PubRank

David H Rowitch

Author PubWeight™ 162.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 2010 9.81
2 Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 2002 5.64
3 Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002 5.11
4 Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 2008 5.06
5 Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 2008 4.68
6 Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 2004 4.55
7 Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 2007 4.47
8 Corridors of migrating neurons in the human brain and their decline during infancy. Nature 2011 4.12
9 Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 2003 3.88
10 bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 2004 3.20
11 Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev 2009 2.96
12 Glioma stem cells: a midterm exam. Neuron 2008 2.69
13 The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol 2004 2.66
14 Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A 2003 2.64
15 Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci 2011 2.61
16 Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res 2010 2.56
17 Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science 2012 2.53
18 Development of mice expressing a single D-type cyclin. Genes Dev 2002 2.43
19 Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 2003 2.42
20 Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A 2009 2.41
21 CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell 2010 2.40
22 Astrocytes and disease: a neurodevelopmental perspective. Genes Dev 2012 2.28
23 Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron 2007 2.23
24 Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell 2009 2.18
25 Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev 2004 2.16
26 Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A 2006 2.04
27 Neural stem cell engraftment and myelination in the human brain. Sci Transl Med 2012 1.96
28 The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell 2011 1.92
29 Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol 2008 1.87
30 Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A 2011 1.86
31 Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron 2011 1.83
32 Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res 2011 1.79
33 Olig gene function in CNS development and disease. Glia 2006 1.77
34 Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A 2004 1.77
35 Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A 2004 1.76
36 Myelin regeneration: a recapitulation of development? Annu Rev Neurosci 2011 1.70
37 Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression. J Neurosci 2012 1.68
38 N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res 2006 1.64
39 Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev 2012 1.64
40 Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature 2005 1.62
41 Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A 2011 1.57
42 Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol 2010 1.47
43 Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A 2009 1.46
44 Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol Cell Biol 2007 1.38
45 Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord. Glia 2006 1.35
46 A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci 2013 1.35
47 A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med 2011 1.35
48 Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol 2005 1.34
49 The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell 2005 1.34
50 Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol 2003 1.29
51 Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell 2012 1.28
52 Beta-catenin function is required for cerebellar morphogenesis. Brain Res 2006 1.28
53 Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A 2002 1.27
54 A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci 2009 1.27
55 Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism. J Clin Invest 2009 1.23
56 Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci 2012 1.22
57 Medulloblastoma: a problem of developmental biology. Cancer Cell 2002 1.21
58 Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp Neurol 2010 1.20
59 NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants. Pediatrics 2011 1.20
60 Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A 2012 1.15
61 Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development 2012 1.13
62 Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development 2012 1.13
63 Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci 2003 1.13
64 Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. J Clin Invest 2012 1.12
65 Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. J Neuropathol Exp Neurol 2006 1.10
66 Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathol 2012 1.05
67 Towards improved animal models of neonatal white matter injury associated with cerebral palsy. Dis Model Mech 2010 1.05
68 Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years. Neuron 2013 1.00
69 Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development 2003 0.99
70 Myelin regeneration in multiple sclerosis: targeting endogenous stem cells. Neurotherapeutics 2011 0.93
71 Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity. PLoS One 2012 0.92
72 STAT3-mediated astrogliosis protects myelin development in neonatal brain injury. Ann Neurol 2012 0.91
73 Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia 2013 0.90
74 Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination. Exp Neurol 2012 0.90
75 Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev 2002 0.89
76 Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis. Mol Cell Neurosci 2006 0.88
77 Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res 2008 0.88
78 Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma. Cancer Res 2010 0.86
79 Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease. Hum Mol Genet 2013 0.86
80 Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One 2013 0.85
81 Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol 2006 0.85
82 Myelin restoration: progress and prospects for human cell replacement therapies. Arch Immunol Ther Exp (Warsz) 2011 0.85
83 Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol 2012 0.85
84 NIH consensus development conference: Inhaled nitric oxide therapy for premature infants. NIH Consens State Sci Statements 2010 0.84
85 Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain. Neurobiol Dis 2010 0.84
86 Postnatal growth of the human pons: a morphometric and immunohistochemical analysis. J Comp Neurol 2014 0.83
87 Role of academic medical centers in cell-based therapeutic clinical trials. Transl Res 2011 0.75
88 Synchronization of goat fibroblast cells at quiescent stage and determination of their transition from G0 to G1 by detection of cyclin D1 mRNA. Cloning Stem Cells 2004 0.75