Published in Hepatology on January 01, 2002
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Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. Acta Pharmacol Sin (2010) 1.40
Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc Natl Acad Sci U S A (2004) 1.39
HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress. Future Virol (2011) 1.10
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Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer Lett (2008) 0.93
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. J Proteome Res (2010) 0.90
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Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma. Oncogene (2016) 0.78
Virus-Host Interactions and the ARTD/PARP Family of Enzymes. PLoS Pathog (2016) 0.78
A Non-Synonymous Single Nucleotide Polymorphism in the HJURP Gene Associated with Susceptibility to Hepatocellular Carcinoma among Chinese. PLoS One (2016) 0.78
Mechanism of Hepatitis B Virus Persistence in Hepatocytes and Its Carcinogenic Potential. Clin Infect Dis (2016) 0.77
Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. PLoS One (2013) 0.76
Reduced Expression of DNA Damage Repair Genes High Mobility Group Box1 and Poly(ADP-ribose) Polymerase1 in Inactive Carriers of Hepatitis B Virus Infection-A Possible Stage of Viral Integration. J Clin Exp Hepatol (2013) 0.75
Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis (2017) 0.75
Inverse Association of Plasma Level of Glutathione Peroxidase with Liver Fibrosis in Chronic Hepatitis B: Potential Role of Iron. Middle East J Dig Dis (2016) 0.75
Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis. Oncotarget (2016) 0.75
Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes. Am J Cancer Res (2016) 0.75
Extraction of protoporphyrin disodium and its inhibitory effects on HBV-DNA. World J Gastroenterol (2004) 0.75
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol (2008) 3.50
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol (2002) 3.24
Variant of hepatitis B virus with primary resistance to adefovir. N Engl J Med (2006) 2.42
Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism. Hepatology (2014) 2.39
Lethal recessive myelin toxicity of prion protein lacking its central domain. EMBO J (2007) 2.27
Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology (2006) 2.05
Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol (2008) 2.03
Hepatitis B virus rtI233V mutation and resistance to adefovir. N Engl J Med (2014) 1.99
Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis. Gut (2012) 1.86
Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown. Biotechniques (2006) 1.86
IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J Clin Invest (2012) 1.81
Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients. Gastroenterology (2007) 1.75
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length. Nucleic Acids Res (2007) 1.73
Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremia. Hepatology (2008) 1.68
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc Res (2008) 1.43
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res (2003) 1.32
FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. EMBO J (2007) 1.26
Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein. Nucleic Acids Res (2003) 1.26
Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver. Hepatology (2007) 1.21
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res (2003) 1.19
Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB. Mol Cancer Res (2010) 1.18
Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA. J Biol Chem (2004) 1.18
Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice. Gastroenterology (2011) 1.17
New hepatitis B virus of cranes that has an unexpected broad host range. J Virol (2003) 1.17
Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death. Aging Cell (2012) 1.15
Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy. Eur J Cell Biol (2008) 1.14
Poly(ADP-ribosyl)ation in mammalian ageing. Nucleic Acids Res (2007) 1.13
Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells. Int J Cancer (2003) 1.11
Poly(ADP-ribosyl)ation inhibitors: promising drug candidates for a wide variety of pathophysiologic conditions. Int J Cancer (2004) 1.10
New components of the spliced leader RNP required for nematode trans-splicing. Nature (2002) 1.09
Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes. J Hepatol (2005) 1.09
Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism. World J Gastroenterol (2007) 1.08
Tracking of human cells in mice. Histochem Cell Biol (2008) 1.06
Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Res (2008) 1.06
Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays. Hepatology (2004) 1.06
Identification of a structural motif crucial for infectivity of hepatitis B viruses. Proc Natl Acad Sci U S A (2006) 1.05
Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients. Hepatology (2002) 1.04
Seven-year efficacy and safety of treatment with tenofovir disoproxil fumarate for chronic hepatitis B virus infection. Dig Dis Sci (2014) 1.02
How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation. Int J Cancer (2010) 1.02
Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R. Hepatology (2003) 1.02
A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks. BMC Biotechnol (2009) 1.01
Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells. Aging Cell (2012) 1.00
Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents. FASEB J (2009) 1.00
Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor. Traffic (2006) 0.99
Itinerary of hepatitis B viruses: delineation of restriction points critical for infectious entry. J Virol (2004) 0.99
Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. J Biol Chem (2010) 0.99
Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia. Hum Mol Genet (2013) 0.98
Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma (2005) 0.97
Quantitative gene expression analysis reveals transition of fetal liver progenitor cells to mature hepatocytes after transplantation in uPA/RAG-2 mice. Am J Pathol (2003) 0.96
Up-regulation of cathepsin B and cathepsin L activities in scrapie-infected mouse Neuro2a cells. J Gen Virol (2003) 0.95
In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice. Hepatology (2010) 0.93
Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol (2008) 0.93
Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. J Biol Chem (2005) 0.93
The hepatitis B virus PRE contains a splicing regulatory element. Nucleic Acids Res (2006) 0.93
cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV. J Med Virol (2005) 0.93
Functional characterization of the interaction between human La and hepatitis B virus RNA. J Biol Chem (2004) 0.92
pH-independent entry and sequential endosomal sorting are major determinants of hepadnaviral infection in primary hepatocytes. Hepatology (2006) 0.91
The replication cycle of hepatitis B virus. J Hepatol (2009) 0.91
Morphological and functional analysis of rat hepatocyte spheroids generated on poly(L-lactic acid) polymer in a pulsatile flow bioreactor. Tissue Eng (2006) 0.90
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1. Mech Ageing Dev (2010) 0.90
Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins. Virology (2002) 0.90
Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation. Oxid Med Cell Longev (2012) 0.90
Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo. Nucleic Acids Res (2003) 0.90
High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. Biochemistry (2010) 0.90
Effect of zinc on cellular poly(ADP-ribosyl)ation capacity. Exp Gerontol (2007) 0.89
Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. Oncogene (2003) 0.89
Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III. Cancer Res (2003) 0.89
Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools. Eur J Pharmacol (2004) 0.88
SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res (2012) 0.88
Conserved transactivating and pro-apoptotic functions of hepadnaviral X protein in ortho- and avihepadnaviruses. Oncogene (2002) 0.88
The automated FADU-assay, a potential high-throughput in vitro method for early screening of DNA breakage. ALTEX (2011) 0.88
Sequential combination therapy leads to biochemical and histological improvement despite low ongoing intrahepatic hepatitis B virus replication. Antivir Ther (2008) 0.87
Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation. PLoS One (2012) 0.87
Selection of a secretion-incompetent mutant in the serum of a patient with severe hepatitis B. Gastroenterology (2003) 0.86
SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation. J Cell Sci (2009) 0.86
Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells. Nucleic Acids Res (2004) 0.86
Reduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: results of a case-control study. Int J Cancer (2002) 0.86
Regulation of p53 functions: let's meet at the nuclear bodies. Curr Opin Cell Biol (2003) 0.86
DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress. PLoS Genet (2012) 0.85
Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. Toxicology (2008) 0.85
PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies. Exp Cell Res (2006) 0.85
Antiviral activity of interferon-alpha against hepatitis B virus can be studied in non-hepatic cells and Is independent of MxA. J Biol Chem (2002) 0.85
Site-specific noncovalent interaction of the biopolymer poly(ADP-ribose) with the Werner syndrome protein regulates protein functions. ACS Chem Biol (2012) 0.85
Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics. ACS Chem Biol (2013) 0.85
Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span. Mech Ageing Dev (2010) 0.84
Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia. Histochem Cell Biol (2012) 0.84
Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells. Biochem Pharmacol (2010) 0.84
Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. FEBS J (2014) 0.84
Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress. Psychother Psychosom (2014) 0.84
Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles. Hepatology (2007) 0.84
Hit-and-run mechanism of HBV-mediated progression to hepatocellular carcinoma. Tumori (2005) 0.83
Aging of different avian cultured cells: lack of ROS-induced damage and quality control mechanisms. Mech Ageing Dev (2009) 0.83
SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection. PLoS Pathog (2013) 0.83
Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry. Mech Ageing Dev (2012) 0.83
Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53. Nucleic Acids Res (2006) 0.82