Published in PLoS One on October 04, 2013
Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure. BMC Cancer (2015) 0.96
Tissue-engineered models of human tumors for cancer research. Expert Opin Drug Discov (2015) 0.95
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment. Nat Rev Cancer (2015) 0.88
In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer. Adv Drug Deliv Rev (2013) 0.85
Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration. BMC Cancer (2015) 0.84
Microfluidic 3D models of cancer. Adv Drug Deliv Rev (2014) 0.84
Streamlining gene expression analysis: integration of co-culture and mRNA purification. Integr Biol (Camb) (2014) 0.81
Evaluation of MCF10A as a Reliable Model for Normal Human Mammary Epithelial Cells. PLoS One (2015) 0.81
The importance of being a lumen. FASEB J (2014) 0.78
Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment. Sci Rep (2016) 0.77
Quantification of breast cancer cell invasiveness using a three-dimensional (3D) model. J Vis Exp (2014) 0.77
Microfluidic models for adoptive cell-mediated cancer immunotherapies. Drug Discov Today (2016) 0.76
A synthetic modular approach for modeling the role of the 3D microenvironment in tumor progression. Sci Rep (2015) 0.76
Microscale 3D collagen cell culture assays in conventional flat-bottom 384-well plates. J Lab Autom (2014) 0.76
Microphysiological Human Brain and Neural Systems-on-a-Chip: Potential Alternatives to Small Animal Models and Emerging Platforms for Drug Discovery and Personalized Medicine. Stem Cell Rev (2017) 0.75
Evaluation of methods for pore generation and their influence on physio-chemical properties of a protein based hydrogel. Biotechnol Rep (Amst) (2016) 0.75
Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments. Biomed Microdevices (2016) 0.75
Pathomimetic cancer avatars for live-cell imaging of protease activity. Biochimie (2015) 0.75
LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels. Adv Healthc Mater (2015) 0.75
A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening. Sci Adv (2017) 0.75
Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
Taking cell-matrix adhesions to the third dimension. Science (2001) 15.21
Putting tumours in context. Nat Rev Cancer (2001) 12.37
Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol (2006) 8.81
Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96
Ductal carcinoma in situ of the breast. N Engl J Med (2004) 6.63
Collagen density promotes mammary tumor initiation and progression. BMC Med (2008) 5.13
Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol (2003) 4.55
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
Cell interactions with three-dimensional matrices. Curr Opin Cell Biol (2002) 4.34
Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science (2006) 4.12
A passive pumping method for microfluidic devices. Lab Chip (2002) 3.87
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med (2009) 3.86
Controlled microfluidic interfaces. Nature (2005) 3.60
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res (2001) 3.48
MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ. J Natl Cancer Inst (2000) 3.44
Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs. Proc Natl Acad Sci U S A (2008) 3.17
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03
Cancer-associated fibroblasts and tumor growth--bystanders turning into key players. Curr Opin Genet Dev (2009) 2.85
Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. Proc Natl Acad Sci U S A (2000) 2.83
Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab Chip (2008) 2.70
MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol (1996) 2.62
Three-dimensional context regulation of metastasis. Clin Exp Metastasis (2008) 2.49
Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Proc Natl Acad Sci U S A (2009) 2.07
Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res (1997) 2.06
Fundamentals of microfluidic cell culture in controlled microenvironments. Chem Soc Rev (2010) 2.04
Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. Proc Natl Acad Sci U S A (2009) 1.81
Engineering microscale cellular niches for three-dimensional multicellular co-cultures. Lab Chip (2009) 1.77
How to make tubes: signaling by the Met receptor tyrosine kinase. Trends Cell Biol (2003) 1.77
Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models. Proc Natl Acad Sci U S A (2001) 1.58
Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments. Biomaterials (2008) 1.56
Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ. Breast Cancer Res Treat (2009) 1.55
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts. Int J Cancer (2007) 1.50
Signaling by integrin receptors. Oncogene (1998) 1.48
Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ. Cancer Res (2009) 1.41
Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integr Biol (Camb) (2010) 1.41
Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma. Opt Express (2008) 1.40
Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proc Natl Acad Sci U S A (2010) 1.37
Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials (2009) 1.37
Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. J Biol Chem (2007) 1.35
Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival. PLoS One (2010) 1.35
Cellular observations enabled by microculture: paracrine signaling and population demographics. Integr Biol (Camb) (2009) 1.33
Host microenvironment in breast cancer development: epithelial-cell-stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland. Breast Cancer Res (2003) 1.32
Three-dimensional microenvironments modulate fibroblast signaling responses. Adv Drug Deliv Rev (2007) 1.27
Managing evaporation for more robust microscale assays. Part 2. Characterization of convection and diffusion for cell biology. Lab Chip (2008) 1.24
Automated high-throughput microchannel assays for cell biology: Operational optimization and characterization. JALA Charlottesv Va (2010) 1.18
The role of hepatocyte growth factor (scatter factor) in epithelial-mesenchymal transition and breast cancer. Can J Physiol Pharmacol (2002) 1.17
Second-harmonic generation in collagen as a potential cancer diagnostic parameter. J Biomed Opt (2008) 1.08
Decreased TGFbeta signaling and increased COX2 expression in high risk women with increased mammographic breast density. Breast Cancer Res Treat (2009) 1.04
Fibroblast mechanics in three-dimensional collagen matrices. J Bodyw Mov Ther (2008) 1.00
HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop. BMC Cancer (2011) 1.00
Matrix metalloproteinase-1 produced by human CXCL12-stimulated natural killer cells. Am J Pathol (2006) 0.96
Automation of three-dimensional cell culture in arrayed microfluidic devices. J Lab Autom (2011) 0.95
MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis. Front Pharmacol (2011) 0.94
Extracting diagnostic stromal organization features based on intrinsic two-photon excited fluorescence and second-harmonic generation signals. J Biomed Opt (2009) 0.92
Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells. Integr Biol (Camb) (2013) 0.92
Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma. Mol Cancer Ther (2009) 0.91
Cyclooxygenase-2 expression during immortalization and breast cancer progression. Cancer Res (2008) 0.88
Gain in cellular organization of inflammatory breast cancer: A 3D in vitro model that mimics the in vivo metastasis. BMC Cancer (2009) 0.86
3D trumps 2D when studying endothelial cells. Blood (2010) 0.77
A passive pumping method for microfluidic devices. Lab Chip (2002) 3.87
Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol (2011) 3.70
Controlled microfluidic interfaces. Nature (2005) 3.60
Adaptive liquid microlenses activated by stimuli-responsive hydrogels. Nature (2006) 2.91
PDMS absorption of small molecules and consequences in microfluidic applications. Lab Chip (2006) 2.86
Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study. Am J Transplant (2003) 2.83
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat Genet (2012) 2.74
Biological implications of polydimethylsiloxane-based microfluidic cell culture. Lab Chip (2009) 2.59
Flow rate analysis of a surface tension driven passive micropump. Lab Chip (2007) 2.37
Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays. Bioessays (2008) 2.36
Microenvironment design considerations for cellular scale studies. Lab Chip (2004) 2.34
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol (2014) 2.14
Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab Chip (2006) 2.11
Fundamentals of microfluidic cell culture in controlled microenvironments. Chem Soc Rev (2010) 2.04
Automated cell culture in high density tubeless microfluidic device arrays. Lab Chip (2008) 1.90
One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST). Lab Chip (2011) 1.86
Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat (2007) 1.85
Cell culture models in microfluidic systems. Annu Rev Anal Chem (Palo Alto Calif) (2008) 1.83
HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Cancer Res (2006) 1.71
A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab Chip (2008) 1.58
Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis. J Biol Chem (2006) 1.51
Managing evaporation for more robust microscale assays. Part 1. Volume loss in high throughput assays. Lab Chip (2008) 1.44
An evaporation-based microfluidic sample concentration method. Lab Chip (2002) 1.43
Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integr Biol (Camb) (2010) 1.41
High-throughput microfluidics: improved sample treatment and washing over standard wells. Lab Chip (2007) 1.40
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays. Anal Chem (2011) 1.39
From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures. Integr Biol (Camb) (2009) 1.38
Flow control with hydrogels. Adv Drug Deliv Rev (2004) 1.37
Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials (2009) 1.37
Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. J Biol Chem (2007) 1.35
Cellular observations enabled by microculture: paracrine signaling and population demographics. Integr Biol (Camb) (2009) 1.33
Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol (2003) 1.33
Understanding microchannel culture: parameters involved in soluble factor signaling. Lab Chip (2007) 1.31
Managing evaporation for more robust microscale assays. Part 2. Characterization of convection and diffusion for cell biology. Lab Chip (2008) 1.24
Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clin Cancer Res (2005) 1.23
Diffusion dependent cell behavior in microenvironments. Lab Chip (2005) 1.22
Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. Am J Pathol (2006) 1.21
Embryonic development in the mouse is enhanced via microchannel culture. Lab Chip (2004) 1.19
Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res (2004) 1.18
Automated high-throughput microchannel assays for cell biology: Operational optimization and characterization. JALA Charlottesv Va (2010) 1.18
A plate reader-compatible microchannel array for cell biology assays. Lab Chip (2007) 1.17
The transcription factor REST is lost in aggressive breast cancer. PLoS Genet (2010) 1.17
Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels. Biomaterials (2012) 1.16
Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST). Biomed Microdevices (2011) 1.16
Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype. Breast Cancer Res Treat (2006) 1.14
Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J Biol Chem (2012) 1.14
Syndecan-1 in breast cancer stroma fibroblasts regulates extracellular matrix fiber organization and carcinoma cell motility. Am J Pathol (2010) 1.13
3D microchannel co-culture: method and biological validation. Integr Biol (Camb) (2010) 1.13
Protocol for the fabrication of enzymatically crosslinked gelatin microchannels for microfluidic cell culture. Nat Protoc (2007) 1.12
Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood (2012) 1.11
Microfluidic logic gates and timers. Lab Chip (2007) 1.10
Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms. Am J Physiol Heart Circ Physiol (2002) 1.10
Continuous fabrication of biocatalyst immobilized microparticles using photopolymerization and immiscible liquids in microfluidic systems. Langmuir (2005) 1.10
Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices. Lab Chip (2015) 1.07
A method for dynamic system characterization using hydraulic series resistance. Lab Chip (2006) 1.07
Circulating tumor cells: getting more from less. Sci Transl Med (2012) 1.07
The VerIFAST: an integrated method for cell isolation and extracellular/intracellular staining. Lab Chip (2013) 1.07
Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 receptor binding in breast carcinomas. Am J Pathol (2002) 1.05
An adaptable hydrogel array format for 3-dimensional cell culture and analysis. Biomaterials (2008) 1.05
Control and applications of immiscible liquids in microchannels. J Am Chem Soc (2002) 1.05
Streamlining immunoassays with immiscible filtrations assisted by surface tension. Anal Chem (2012) 1.04
Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system. Electrophoresis (2004) 1.04
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis. Cancer Res (2009) 1.04
Hydrodynamic microfabrication via"on the fly" photopolymerization of microscale fibers and tubes. Lab Chip (2004) 1.03
Spatiotemporal micropatterning of cells on arbitrary substrates. Anal Chem (2007) 1.03
Hax1 regulates neutrophil adhesion and motility through RhoA. J Cell Biol (2011) 1.02
Lack of association between EBV and breast carcinoma. Cancer Epidemiol Biomarkers Prev (2005) 1.02
Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis. J Biol Chem (2003) 1.02
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis (2002) 1.02
Selective nucleic acid removal via exclusion (SNARE): capturing mRNA and DNA from a single sample. Anal Chem (2013) 1.02
Automated operation of immiscible filtration assisted by surface tension (IFAST) arrays for streamlined analyte isolation. J Lab Autom (2012) 1.01
Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. Cancer Res (2008) 1.00
Alterations in the p16/pRb cell cycle checkpoint occur commonly in primary and metastatic human prostate cancer. Cancer Lett (2002) 0.99
Reduction of polyspermic penetration using biomimetic microfluidic technology during in vitro fertilization. Lab Chip (2005) 0.98
Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab Chip (2013) 0.98
Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends Biotechnol (2011) 0.97
Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth. Integr Biol (Camb) (2012) 0.97
Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels. J Biomol Screen (2010) 0.96
Microscale functional cytomics for studying hematologic cancers. Blood (2012) 0.95
Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells. Matrix Biol (2003) 0.95
Automation of three-dimensional cell culture in arrayed microfluidic devices. J Lab Autom (2011) 0.95
Facile and rapid DNA extraction and purification from food matrices using IFAST (immiscible filtration assisted by surface tension). Analyst (2012) 0.95
Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays. Biomed Microdevices (2009) 0.94
Expanding the available assays: adapting and validating In-Cell Westerns in microfluidic devices for cell-based assays. Assay Drug Dev Technol (2010) 0.94
A Cell Programmable Assay (CPA) chip. Lab Chip (2010) 0.94
Development of macroporous poly(ethylene glycol) hydrogel arrays within microfluidic channels. Biomacromolecules (2010) 0.93
Retracted Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells. J Biol Chem (2011) 0.93
Hydrogel-based reconfigurable components for microfluidic devices. Lab Chip (2006) 0.93
Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry. J Proteome Res (2013) 0.93