Published in Am J Pathol on December 23, 2010
Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol (2011) 3.70
Molecular functions of syndecan-1 in disease. Matrix Biol (2011) 1.47
Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers. Cell Adh Migr (2012) 1.41
Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. J Mammary Gland Biol Neoplasia (2011) 1.37
3D collagen alignment limits protrusions to enhance breast cancer cell persistence. Biophys J (2014) 1.19
The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis. Genes Cancer (2011) 1.14
Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends Biotechnol (2015) 0.99
An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity. Cell Adh Migr (2012) 0.99
Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types. Sci Rep (2015) 0.95
Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer. BMC Cancer (2013) 0.93
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta (2015) 0.92
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers. Oncotarget (2016) 0.92
Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression. Crit Rev Eukaryot Gene Expr (2013) 0.90
Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression. BMC Cancer (2015) 0.87
Novel genes and pathways modulated by syndecan-1: implications for the proliferation and cell-cycle regulation of malignant mesothelioma cells. PLoS One (2012) 0.85
Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β. Aging (Albany NY) (2016) 0.84
Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. PLoS One (2012) 0.82
Characterization of breast cancer interstitial fluids by TmT labeling, LTQ-Orbitrap Velos mass spectrometry, and pathway analysis. J Proteome Res (2012) 0.81
Human breast cancer histoid: an in vitro 3-dimensional co-culture model that mimics breast cancer tissue. J Histochem Cytochem (2011) 0.81
Stretching fibroblasts remodels fibronectin and alters cancer cell migration. Sci Rep (2015) 0.81
Synergistic modulation of cellular contractility by mixed extracellular matrices. Int J Cell Biol (2012) 0.79
The role of syndecan-1 in cellular signaling and its effects on heparan sulfate biosynthesis in mesenchymal tumors. Front Oncol (2013) 0.79
Capturing relevant extracellular matrices for investigating cell migration. F1000Res (2015) 0.78
Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration. Biomed Res Int (2015) 0.77
Molecular and clinical profiles of syndecan-1 in solid and hematological cancer for prognosis and precision medicine. Oncotarget (2015) 0.76
Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis. Aging (Albany NY) (2016) 0.75
Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation. Sci Rep (2016) 0.75
Syndecan-1 is a potential biomarker for triple-positive breast carcinomas in Asian women with correlation to survival. Singapore Med J (2014) 0.75
Syndecan-1-Induced ECM Fiber Alignment Requires Integrin αvβ3 and Syndecan-1 Ectodomain and Heparan Sulfate Chains. PLoS One (2016) 0.75
Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection. Oncotarget (2016) 0.75
IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules. Sci Rep (2017) 0.75
Tumor-induced remote ECM network orientation steers angiogenesis. Sci Rep (2016) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30
Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol (1999) 11.18
Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J (1979) 8.95
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature (1997) 8.52
Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol (2006) 6.64
Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med (2006) 6.44
Collagen density promotes mammary tumor initiation and progression. BMC Med (2008) 5.13
A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol (2005) 4.40
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res (2002) 3.94
Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol (1993) 3.74
Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol (2005) 3.62
Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J Cell Physiol (1992) 3.15
Cell migration at a glance. J Cell Sci (2005) 2.80
Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol Biol Cell (2002) 2.62
The ins and outs of fibronectin matrix assembly. J Cell Sci (2003) 2.58
Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proc Natl Acad Sci U S A (1999) 2.47
Beta 1 integrin-dependent and -independent polymerization of fibronectin. J Cell Biol (1996) 2.44
Syndecans: new kids on the signaling block. Circ Res (2005) 2.43
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell (1995) 2.36
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell (2008) 2.27
Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1. J Biol Chem (2002) 2.26
Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol (2005) 2.02
The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells. J Cell Biol (2004) 1.91
The E8 subfragment of laminin promotes locomotion of myoblasts over extracellular matrix. J Cell Biol (1989) 1.88
Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat (2007) 1.85
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med (2009) 1.83
Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies. J Cell Biol (1990) 1.75
Syndecan-4 modulates focal adhesion kinase phosphorylation. J Biol Chem (2002) 1.60
The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly. J Biol Chem (1993) 1.49
The compact conformation of fibronectin is determined by intramolecular ionic interactions. J Biol Chem (1999) 1.44
The syndecans, tuners of transmembrane signaling. FASEB J (1999) 1.40
Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts. J Cell Sci (2006) 1.39
Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins. Mol Biol Cell (1996) 1.37
Control of extracellular matrix assembly by syndecan-2 proteoglycan. J Cell Sci (2000) 1.37
Syndecan-1 expression by stromal fibroblasts promotes breast carcinoma growth in vivo and stimulates tumor angiogenesis. Oncogene (2006) 1.36
Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. J Biol Chem (2007) 1.35
Identification of a new biological function for the integrin alpha v beta 3: initiation of fibronectin matrix assembly. Cell Adhes Commun (1996) 1.34
Migration-stimulating factor: a genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumor-associated stromal cells. Cancer Res (2003) 1.32
The dynamic dialogue between cells and matrices: implications of fibronectin's elasticity. Proc Natl Acad Sci U S A (1999) 1.29
FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci (2003) 1.28
Three-dimensional microenvironments modulate fibroblast signaling responses. Adv Drug Deliv Rev (2007) 1.27
A novel RGD-independent fibronectin assembly pathway initiated by alpha4beta1 integrin binding to the alternatively spliced V region. J Cell Sci (2000) 1.25
Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences. J Biol Chem (2000) 1.23
Syndecan-1, a cell-surface proteoglycan, changes in size and abundance when keratinocytes stratify. J Invest Dermatol (1992) 1.22
Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res (2004) 1.18
Syndecan-1 expression is induced in the stroma of infiltrating breast carcinoma. Am J Clin Pathol (1999) 1.15
Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype. Breast Cancer Res Treat (2006) 1.14
Elimination of transformed cells by normal cells: a novel concept for the control of carcinogenesis. Histol Histopathol (1996) 1.10
The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain. Mol Biol Cell (2007) 1.06
Regulatory role for SRC and phosphatidylinositol 3-kinase in initiation of fibronectin matrix assembly. J Biol Chem (2002) 1.05
Cell migration analyses within fibroblast-derived 3-D matrices. Methods Mol Biol (2005) 1.05
Desmoplastic breast carcinoma as a source of human myofibroblasts. Am J Pathol (1984) 0.94
Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling. Braz J Med Biol Res (2006) 0.88
Fibrin-fibronectin compounds in human ovarian tumor ascites and their possible relation to the tumor stroma. Cancer Res (1988) 0.83
Study of fibronectin and mRNA in human laryngeal and ectocervical carcinomas by in situ hybridization and image analysis. Int J Cancer (1992) 0.78
Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol (2011) 3.70
Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study. Am J Transplant (2003) 2.83
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat Genet (2012) 2.74
Telomere length varies by DNA extraction method: implications for epidemiologic research. Cancer Epidemiol Biomarkers Prev (2013) 2.14
Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat (2007) 1.85
Engineers are from PDMS-land, Biologists are from Polystyrenia. Lab Chip (2012) 1.77
HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Cancer Res (2006) 1.71
PDMS bonding by means of a portable, low-cost corona system. Lab Chip (2006) 1.56
Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res (2010) 1.51
Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integr Biol (Camb) (2010) 1.41
Intrathoracic pressure regulation to treat intraoperative hypotension: A phase II pilot study. Eur J Anaesthesiol (2015) 1.39
Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials (2009) 1.37
Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. J Biol Chem (2007) 1.35
Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol (2003) 1.33
Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clin Cancer Res (2005) 1.23
An arrayed high-content chemotaxis assay for patient diagnosis. Integr Biol (Camb) (2010) 1.22
Aggressive surgical management of peritoneal carcinomatosis with low mortality in a high-volume tertiary cancer center. Ann Surg Oncol (2007) 1.21
Lower intraocular oxygen tension in diabetic patients: possible contribution to decreased incidence of nuclear sclerotic cataract. Am J Ophthalmol (2006) 1.21
Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. Am J Pathol (2006) 1.21
Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res (2004) 1.18
The transcription factor REST is lost in aggressive breast cancer. PLoS Genet (2010) 1.17
Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys. Magn Reson Imaging (2010) 1.17
Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype. Breast Cancer Res Treat (2006) 1.14
3D microchannel co-culture: method and biological validation. Integr Biol (Camb) (2010) 1.13
Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma. J Clin Oncol (2014) 1.09
Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 receptor binding in breast carcinomas. Am J Pathol (2002) 1.05
Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer. PLoS One (2013) 1.05
Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models. PLoS One (2013) 1.04
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis. Cancer Res (2009) 1.04
Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis. J Biol Chem (2003) 1.02
Lack of association between EBV and breast carcinoma. Cancer Epidemiol Biomarkers Prev (2005) 1.02
Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. Cancer Res (2008) 1.00
Reirradiation of large-volume recurrent glioma with pulsed reduced-dose-rate radiotherapy. Int J Radiat Oncol Biol Phys (2010) 1.00
Alterations in the p16/pRb cell cycle checkpoint occur commonly in primary and metastatic human prostate cancer. Cancer Lett (2002) 0.99
Comparing kidney perfusion using noncontrast arterial spin labeling MRI and microsphere methods in an interventional swine model. Invest Radiol (2011) 0.95
Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells. Matrix Biol (2003) 0.95
Microfluidic based platform for characterization of protein interactions in hydrogel nanoenvironments. Anal Chem (2007) 0.95
Retracted Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells. J Biol Chem (2011) 0.93
Regulation of fibroblast growth factor-2 activity by human ovarian cancer tumor endothelium. Clin Cancer Res (2005) 0.92
Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction. Transplantation (2004) 0.92
Colorectal cancer desmoplastic reaction up-regulates collagen synthesis and restricts cancer cell invasion. Cell Tissue Res (2011) 0.91
Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention. J Immunol (2012) 0.91
Functional screen of paracrine signals in breast carcinoma fibroblasts. PLoS One (2012) 0.91
Karyomegalic tubulointerstitial nephritis--a case report. Pathol Res Pract (2006) 0.89
Measurement and comparison of T1 relaxation times in native and transplanted kidney cortex and medulla. J Magn Reson Imaging (2011) 0.89
Effects of a monoclonal anti-alphavbeta3 integrin antibody on blood vessels - a pharmacodynamic study. Invest New Drugs (2006) 0.89
Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells. Mol Biol Cell (2008) 0.87
STAT5 and prolactin participate in a positive autocrine feedback loop that promotes angiogenesis. J Biol Chem (2013) 0.87
Helical tomotherapy setup variations in canine nasal tumor patients immobilized with a bite block. Vet Radiol Ultrasound (2012) 0.87
Survivors of endometrial cancer: who is at risk for sexual dysfunction? Gynecol Oncol (2011) 0.87
Colonic adenocarcinoma in a 13-year-old with cystic fibrosis. J Pediatr Surg (2007) 0.86
Reproducibility of renal perfusion MR imaging in native and transplanted kidneys using non-contrast arterial spin labeling. J Magn Reson Imaging (2011) 0.86
A microfluidic cell concentrator. Anal Chem (2010) 0.85
Increased Notch1 expression is associated with poor overall survival in patients with ovarian cancer. Int J Gynecol Cancer (2015) 0.83
A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells. Methods (2013) 0.83
The role of appendectomy for mucinous ovarian neoplasms. Am J Obstet Gynecol (2012) 0.82
Small-gauge vitrectomy does not protect against nuclear sclerotic cataract. Retina (2012) 0.81
p16 Is upregulated in proliferative inflammatory atrophy of the prostate. Prostate (2005) 0.81
Retracted Glypican 1 stimulates S phase entry and DNA replication in human glioma cells and normal astrocytes. Mol Cell Biol (2013) 0.81
Quantification of small cell numbers with a microchannel device. Biotechniques (2008) 0.80
Normal mammary fibroblasts induce reversion of the malignant phenotype in human primary breast cancer. Anticancer Res (2013) 0.79
A positive feedback loop between prolactin and STAT5 promotes angiogenesis. Adv Exp Med Biol (2015) 0.79
Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival. Cancer Immunol Immunother (2013) 0.79
A phase II study of oxaliplatin, 5-fluorouracil, leucovorin, and high-dose capecitabine in patients with metastatic colorectal cancer. Clin Colorectal Cancer (2010) 0.78
Diminished Utilization of in Vitro Fertilization Following Ovarian Transposition in Cervical Cancer Patients. J Reprod Med (2015) 0.77
Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes. Bioorg Med Chem Lett (2009) 0.77
Angiogenesis induced by signal transducer and activator of transcription 5A (STAT5A) is dependent on autocrine activity of proliferin. J Biol Chem (2011) 0.77
Vorinostat in combination with bortezomib in patients with advanced malignancies directly alters transcription of target genes. Cancer Chemother Pharmacol (2013) 0.77
Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors. Cancer Res (2012) 0.77
Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals. Cancer Lett (2012) 0.76
Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy. Int Immunopharmacol (2011) 0.76
A new diagnostic test for endometrial cancer?: Cytology analysis of sonohysterography distention media. Int J Gynecol Cancer (2013) 0.76
Heparan sulphate proteoglycan in scleromyxedema promotes FGF-2 activity. Pathol Res Pract (2002) 0.76
High speed droplet-based delivery system for passive pumping in microfluidic devices. J Vis Exp (2009) 0.75
Phase I study of sunitinib and erlotinib in advanced nonsquamous non-small cell lung cancer. J Thorac Oncol (2011) 0.75
Prevention of recurrent urinary tract infections by intravesical administration of heparin: a pilot study. Ther Adv Urol (2013) 0.75
Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells. J Biol Chem (2016) 0.75
Thrombocytosis is Predictive of Postoperative Pulmonary Embolism in Patients With Gynecologic Cancer. Int J Gynecol Cancer (2015) 0.75
Epithelial cell polarity and improved early outcomes in delayed graft function: a pilot study of polyclonal vs monoclonal antibodies. Nephrol Dial Transplant (2004) 0.75
The development of integrative biology: bridging the gap--a view from the Scientific Editors. [An interview with David Beebe and Mary Helen Barcellos-Hoff by Kathleen Too]. Integr Biol (Camb) (2009) 0.75
Integrating biology and technology. Integr Biol (Camb) (2009) 0.75
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting. J Med Chem (2020) 0.75
Introducing a new Method section for Integrative Biology. Integr Biol (Camb) (2009) 0.75