Published in PLoS Biol on June 01, 2007
Glutamate is a positive autocrine signal for glucagon release. Cell Metab (2008) 2.01
Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia (2010) 1.67
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metab (2010) 1.64
Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes (2008) 1.61
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet. J Physiol (2010) 1.55
Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance. Endocrinology (2014) 1.44
Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets. J Biol Chem (2010) 1.38
Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. J Physiol (2009) 1.34
K(ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol (2013) 1.33
Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium (2011) 1.29
Inhibitory effects of leptin on pancreatic alpha-cell function. Diabetes (2009) 1.20
Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab (2013) 1.18
ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation. Diabetes (2009) 1.16
UCP2 regulates the glucagon response to fasting and starvation. Diabetes (2013) 1.13
The metabolic actions of glucagon revisited. Nat Rev Endocrinol (2010) 1.12
Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells. Diabetes (2008) 1.11
Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. Diabetes (2010) 1.09
UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Proc Natl Acad Sci U S A (2008) 1.09
Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells. Diabetes (2013) 1.06
Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis. Compr Physiol (2012) 1.01
How ATP inhibits the open K(ATP) channel. J Gen Physiol (2008) 0.97
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem (2009) 0.96
Glucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell. Pflugers Arch (2011) 0.95
Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release. Diabetes (2014) 0.93
Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans. Diabetes Care (2009) 0.93
Glucagon secretion and signaling in the development of diabetes. Front Physiol (2012) 0.90
Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells. PLoS One (2012) 0.89
Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. J Physiol (2014) 0.87
Modeling the pancreatic α-cell: dual mechanisms of glucose suppression of glucagon secretion. Biophys J (2014) 0.85
ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion. Diabetologia (2014) 0.84
Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis. Trends Endocrinol Metab (2011) 0.84
Mathematical modelling of local calcium and regulated exocytosis during inhibition and stimulation of glucagon secretion from pancreatic alpha-cells. J Physiol (2015) 0.82
A computational systems analysis of factors regulating α cell glucagon secretion. Islets (2012) 0.82
Glucagon secretion from pancreatic α-cells. Ups J Med Sci (2016) 0.81
Model for glucagon secretion by pancreatic α-cells. PLoS One (2012) 0.81
Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon. Diabetologia (2008) 0.81
Cyclic GMP kinase I modulates glucagon release from pancreatic α-cells. Diabetes (2010) 0.81
SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells. J Physiol (2014) 0.80
Glucose control of glucagon secretion-'There's a brand-new gimmick every year'. Ups J Med Sci (2016) 0.80
TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion. Mol Endocrinol (2015) 0.80
Intra-islet glucagon secretion and action in the regulation of glucose homeostasis. Front Physiol (2013) 0.79
Pancreatic islet cells: a model for calcium-dependent peptide release. HFSP J (2010) 0.79
Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells. PLoS One (2014) 0.77
Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders. Acta Pharmacol Sin (2011) 0.77
The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing. Diabetes (2009) 0.76
Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia. Diabetes (2011) 0.76
Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. Sci Rep (2016) 0.76
Obesity: Current and potential pharmacotherapeutics and targets. Pharmacol Ther (2016) 0.75
CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells. Sci Rep (2017) 0.75
Response to Comment on: Allister et al. UCP2 regulates the glucagon response to fasting and starvation. Diabetes 2013;62:1623-1633. Diabetes (2013) 0.75
Functional identification of islet cell types by electrophysiological fingerprinting. J R Soc Interface (2017) 0.75
Paracrine regulation of glucagon secretion: the β/α/δ model. Am J Physiol Endocrinol Metab (2016) 0.75
Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia. Circulation (2017) 0.75
Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes. Diabetologia (2002) 6.00
Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev (2007) 3.86
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci (2001) 3.72
ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest (2005) 3.56
Diverse causes of hypoglycemia-associated autonomic failure in diabetes. N Engl J Med (2004) 3.15
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol (2003) 2.55
Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest (1984) 2.52
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature (1989) 2.50
Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes (2005) 2.20
Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels. J Physiol (2000) 2.05
Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes (2005) 2.04
Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes (2000) 1.88
Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.83
A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome (2004) 1.82
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes (2004) 1.73
Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells. Diabetologia (2006) 1.70
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells. Diabetes (2004) 1.66
Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells. Naunyn Schmiedebergs Arch Pharmacol (1988) 1.66
Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels. J Gen Physiol (1997) 1.62
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol (2004) 1.60
Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans. Diabetes (1999) 1.55
Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes (2002) 1.49
Impact of lack of suppression of glucagon on glucose tolerance in humans. Am J Physiol (1999) 1.44
Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes (2004) 1.43
A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell. Cell Calcium (2004) 1.41
Paradoxical stimulation of glucagon secretion by high glucose concentrations. Diabetes (2006) 1.40
Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology (2005) 1.35
In vivo inhibition of glucagon secretion by paracrine beta cell activity in man. J Clin Invest (1981) 1.33
Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells. Pflugers Arch (1999) 1.32
Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans. Endocrine (2000) 1.22
Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis. Diabetes (2004) 1.14
Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J Physiol (2006) 1.09
The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia. Diabetes (2002) 1.08
Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat. Endocrinology (2006) 1.05
Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition. Endocrinology (2006) 1.05
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor. Am J Physiol Endocrinol Metab (2005) 1.04
The Berson memorial lecture. Insulin-glucagon relationships in the defense against hypoglycemia. Diabetes (1983) 1.03
Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes (2004) 1.02
Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism. Diabetes (2005) 0.96
A high concentration of circulating insulin suppresses the glucagon response to hypoglycemia in normal man. J Clin Endocrinol Metab (1991) 0.95
The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans. J Clin Endocrinol Metab (1997) 0.93
Glucose regulation of glucagon secretion independent of B cell activity. Metabolism (1983) 0.90
Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement. Endocrinology (2005) 0.90
Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreas. Diabetes (1997) 0.88
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. Diabetes (1993) 0.87
Effect of physiological hyperinsulinemia on counterregulatory hormone responses during hypoglycemia in humans. J Clin Endocrinol Metab (1992) 0.86
Increased glucose tolerance in N-type Ca2+ channel alpha(1B)-subunit gene-deficient mice. Int J Mol Med (2005) 0.83
Immuno-localization of sulphonylurea receptor 1 in rat pancreas. Diabetologia (1999) 0.83
Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: evidence for a direct, non-paracrine effect. Diabetologia (1986) 0.82
The actions of arginine and glucose on glucagon secretion are mediated by opposite effects on cytoplasmic Ca2+. Biochem Biophys Res Commun (1987) 0.81
Mechanism, temporal patterns, and magnitudes of the metabolic responses to the KATP channel agonist diazoxide. Am J Physiol Endocrinol Metab (2004) 0.81
Fluctuations of calcium, phosphorus, sodium, potassium, and chlorine in single alpha and beta cells during glucose perifusion of rat islets. J Clin Invest (1981) 0.81
Calcium dependency of glucagon release: its modulation by nutritional factors. Am J Physiol (1979) 0.80
Cell type-specific activation of metabolism reveals that beta-cell secretion suppresses glucagon release from alpha-cells in rat pancreatic islets. Am J Physiol Endocrinol Metab (2005) 0.78
In vivo and in vitro effects of somatostatin and insulin on glucagon release in a human glucagonoma. Clin Endocrinol (Oxf) (1997) 0.77
The role of calcium in glucagon release. Interactions between arginine and calcium. Horm Res (1976) 0.77
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Res (2005) 4.98
miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A (2009) 3.89
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69
Diabetes mellitus and the β cell: the last ten years. Cell (2012) 3.31
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet (2009) 3.07
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell (2009) 2.57
Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes (2008) 2.48
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab (2012) 2.46
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch (2002) 2.21
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet (2003) 2.21
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology (2008) 2.09
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab (2012) 1.93
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science (2009) 1.90
The Cell Physiology of Biphasic Insulin Secretion. News Physiol Sci (2000) 1.83
Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.83
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes (2004) 1.73
Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. Basic Clin Pharmacol Toxicol (2004) 1.73
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. J Clin Invest (2004) 1.69
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol (2003) 1.68
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells. Diabetes (2004) 1.66
Quantification of mRNA in single cells and modelling of RT-qPCR induced noise. BMC Mol Biol (2008) 1.63
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes (2012) 1.61
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. J Physiol (2004) 1.60
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells. Diabetes (2002) 1.53
Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells. Neuron (2002) 1.51
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J (2003) 1.51
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest (2008) 1.50
Novel aspects of the molecular mechanisms controlling insulin secretion. J Physiol (2008) 1.49
A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes (2009) 1.42
Selective nucleotide-release from dense-core granules in insulin-secreting cells. J Cell Sci (2005) 1.39
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev (2008) 1.38
Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β. PLoS One (2012) 1.36
CaV2.3 calcium channels control second-phase insulin release. J Clin Invest (2005) 1.35
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes (2010) 1.34
Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. J Physiol (2009) 1.34
K(ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol (2013) 1.33
Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. J Gen Physiol (2004) 1.31
Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science (2010) 1.31
Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metab (2009) 1.26
Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum. Hum Mol Genet (2009) 1.24
Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells. Cell Metab (2006) 1.24
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. Eur J Endocrinol (2007) 1.23
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3. Cell Metab (2009) 1.22
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse. Proc Natl Acad Sci U S A (2007) 1.22
Type 2 diabetes mellitus: not quite exciting enough? Hum Mol Genet (2004) 1.21
Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. J Physiol (2004) 1.20
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proc Natl Acad Sci U S A (2003) 1.20
Differential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat. PLoS One (2011) 1.19
Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab (2013) 1.18
MicroRNA-7a regulates pancreatic β cell function. J Clin Invest (2014) 1.18
Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol. FASEB J (2008) 1.17
Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane. Diabetes (2007) 1.15