Published in Bioorg Med Chem on September 25, 2007
Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Mar Drugs (2010) 1.08
Aminoglycoside binding to Oxytricha nova telomeric DNA. Biochemistry (2010) 0.98
Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer. Nucleic Acids Res (2010) 0.94
Controlled-folding of a small molecule modulates DNA G-quadruplex recognition. Chem Commun (Camb) (2008) 0.86
Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA. Sci Rep (2016) 0.75
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Res (2005) 5.34
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell (2009) 4.11
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
The structure of telomeric DNA. Curr Opin Struct Biol (2003) 2.32
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol (2002) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Influence of loop size on the stability of intramolecular DNA quadruplexes. Nucleic Acids Res (2004) 1.99
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J (2013) 1.86
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res (2005) 1.84
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
Stability of intramolecular DNA quadruplexes: comparison with DNA duplexes. Biochemistry (2003) 1.66
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61
High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler. Nucleic Acids Res (2002) 1.56
The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chem Soc Rev (2011) 1.54
Structure of a G-quadruplex-ligand complex. J Mol Biol (2003) 1.49
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Structural basis for binding of porphyrin to human telomeres. Biochemistry (2007) 1.37
Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem (2007) 1.37
Four base recognition by triplex-forming oligonucleotides at physiological pH. Nucleic Acids Res (2005) 1.37
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 1.33
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem (2006) 1.32
Effects of magnesium and related divalent metal ions in topoisomerase structure and function. Nucleic Acids Res (2009) 1.32
Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery. Curr Top Med Chem (2008) 1.32
Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Res (2007) 1.30
H-NS forms a superhelical protein scaffold for DNA condensation. Proc Natl Acad Sci U S A (2010) 1.30
Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc (2003) 1.26
Footprinting: a method for determining the sequence selectivity, affinity and kinetics of DNA-binding ligands. Methods (2007) 1.25
Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc (2008) 1.25
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
Protein kinase CK2 inhibitors: a patent review. Expert Opin Ther Pat (2012) 1.21
Quadruplex melting. Methods (2007) 1.20
Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site. J Biol Chem (2005) 1.19
Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes. Biochemistry (2007) 1.16
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res (2010) 1.16
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study. Biochemistry (2004) 1.16
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J (2008) 1.16
Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. J Am Chem Soc (2006) 1.15
Quadruplex DNA crystal structures and drug design. Biochimie (2008) 1.15
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J Med Chem (2009) 1.15
Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther (2002) 1.15
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry (2005) 1.12
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem (2006) 1.11
Sequence effects of single base loops in intramolecular quadruplex DNA. FEBS Lett (2007) 1.11
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther (2004) 1.11
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. J Med Chem (2008) 1.10
A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res (2009) 1.10
MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol (2011) 1.09
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Org Biomol Chem (2004) 1.09
Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorg Chem (2008) 1.09
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J Mol Biol (2008) 1.08
The design of G-quadruplex ligands as telomerase inhibitors. Mini Rev Med Chem (2003) 1.08
Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium. Bioorg Med Chem Lett (2005) 1.08
Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. J Am Chem Soc (2010) 1.07
Thermodynamic and kinetic stability of intermolecular triple helices containing different proportions of C+*GC and T*AT triplets. Nucleic Acids Res (2003) 1.06
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J Am Chem Soc (2002) 1.06
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res (2008) 1.06
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J Med Chem (2003) 1.05
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents. J Am Chem Soc (2009) 1.04
Characterization of a novel DNA minor-groove complex. Biophys J (2004) 1.04
Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc (2011) 1.03
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Res (2006) 1.02
Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases. Nucleic Acids Res (2007) 1.02
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry (2006) 1.02
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J (2009) 1.02
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res (2012) 1.01
Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J Am Chem Soc (2012) 1.01
Discovery of novel A3 adenosine receptor ligands based on chromone scaffold. Biochem Pharmacol (2012) 0.99
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist. J Med Chem (2002) 0.99
The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective. Biochimie (2011) 0.99
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. J Med Chem (2003) 0.99
Hemolytic effects of water-soluble fullerene derivatives. J Med Chem (2004) 0.98
Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett (2013) 0.98
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. J Med Chem (2002) 0.98