Published in Methods Mol Biol on January 01, 2002
Laboratory-directed protein evolution. Microbiol Mol Biol Rev (2005) 1.69
Directing the evolution of Rubisco and Rubisco activase: first impressions of a new tool for photosynthesis research. Photosynth Res (2008) 1.09
Site-saturation mutagenesis is more efficient than DNA shuffling for the directed evolution of beta-fucosidase from beta-galactosidase. J Mol Biol (2005) 1.02
Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins in Staphylococcus aureus. Mol Microbiol (2012) 0.82
Method to protect a targeted amino acid residue during random mutagenesis. Nucleic Acids Res (2003) 0.79
Directed evolution of aminoglycoside phosphotransferase (3') type IIIa variants that inactivate amikacin but impose significant fitness costs. PLoS One (2013) 0.78
Synthetic biology: engineering Escherichia coli to see light. Nature (2005) 4.58
A synthetic genetic edge detection program. Cell (2009) 3.20
High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat Biotechnol (2013) 2.81
Aptamer mediated siRNA delivery. Nucleic Acids Res (2006) 2.77
Applications of aptamers as sensors. Annu Rev Anal Chem (Palo Alto Calif) (2009) 2.45
Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat Biotechnol (2010) 2.41
Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation. Proc Natl Acad Sci U S A (2009) 2.39
Aptamer:toxin conjugates that specifically target prostate tumor cells. Cancer Res (2006) 2.23
Protein-dependent ribozymes report molecular interactions in real time. Nat Biotechnol (2002) 2.00
Aptamer therapeutics advance. Curr Opin Chem Biol (2006) 1.69
Ribozyme catalysis of metabolism in the RNA world. Chem Biodivers (2007) 1.66
Aptamer database. Nucleic Acids Res (2004) 1.60
Inhibition of cell proliferation by an anti-EGFR aptamer. PLoS One (2011) 1.59
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol (2012) 1.58
Identification and characterization of the constituent human serum antibodies elicited by vaccination. Proc Natl Acad Sci U S A (2014) 1.50
Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods. Nucleic Acids Res (2011) 1.48
DNA hybridization and discrimination of single-nucleotide mismatches using chip-based microbead arrays. Anal Chem (2003) 1.46
Probing prokaryotic social behaviors with bacterial "lobster traps". MBio (2010) 1.39
Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates. Biosens Bioelectron (2006) 1.38
Aptamer-based sensor arrays for the detection and quantitation of proteins. Anal Chem (2004) 1.37
Selection of fluorescent aptamer beacons that light up in the presence of zinc. Anal Bioanal Chem (2007) 1.37
Arginine-rich motifs present multiple interfaces for specific binding by RNA. RNA (2005) 1.36
Synthetic RNA circuits. Nat Chem Biol (2007) 1.35
Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer. Nucleic Acids Res (2002) 1.29
Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response. Proc Natl Acad Sci U S A (2013) 1.26
Surface-immobilized aptamers for cancer cell isolation and microscopic cytology. Cancer Res (2010) 1.26
Micromechanical detection of proteins using aptamer-based receptor molecules. Anal Chem (2004) 1.24
AANT: the Amino Acid-Nucleotide Interaction Database. Nucleic Acids Res (2004) 1.22
Group I aptazymes as genetic regulatory switches. BMC Biotechnol (2002) 1.20
Structure-based design of supercharged, highly thermoresistant antibodies. Chem Biol (2012) 1.19
Recursive genomewide recombination and sequencing reveals a key refinement step in the evolution of a metabolic innovation in Escherichia coli. Proc Natl Acad Sci U S A (2013) 1.19
Technical and biological issues relevant to cell typing with aptamers. J Proteome Res (2009) 1.17
The robustness of naturally and artificially selected nucleic acid secondary structures. J Mol Evol (2004) 1.17
Construction and selection of bead-bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing. Nucleic Acids Res (2002) 1.16
Production and processing of aptamer microarrays. Methods (2005) 1.16
Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes. Genome Biol (2006) 1.16
Using a deoxyribozyme ligase and rolling circle amplification to detect a non-nucleic acid analyte, ATP. J Am Chem Soc (2005) 1.16
A CMOS Electrochemical Impedance Spectroscopy (EIS) Biosensor Array. IEEE Trans Biomed Circuits Syst (2010) 1.15
Simultaneous detection of diverse analytes with an aptazyme ligase array. Anal Biochem (2003) 1.15
Dynamic reorganization of metabolic enzymes into intracellular bodies. Annu Rev Cell Dev Biol (2012) 1.15
Optimization of aptamer microarray technology for multiple protein targets. Anal Chim Acta (2006) 1.14
Shaping up nucleic acid computation. Curr Opin Biotechnol (2010) 1.14
Tuning the specificity of a synthetic receptor using a selected nucleic acid receptor. J Am Chem Soc (2004) 1.13
Evolution of phage with chemically ambiguous proteomes. BMC Evol Biol (2003) 1.11
Abiotic self-replication. Acc Chem Res (2012) 1.11
Quantum-dot aptamer beacons for the detection of proteins. Chembiochem (2005) 1.10
Rapid construction and characterization of synthetic antibody libraries without DNA amplification. Biotechnol Bioeng (2010) 1.10
Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One (2012) 1.09
Directed evolution of gold nanoparticle delivery to cells. Chem Commun (Camb) (2009) 1.09
Stacking nonenzymatic circuits for high signal gain. Proc Natl Acad Sci U S A (2013) 1.08
Real-time detection of isothermal amplification reactions with thermostable catalytic hairpin assembly. J Am Chem Soc (2013) 1.08
Automated acquisition of aptamer sequences. Comb Chem High Throughput Screen (2002) 1.08
Modelling amorphous computations with transcription networks. J R Soc Interface (2009) 1.07
Functional RNA microarrays for high-throughput screening of antiprotein aptamers. Anal Biochem (2005) 1.06
Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA. Nat Biotechnol (2004) 1.06
Exponential growth by cross-catalytic cleavage of deoxyribozymogens. Proc Natl Acad Sci U S A (2003) 1.05
Functional DNAzymes organized into two-dimensional arrays. Nano Lett (2006) 1.03
Pattern transformation with DNA circuits. Nat Chem (2013) 1.02
Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology. Cancer (2011) 1.02
Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. ACS Chem Biol (2012) 1.01
Aptamers as potential tools for super-resolution microscopy. Nat Methods (2012) 1.01
Directed evolution of streptavidin variants using in vitro compartmentalization. Chem Biol (2008) 1.00
Design principles for ligand-sensing, conformation-switching ribozymes. PLoS Comput Biol (2009) 1.00
Computational selection of nucleic acid biosensors via a slip structure model. Biosens Bioelectron (2006) 0.99
Direct selection of trans-acting ligase ribozymes by in vitro compartmentalization. RNA (2005) 0.99
Selecting nucleic acids for biosensor applications. Comb Chem High Throughput Screen (2002) 0.98
A (ribo) switch in the paradigms of genetic regulation. Nat Struct Biol (2002) 0.98
Probing spatial organization of DNA strands using enzyme-free hairpin assembly circuits. J Am Chem Soc (2012) 0.98
Engineering regulatory RNAs. Trends Biotechnol (2005) 0.97
Diagnostic applications of nucleic acid circuits. Acc Chem Res (2014) 0.97
Structure of the Escherichia coli phosphonate binding protein PhnD and rationally optimized phosphonate biosensors. J Mol Biol (2011) 0.96
Adapting enzyme-free DNA circuits to the detection of loop-mediated isothermal amplification reactions. Anal Chem (2012) 0.96
Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J Proteome Res (2009) 0.96
Increasing the thermal stability of an oligomeric protein, beta-glucuronidase. J Mol Biol (2002) 0.96
SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis. ACS Synth Biol (2012) 0.96
Real-time rolling circle amplification for protein detection. Anal Chem (2007) 0.96
Capture, isolation and release of cancer cells with aptamer-functionalized glass bead array. Lab Chip (2012) 0.95
Identification of novel specific allosteric modulators of the glycine receptor using phage display. J Biol Chem (2010) 0.95
Alternative computational protocols for supercharging protein surfaces for reversible unfolding and retention of stability. PLoS One (2013) 0.94
A general RNA motif for cellular transfection. Mol Ther (2012) 0.94
Engineering stochasticity in gene expression. Mol Biosyst (2008) 0.94
Gene synthesis: methods and applications. Methods Enzymol (2011) 0.93
Rational design of an orthogonal tryptophanyl nonsense suppressor tRNA. Nucleic Acids Res (2010) 0.93
Bioinformatic analysis of the contribution of primer sequences to aptamer structures. J Mol Evol (2008) 0.93
Aptamers that recognize drug-resistant HIV-1 reverse transcriptase. Nucleic Acids Res (2008) 0.93
DNA circuits as amplifiers for the detection of nucleic acids on a paperfluidic platform. Lab Chip (2012) 0.92
Design and application of cotranscriptional non-enzymatic RNA circuits and signal transducers. Nucleic Acids Res (2014) 0.92
Direct selection for ribozyme cleavage activity in cells. RNA (2009) 0.91
Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis. Mob DNA (2014) 0.91
Binding of herpes simplex virus-1 US11 to specific RNA sequences. Nucleic Acids Res (2005) 0.91
Deoxyribozymes that recode sequence information. Nucleic Acids Res (2006) 0.91
Generalized bacterial genome editing using mobile group II introns and Cre-lox. Mol Syst Biol (2013) 0.90
In vitro selection of ribozymes dependent on peptides for activity. RNA (2004) 0.90
In vitro selection of molecular beacons. Nucleic Acids Res (2003) 0.90
ATP-dependent allosteric DNA enzymes. Chem Biol (2002) 0.89
Aptamers: prospects in therapeutics and biomedicine. Front Biosci (2005) 0.89
Using aptamers to identify and enter cells. Curr Opin Mol Ther (2007) 0.88
In vitro selection of proteins via emulsion compartments. Methods (2012) 0.88
Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. Nucleic Acid Ther (2012) 0.87
Selective uptake and imaging of aptamer- and antibody-conjugated hollow nanospheres targeted to epidermal growth factor receptors overexpressed in head and neck cancer. ACS Nano (2014) 0.87