Published in Am J Pathol on January 01, 2002
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res (2010) 3.89
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med (2011) 2.21
Structure and function of the skeletal muscle extracellular matrix. Muscle Nerve (2011) 2.00
Syndecans in tumor cell adhesion and signaling. Reprod Biol Endocrinol (2004) 1.88
Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma. PLoS One (2014) 1.42
Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. Am J Pathol (2006) 1.21
Clonogenic growth of human breast cancer cells co-cultured in direct contact with serum-activated fibroblasts. Breast Cancer Res (2005) 1.05
Gene set internal coherence in the context of functional profiling. BMC Genomics (2009) 1.04
Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma. J Histochem Cytochem (2011) 1.00
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta (2015) 0.92
Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans. J Histochem Cytochem (2012) 0.89
Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity. J Cell Biochem (2014) 0.82
Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication. Dis Markers (2015) 0.80
The motile breast cancer phenotype roles of proteoglycans/glycosaminoglycans. Biomed Res Int (2014) 0.80
Heparan sulfate and heparanase as modulators of breast cancer progression. Biomed Res Int (2013) 0.79
Roles of glycosaminoglycans and glycanmimetics in tumor progression and metastasis. Glycoconj J (2014) 0.79
Heparanase and hepatocellular carcinoma: promoter or inhibitor? World J Gastroenterol (2010) 0.78
Proteoglycans: master modulators of paracrine fibroblast-carcinoma cell interactions. Semin Cell Dev Biol (2009) 0.78
A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer. Sci Rep (2016) 0.77
Structural and functional changes in heparan sulfate proteoglycan expression associated with the myofibroblastic phenotype. Am J Pathol (2003) 0.77
Acquisition of anoikis resistance up-regulates syndecan-4 expression in endothelial cells. PLoS One (2014) 0.76
Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours. Biomed Res Int (2013) 0.76
Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix. Open Biol (2016) 0.76
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell (1991) 8.99
Receptor specificity of the fibroblast growth factor family. J Biol Chem (1996) 7.58
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell (2000) 5.72
Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science (1991) 5.64
Regulated diversity of heparan sulfate. J Biol Chem (1998) 3.93
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature (2000) 3.90
Specificities of heparan sulphate proteoglycans in developmental processes. Nature (2000) 3.46
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol Cell Biol (1992) 3.41
Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J Clin Invest (2001) 2.78
Developmental changes in heparan sulfate expression: in situ detection with mAbs. J Cell Biol (1992) 2.61
Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell (1994) 2.23
Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4. J Biol Chem (1993) 2.23
The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J Clin Invest (1998) 2.22
Control of morphology, cytoskeleton and migration by syndecan-4. J Cell Sci (1999) 2.17
Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity. J Biol Chem (1998) 1.97
Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney. J Biol Chem (1998) 1.97
Fibroblast growth factors as multifunctional signaling factors. Int Rev Cytol (1999) 1.88
Sequencing complex polysaccharides. Science (1999) 1.85
An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science (1993) 1.81
Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med (1998) 1.76
Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan. Science (1993) 1.67
Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol (1984) 1.64
Signal transduction by fibroblast growth factor receptors. Front Biosci (1999) 1.61
Examination of the substrate specificity of heparin and heparan sulfate lyases. Biochemistry (1990) 1.60
Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells. Cancer Res (2001) 1.55
FGF signals for cell proliferation and migration through different pathways. Cytokine Growth Factor Rev (2000) 1.39
Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican. J Cell Biol (1996) 1.35
Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer. Proc Natl Acad Sci U S A (1988) 1.28
A strategy for rapid sequencing of heparan sulfate and heparin saccharides. Proc Natl Acad Sci U S A (1999) 1.27
Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ. FASEB J (2000) 1.26
Syndecan-1 expression is induced in the stroma of infiltrating breast carcinoma. Am J Clin Pathol (1999) 1.15
MDA-MB-134 breast carcinoma cells overexpress fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands. Cancer Res (1994) 1.14
Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro. J Biol Chem (1998) 1.14
The role of syndecan cytoplasmic domain in basic fibroblast growth factor-dependent signal transduction. J Biol Chem (1999) 1.13
Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated? J Clin Invest (1997) 1.10
Interaction of heparan sulfate from mammary cells with acidic fibroblast growth factor (FGF) and basic FGF. Regulation of the activity of basic FGF by high and low affinity binding sites in heparan sulfate. J Biol Chem (1998) 1.10
Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues. Am J Pathol (1997) 1.05
Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts. J Biol Chem (1998) 1.02
The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates. J Biol Chem (2000) 0.99
Two hierarchies of FGF-2 signaling in heparin: mitogenic stimulation and high-affinity binding/receptor transphosphorylation. Biochemistry (1996) 0.91
Activation of an enhancer on the syndecan-1 gene is restricted to fibroblast growth factor family members in mesenchymal cells. Mol Cell Biol (1997) 0.87
Fibroblast growth factor-2 has opposite effects on human breast cancer MCF-7 cell growth depending on the activation level of the mitogen-activated protein kinase pathway. Eur J Biochem (1998) 0.83
Tissue-specific binding by FGF and FGF receptors to endogenous heparan sulfates. Methods Mol Biol (2001) 0.82
Basic fibroblast growth factor (bFGF): mitogenic activity and binding sites in human breast cancer. J Steroid Biochem Mol Biol (1992) 0.82
Extracellular matrix-dependent activation of syndecan-1 expression in keratinocyte growth factor-treated keratinocytes. J Biol Chem (1999) 0.79
Differential regulation of FGF-1 and -2 mitogenic activity is related to their kinetics of binding to heparan sulfate in MDA-MB-231 human breast cancer cells. Biochem Biophys Res Commun (2000) 0.78
Differential responsiveness of human breast cancer cells to basic fibroblast growth factor: a cell kinetics study. Oncol Res (1995) 0.77
Heparan sulphate in breast cancer cells. Biochem Soc Trans (1996) 0.77
The role of fibroblast growth factors and related oncogenes in tumor growth. Cancer Treat Res (1992) 0.77
Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol (2011) 3.70
Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study. Am J Transplant (2003) 2.83
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat Genet (2012) 2.74
Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat (2007) 1.85
HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Cancer Res (2006) 1.71
A colorful future of quantitative pathology: validation of Vectra technology using chromogenic multiplexed immunohistochemistry and prostate tissue microarrays. Hum Pathol (2012) 1.42
Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integr Biol (Camb) (2010) 1.41
Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials (2009) 1.37
Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. J Biol Chem (2007) 1.35
Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol (2003) 1.33
Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clin Cancer Res (2005) 1.23
Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. Am J Pathol (2006) 1.21
Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res (2004) 1.18
The transcription factor REST is lost in aggressive breast cancer. PLoS Genet (2010) 1.17
Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype. Breast Cancer Res Treat (2006) 1.14
3D microchannel co-culture: method and biological validation. Integr Biol (Camb) (2010) 1.13
Syndecan-1 in breast cancer stroma fibroblasts regulates extracellular matrix fiber organization and carcinoma cell motility. Am J Pathol (2010) 1.13
Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models. PLoS One (2013) 1.04
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis. Cancer Res (2009) 1.04
Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis. J Biol Chem (2003) 1.02
Lack of association between EBV and breast carcinoma. Cancer Epidemiol Biomarkers Prev (2005) 1.02
Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. Cancer Res (2008) 1.00
Alterations in the p16/pRb cell cycle checkpoint occur commonly in primary and metastatic human prostate cancer. Cancer Lett (2002) 0.99
Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells. Matrix Biol (2003) 0.95
Retracted Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells. J Biol Chem (2011) 0.93
Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction. Transplantation (2004) 0.92
Regulation of fibroblast growth factor-2 activity by human ovarian cancer tumor endothelium. Clin Cancer Res (2005) 0.92
Colorectal cancer desmoplastic reaction up-regulates collagen synthesis and restricts cancer cell invasion. Cell Tissue Res (2011) 0.91
Functional screen of paracrine signals in breast carcinoma fibroblasts. PLoS One (2012) 0.91
Karyomegalic tubulointerstitial nephritis--a case report. Pathol Res Pract (2006) 0.89
Effects of a monoclonal anti-alphavbeta3 integrin antibody on blood vessels - a pharmacodynamic study. Invest New Drugs (2006) 0.89
Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells. Mol Biol Cell (2008) 0.87
Oncocytoma can be differentiated from its renal cell carcinoma mimics by a panel of markers: an automated tissue microarray study. Appl Immunohistochem Mol Morphol (2009) 0.87
STAT5 and prolactin participate in a positive autocrine feedback loop that promotes angiogenesis. J Biol Chem (2013) 0.87
Colonic adenocarcinoma in a 13-year-old with cystic fibrosis. J Pediatr Surg (2007) 0.86
p16 Is upregulated in proliferative inflammatory atrophy of the prostate. Prostate (2005) 0.81
Retracted Glypican 1 stimulates S phase entry and DNA replication in human glioma cells and normal astrocytes. Mol Cell Biol (2013) 0.81
A positive feedback loop between prolactin and STAT5 promotes angiogenesis. Adv Exp Med Biol (2015) 0.79
Normal mammary fibroblasts induce reversion of the malignant phenotype in human primary breast cancer. Anticancer Res (2013) 0.79
Angiogenesis induced by signal transducer and activator of transcription 5A (STAT5A) is dependent on autocrine activity of proliferin. J Biol Chem (2011) 0.77
Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors. Cancer Res (2012) 0.77
Heparan sulphate proteoglycan in scleromyxedema promotes FGF-2 activity. Pathol Res Pract (2002) 0.76
Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals. Cancer Lett (2012) 0.76
Epithelial cell polarity and improved early outcomes in delayed graft function: a pilot study of polyclonal vs monoclonal antibodies. Nephrol Dial Transplant (2004) 0.75
Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells. J Biol Chem (2016) 0.75