Cell death during development of the nervous system.

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J (1992) 8.86

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31

Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology (2009) 3.26

An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A (2000) 3.13

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol (1994) 2.75

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J Cell Biol (1993) 2.67

Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol (1998) 2.64

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest (1998) 2.64

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am J Pathol (2000) 2.53

Do all programmed cell deaths occur via apoptosis? Proc Natl Acad Sci U S A (1993) 2.35

Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J (1996) 2.31

Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci (2006) 2.28

Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol (2007) 2.27

Origin and function of olfactory bulb interneuron diversity. Trends Neurosci (2008) 2.25

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J Cell Biol (1996) 2.14

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci (2010) 2.12

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem (2005) 2.08

Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J Cell Biol (2000) 1.98

Peripheral nerve regeneration and neurotrophic factors. J Anat (1999) 1.96

Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology (2011) 1.95

Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol (1997) 1.90

Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J Virol (1997) 1.84

Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol (2000) 1.83

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J Cell Biol (1991) 1.68

Apoptosis in pressure overload-induced heart hypertrophy in the rat. J Clin Invest (1996) 1.65

Deletion of Bax eliminates sex differences in the mouse forebrain. Proc Natl Acad Sci U S A (2004) 1.64

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Mol Cell Biol (2008) 1.62

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J Cell Biol (1996) 1.59

Inhibition of apoptosis by the retinoblastoma gene product. EMBO J (1995) 1.58

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature (2010) 1.56

Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans. EMBO J (1994) 1.54

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J (2006) 1.53

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons. J Cell Biol (1997) 1.52

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. Proc Natl Acad Sci U S A (1993) 1.51

Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem (2009) 1.51

Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization. J Cell Biol (2000) 1.48

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons. EMBO J (1996) 1.48

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis. Genes Dev (2011) 1.48

Blocking cytochrome c activity within intact neurons inhibits apoptosis. J Cell Biol (1998) 1.45

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol (2011) 1.45

Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol (1992) 1.44

Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells. Philos Trans R Soc Lond B Biol Sci (2006) 1.44

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J Cell Biol (1996) 1.44

Intrinsically determined cell death of developing cortical interneurons. Nature (2012) 1.43

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification. Am J Pathol (1993) 1.42

A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster. Development (2008) 1.41

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol Cell Biol (1998) 1.41

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci U S A (1995) 1.40

Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability. Proc Natl Acad Sci U S A (2011) 1.39

Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. Mol Cell Biol (2000) 1.39

ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol (2004) 1.38

Programmed cell death of embryonic motoneurons triggered through the Fas death receptor. J Cell Biol (1999) 1.37

A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice. J Clin Invest (1997) 1.37

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci (2006) 1.36

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. J Cell Biol (1998) 1.36

Cell cycle molecules define a pathway required for neuron death in development and disease. Biochim Biophys Acta (2006) 1.35

Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival. J Cell Biol (1999) 1.32

Cell death in the Schwann cell lineage and its regulation by neuregulin. Proc Natl Acad Sci U S A (1996) 1.31

Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J Cell Biol (1995) 1.31

Chemoafferent degeneration and carotid body hypoplasia following chronic hyperoxia in newborn rats. J Physiol (1998) 1.30

NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis. Proc Natl Acad Sci U S A (2009) 1.30

Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron (2012) 1.30

Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci (2004) 1.29

c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. J Cell Biol (2002) 1.28

Poliovirus induces apoptosis in the mouse central nervous system. J Virol (1999) 1.27

Are anaesthetics toxic to the brain? Br J Anaesth (2011) 1.26

Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24

Control of lens epithelial cell survival. J Cell Biol (1993) 1.24

Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc Natl Acad Sci U S A (1997) 1.24

Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinonucleoside-induced apoptosis in cultured cerebellar neurons. Proc Natl Acad Sci U S A (1996) 1.23

Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol (2008) 1.22

Dicer is required for survival of differentiating neural crest cells. Dev Biol (2010) 1.19

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal. J Cell Biol (1994) 1.18

Regulation of endothelial monocyte-activating polypeptide II release by apoptosis. Proc Natl Acad Sci U S A (1998) 1.18

bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc Natl Acad Sci U S A (1995) 1.18

Adolescent neurodevelopment. J Adolesc Health (2013) 1.18

Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease. Pharmacol Ther (2007) 1.17

Regulation of neuronal survival and death by extracellular signals during development. EMBO J (2003) 1.16

A fast signal-induced activation of Poly(ADP-ribose) polymerase: a novel downstream target of phospholipase c. J Cell Biol (2000) 1.16

Internucleosomal DNA cleavage and neuronal cell survival/death. J Cell Biol (1993) 1.16

Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures. Mol Cell Neurosci (2006) 1.15

Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Proc Natl Acad Sci U S A (2001) 1.13

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J (2002) 1.13

Synapse-to-neuron ratio is inversely related to neuronal density in mature neuronal cultures. Brain Res (2010) 1.12

PHACES syndrome: a review of eight previously unreported cases with late arterial occlusions. Neuroradiology (2004) 1.11

Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo. Nucleic Acids Res (1992) 1.11

Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci (2009) 1.11

Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol (2000) 1.10

Control of cell number in the sexually dimorphic brain and spinal cord. J Neuroendocrinol (2009) 1.10

Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts. Proc Natl Acad Sci U S A (1995) 1.10

TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal. J Cell Biol (2001) 1.09

Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models. Exp Eye Res (2009) 1.08

Construction and analysis of a modular model of caspase activation in apoptosis. Theor Biol Med Model (2008) 1.08

Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity. Proc Natl Acad Sci U S A (2010) 1.08

Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5. Cell Death Differ (2009) 1.07

Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons. J Neurosci (2010) 1.07

Human Bak induces cell death in Schizosaccharomyces pombe with morphological changes similar to those with apoptosis in mammalian cells. Mol Cell Biol (1997) 1.07

Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development. Neural Dev (2011) 1.07

Key note lecture: toward a mechanistic taxonomy for cell death programs. Stroke (2007) 1.06

Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration. Mol Biol Cell (2010) 1.06