Published in J Clin Invest on June 01, 2008
Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. Circ Res (2011) 2.37
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06
Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med (2009) 1.97
Detection of protein S-nitrosylation with the biotin-switch technique. Free Radic Biol Med (2008) 1.95
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol Med (2012) 1.93
Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2012) 1.80
Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice. Cardiovasc Res (2012) 1.77
Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77
Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell (2012) 1.75
Calcium cycling proteins and heart failure: mechanisms and therapeutics. J Clin Invest (2013) 1.74
De novo mutations in moderate or severe intellectual disability. PLoS Genet (2014) 1.64
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A (2010) 1.63
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res (2010) 1.61
Special article: Future directions in malignant hyperthermia research and patient care. Anesth Analg (2011) 1.61
In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell Physiol Biochem (2011) 1.43
Beta-adrenergic stimulation and myocardial function in the failing heart. Heart Fail Rev (2009) 1.40
Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A (2016) 1.39
Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res (2013) 1.37
Ryanodine receptor channelopathies. Pflugers Arch (2010) 1.33
Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol (2010) 1.31
Endoplasmic-reticulum calcium depletion and disease. Cold Spring Harb Perspect Biol (2011) 1.31
Ryanodine receptors: structure and function. J Biol Chem (2012) 1.30
Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Proc Natl Acad Sci U S A (2008) 1.26
Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents? Am J Physiol Heart Circ Physiol (2012) 1.22
Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signaling. Am J Physiol Cell Physiol (2009) 1.21
Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart. Heart Fail Rev (2009) 1.19
Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin. J Mol Cell Cardiol (2011) 1.19
Ca2+ cycling and new therapeutic approaches for heart failure. Circulation (2010) 1.16
Mitochondria in cardiomyocyte Ca2+ signaling. Int J Biochem Cell Biol (2009) 1.14
The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol (2010) 1.09
Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep (2015) 1.09
Calsequestrin 2 and arrhythmias. Am J Physiol Heart Circ Physiol (2011) 1.08
Epilepsy is a risk factor for sudden cardiac arrest in the general population. PLoS One (2012) 1.08
Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases. J Mol Cell Cardiol (2013) 1.08
Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects. Cell Calcium (2013) 1.07
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res (2010) 1.05
Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle. Drug Discov Today Dis Mech (2010) 1.04
Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med (2010) 1.02
Superresolution modeling of calcium release in the heart. Biophys J (2014) 1.02
Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity. J Gen Physiol (2010) 1.01
Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proc Natl Acad Sci U S A (2011) 1.00
Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res (2013) 0.98
Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia. Circulation (2011) 0.96
A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circ Res (2011) 0.96
Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo. J Biol Chem (2013) 0.96
Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skelet Muscle (2012) 0.95
Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface. Nat Commun (2013) 0.95
Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence. Annu Rev Physiol (2014) 0.92
Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res (2009) 0.92
Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.92
Ryanodine receptor studies using genetically engineered mice. FEBS Lett (2010) 0.92
Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine. J Mol Cell Cardiol (2009) 0.90
Role of ryanodine receptor subtypes in initiation and formation of calcium sparks in arterial smooth muscle: comparison with striated muscle. J Biomed Biotechnol (2009) 0.90
Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin (2011) 0.88
Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet (2013) 0.87
Genomic biomarkers of SUDEP in brain and heart. Epilepsy Behav (2013) 0.87
Targeting cardiomyocyte Ca2+ homeostasis in heart failure. Curr Pharm Des (2015) 0.87
Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol Pharmacol (2011) 0.87
Posttranslational modifications of cardiac ryanodine receptors: Ca(2+) signaling and EC-coupling. Biochim Biophys Acta (2012) 0.86
Calsequestrin mutations and catecholaminergic polymorphic ventricular tachycardia. Pediatr Cardiol (2012) 0.85
Regulation of Ryanodine Receptor Ion Channels Through Posttranslational Modifications. Curr Top Membr (2010) 0.84
Axial tubule junctions control rapid calcium signaling in atria. J Clin Invest (2016) 0.83
Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide. Heart Rhythm (2012) 0.83
Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification. Front Physiol (2013) 0.83
The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. J Comp Neurol (2013) 0.83
CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm (2010) 0.82
Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention. Epilepsia (2016) 0.81
Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107. PLoS One (2013) 0.80
Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo. Neurotoxicology (2011) 0.80
Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.80
Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions. Int J Cardiol (2014) 0.79
Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice. Heart Rhythm (2014) 0.79
Mechanisms of sudden unexplained death in epilepsy. Curr Opin Neurol (2015) 0.79
Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies. Ther Clin Risk Manag (2016) 0.78
Carvedilol tweaks calcium release to ease arrhythmias. Nat Med (2011) 0.78
Intracellular calcium release channels: an update. J Physiol (2017) 0.78
Cross-reactivity of ryanodine receptors with plasma membrane ion channel modulators. Mol Pharmacol (2011) 0.77
Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients. Cell Calcium (2015) 0.77
Novel strategies for the treatment of heart failure. Rambam Maimonides Med J (2012) 0.77
Ryanodine receptor sensitivity governs the stability and synchrony of local calcium release during cardiac excitation-contraction coupling. J Mol Cell Cardiol (2016) 0.76
Novel drug targets in clinical development for heart failure. Eur J Clin Pharmacol (2014) 0.76
Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor. PLoS One (2014) 0.76
The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis. Heart Fail Rev (2013) 0.76
Novel carvedilol analogues that suppress store-overload-induced Ca2+ release. J Med Chem (2013) 0.76
Genetic biomarkers for the risk of seizures in long QT syndrome. Neurology (2016) 0.75
Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals. Circ Arrhythm Electrophysiol (2017) 0.75
RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism. JCI Insight (2017) 0.75
Array comparative genomic hybridization identifies a heterozygous deletion of exon 3 of the RYR2 gene. Ups J Med Sci (2015) 0.75
Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs. Int J Cardiol (2016) 0.75
Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release. Cardiovasc Res (2016) 0.75
Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease. Expert Opin Ther Targets (2011) 0.75
Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias. Front Physiol (2014) 0.75
Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability. J Neurophysiol (2016) 0.75
Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival. Sci Rep (2016) 0.75
Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia. Sci Rep (2016) 0.75
Calcium Signaling and Cardiac Arrhythmias. Circ Res (2017) 0.75
Murine Electrophysiological Models of Cardiac Arrhythmogenesis. Physiol Rev (2017) 0.75
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell (1995) 7.73
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature (1998) 7.26
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature (2003) 5.94
Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation (2002) 5.94
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation (2001) 5.68
De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy. Am J Hum Genet (2001) 5.61
Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet (1998) 4.91
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68
A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet (1998) 4.25
Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients. Circulation (1995) 4.19
A potassium channel mutation in neonatal human epilepsy. Science (1998) 4.17
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res (2004) 4.11
Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59
Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol (1998) 3.58
An astrocytic basis of epilepsy. Nat Med (2005) 3.50
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (2004) 3.45
Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor. Circ Res (2005) 3.44
A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Am J Hum Genet (2001) 3.38
Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation (2001) 3.34
Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2007) 3.20
Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor. Nature (1989) 3.17
First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet (2001) 3.15
Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet (2001) 3.12
Cardiac arrhythmias in focal epilepsy: a prospective long-term study. Lancet (2004) 3.02
FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem (1992) 3.02
Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circ Res (2006) 2.81
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation (2004) 2.69
High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system. Circ Res (2000) 2.61
Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J Neurosci (1997) 2.60
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A (2008) 2.16
Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem (2007) 2.14
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm (2007) 1.98
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients. J Med Genet (2005) 1.78
Pathogenesis of unexplained drowning: new insights from a molecular autopsy. Mayo Clin Proc (2005) 1.76
Effects of rapamycin on ryanodine receptor/Ca(2+)-release channels from cardiac muscle. Circ Res (1996) 1.62
Incidence of sudden unexpected death in an adult outpatient cohort with epilepsy at a tertiary referral centre. J Neurol Neurosurg Psychiatry (1995) 1.58
Characteristics and function of Ca(2+)- and inositol 1,4,5-trisphosphate-releasable stores of Ca2+ in neurons. Neuroscience (1992) 1.53
Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. J Neurosci (1999) 1.52
Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia. J Cell Physiol (2002) 1.43
Risk factors in sudden death in epilepsy (SUDEP): the quest for mechanisms. Epilepsia (2007) 1.39
Astrocytes in adult rat brain express type 2 inositol 1,4,5-trisphosphate receptors. Glia (2002) 1.33
Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies. Physiol Genomics (2003) 1.31
The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse. J Neurosci (1997) 1.30
Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. J Biol Chem (2007) 1.17
Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain. Nat Neurosci (1999) 1.17
Intracellular calcium release channel expression during embryogenesis. Dev Biol (1999) 1.15
Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br J Pharmacol (2007) 1.08
The Long QT and Brugada syndromes: causes of unexpected syncope and sudden cardiac death in children and young adults. Semin Pediatr Neurol (2005) 1.02
Brugada syndrome: an unusual cause of convulsive syncope. Arch Intern Med (2002) 1.01
Regulation of ryanodine receptors in the heart. Circ Res (2007) 1.00
2APB- and JTV519(K201)-sensitive micro Ca2+ waves in arrhythmogenic Purkinje cells that survive in infarcted canine heart. Heart Rhythm (2004) 1.00
Calcium stores in neurons and glia. Neuroscience (1994) 0.99
Sudden death in epilepsy: a wake-up call for management. Lancet (2002) 0.95
Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus. Epilepsy Res (2005) 0.88
Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel. Epilepsia (2006) 0.88
K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization. Eur J Pharmacol (2006) 0.86
Altered hippocampal network excitability in the hypernoradrenergic mutant mouse tottering. Brain Res (1990) 0.85
Characteristics of Chinese patients with symptomatic Brugada syndrome in Taiwan. Cardiology (2003) 0.83
Brugada syndrome: a case study of aborted sudden cardiac death manifesting as seizures. Crit Care Nurse (2001) 0.78
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science (1993) 17.63
Relaxation of arterial smooth muscle by calcium sparks. Science (1995) 10.27
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol (2003) 6.34
The control of calcium release in heart muscle. Science (1995) 6.05
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature (2003) 5.94
Calmodulin kinase II inhibition protects against structural heart disease. Nat Med (2005) 5.87
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature (1993) 5.69
Sodium/calcium exchange: its physiological implications. Physiol Rev (1999) 5.42
Calcium sparks and [Ca2+]i waves in cardiac myocytes. Am J Physiol (1996) 5.18
Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes. Biophys J (1994) 5.14
Two mechanisms of quantized calcium release in skeletal muscle. Nature (1996) 4.95
Rescuing the NIH before it is too late. J Clin Invest (2006) 4.85
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science (1997) 4.81
Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. J Physiol (1978) 4.72
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68
Effect of membrane potential changes on the calcium transient in single rat cardiac muscle cells. Science (1987) 4.55
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (2002) 4.49
Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (2002) 4.40
Molecular physiology of cardiac repolarization. Physiol Rev (2005) 4.37
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res (2004) 4.11
Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A (2006) 3.99
Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation (2002) 3.76
Calcium sparks. Physiol Rev (2008) 3.64
Calcium sparks in smooth muscle. Am J Physiol Cell Physiol (2000) 3.57
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (2004) 3.45
Cellular and subcellular heterogeneity of [Ca2+]i in single heart cells revealed by fura-2. Science (1987) 3.39
Relation between the sarcolemmal Ca2+ current and Ca2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ Res (1996) 3.30
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med (2009) 3.27
X-ROS signaling: rapid mechano-chemo transduction in heart. Science (2011) 3.20
Intracellular calcium release and cardiac disease. Annu Rev Physiol (2005) 3.14
Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation. Science (1995) 3.05
A simple numerical model of calcium spark formation and detection in cardiac myocytes. Biophys J (1998) 3.04
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81
Voltage-independent calcium release in heart muscle. Science (1990) 2.80
Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres. J Physiol (1976) 2.78
Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol (1991) 2.76
Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron (2013) 2.74
Long QT syndrome: from channels to cardiac arrhythmias. J Clin Invest (2005) 2.71
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation (2004) 2.69
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation (2003) 2.57
Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc Natl Acad Sci U S A (2007) 2.49
Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation (2003) 2.46
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci U S A (2008) 2.37
Excitation-contraction coupling in heart: new insights from Ca2+ sparks. Cell Calcium (1996) 2.30
Ca2+ ions can affect intracellular pH in mammalian cardiac muscle. Nature (1983) 2.29
Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature (1991) 2.28
Inotropic and arrhythmogenic effects of potassium-depleted solutions on mammalian cardiac muscle. J Physiol (1979) 2.28
The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest (2002) 2.26
Fear erasure in mice requires synergy between antidepressant drugs and extinction training. Science (2011) 2.25
Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A (2008) 2.16
The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres. J Physiol (1981) 2.15
Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation (2005) 2.15
Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem (2007) 2.14
The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nat Methods (2006) 2.14
Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium. Circ Res (1989) 2.11
Propagation of excitation-contraction coupling into ventricular myocytes. Pflugers Arch (1994) 2.11
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06
Ca2+ flux through promiscuous cardiac Na+ channels: slip-mode conductance. Science (1998) 2.04
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J Physiol (2007) 2.03
Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J (2006) 2.03
Intracellular Ca transients in rat cardiac myocytes: role of Na-Ca exchange in excitation-contraction coupling. Am J Physiol (1990) 1.99
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A (2005) 1.99
Ca2+ diffusion and sarcoplasmic reticulum transport both contribute to [Ca2+]i decline during Ca2+ sparks in rat ventricular myocytes. J Physiol (1996) 1.98
A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm (2007) 1.98
Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends Cardiovasc Med (2005) 1.97
Characterization of the electrogenic sodium pump in cardiac Purkinje fibres. J Physiol (1980) 1.96
Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nat Neurosci (2008) 1.92
Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone. Acta Physiol Scand (1998) 1.91
Ca2+ and voltage inactivate Ca2+ channels in guinea-pig ventricular myocytes through independent mechanisms. J Physiol (1991) 1.91
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
Calmodulin mediates Ca2+ sensitivity of sodium channels. J Biol Chem (2004) 1.85
In vivo monitoring of Ca(2+) uptake into mitochondria of mouse skeletal muscle during contraction. J Cell Biol (2004) 1.85
Na-Ca exchange: stoichiometry and electrogenicity. Am J Physiol (1985) 1.83
Thick slurry bevelling: a new technique for bevelling extremely fine microelectrodes and micropipettes. Pflugers Arch (1979) 1.82
Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2012) 1.80
Secondary structure of the human cardiac Na+ channel C terminus: evidence for a role of helical structures in modulation of channel inactivation. J Biol Chem (2001) 1.78