liraglutide is correlated with its anti-inflammatory properties. Br J Pharmacol (2016) 0.75
Improved human islet preparations using glucocorticoid and exendin-4. Pancreas (2014) 0.75
Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes. PLoS One (2016) 0.75
Thioredoxin-1 attenuates early graft loss after intraportal islet transplantation in mice. PLoS One (2013) 0.75
The Spleen Is an Ideal Site for Inducing Transplanted Islet Graft Expansion in Mice. PLoS One (2017) 0.75
Streptozotocin-associated lymphopenia in cynomolgus monkeys. Islets (2014) 0.75
Evidence of stress in β cells obtained with laser capture microdissection from pancreases of brain dead donors. Islets (2017) 0.75
Cancer-related inflammation. Nature (2008) 34.21
The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 19.38
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol (2002) 17.85
International trial of the Edmonton protocol for islet transplantation. N Engl J Med (2006) 13.43
Macrophage activation and polarization. Front Biosci (2008) 11.17
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis (2009) 7.55
Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol (2010) 6.85
A map of open chromatin in human pancreatic islets. Nat Genet (2010) 6.75
Macrophage polarization comes of age. Immunity (2005) 5.67
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer (2006) 5.60
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol (2005) 4.86
Macrophage polarization in tumour progression. Semin Cancer Biol (2008) 4.62
Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol (2012) 4.30
Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev (2006) 4.02
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol (2007) 3.95
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood (2005) 3.85
Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med (2003) 3.71
Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J Exp Med (2011) 3.59
The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev (2008) 3.33
Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care (2012) 3.20
Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg (2009) 3.15
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci U S A (2009) 3.01
Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature (2002) 3.01
New vistas on macrophage differentiation and activation. Eur J Immunol (2007) 2.99
Cancer related inflammation: the macrophage connection. Cancer Lett (2008) 2.88
p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res (2006) 2.76
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med (2007) 2.71
Laparoscopic versus open colorectal surgery: a randomized trial on short-term outcome. Ann Surg (2002) 2.50
CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study. Lancet Oncol (2009) 2.47
Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood (2005) 2.39
Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell (2013) 2.35
Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res (2004) 2.31
Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation (2004) 2.31
Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J Immunol (2008) 2.26
Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol (2003) 2.24
Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum Immunol (2009) 2.19
Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trial. Lancet Oncol (2005) 2.18
Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol (2011) 2.13
Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. Eur J Cancer (2004) 2.12
Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility. J Immunol (2010) 2.07
M2 macrophages phagocytose rituximab-opsonized leukemic targets more efficiently than m1 cells in vitro. J Immunol (2009) 2.06
A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology (2002) 2.05
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron (2010) 1.96
Pathways connecting inflammation and cancer. Curr Opin Genet Dev (2008) 1.95
Islet transplantation is associated with improvement of renal function among uremic patients with type I diabetes mellitus and kidney transplants. J Am Soc Nephrol (2003) 1.85
Cytokines as a key component of cancer-related inflammation. Cytokine (2008) 1.85
IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection. Microbes Infect (2004) 1.82
Carbohydrate antigen 19-9 change during chemotherapy for advanced pancreatic adenocarcinoma. Cancer (2009) 1.82
Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection? Ann Surg Oncol (2008) 1.81
Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res (2005) 1.80
Laparoscopic vs. open colectomy in cancer patients: long-term complications, quality of life, and survival. Dis Colon Rectum (2005) 1.79
Cellular and molecular pathways linking inflammation and cancer. Immunobiology (2009) 1.78
Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality. Intensive Care Med (2010) 1.75
The chemokine system in cancer biology and therapy. Cytokine Growth Factor Rev (2009) 1.75
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest (2008) 1.73
The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death. J Biol Chem (2011) 1.72
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene. Proc Natl Acad Sci U S A (2005) 1.70
Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res (2010) 1.68
Macrophage activation and polarization as an adaptive component of innate immunity. Adv Immunol (2013) 1.67
Laparoscopic resection in rectal cancer patients: outcome and cost-benefit analysis. Dis Colon Rectum (2007) 1.65
Bone marrow as an alternative site for islet transplantation. Blood (2009) 1.61
Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB. Blood (2009) 1.59
Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by rapamycin. Transplantation (2006) 1.58
Surgical management of insulinomas: short- and long-term outcomes after enucleations and pancreatic resections. Arch Surg (2012) 1.58
Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg (2002) 1.57
IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes. Blood (2008) 1.55
Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J Biol Chem (2002) 1.55
Tumor-associated macrophages: functional diversity, clinical significance, and open questions. Semin Immunopathol (2013) 1.54
Extending indications for islet autotransplantation in pancreatic surgery. Ann Surg (2013) 1.52