Published in PLoS One on September 22, 2011
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Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Proc Natl Acad Sci U S A (2009) 4.58
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Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med (2003) 3.21
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AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95
Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci (2006) 1.87
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The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A (2006) 1.77
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. J Clin Invest (2009) 1.77
Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma. Nat Genet (1999) 1.74
Recognition and elimination of nonsense mRNA. Biochim Biophys Acta (2008) 1.74
Regulation of gene expression by dietary fat. Annu Rev Nutr (1999) 1.69
Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol (2006) 1.67
AMPK as a mediator of hormonal signalling. J Mol Endocrinol (2009) 1.53
A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics (2002) 1.53
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc Natl Acad Sci U S A (2001) 1.53
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J Biol Chem (2008) 1.40
The role of hypothalamic malonyl-CoA in energy homeostasis. J Biol Chem (2006) 1.35
Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. Cell (2003) 1.32
Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet (2009) 1.31
Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology (2009) 1.29
Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells. J Lipid Res (2005) 1.18
AMP-activated protein kinase: a master switch in glucose and lipid metabolism. Rev Endocr Metab Disord (2004) 1.18
Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system. Annu Rev Nutr (2006) 1.15
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem (2008) 1.13
Sucrose control of translation mediated by an upstream open reading frame-encoded peptide. Plant Physiol (2009) 1.12
Role of hypothalamic AMP-kinase in food intake regulation. Nutrition (2008) 1.11
Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy. Can J Physiol Pharmacol (2005) 1.08
Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons. Endocrinology (2006) 1.04
Hypothalamic AMP-activated protein kinase regulates glucose production. Diabetes (2010) 1.02
Control of food intake by fatty acid oxidation and ketogenesis. Nutrition (1999) 0.98
Palmitate induces apoptosis via a direct effect on mitochondria. Apoptosis (1999) 0.95
her-2 upstream open reading frame effects on the use of downstream initiation codons. Biochem Biophys Res Commun (2006) 0.92
Fatty acid sensing and nervous control of energy homeostasis. Diabetes Metab (2007) 0.92
Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. Diabetologia (2009) 0.91
Localization and effect of ectopic expression of CPT1c in CNS feeding centers. Biochem Biophys Res Commun (2007) 0.89
Influence of ghrelin and growth hormone deficiency on AMP-activated protein kinase and hypothalamic lipid metabolism. J Neuroendocrinol (2010) 0.87
The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics. Int J Biochem Cell Biol (2009) 0.84
Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame. Biochem Biophys Res Commun (2000) 0.84
Expression of three carnitine palmitoyltransferase-I isoforms in 10 regions of the rat brain during feeding, fasting, and diabetes. Biochem Biophys Res Commun (2004) 0.82
Making the case for a paradigm shift in trauma surgery. J Am Coll Surg (2006) 3.42
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10
Abdominal compartment syndrome in the open abdomen. Arch Surg (2002) 1.70
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A (2004) 1.43
Pitfalls in percutaneous dilational tracheostomy using the Ciaglia one-step technique. South Med J (2008) 1.39
Telemedicine for anger management therapy in a rural population of combat veterans with posttraumatic stress disorder: a randomized noninferiority trial. J Clin Psychiatry (2010) 1.21
The use of photon beams of a flattening filter-free linear accelerator for hypofractionated volumetric modulated arc therapy in localized prostate cancer. Int J Radiat Oncol Biol Phys (2012) 1.16
Complications following thoracic trauma managed with tube thoracostomy. Injury (2011) 1.10
The surgical revolving door: risk factors for hospital readmission. J Surg Res (2011) 1.04
Effect of high dose per pulse flattening filter-free beams on cancer cell survival. Radiother Oncol (2011) 1.01
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. Cancer Res (2005) 1.00
Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells. Circ Res (2012) 0.98
Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria. Am J Physiol Cell Physiol (2009) 0.98
Early hospital readmission in the trauma population: are the risk factors different? Injury (2013) 0.94
Trigger-dependent gene expression profiles in cardiac preconditioning: evidence for distinct genetic programs in ischemic and anesthetic preconditioning. Anesthesiology (2004) 0.94
Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevoflurane exposure: preconditioning of angiogenic cells by volatile anesthetics. Anesth Analg (2009) 0.90
Generation and characterization of the Anp32e-deficient mouse. PLoS One (2010) 0.89
Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors. Proc Natl Acad Sci U S A (2010) 0.89
Factors associated with mortality and brain injury after falls from the standing position. J Trauma (2009) 0.88
Clinical impact of 18F-choline PET/CT in patients with recurrent prostate cancer. Eur J Nucl Med Mol Imaging (2012) 0.88
Helium breathing provides modest antiinflammatory, but no endothelial protection against ischemia-reperfusion injury in humans in vivo. Anesth Analg (2009) 0.87
Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB. Cardiovasc Res (2008) 0.85
Metastatic bone pain: treatment options with an emphasis on bisphosphonates. Support Care Cancer (2008) 0.84
Interdisciplinary evidence-based recommendations for the follow-up of testicular cancer patients: a joint effort. Swiss Med Wkly (2010) 0.83
Exception from informed consent for emergency research: consulting the trauma community. J Trauma Acute Care Surg (2013) 0.81
Increased bone marrow activity on F-18-FDG PET/CT in granulocyte colony stimulating factor producing anaplastic thyroid carcinoma. Clin Nucl Med (2010) 0.80
Importing controversy. U.S. hospitals' recruitment of foreign nurses stirs debate as poorer countries struggle with staffing shortages of their own. Mod Healthc (2003) 0.78
The use of retrievable inferior vena cava filters in trauma: implications for the trauma team. J Trauma Nurs (2006) 0.78
Staying put. With CEO turnover at its lowest in years, healthcare industry insiders cite economy, board support as reasons behind the numbers. Mod Healthc (2003) 0.78
Picking patients. GAO: specialty hospitals serve fewer uninsured. Mod Healthc (2003) 0.77
Comparing the risk of developing uveitis in patients initiating anti-tumor necrosis factor therapy for ankylosing spondylitis: an analysis of a large US claims database. Curr Med Res Opin (2014) 0.75
Radiologic diagnosis of brain death. JAMA (2002) 0.75
Colonic injuries and the damage control abdomen: does management strategy matter? J Surg Res (2012) 0.75
A rare but severe pulmonary side effect of cetuximab in two patients. BMJ Case Rep (2012) 0.75
Compensation coalition. Groups seek new claims process for immigrant care. Mod Healthc (2004) 0.75
Executive suite squeeze. Retiring CEOs don't see enough talent to replace them. Mod Healthc (2003) 0.75
Under siege. The proposed sale of Health Midwest has landed the not-for-profit in the fight of its life. At stake--control of an $800 million foundation. Mod Healthc (2002) 0.75
A Novel Method of Optimizing Patient and Family Centered Care in the ICU: Family presence on ICU rounds. J Trauma Acute Care Surg (2016) 0.75
Trying to keep their own. Mentoring program aims to improve nurse retention. Mod Healthc (2003) 0.75
Listing their top concerns. Mod Healthc (2003) 0.75
Theology meets business. Catholic system adds lay members to board. Mod Healthc (2004) 0.75
Moral obligations. Pope: Catholic hospitals must feed vegetative patients. Mod Healthc (2004) 0.75
Setting priorities. AHA's new chairman-elect puts disaster preparedness, worker retention on agenda. Mod Healthc (2002) 0.75
Calif. moves ahead on ratios. Davis issues controversial nurse-staffing regulations. Mod Healthc (2002) 0.75
Hospitals' holiday wishes come true. Behind the drug benefit is a lot of help for hospitals, especially rural providers. Mod Healthc (2004) 0.75
States vary in support. Mod Healthc (2002) 0.75
The influence of unit-based nurse practitioners on hospital outcomes and readmission rates for patients with trauma. J Trauma Acute Care Surg (2012) 0.75
AHA's specialty hospital task force suggests policy changes. Physician investors consider proposals unfair control of competition. Mod Healthc (2002) 0.75
The driving forces behind soaring healthcare costs. Spending climbs 10% as increase in hospital services, outpatient care brings higher price tag. Mod Healthc (2002) 0.75
Healthcare's Maine man. Gov. Baldacci delivers on promise of expanded coverage for the state's uninsured population. Mod Healthc (2003) 0.75
Despite some positive results, AHA says glass still half empty. Group will push hard for payment relief despite only slight decline in hospital margins for 2001. Mod Healthc (2003) 0.75
Early pulmonary embolism after injury: a different clinical entity? Injury (2013) 0.75
Enhancing data quality through the formation of a trauma registry workgroup. J Trauma Nurs (2005) 0.75
How much do they make? When it comes to the size of their paychecks, healthcare association chiefs face a long-running debate over whether it's fair or foul. Mod Healthc (2003) 0.75
Handsomely compensated. Despite drop in assets, AHA president gets $1 million. Mod Healthc (2003) 0.75
Sweetening the offer. Organizations adding retirement, ancillary benefits to lure workers. Mod Healthc (2003) 0.75
Reviewing restrictions. GAO report calls for easing of critical-access rules in rural areas. Mod Healthc (2003) 0.75
Mass exodus. Catholic system CEO 4th to step down in 2 months. Mod Healthc (2004) 0.75
Familiar themes for ACHE. Labor shortfalls, malpractice insurance reform, reimbursement issues top agenda for organization's 46th annual congress next month. Mod Healthc (2003) 0.75
Reaping rewards. CHW breaks six-year streak in the red. Mod Healthc (2003) 0.75
AHA links with 'U.S. News'. Hospital directory to be separate from rankings. Mod Healthc (2003) 0.75
Workforce Report 2004. One answer: productivity. A worsening worker shortage forces providers to use IT, other efficiencies to meet demand. Mod Healthc (2004) 0.75
In the crossfire. Missouri hospitals ready defenses against law allowing concealed weapons. Mod Healthc (2003) 0.75
AHA report says hospital profits are up for the first time since 1996. With admissions, ER visits and number of uninsured on the rise, acute-care facilities have to work harder. Mod Healthc (2004) 0.75
A case for more nurses. JAMA study: chance of dying increases with more patients under nurse's care. Mod Healthc (2002) 0.75
How much are they making? Is it money well-spent or too much for too little? Modern Healthcare presents its third annual association executive compensation report. Mod Healthc (2004) 0.75
Changing the subject. Tenet names six new CMOs to reinforce patient safety. Mod Healthc (2004) 0.75
Leaders of the pack. Solucient's annual list of the nation's 100 top hospitals features organizations that take excellence several steps further. Mod Healthc (2002) 0.75
Still leader of the pack. Intermountain tops ranking of integrated networks. Mod Healthc (2003) 0.75
Front lines to front office. Nurses draw on patient-care experience, interdepartmental knowledge as they graduate to top executive positions. Mod Healthc (2004) 0.75
Extracting payment. Hospitals try collecting before patients leave ER. Mod Healthc (2003) 0.75
Foreign certification. AHA seeks delay on regs for immigrant nurses. Mod Healthc (2004) 0.75
Power of attorneys. Minn. ruling may give states' top lawyers more say. Mod Healthc (2003) 0.75
Not adding up. Catholic health system admits misstating earnings. Mod Healthc (2003) 0.75
1059: ABSENT ON ROUNDS: VENTILATOR WAVEFORM ANALYSIS. Crit Care Med (2016) 0.75
Back to basics. Minn. Blues to abandon hospital ownership. Mod Healthc (2003) 0.75
Moving up. Top nurses take on more executive duties as they work their way up. Mod Healthc (2003) 0.75
Off into the sunset. Early retirement of CEOs poses growing problem. Mod Healthc (2004) 0.75
Mergers minus the mania. Smaller deals rule as economic uncertainties contribute to a fourth annual decrease in hospital consolidation activity. Mod Healthc (2003) 0.75
Charity under fire? Providers say regs prevent them from giving care. Mod Healthc (2004) 0.75
Lullaby and good night. Two Fla. hospitals decide to close maternity units. Mod Healthc (2002) 0.75
Learning on the job. Federal initiative trains hospital employees at work. Mod Healthc (2004) 0.75
Going to the pols. San Antonio health system pushes tax plan to help fund trauma centers in Texas. Mod Healthc (2003) 0.75
The right thing to do. ACHE nails down exactly how ethics apply. Mod Healthc (2004) 0.75
JCAHO, NCQA join forces. Mod Healthc (2003) 0.75
Where have all the good deals gone? '90s mergers and acquisition explosion looks more like an anomaly, not a trend. Mod Healthc (2004) 0.75
An ounce of prevention. The AHA tries to ward off political attacks by showing its worth through healthcare ROI study, election cards and a new logo. Mod Healthc (2004) 0.75
Special treatment. The CHA says it's leading the fight for all not-for-profit hospitals to receive fair compensation for being nation's healthcare safety net. Mod Healthc (2002) 0.75
In need of nurses. Illinois hospital makes name for itself through RN retention, recruitment. Mod Healthc (2003) 0.75
Lobbying offensive. Congress asked to limit physician investments. Mod Healthc (2003) 0.75
California bonanza? Providers and insurers cheer mandatory health insurance law, but business interests look at legal challenge to newly signed bill. Mod Healthc (2003) 0.75
Indigent-care spending low. Mod Healthc (2004) 0.75
New arrival. AHA names George Lynn chairman-elect for 2004. Mod Healthc (2003) 0.75
AHA pushes regulation for specialty hospitals. Mod Healthc (2002) 0.75
Ratio law hits hard in Calif. Mod Healthc (2004) 0.75
AHA's profits take tumble. Mod Healthc (2002) 0.75
Assessing the problem. AHA tool to probe racial, ethnic disparities in care. Mod Healthc (2004) 0.75
Minority report. SSM Health Care works to diversify its ranks. Mod Healthc (2003) 0.75
Caught in the middle. A booming specialty hospital market has the AHA and state hospital associations working to balance competing interests. Mod Healthc (2002) 0.75