| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Effects of magnesium and related divalent metal ions in topoisomerase structure and function.
|
Nucleic Acids Res
|
2009
|
1.32
|
|
2
|
Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.
|
J Biol Chem
|
2005
|
1.19
|
|
3
|
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation.
|
J Med Chem
|
2008
|
1.10
|
|
4
|
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.
|
J Am Chem Soc
|
2009
|
1.04
|
|
5
|
Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases.
|
Nucleic Acids Res
|
2007
|
1.02
|
|
6
|
The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective.
|
Biochimie
|
2011
|
0.99
|
|
7
|
The quinolone family: from antibacterial to anticancer agents.
|
Curr Med Chem Anticancer Agents
|
2003
|
0.97
|
|
8
|
A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter.
|
J Med Chem
|
2013
|
0.96
|
|
9
|
Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents.
|
J Am Chem Soc
|
2010
|
0.96
|
|
10
|
New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action.
|
Antimicrob Agents Chemother
|
2003
|
0.94
|
|
11
|
Binol quinone methides as bisalkylating and DNA cross-linking agents.
|
J Am Chem Soc
|
2004
|
0.92
|
|
12
|
In front of and behind the replication fork: bacterial type IIA topoisomerases.
|
Cell Mol Life Sci
|
2010
|
0.92
|
|
13
|
Toward efficient Zn(II)-based artificial nucleases.
|
J Am Chem Soc
|
2004
|
0.91
|
|
14
|
Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.
|
Antimicrob Agents Chemother
|
2004
|
0.89
|
|
15
|
Structure modifications of 6-aminoquinolones with potent anti-HIV activity.
|
J Med Chem
|
2004
|
0.88
|
|
16
|
Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.
|
PLoS One
|
2013
|
0.87
|
|
17
|
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives.
|
Bioorg Med Chem
|
2007
|
0.86
|
|
18
|
Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.
|
Nucleic Acids Res
|
2003
|
0.86
|
|
19
|
Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage.
|
Autophagy
|
2012
|
0.86
|
|
20
|
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.
|
Int J Cancer
|
2003
|
0.86
|
|
21
|
DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action.
|
Biochemistry
|
2008
|
0.85
|
|
22
|
The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.
|
Antimicrob Agents Chemother
|
2010
|
0.85
|
|
23
|
Heterocyclic dications as a new class of telomeric G-quadruplex targeting agents.
|
Curr Pharm Des
|
2012
|
0.85
|
|
24
|
Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents.
|
J Med Chem
|
2003
|
0.85
|
|
25
|
Antiviral properties of quinolone-based drugs.
|
Curr Drug Targets Infect Disord
|
2004
|
0.84
|
|
26
|
BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photocytotoxic agents.
|
J Med Chem
|
2007
|
0.84
|
|
27
|
Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.
|
Bioorg Med Chem Lett
|
2008
|
0.84
|
|
28
|
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage.
|
Nucleic Acids Res
|
2008
|
0.84
|
|
29
|
Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.
|
Biochimie
|
2011
|
0.83
|
|
30
|
Quinone methide generation via photoinduced electron transfer.
|
J Org Chem
|
2011
|
0.83
|
|
31
|
Differential targeting of unpaired bases within duplex DNA by the natural compound clerocidin: a valuable tool to dissect DNA secondary structure.
|
PLoS One
|
2012
|
0.82
|
|
32
|
Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage.
|
Nucleic Acids Res
|
2006
|
0.82
|
|
33
|
Concerted bis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA.
|
Nucleic Acids Res
|
2004
|
0.82
|
|
34
|
Antiviral 6-amino-quinolones: molecular basis for potency and selectivity.
|
Bioorg Med Chem Lett
|
2005
|
0.81
|
|
35
|
Clerocidin-mediated DNA footprinting discriminates among different G-quadruplex conformations and detects tetraplex folding in a duplex environment.
|
Biochim Biophys Acta
|
2013
|
0.81
|
|
36
|
Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers.
|
Biochem Pharmacol
|
2004
|
0.81
|
|
37
|
Folding versus charge: understanding selective target recognition by the thrombin aptamers.
|
Curr Pharm Des
|
2012
|
0.80
|
|
38
|
Effects of common buffer systems on drug activity: the case of clerocidin.
|
Chem Res Toxicol
|
2004
|
0.80
|
|
39
|
Reactivity of clerocidin towards adenine: implications for base-modulated DNA damage.
|
Org Biomol Chem
|
2009
|
0.80
|
|
40
|
Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges.
|
Curr Med Chem Anticancer Agents
|
2004
|
0.79
|
|
41
|
Efficient plasmid DNA cleavage by a mononuclear copper(II) complex.
|
Inorg Chem
|
2005
|
0.79
|
|
42
|
Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences.
|
Bioorg Med Chem
|
2008
|
0.79
|
|
43
|
Tuning G-quadruplex vs double-stranded DNA recognition in regioisomeric lysyl-peptidyl-anthraquinone conjugates.
|
Bioconjug Chem
|
2011
|
0.79
|
|
44
|
Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G.
|
Biochem Pharmacol
|
2005
|
0.79
|
|
45
|
Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives.
|
ChemMedChem
|
2010
|
0.78
|
|
46
|
Metal ion and inter-domain interactions as functional networks in E. coli topoisomerase I.
|
Gene
|
2013
|
0.78
|
|
47
|
Tuning the activity of Zn(II) complexes in DNA cleavage: clues for design of new efficient metallo-hydrolases.
|
Inorg Chem
|
2008
|
0.77
|
|
48
|
Effect of G-quadruplex polymorphism on the recognition of telomeric DNA by a metal complex.
|
PLoS One
|
2013
|
0.77
|
|
49
|
Metal ion-mediated assembly of effective phenanthroline-based G-quadruplex ligands.
|
Dalton Trans
|
2009
|
0.77
|
|
50
|
Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition.
|
Bioorg Med Chem
|
2006
|
0.77
|
|
51
|
Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites.
|
Chem Commun (Camb)
|
2013
|
0.77
|
|
52
|
Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting.
|
Bioorg Med Chem Lett
|
2009
|
0.77
|
|
53
|
Interaction model for anthracycline activity against DNA topoisomerase II.
|
Biochemistry
|
2004
|
0.77
|
|
54
|
Effective DNA inhibitors of cathepsin g by in vitro selection.
|
Int J Mol Sci
|
2008
|
0.76
|
|
55
|
Modulation of antithrombin-protease interactions by semisynthetic low-molecular-weight heparins with different sulfation patterns.
|
Semin Thromb Hemost
|
2003
|
0.76
|
|
56
|
Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer.
|
Biochem Pharmacol
|
2010
|
0.76
|
|
57
|
Topoisomerase I involvement in schedule-dependent interaction between 5-fluoro-uracil and irinotecan in the treatment of colorectal cancer.
|
Cancer Chemother Pharmacol
|
2009
|
0.76
|
|
58
|
2-Phenylquinolones as inhibitors of the HIV-1 Tat-TAR interaction.
|
ChemMedChem
|
2009
|
0.76
|
|
59
|
Inhibitory effects of glycosaminoglycans on basal and stimulated transforming growth factor-β1 expression in mesangial cells: biochemical and structural considerations.
|
Glycobiology
|
2011
|
0.75
|
|
60
|
Antitumor potential of aza-bioisosterism in anthracenedione-based drugs.
|
Curr Top Med Chem
|
2004
|
0.75
|
|
61
|
Effects of calcium ions on the interactions between antithrombin and factor Xa mediated by variously sulfated, semisynthetic low-molecular-weight heparins.
|
Semin Thromb Hemost
|
2002
|
0.75
|
|
62
|
Alternative approaches to the discovery and development of telomerase-targeted anticancer drugs.
|
Mini Rev Med Chem
|
2003
|
0.75
|
|
63
|
Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking.
|
Org Biomol Chem
|
2006
|
0.75
|
|
64
|
2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents.
|
J Med Chem
|
2002
|
0.75
|
|
65
|
Rational design, synthesis, and DNA binding properties of novel sequence-selective peptidyl congeners of ametantrone.
|
ChemMedChem
|
2010
|
0.75
|
|
66
|
Novel ametantrone-amsacrine related hybrids as topoisomerase IIβ poisons and cytotoxic agents.
|
Arch Pharm (Weinheim)
|
2014
|
0.75
|
|
67
|
Intralesional topotecan in advanced ovarian cancer: a clinical report, based on a preclinical study.
|
Oncol Rep
|
2002
|
0.75
|
|
68
|
Dissecting reactivity of clerocidin toward common buffer systems by means of selected drug analogues.
|
Chem Res Toxicol
|
2005
|
0.75
|