Published in J Immunol on January 15, 2002
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97
Expression and function of epithelial anoctamins. J Biol Chem (2010) 1.95
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Changes in ion transport in inflammatory disease. J Inflamm (Lond) (2006) 1.39
Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus. Am J Respir Crit Care Med (2005) 1.16
Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes. J Physiol (2013) 1.09
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia. J Physiol (2012) 1.09
Ion channels in inflammation. Pflugers Arch (2011) 1.08
Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cells. Am J Physiol Regul Integr Comp Physiol (2010) 1.00
Tgf-β1 inhibits Cftr biogenesis and prevents functional rescue of ΔF508-Cftr in primary differentiated human bronchial epithelial cells. PLoS One (2013) 0.90
IL-12 can target human lung adenocarcinoma cells and normal bronchial epithelial cells surrounding tumor lesions. PLoS One (2009) 0.89
Cellular functions of TMEM16/anoctamin. Pflugers Arch (2016) 0.89
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases. Mediators Inflamm (2015) 0.87
Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6). FASEB J (2014) 0.85
Activation of Ca(2+) -activated Cl(-) channel ANO1 by localized Ca(2+) signals. J Physiol (2014) 0.84
Role of epithelial sodium channels in the regulation of lung fluid homeostasis. Am J Physiol Lung Cell Mol Physiol (2015) 0.83
Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol (2005) 0.81
Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance in the human airway epithelium. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.78
New pulmonary therapies directed at targets other than CFTR. Cold Spring Harb Perspect Med (2013) 0.78
Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release. Sci Rep (2016) 0.78
Nasal potential difference to detect Na+ channel dysfunction in acute lung injury. Am J Physiol Lung Cell Mol Physiol (2010) 0.77
Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis and Other Diseases of Mucus Clearance. Clin Chest Med (2015) 0.76
The Contribution of the Airway Epithelial Cell to Host Defense. Mediators Inflamm (2015) 0.75
Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators Inflamm (2016) 0.75
Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin. PLoS One (2015) 0.75
Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line. Front Immunol (2017) 0.75
Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines. Front Immunol (2017) 0.75
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest (2002) 4.97
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. J Clin Invest (2005) 4.19
In silico prediction of the deleterious effect of a mutation: proceed with caution in clinical genetics. Clin Chem (2004) 3.43
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature (2011) 2.59
Review and update of mutations causing Waardenburg syndrome. Hum Mutat (2010) 2.59
Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem (2003) 2.25
Regulation of TMEM16A chloride channel properties by alternative splicing. J Biol Chem (2009) 2.16
Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities. Am J Hum Genet (2009) 2.07
MYH9-related disease: May-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness. Medicine (Baltimore) (2003) 2.05
High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem (2002) 1.89
Poland syndrome with bilateral features: case description with review of the literature. Am J Med Genet A (2009) 1.82
Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol (2005) 1.80
Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1. J Cell Sci (2011) 1.64
ZFHX1B mutations in patients with Mowat-Wilson syndrome. Hum Mutat (2007) 1.55
Deletions at the SOX10 gene locus cause Waardenburg syndrome types 2 and 4. Am J Hum Genet (2007) 1.54
Polymorphisms in the osteopontin promoter affect its transcriptional activity. Physiol Genomics (2004) 1.54
Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet (2008) 1.46
Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways. Am J Respir Crit Care Med (2005) 1.45
Pyruvate kinase deficiency in France: a 3-year study reveals 27 new mutations. Br J Haematol (2006) 1.44
Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis. Biochem J (2008) 1.44
Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology (2007) 1.42
Severe hemolytic anemia in a Vietnamese family, associated with novel mutations in the gene encoding for pyruvate kinase. Haematologica (2005) 1.41
Genetics, clinical and pathological features of glomerulonephritis associated with mutations of nonmuscle myosin IIA (Fechtner syndrome). Am J Kidney Dis (2003) 1.36
Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels. J Immunol (2007) 1.35
Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett (2004) 1.35
Mutational analysis of the ACVR1 gene in Italian patients affected with fibrodysplasia ossificans progressiva: confirmations and advancements. Eur J Hum Genet (2008) 1.34
Partial C antigen in sickle cell disease patients: clinical relevance and prevention of alloimmunization. Transfusion (2009) 1.29
Clinical evaluation of a reverse hybridization assay for the molecular detection of twelve MEFV gene mutations. Clin Chem (2003) 1.27
Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: relevance for MYH9-related disease. Int J Mol Med (2006) 1.26
Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. Dev Biol (2006) 1.22
Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). Ann Rheum Dis (2012) 1.19
BCOR analysis in patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac laterality defects. Eur J Hum Genet (2009) 1.15
Betaine, dimethyl sulfoxide, and 7-deaza-dGTP, a powerful mixture for amplification of GC-rich DNA sequences. J Mol Diagn (2006) 1.15
Epstein syndrome: another renal disorder with mutations in the nonmuscle myosin heavy chain 9 gene. Hum Genet (2001) 1.15
Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway. Lab Invest (2012) 1.15
Overexpression of the C-type natriuretic peptide (CNP) is associated with overgrowth and bone anomalies in an individual with balanced t(2;7) translocation. Hum Mutat (2007) 1.14
Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness. Am J Hum Genet (2013) 1.14
Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications. Arthritis Rheum (2006) 1.13
Interaction of adenovirus type 5 fiber with the coxsackievirus and adenovirus receptor activates inflammatory response in human respiratory cells. J Virol (2006) 1.09
Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides. Chem Biol (2008) 1.09
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia. J Physiol (2012) 1.09
A minimal isoform of the TMEM16A protein associated with chloride channel activity. Biochim Biophys Acta (2011) 1.08
Familial vesicoureteral reflux: testing replication of linkage in seven new multigenerational kindreds. J Am Soc Nephrol (2005) 1.08
Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells. J Immunol (2011) 1.08
Estimation of the difference in HbF expression due to loss of the 5' δ-globin BCL11A binding region. Haematologica (2012) 1.06
Molecular characterization of a t(2;6) balanced translocation that is associated with a complex phenotype and leads to truncation of the TCBA1 gene. Hum Mutat (2005) 1.06
Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07. Br J Pharmacol (2002) 1.05
Anti-inflammatory effects of azithromycin in cystic fibrosis airway epithelial cells. Biochem Biophys Res Commun (2006) 1.05
SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism. Hum Genet (2002) 1.04
A recessive gene for primary vesicoureteral reflux maps to chromosome 12p11-q13. J Am Soc Nephrol (2009) 1.04
Sumoylation of the SOX10 transcription factor regulates its transcriptional activity. FEBS Lett (2006) 1.03
Oxidative stress and antioxidant therapy in cystic fibrosis. Biochim Biophys Acta (2011) 1.03
Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum. Hum Mutat (2011) 1.03
CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol (2003) 1.03
Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2. PLoS One (2012) 1.03
Proteomic analysis of the airway surface liquid: modulation by proinflammatory cytokines. Am J Physiol Lung Cell Mol Physiol (2007) 1.00
Cystic fibrosis carrier frequency and estimated prevalence of the disease in Morocco. J Cyst Fibros (2008) 1.00
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia. Cancer Genet Cytogenet (2008) 0.99
Connexin 32 promoter P2 mutations: a mechanism of peripheral nerve dysfunction. Ann Neurol (2004) 0.99
A common haplotype at the 5' end of the RET proto-oncogene, overrepresented in Hirschsprung patients, is associated with reduced gene expression. Hum Mutat (2005) 0.98
COMMD1-mediated ubiquitination regulates CFTR trafficking. PLoS One (2011) 0.98
Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling. Am J Physiol Cell Physiol (2011) 0.98
Previously undescribed nonsense mutation in SHH caused autosomal dominant holoprosencephaly with wide intrafamilial variability. Am J Med Genet A (2003) 0.97
A quantitative description of the activation and inhibition of CFTR by potentiators: Genistein. FEBS Lett (2005) 0.97
Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations. J Biol Chem (2011) 0.97
Clara cell 16 protein in COPD sputum: a marker of small airways damage? Respir Med (2007) 0.97
TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels. Biochem J (2013) 0.97
TCF4 deletions in Pitt-Hopkins Syndrome. Hum Mutat (2008) 0.96
Cell-specific posttranscriptional regulation of CFTR gene expression via influence of MAPK cascades on 3'UTR part of transcripts. Am J Physiol Cell Physiol (2005) 0.96
Myotubularin-related 2 protein phosphatase and neurofilament light chain protein, both mutated in CMT neuropathies, interact in peripheral nerve. Hum Mol Genet (2003) 0.96
Association of alleles at polymorphic sites in the Osteopontin encoding gene in young type 1 diabetic patients. Clin Immunol (2009) 0.95
Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations. Mol Pharmacol (2005) 0.95
MVK mutations and associated clinical features in Italian patients affected with autoinflammatory disorders and recurrent fever. Eur J Hum Genet (2005) 0.95
Identification and functional analysis of SOX10 missense mutations in different subtypes of Waardenburg syndrome. Hum Mutat (2011) 0.95