Steven Reiken

Author PubWeight™ 53.29‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 2002 4.49
2 Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med 2009 3.27
3 Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell 2005 3.01
4 Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A 2006 2.81
5 Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest 2008 2.45
6 The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest 2002 2.26
7 Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A 2008 2.16
8 Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab 2011 2.06
9 Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A 2005 1.99
10 A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm 2007 1.98
11 Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A 2006 1.87
12 Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res 2012 1.80
13 Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest 2010 1.77
14 Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A 2010 1.67
15 Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A 2010 1.63
16 Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest 2010 1.60
17 Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. J Clin Invest 2011 1.41
18 Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest 2015 1.38
19 Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor? Circulation 2002 1.16
20 Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties. J Am Coll Cardiol 2005 1.13
21 Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A 2006 1.13
22 Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex. J Biol Chem 2002 1.09
23 Overexpression of beta2-adrenergic receptors cAMP-dependent protein kinase phosphorylates and modulates slow delayed rectifier potassium channels expressed in murine heart: evidence for receptor/channel co-localization. J Biol Chem 2004 0.98
24 Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor. J Physiol 2012 0.97
25 Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers. Trends Cardiovasc Med 2002 0.96
26 A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circ Res 2011 0.96
27 Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skelet Muscle 2012 0.95
28 Nonshivering thermogenesis protects against defective calcium handling in muscle. FASEB J 2008 0.95
29 Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB J 2011 0.94
30 Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest 2015 0.87
31 Bradycardic therapy improves left ventricular function and remodeling in dogs with coronary embolization-induced chronic heart failure. J Pharmacol Exp Ther 2007 0.85
32 Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure. J Heart Lung Transplant 2013 0.83
33 Reply from Daniel C. Andersson, Matthew J. Betzenhauser, Steven Reiken, Alisa Umanskaya, Takayuki Shiomi and Andrew R. Marks. J Physiol 2013 0.75