Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 3699660)

Published in PLoS One on July 02, 2013

Authors

Li Xie1, Dan Zhu, Youhou Kang, Tao Liang, Yu He, Herbert Y Gaisano

Author Affiliations

1: Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Articles cited by this

Membrane fusion and exocytosis. Annu Rev Biochem (1999) 7.35

The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J (1996) 6.26

Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol (1997) 3.94

The exocyst is a Ral effector complex. Nat Cell Biol (2002) 3.33

Vesicle tethering complexes in membrane traffic. J Cell Sci (2002) 3.17

Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Dev Cell (2005) 2.75

Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron (1998) 2.70

Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules. Neuron (1996) 2.59

The exocyst defrocked, a framework of rods revealed. Nat Struct Mol Biol (2006) 2.52

Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes (2001) 2.51

Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. Neuron (2003) 2.45

The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat Cell Biol (2002) 2.40

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. J Cell Sci (2009) 2.39

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell (2011) 2.34

Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23

Protein complexes in transport vesicle targeting. Trends Cell Biol (2000) 2.15

Ordering the final events in yeast exocytosis. J Cell Biol (2000) 2.03

Exorcising the exocyst complex. Traffic (2012) 1.88

Subunit structure of the mammalian exocyst complex. Proc Natl Acad Sci U S A (1997) 1.87

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. EMBO J (2005) 1.75

Cell lines derived from pancreatic islets. Mol Cell Endocrinol (2004) 1.54

Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells. J Cell Biol (2005) 1.51

Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells. Neuron (2002) 1.51

Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. EMBO J (2003) 1.43

Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. J Clin Invest (1996) 1.35

CaV2.3 calcium channels control second-phase insulin release. J Clin Invest (2005) 1.35

Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes (2006) 1.22

Exocyst function is regulated by effector phosphorylation. Nat Cell Biol (2011) 1.08

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment. Endocrinology (2002) 1.07

Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. J Biol Chem (2005) 1.07

Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps. J Physiol (1996) 1.06

Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth. Cell Metab (2012) 1.03

RalA-exocyst interaction mediates GTP-dependent exocytosis. J Biol Chem (2004) 1.00

The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells. J Biol Chem (2008) 0.93

Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets. Diabetologia (2012) 0.91

RalA and RalB differentially regulate development of epithelial tight junctions. Mol Biol Cell (2011) 0.91

Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells. Diabetologia (2012) 0.91

Live pancreatic acinar imaging of exocytosis using syncollin-pHluorin. Am J Physiol Cell Physiol (2011) 0.90

Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells. Diabetes (2013) 0.88

The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells. PLoS One (2009) 0.81

Deploying insulin granule-granule fusion to rescue deficient insulin secretion in diabetes. Diabetologia (2012) 0.81

Stimulation of Ca(2+)-independent exocytosis in rat pituitary gonadotrophs by G-protein. J Physiol (2000) 0.80

RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding α2 δ-1 subunit. Traffic (2013) 0.80

Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. J Endocrinol (2005) 0.80

Articles by these authors

Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res (2013) 7.41

Graphene-like two-dimensional materials. Chem Rev (2013) 2.90

The impacts of climate change and human activities on biogeochemical cycles on the Qinghai-Tibetan Plateau. Glob Chang Biol (2013) 1.69

Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis. J Biol Chem (2004) 1.66

A DNAzyme that walks processively and autonomously along a one-dimensional track. Angew Chem Int Ed Engl (2005) 1.65

Conformational flexibility facilitates self-assembly of complex DNA nanostructures. Proc Natl Acad Sci U S A (2008) 1.60

On-demand semiconductor single-photon source with near-unity indistinguishability. Nat Nanotechnol (2013) 1.60

Retracted Effects of organic ligands on fractionation of rare earth elements (REEs) in hydroponic plants: an application to the determination of binding capacities by humic acid for modeling. Chemosphere (2006) 1.52

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. Diabetologia (2013) 1.51

S-1-based therapy versus S-1 monotherapy in advanced gastric cancer: a meta-analysis. Tumour Biol (2014) 1.48

Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med (2010) 1.44

Usefulness of lumen area parameters determined by intravascular ultrasound to predict functional significance of intermediate coronary artery stenosis. Chin Med J (Engl) (2013) 1.42

Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). J Biol Chem (2004) 1.41

Role of surgical ventricular restoration in the treatment of ischemic cardiomyopathy. Ann Thorac Surg (2013) 1.39

Black carbon emissions in China from 1949 to 2050. Environ Sci Technol (2012) 1.38

The contribution of the inferior parietal lobe to auditory spatial working memory. J Cogn Neurosci (2008) 1.38

Left versus right repetitive transcranial magnetic stimulation in treating major depression: a meta-analysis of randomised controlled trials. Psychiatry Res (2013) 1.27

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol Cell Biol (2005) 1.26

Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells. Mol Biol Cell (2007) 1.26

SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins. Endocr Rev (2007) 1.25

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Mol Biol Cell (2009) 1.24

VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. J Clin Invest (2008) 1.23

Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia. Cereb Cortex (2002) 1.23

Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes (2006) 1.22

Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking. J Biol Chem (2003) 1.19

Approaching the limit: can one DNA oligonucleotide assemble into large nanostructures? Angew Chem Int Ed Engl (2006) 1.17

Correlates of methadone client retention: a prospective cohort study in Guizhou province, China. Int J Drug Policy (2008) 1.16

The effect of temperature on the development of Angiostrongylus cantonensis (Chen 1935) in Pomacea canaliculata (Lamarck 1822). Parasitol Res (2006) 1.16

Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway. Hepatology (2012) 1.13

Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase C alpha phosphorylation of Munc18c. J Biol Chem (2007) 1.13

Downregulation of miR-21 modulates Ras expression to promote apoptosis and suppress invasion of Laryngeal squamous cell carcinoma. Eur J Cancer (2010) 1.13

In vivo skin optical clearing by glycerol solutions: mechanism. J Biophotonics (2010) 1.13

UCP2 regulates the glucagon response to fasting and starvation. Diabetes (2013) 1.13

Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. Mol Endocrinol (2002) 1.13

Glucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet beta-cells. Diabetes (2005) 1.12

Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology (2005) 1.12

Effect of aspirin and other non-steroidal anti-inflammatory drugs on prostate cancer incidence and mortality: a systematic review and meta-analysis. BMC Med (2014) 1.12

PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons. Neuron (2007) 1.10

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology (2008) 1.10

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes (2011) 1.09

Perceptual learning modulates sensory evoked response during vowel segregation. Brain Res Cogn Brain Res (2003) 1.09

Global atmospheric emissions of polycyclic aromatic hydrocarbons from 1960 to 2008 and future predictions. Environ Sci Technol (2013) 1.08

Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. J Biol Chem (2011) 1.07

Meta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children. Eur J Pediatr (2013) 1.07

Expression of wild soybean WRKY20 in Arabidopsis enhances drought tolerance and regulates ABA signalling. J Exp Bot (2013) 1.06

Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition. Endocrinology (2006) 1.05

Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A. J Biol Chem (2004) 1.05

Changes in auditory cortex parallel rapid perceptual learning. Cereb Cortex (2006) 1.05

Transgenic mouse overexpressing syntaxin-1A as a diabetes model. Diabetes (2005) 1.05

Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth. Cell Metab (2012) 1.03

Quantitative hepatitis B surface antigen titres in Chinese chronic hepatitis B patients over 4 years of entecavir treatment. Antivir Ther (2013) 1.02

Association between statin use and colorectal cancer risk: a meta-analysis of 42 studies. Cancer Causes Control (2013) 1.02

Ca2+-dependent activator protein for secretion 1 is critical for constitutive and regulated exocytosis but not for loading of transmitters into dense core vesicles. J Biol Chem (2007) 1.02

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem (2006) 1.01

Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis. Gastroenterology (2007) 1.00

Regulation of insulin exocytosis by Munc13-1. J Biol Chem (2003) 1.00

Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase. J Pharmacol Exp Ther (2004) 1.00

Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development (2013) 1.00

Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis. Traffic (2007) 0.99

Modulation of L-type Ca(2+) channels by distinct domains within SNAP-25. Diabetes (2002) 0.99

Effects of visual attentional load on low-level auditory scene analysis. Cogn Affect Behav Neurosci (2005) 0.98

Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells. Diabetes (2007) 0.98

Detecting one-hundred-year environmental changes in Western China using seven-year repeat photography. PLoS One (2011) 0.98

Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells. Endocrinology (2006) 0.98

Direct interaction of target SNAREs with the Kv2.1 channel. Modal regulation of channel activation and inactivation gating. J Biol Chem (2003) 0.98

Two-phase electrochemical lithiation in amorphous silicon. Nano Lett (2013) 0.98

H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2. J Biol Chem (2004) 0.97

Unperturbed islet α-cell function examined in mouse pancreas tissue slices. J Physiol (2010) 0.97

Identification of host-defense genes and development of microsatellite markers from ESTs of hard clam Meretrix meretrix. Mol Biol Rep (2010) 0.97

High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice. Am J Physiol Endocrinol Metab (2009) 0.96

[Risk factors associated with continued heroin use during methadone maintenance treatment in Guizhou province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2008) 0.96

Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel. J Biol Chem (2003) 0.96

Dynamin is functionally coupled to insulin granule exocytosis. J Biol Chem (2007) 0.96

Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis. J Gastrointest Surg (2011) 0.96

Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells. Am J Physiol Endocrinol Metab (2009) 0.96

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem (2009) 0.96

Laser modulated transmembrane convection: Implementation in cancer chemotherapy. J Control Release (2010) 0.95

Hearing two things at once: neurophysiological indices of speech segregation and identification. J Cogn Neurosci (2005) 0.95

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes (2012) 0.94

A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Mol Biol Cell (2007) 0.93

Inter-annual variations of methane emission from an open fen on the Qinghai-Tibetan Plateau: a three-year study. PLoS One (2013) 0.93

Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases. Int J Biochem Cell Biol (2006) 0.93

Intraocular pressure and its relationship to ocular and systemic factors in a healthy Chinese rural population: the Handan Eye Study. Ophthalmic Epidemiol (2012) 0.93

The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells. J Biol Chem (2008) 0.93

Enhancement of skin optical clearing efficacy using photo-irradiation. Lasers Surg Med (2010) 0.93