Published in Neuron on January 17, 2002
Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.83
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol (2004) 1.60
Recapture after exocytosis causes differential retention of protein in granules of bovine chromaffin cells. J Physiol (2004) 1.60
Novel aspects of the molecular mechanisms controlling insulin secretion. J Physiol (2008) 1.49
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp Brain Res (2009) 1.42
Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion. Mol Biol Cell (2008) 1.42
Dual-mode of insulin action controls GLUT4 vesicle exocytosis. J Cell Biol (2011) 1.39
Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium (2011) 1.29
Elementary properties of spontaneous fusion of peptidergic vesicles: fusion pore gating. J Physiol (2007) 1.20
MicroRNA-7a regulates pancreatic β cell function. J Clin Invest (2014) 1.18
Syntaxin clusters assemble reversibly at sites of secretory granules in live cells. Proc Natl Acad Sci U S A (2010) 1.17
Role of zinc in human islet amyloid polypeptide aggregation. J Am Chem Soc (2010) 1.11
Newcomer insulin secretory granules as a highly calcium-sensitive pool. Proc Natl Acad Sci U S A (2009) 1.08
Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR). Proc Natl Acad Sci U S A (2011) 1.08
Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. Diabetes (2010) 1.06
Identifying the targets of the amplifying pathway for insulin secretion in pancreatic beta-cells by kinetic modeling of granule exocytosis. Biophys J (2008) 1.03
Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis. Biophys J (2004) 1.02
Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane. Mol Biol Cell (2011) 1.00
Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents. J Physiol (2005) 0.97
Trafficking and fusion of neuropeptide Y-containing dense-core granules in astrocytes. J Neurosci (2008) 0.95
The mouth of a dense-core vesicle opens and closes in a concerted action regulated by calcium and amphiphysin. J Cell Biol (2008) 0.93
Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells. Pflugers Arch (2008) 0.92
Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events. J Cell Sci (2008) 0.91
Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal. Proc Natl Acad Sci U S A (2011) 0.90
Lumenal protein within secretory granules affects fusion pore expansion. Biophys J (2014) 0.90
Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. PLoS One (2013) 0.86
Differential modulation of L-type calcium channel subunits by oleate. Am J Physiol Endocrinol Metab (2008) 0.85
cAMP-mediated stabilization of fusion pores in cultured rat pituitary lactotrophs. J Neurosci (2013) 0.83
The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells. PLoS One (2009) 0.81
Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content. Interface Focus (2010) 0.81
Hypotonicity and peptide discharge from a single vesicle. Am J Physiol Cell Physiol (2008) 0.80
Hindered submicron mobility and long-term storage of presynaptic dense-core granules revealed by single-particle tracking. Dev Neurobiol (2012) 0.79
The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy. Islets (2010) 0.79
Intravesicular factors controlling exocytosis in chromaffin cells. Cell Mol Neurobiol (2010) 0.79
Synaptic neuropeptide release by dynamin-dependent partial release from circulating vesicles. Mol Biol Cell (2015) 0.78
L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression. Front Mol Neurosci (2013) 0.78
Fusion pores and their control of neurotransmitter and hormone release. J Gen Physiol (2017) 0.78
Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells. PLoS One (2014) 0.77
Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis. PLoS One (2015) 0.77
'Full fusion' is not ineluctable during vesicular exocytosis of neurotransmitters by endocrine cells. Proc Math Phys Eng Sci (2017) 0.75
Laplacian Dynamics with Synthesis and Degradation. Bull Math Biol (2015) 0.75
Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells. PLoS One (2014) 0.75
Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes. J Clin Invest (2017) 0.75
Retention of peptide hormones during partial secretion in pituitary somatotrophs and corticotrophs. Pflugers Arch (2004) 0.75
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Res (2005) 4.98
miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A (2009) 3.89
Diabetes mellitus and the β cell: the last ten years. Cell (2012) 3.31
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell (2009) 2.57
Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes (2008) 2.48
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab (2012) 2.46
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch (2002) 2.21
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology (2008) 2.09
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab (2012) 1.93
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science (2009) 1.90
The Cell Physiology of Biphasic Insulin Secretion. News Physiol Sci (2000) 1.83
Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.83
Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes (2005) 1.81
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol (2007) 1.77
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab (2006) 1.76
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes (2004) 1.73
Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. Basic Clin Pharmacol Toxicol (2004) 1.73
Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. J Clin Invest (2004) 1.69
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol (2003) 1.68
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells. Diabetes (2004) 1.66
Quantification of mRNA in single cells and modelling of RT-qPCR induced noise. BMC Mol Biol (2008) 1.63
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes (2012) 1.61
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol (2004) 1.60
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells. Diabetes (2002) 1.53
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J (2003) 1.51
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest (2008) 1.50
Novel aspects of the molecular mechanisms controlling insulin secretion. J Physiol (2008) 1.49
Selective nucleotide-release from dense-core granules in insulin-secreting cells. J Cell Sci (2005) 1.39
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev (2008) 1.38
CaV2.3 calcium channels control second-phase insulin release. J Clin Invest (2005) 1.35
Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol (2012) 1.35
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes (2010) 1.34
Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. J Physiol (2009) 1.34
K(ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol (2013) 1.33
Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. J Gen Physiol (2004) 1.31
Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science (2010) 1.31
The adult human brain harbors multipotent perivascular mesenchymal stem cells. PLoS One (2012) 1.30
Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metab (2009) 1.26
Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum. Hum Mol Genet (2009) 1.24
Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells. Cell Metab (2006) 1.24
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis. Hum Mol Genet (2005) 1.24
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. Eur J Endocrinol (2007) 1.23
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3. Cell Metab (2009) 1.22
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse. Proc Natl Acad Sci U S A (2007) 1.22
Type 2 diabetes mellitus: not quite exciting enough? Hum Mol Genet (2004) 1.21
Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. J Physiol (2004) 1.20
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proc Natl Acad Sci U S A (2003) 1.20
Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab (2013) 1.18
MicroRNA-7a regulates pancreatic β cell function. J Clin Invest (2014) 1.18
Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane. Diabetes (2007) 1.15
Dynamic magnetic fields remote-control apoptosis via nanoparticle rotation. ACS Nano (2014) 1.13
Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans. Philos Trans A Math Phys Eng Sci (2008) 1.13
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nat Cell Biol (2007) 1.12
Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol (2004) 1.12
The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets. J Pharmacol Exp Ther (2011) 1.11
Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells. J Gen Physiol (2007) 1.10
Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. Diabetes (2010) 1.09
Myosin 5a controls insulin granule recruitment during late-phase secretion. Traffic (2005) 1.08
Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes (2011) 1.08
An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans. Pharmacol Ther (2013) 1.08
Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. Curr Diab Rep (2010) 1.08
Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements. Methods (2004) 1.07
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease. Am J Physiol Renal Physiol (2009) 1.06
Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. Diabetes (2010) 1.06
Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors. Mol Endocrinol (2004) 1.06
Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. PLoS One (2011) 1.04
Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet. Neurosci Res (2002) 1.03
Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells. J Cell Sci (2005) 1.03
Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway. Hum Mol Genet (2011) 1.03
Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans. Diabetes (2013) 1.02
Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes (2006) 1.02
CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. Cell Metab (2008) 1.02
Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes (2004) 1.02
Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis. J Cell Sci (2006) 0.99
Exocytotic properties of human pancreatic beta-cells. Ann N Y Acad Sci (2009) 0.99
GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. J Physiol (2004) 0.99
Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. J Biol Chem (2002) 0.99
SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. PLoS One (2010) 0.99
Defective secretion of islet hormones in chromogranin-B deficient mice. PLoS One (2010) 0.99