Published in Proc Natl Acad Sci U S A on December 26, 2001
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest (2006) 1.94
Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci U S A (2003) 1.82
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A (2002) 1.82
Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov (2009) 1.45
Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc Natl Acad Sci U S A (2002) 1.40
Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A (2008) 1.38
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci (2010) 1.27
Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. Proc Natl Acad Sci U S A (2005) 1.25
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem (2008) 1.13
Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A (2003) 1.12
Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A (2006) 1.07
The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer (2016) 0.95
Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system. Diabetes (2008) 0.92
Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. Proc Natl Acad Sci U S A (2005) 0.91
Hypothalamic malonyl-coenzyme A and the control of energy balance. Mol Endocrinol (2008) 0.90
Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction. Mol Cell Endocrinol (2008) 0.89
The search for new ways to treat obesity. Proc Natl Acad Sci U S A (2002) 0.87
Hypothalamic malonyl-CoA and the control of food intake. Physiol Behav (2013) 0.86
Effects of chronic social defeat stress on peripheral leptin and its hypothalamic actions. BMC Neurosci (2014) 0.81
The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK. PLoS One (2011) 0.80
A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics. J Pediatr Endocrinol Metab (2011) 0.80
Regulation of peripheral metabolism by substrate partitioning in the brain. Endocrinol Metab Clin North Am (2013) 0.79
3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compounds. PLoS One (2013) 0.78
Effect of food deprivation and hormones of glucose homeostasis on the acetyl CoA carboxylase activity in mouse brain: a potential role of acc in the regulation of energy balance. Nutr Metab (Lond) (2006) 0.75
The central administration of C75, a fatty acid synthase inhibitor, activates sympathetic outflow and thermogenesis in interscapular brown adipose tissue. Pflugers Arch (2013) 0.75
S-nitrosylation of fatty acid synthase regulates its activity through dimerization. J Lipid Res (2016) 0.75
The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice. PLoS One (2012) 0.75
Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice. Diabetologia (2017) 0.75
Central nervous system control of food intake. Nature (2000) 15.85
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science (1995) 9.09
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med (1999) 4.78
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science (2000) 4.62
Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature (2001) 3.70
Activation of downstream signals by the long form of the leptin receptor. J Biol Chem (2000) 3.52
Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol (1999) 3.48
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol (1998) 3.01
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology (1997) 2.32
In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis. J Biol Chem (1979) 2.00
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci U S A (2001) 1.79
Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes (1999) 1.57
Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology (2001) 1.11
Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinology (2001) 1.05
Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res (2001) 0.98
Circumventing leptin resistance for weight control. Proc Natl Acad Sci U S A (2001) 0.93
Central administration of alpha-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks. Eur J Pharmacol (2000) 0.90
Chronic intracerebroventricular administration of recombinant CART(42-89) peptide inhibits and causes weight loss in lean and obese Zucker (fa/fa) rats. Obes Res (2000) 0.89
Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci U S A (2002) 3.67
Adipose development: from stem cell to adipocyte. Crit Rev Biochem Mol Biol (2005) 3.15
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (2002) 3.08
Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis. J Biol Chem (2005) 2.74
CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc Natl Acad Sci U S A (2003) 2.65
Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A (2004) 2.56
Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Proc Natl Acad Sci U S A (2005) 2.51
Adipogenesis: from stem cell to adipocyte. Annu Rev Biochem (2012) 2.46
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways. J Biol Chem (2003) 1.99
BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A (2009) 1.90
Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci U S A (2003) 1.82
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A (2006) 1.77
Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis. J Biol Chem (2003) 1.75
Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene. Proc Natl Acad Sci U S A (2006) 1.70
Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A (2003) 1.57
Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling. J Biol Chem (2008) 1.45
Effect of phosphorylation and S-S bond-induced dimerization on DNA binding and transcriptional activation by C/EBPbeta. Proc Natl Acad Sci U S A (2007) 1.42
Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. Proc Natl Acad Sci U S A (2002) 1.40
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. Am J Physiol Endocrinol Metab (2009) 1.39
Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A (2008) 1.38
A role for bone morphogenetic protein-4 in adipocyte development. Cell Cycle (2007) 1.37
The role of hypothalamic malonyl-CoA in energy homeostasis. J Biol Chem (2006) 1.35
Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. Proc Natl Acad Sci U S A (2002) 1.34
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. J Biol Chem (2009) 1.28
A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem (2005) 1.28
Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proc Natl Acad Sci U S A (2007) 1.26
Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation. Proc Natl Acad Sci U S A (2007) 1.25
Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. Proc Natl Acad Sci U S A (2005) 1.25
Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. Annu Rev Biochem (2005) 1.20
Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system. Annu Rev Nutr (2006) 1.15
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem (2008) 1.13
Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A (2003) 1.12
Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A (2006) 1.07
Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity. FEBS J (2010) 1.05
O-linked N-acetylglucosamine modification on CCAAT enhancer-binding protein beta: role during adipocyte differentiation. J Biol Chem (2009) 1.04
Wnt signaling and adipocyte lineage commitment. Cell Cycle (2008) 0.99
Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3. Biochem Biophys Res Commun (2004) 0.96
Upstream stimulatory factors regulate the C/EBP alpha gene during differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun (2007) 0.93
Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway. Biochem Biophys Res Commun (2009) 0.92
Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. Proc Natl Acad Sci U S A (2005) 0.91
Hypothalamic malonyl-coenzyme A and the control of energy balance. Mol Endocrinol (2008) 0.90
Localization and effect of ectopic expression of CPT1c in CNS feeding centers. Biochem Biophys Res Commun (2007) 0.89
BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13. Biochem Biophys Res Commun (2006) 0.86
Effect of serum on the down-regulation of CHOP-10 during differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun (2005) 0.83
Regulatory sequence elements of mouse GLUT4 gene expression in adipose tissues. Biochem Biophys Res Commun (2003) 0.80
Nuclear factor 1 regulates adipose tissue-specific expression in the mouse GLUT4 gene. Biochem Biophys Res Commun (2004) 0.77
C/EBPalpha reverses the anti-adipogenic effects of the HIV protease inhibitor nelfinavir. Biochem Biophys Res Commun (2005) 0.76
NPY and neuron-adipocyte interactions in the regulation of metabolism. EXS (2006) 0.76