TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal.

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Published in J Cell Biol on December 24, 2001

Authors

M Majdan1, G S Walsh, R Aloyz, F D Miller

Author Affiliations

1: Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4.

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Physiology of nerve growth factor. Physiol Rev (1980) 4.58

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BAX is required for neuronal death after trophic factor deprivation and during development. Neuron (1996) 4.02

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Expression and structure of the human NGF receptor. Cell (1986) 3.82

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Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature (1987) 2.98

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