Published in J Med Chem on September 25, 2008
DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes. J Biol Inorg Chem (2009) 0.78
Inhibition of the thioesterase activity of human fatty acid synthase by 1,4- and 9,10-diones. Chem Pharm Bull (Tokyo) (2014) 0.77
Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences. Sci Rep (2016) 0.76
Thiol-functionalized anthraquinones: mass spectrometry and electrochemical studies. Monatsh Chem (2011) 0.75
Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach. Int J Med Chem (2014) 0.75
Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway. ACS Med Chem Lett (2013) 0.75
Structure of a stacked anthraquinone-DNA complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation. Oncotarget (2016) 0.75
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Res (2005) 5.34
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol (2002) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Influence of loop size on the stability of intramolecular DNA quadruplexes. Nucleic Acids Res (2004) 1.99
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res (2005) 1.84
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
Stability of intramolecular DNA quadruplexes: comparison with DNA duplexes. Biochemistry (2003) 1.66
High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler. Nucleic Acids Res (2002) 1.56
Structure of a G-quadruplex-ligand complex. J Mol Biol (2003) 1.49
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Structural basis for binding of porphyrin to human telomeres. Biochemistry (2007) 1.37
Four base recognition by triplex-forming oligonucleotides at physiological pH. Nucleic Acids Res (2005) 1.37
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 1.33
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem (2006) 1.32
Effects of magnesium and related divalent metal ions in topoisomerase structure and function. Nucleic Acids Res (2009) 1.32
Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Res (2007) 1.30
Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc (2003) 1.26
Footprinting: a method for determining the sequence selectivity, affinity and kinetics of DNA-binding ligands. Methods (2007) 1.25
Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc (2008) 1.25
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
Quadruplex melting. Methods (2007) 1.20
Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site. J Biol Chem (2005) 1.19
Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes. Biochemistry (2007) 1.16
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res (2010) 1.16
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J (2008) 1.16
Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. J Am Chem Soc (2006) 1.15
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J Med Chem (2009) 1.15
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry (2005) 1.12
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem (2006) 1.11
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther (2004) 1.11
Sequence effects of single base loops in intramolecular quadruplex DNA. FEBS Lett (2007) 1.11
A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res (2009) 1.10
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Org Biomol Chem (2004) 1.09
Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorg Chem (2008) 1.09
The design of G-quadruplex ligands as telomerase inhibitors. Mini Rev Med Chem (2003) 1.08
Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium. Bioorg Med Chem Lett (2005) 1.08
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J Mol Biol (2008) 1.08
Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. J Am Chem Soc (2010) 1.07
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J Am Chem Soc (2002) 1.06
Thermodynamic and kinetic stability of intermolecular triple helices containing different proportions of C+*GC and T*AT triplets. Nucleic Acids Res (2003) 1.06
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res (2008) 1.06
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J Med Chem (2003) 1.05
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents. J Am Chem Soc (2009) 1.04
Characterization of a novel DNA minor-groove complex. Biophys J (2004) 1.04
Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc (2011) 1.03
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Res (2006) 1.02
Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases. Nucleic Acids Res (2007) 1.02
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry (2006) 1.02
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res (2012) 1.01
Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J Am Chem Soc (2012) 1.01
The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. EMBO Rep (2006) 1.00
Photocontrolled folding and unfolding of a collagen triple helix. Angew Chem Int Ed Engl (2006) 1.00
The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective. Biochimie (2011) 0.99
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. J Med Chem (2003) 0.99
Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett (2013) 0.98
The quinolone family: from antibacterial to anticancer agents. Curr Med Chem Anticancer Agents (2003) 0.97
On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett (2011) 0.97
Mechanism of acridine-based telomerase inhibition and telomere shortening. Biochem Pharmacol (2007) 0.96
Natural and synthetic G-quadruplex interactive berberine derivatives. Bioorg Med Chem Lett (2006) 0.96
A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter. J Med Chem (2013) 0.96
Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents. J Am Chem Soc (2010) 0.96
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett (2004) 0.95
Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. J Phys Chem B (2009) 0.95
Kinetic stability of intermolecular DNA quadruplexes. Biophys J (2005) 0.95
New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action. Antimicrob Agents Chemother (2003) 0.94
Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc (2011) 0.94
Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U. Biochemistry (2002) 0.94
Selectivity in ligand recognition of G-quadruplex loops. Biochemistry (2009) 0.94
Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. J Am Chem Soc (2006) 0.93
Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. J Am Chem Soc (2006) 0.93
Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. Methods Mol Biol (2010) 0.93
A structural analysis of G-quadruplex/ligand interactions. Biochimie (2011) 0.92
Protein and drug interactions in the minor groove of DNA. Nucleic Acids Res (2002) 0.92
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. J Am Chem Soc (2007) 0.92
Binol quinone methides as bisalkylating and DNA cross-linking agents. J Am Chem Soc (2004) 0.92
In front of and behind the replication fork: bacterial type IIA topoisomerases. Cell Mol Life Sci (2010) 0.92
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents. J Med Chem (2010) 0.92
Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures. Org Biomol Chem (2012) 0.92
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc (2013) 0.92
Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chem Commun (Camb) (2009) 0.91
Toward efficient Zn(II)-based artificial nucleases. J Am Chem Soc (2004) 0.91
Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues. Chem Commun (Camb) (2005) 0.90
Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster. J Am Chem Soc (2013) 0.89
Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative. Antimicrob Agents Chemother (2004) 0.89
Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes. J Med Chem (2011) 0.88
Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands. Molecules (2013) 0.88
Stable recognition of TA interruptions by triplex forming oligonucleotides containing a novel nucleoside. Biochemistry (2005) 0.88
Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer. J Antimicrob Chemother (2009) 0.88
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorg Med Chem Lett (2008) 0.88
Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorg Med Chem Lett (2010) 0.88